Estrogen receptors and gonadal steroids in vulnerability and protection of dopamine neurons in a mouse model of Parkinson's disease

Neuropharmacology

Volumn 61, Issue 4, 2011, Pages 583-591

  Al Sweidi, Sara ^a   Morissette, Marc ^a   Bourque, Mélanie ^a   Di Paolo, Thérse ^a  

^a Université Laval   (Canada)

Author keywords

Dopamine transporters; Estrogen receptor; Knock out; MPTP; Steroid plasma levels; Striatum

Indexed keywords

3BETA ANDROSTANEDIOL; ANDROSTANOLONE; DOPAMINE; DOPAMINE TRANSPORTER; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MESSENGER RNA; SEX HORMONE; TESTOSTERONE; TYROSINE 3 MONOOXYGENASE; VESICULAR MONOAMINE TRANSPORTER 2;

3BETA ANDROSTANEDIOL BLOOD LEVEL; ANDROSTANOLONE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; CYTOTOXICITY; DOPAMINERGIC NERVE CELL; ESTRADIOL BLOOD LEVEL; ESTROGEN ACTIVITY; GENOTYPE; HORMONE BLOOD LEVEL; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN DETERMINATION; SUBSTANTIA NIGRA; TESTOSTERONE BLOOD LEVEL; WILD TYPE;

ANIMALS; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GONADAL STEROID HORMONES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONS; NEUROPROTECTIVE AGENTS; PARKINSONIAN DISORDERS; RECEPTORS, ESTROGEN; SUBSTANTIA NIGRA; VESICULAR MONOAMINE TRANSPORT PROTEINS;

EID: 80955178398     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.04.031     Document Type: Article

References (46)

