A novel Ribozyme-Based prophylaxis inhibits influenza a virus replication and protects from severe disease

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Motard, Julie ^a   Rouxel, Ronan ^b   Paun, Alexandra ^a   von Messling, Veronika ^b   Bisaillon, Martin ^a   Perreault, Jean Pierre ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

^b INRS INSTITUT ARMAND FRAPPIER   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; NUCLEIC ACID; PROTEIN SOFA; RIBOZYME; UNCLASSIFIED DRUG; VIRUS RNA; ANTIVIRUS AGENT; NUCLEOPROTEIN; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; ENZYME ENGINEERING; FEMALE; HEPATITIS DELTA VIRUS; HUMAN; HUMAN CELL; INFLUENZA A; INFLUENZA VIRUS A; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN TARGETING; RNA CLEAVAGE; VIRUS REPLICATION; ANIMAL; BIOCATALYSIS; CELL STRAIN HEK293; DRUG EFFECT; ENZYMOLOGY; GENETICS; INFLUENZA; INFLUENZA VIRUS A H1N1; METABOLISM; PHYSIOLOGY; VIROLOGY;

INFLUENZA A VIRUS; MUS;

ANIMALS; ANTIVIRAL AGENTS; BASE SEQUENCE; BIOCATALYSIS; FEMALE; HEK293 CELLS; HEPATITIS DELTA VIRUS; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA, HUMAN; MICE; NUCLEOPROTEINS; RECOMBINANT PROTEINS; RNA, CATALYTIC; RNA, MESSENGER; RNA, VIRAL; VIRUS REPLICATION;

EID: 81055126606     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027327     Document Type: Article

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