1. M. Bourque, D.E. Dluzen, and T. Di Paolo Neuroprotective actions of sex steroids in Parkinson's disease Front. Neuroendocrinol. 30 2009 142 157
2. P.T. Bywood, and S.M. Johnson Dendrite loss is a characteristic early indicator of toxin-induced neurodegeneration in rat midbrain slices Exp. Neurol. 161 2000 306 316 (Pubitemid 30136552)
3. S. Callier, M. Morissette, M. Grandbois, and T. Di Paolo Stereospecific prevention by 17beta-estradiol of MPTP-induced dopamine depletion in mice Synapse 37 2000 245 251 (Pubitemid 30613021)
4. S. Callier, M. Morissette, M. Grandbois, D. Pelaprat, and T. Di Paolo Neuroprotective properties of 17beta-estradiol, progesterone, and raloxifene in MPTP C57Bl/6 mice Synapse 41 2001 131 138
5. F. Calon, S. Birdi, A.H. Rajput, O. Hornykiewicz, P.J. Bedard, and T. Di Paolo Increase of preproenkephalin mRNA levels in the putamen of Parkinson disease patients with levodopa-induced dyskinesias J. Neuropathol. Exp. Neurol. 61 2002 186 196 (Pubitemid 34127102)
6. B.J. Ciliax, G.W. Drash, J.K. Staley, S. Haber, C.J. Mobley, G.W. Miller, E.J. Mufson, D.C. Mash, and A.I. Levey Immunocytochemical localization of the dopamine transporter in human brain J. Comp. Neurol. 409 1999 38 56 (Pubitemid 29242784)
7. M. D'Astous, P. Mendez, M. Morissette, L.M. Garcia-Segura, and T. Di Paolo Implication of the phosphatidylinositol-3 kinase/protein kinase B signaling pathway in the neuroprotective effect of estradiol in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice Mol. Pharmacol. 69 2006 1492 1498
8. M. D'Astous, M. Morissette, and T. Di Paolo Effect of estrogen receptor agonists treatment in MPTP mice: evidence of neuroprotection by an ER alpha agonist Neuropharmacology 47 2004 1180 1188 (Pubitemid 39572709)
9. M. D'Astous, M. Morissette, B. Tanguay, S. Callier, and T. Di Paolo Dehydroepiandrosterone (DHEA) such as 17beta-estradiol prevents MPTP-induced dopamine depletion in mice Synapse 47 2003 10 14 (Pubitemid 35424538)
10. W. Dauer, and S. Przedborski Parkinson's disease: mechanisms and models Neuron 39 2003 889 909 (Pubitemid 37130207)
11. D.E. Dluzen Neuroprotective effects of estrogen upon the nigrostriatal dopaminergic system J. Neurocytol. 29 2000 387 399 (Pubitemid 32154521)
12. D.B. Dubal, S.W. Rau, P.J. Shughrue, H. Zhu, J. Yu, A.B. Cashion, S. Suzuki, L.M. Gerhold, M.B. Bottner, S.B. Dubal, I. Merchanthaler, M.S. Kindy, and P.M. Wise Differential modulation of estrogen receptors (ERs) in ischemic brain injury: a role for ERalpha in estradiol-mediated protection against delayed cell death Endocrinology 147 2006 3076 3084 (Pubitemid 43764643)
13. A. Ekue, J.F. Boulanger, M. Morissette, and T. Di Paolo Lack of effect of testosterone and dihydrotestosterone compared to 17beta-oestradiol in 1-methyl-4-phenyl-1,2,3,6, tetrahydropyridine-mice J. Neuroendocrinol. 14 2002 731 736
14. K. Franklin, and G. Paxinos The Mouse Brain in Stereotaxic Coordinates 1997 Academic Press San Diego, CA
15. R. Goekoop, E.J. Duschek, D.L. Knol, F. Barkhof, C. Netelenbos, P. Scheltens, and S.A. Rombouts Raloxifene exposure enhances brain activation during memory performance in healthy elderly males; its possible relevance to behavior NeuroImage 25 2005 63 75 (Pubitemid 40289138)
16. S. Green, P. Walter, V. Kumar, A. Krust, J.M. Bornert, P. Argos, and P. Chambon Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A Nature 320 1986 134 139 (Pubitemid 16105150)
17. C.J. Gruber, W. Tschugguel, C. Schneeberger, and J.C. Huber Production and actions of estrogens N. Engl. J. Med. 346 2002 340 352
18. T.S. Guillot, and G.W. Miller Protective actions of the vesicular monoamine transporter 2 (VMAT2) in monoaminergic neurons Mol. Neurobiol. 39 2009 149 170
19. O. Hornykiewicz l-DOPA: from a biologically inactive amino acid to a successful therapeutic agent Amino Acids 23 2002 65 70
20. S. Jourdain, M. Morissette, N. Morin, and T. Di Paolo Oestrogens prevent loss of dopamine transporter (DAT) and vesicular monoamine transporter (VMAT2) in substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice J. Neuroendocrinol. 17 2005 509 517 (Pubitemid 40990692)
21. J.N. Joyce, G. Smutzer, C.J. Whitty, A. Myers, and M.J. Bannon Differential modification of dopamine transporter and tyrosine hydroxylase mRNAs in midbrain of subjects with Parkinson's, Alzheimer's with parkinsonism, and Alzheimer's disease Mov. Disord. 12 1997 885 897 (Pubitemid 27496764)
22. R. Katzenschlager, and A.J. Lees Treatment of Parkinson's disease: levodopa as the first choice J. Neurol. 249 Suppl. 2 2002 II19 II24
23. M. Kilbourn, and K. Frey Striatal concentrations of vesicular monoamine transporters are identical in MPTP-sensitive (C57BL/6) and -insensitive (CD-1) mouse strains Eur. J. Pharmacol. 307 1996 227 232 (Pubitemid 26226227)
24. G.G. Kuiper, and J.A. Gustafsson The novel estrogen receptor-beta subtype: potential role in the cell- and promoter-specific actions of estrogens and anti-estrogens FEBS Lett. 410 1997 87 90 (Pubitemid 27283390)
25. E. Kuppers, and C. Beyer Expression of estrogen receptor-alpha and beta mRNA in the developing and adult mouse striatum Neurosci. Lett. 276 1999 95 98 (Pubitemid 29525498)
26. F. Labrie, A. Belanger, P. Belanger, R. Berube, C. Martel, L. Cusan, J. Gomez, B. Candas, V. Chaussade, I. Castiel, C. Deloche, and J. Leclaire Metabolism of DHEA in postmenopausal women following percutaneous administration J. Steroid Biochem. Mol. Biol. 103 2007 178 188 (Pubitemid 46157181)
27. M. Le Saux, and T. Di Paolo Influence of oestrogenic compounds on monoamine transporters in rat striatum J. Neuroendocrinol. 18 2006 25 32
28. M. Le Saux, M. Morissette, and T. Di Paolo ERbeta mediates the estradiol increase of D2 receptors in rat striatum and nucleus accumbens Neuropharmacology 50 2006 451 457 (Pubitemid 43209041)
29. C. Lewis, and D.E. Dluzen Testosterone enhances dopamine depletion by methamphetamine in male, but not female, mice Neurosci. Lett. 448 2008 130 133
30. P. Mannella, and R.D. Brinton Estrogen receptor protein interaction with phosphatidylinositol 3-kinase leads to activation of phosphorylated Akt and extracellular signal-regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of estrogen action J. Neurosci. 26 2006 9439 9447 (Pubitemid 44396857)
31. R. Marin, C.M. Ramirez, M. Gonzalez, R. Alonso, and M. Diaz Alternative estrogen receptors homologous to classical receptor alpha in murine neural tissues Neurosci. Lett. 395 2006 7 11 (Pubitemid 43175792)
32. A.J. Mhyre, and D.M. Dorsa Estrogen activates rapid signaling in the brain: role of estrogen receptor alpha and estrogen receptor beta in neurons and glia Neuroscience 138 2006 851 858
33. S.W. Mitra, E. Hoskin, J. Yudkovitz, L. Pear, H.A. Wilkinson, S. Hayashi, D.W. Pfaff, S. Ogawa, S.P. Rohrer, J.M. Schaeffer, B.S. McEwen, and S.E. Alves Immunolocalization of estrogen receptor beta in the mouse brain: comparison with estrogen receptor alpha Endocrinology 144 2003 2055 2067 (Pubitemid 36543346)
34. M. Morissette, and T. Di Paolo Sex and estrous cycle variations of rat striatal dopamine uptake sites Neuroendocrinology 58 1993 16 22 (Pubitemid 23279066)
35. M. Morissette, S. Jourdain, S. Al Sweidi, F.S. Menniti, A.D. Ramirez, and T. Di Paolo Role of estrogen receptors in neuroprotection by estradiol against MPTP toxicity Neuropharmacology 52 2007 1509 1520 (Pubitemid 46678085)
36. M. Morissette, M. Le Saux, M. D'Astous, S. Jourdain, S. Al Sweidi, N. Morin, E. Estrada-Camarena, P. Mendez, L.M. Garcia-Segura, and T. Di Paolo Contribution of estrogen receptors alpha and beta to the effects of estradiol in the brain J. Steroid Biochem. Mol. Biol. 108 2008 327 338 (Pubitemid 351179644)
37. C.W. Olanow, M.B. Stern, and K. Sethi The scientific and clinical basis for the treatment of Parkinson disease (2009) Neurology 72 2009 S1 S136
38. E.F. Rissman, S.R. Wersinger, J.A. Taylor, and D.B. Lubahn Estrogen receptor function as revealed by knockout studies: neuroendocrine and behavioral aspects Horm. Behav. 31 1997 232 243 (Pubitemid 27305721)
39. M.G. Sanchez, M. Bourque, M. Morissette, and T. Di Paolo Steroids-dopamine interactions in the pathophysiology and treatment of CNS disorders CNS Neurosci. Ther. 16 2010 e43 e71
40. R. Saunders-Pullman Estrogens and Parkinson disease: neuroprotective, symptomatic, neither, or both? Endocrine 21 2003 81 87
41. P.J. Shughrue Estrogen attenuates the MPTP-induced loss of dopamine neurons from the mouse SNc despite a lack of estrogen receptors (ERalpha and ERbeta) Exp. Neurol. 190 2004 468 477 (Pubitemid 39505000)
42. L.M. Shulman, and V. Bhat Gender disparities in Parkinson's disease Expert Rev. Neurother. 6 2006 407 416
43. A. Siderowf, and M. Stern Update on Parkinson disease Ann. Intern. Med. 138 2003 651 658 (Pubitemid 38124657)
44. C.D. Toran-Allerand Minireview: a plethora of estrogen receptors in the brain: where will it end? Endocrinology 145 2004 1069 1074 (Pubitemid 38280984)
45. L. Wang, S. Andersson, M. Warner, and J.A. Gustafsson Morphological abnormalities in the brains of estrogen receptor beta knockout mice Proc. Natl. Acad. Sci. U S A 98 2001 2792 2796 (Pubitemid 32209562)
46. G.F. Wooten, L.J. Currie, V.E. Bovbjerg, J.K. Lee, and J. Patrie Are men at greater risk for Parkinson's disease than women? J. Neurol. Neurosurg. Psychiatr. 75 2004 637 639 (Pubitemid 38406668)