Genetic variations in FOXO3A are associated with Bipolar Disorder without confering vulnerability for suicidal behavior

Journal of Affective Disorders

Volumn 133, Issue 3, 2011, Pages 633-637

  Magno, Luiz Alexandre V ^a   Santana, Cinthia V N ^a   Sacramento, Érika K ^a   Rezende, Vitor B ^a   Cardoso, Marcus V ^b   Maurício Da Silva, Luiz ^b   Neves, Fernando S ^a   Miranda, Débora M ^a   De Marco, Luiz A ^a   Correa, Humberto ^a   Romano Silva, Marco A ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

Author keywords

Bipolar Disorder; FOXO3A; Genetic variants; Suicide

Indexed keywords

TRANSCRIPTION FACTOR FKHRL1;

ADULT; ARTICLE; BIPOLAR DISORDER; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SUICIDAL BEHAVIOR;

ADULT; BIPOLAR DISORDER; DISEASE SUSCEPTIBILITY; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENETIC VARIATION; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SUICIDAL IDEATION; SUICIDE;

EID: 80955178366     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2011.04.031     Document Type: Article

References (31)

1. P. Amorim Mini International Neuropsychiatric Interview (MINI): validation of a short structured diagnostic psychiatric interview Rev. Bras. Psiquiatr. 22 2000 106 115
2. A.C. Andreazza, M. Kauer-Sant'anna, B.N. Frey, D.J. Bond, F. Kapczinski, L.T. Young, and L.N. Yatham Oxidative stress markers in bipolar disorder: a meta-analysis J. Affect. Disord. 111 2008 135 144
3. J.C. Barrett, B. Fry, J. Maller, and M.J. Daly Haploview: analysis and visualization of LD and haplotype maps Bioinformatics 15 2005 263 265 (Pubitemid 40202029)
4. D.R. Calnan, and A. Brunet The FoxO code Oncogene 27 2008 2276 2288 (Pubitemid 351501779)
5. Y.W. Chen, and S.C. Dilsaver Lifetime rates of suicide attempts among subjects with bipolar and unipolar disorders relative to subjects with other Axis I disorders Biol. Psychiatry 39 1996 896 899 (Pubitemid 26163536)
6. N. Craddock, and I. Jones Molecular genetics of bipolar disorder Br. J. Psychiatry 178 2001 S128 S133
7. F. Dudbridge Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data Hum. Hered. 66 2008 87 98 (Pubitemid 351482562)
8. F. Flachsbart, A. Caliebe, R. Kleindorp, H. Blanché, H. von Eller-Eberstein, S. Nikolaus, S. Schereiber, and A. Nebel Association of FOXO3A variation with human longevity confirmed in German centenarians Proc. Natl. Acad. Sci. USA 106 2009 2700 2705
9. K.N. Fountoulakis, H. Grunze, P. Panagiotidis, and G. Kaprinis Treatment of bipolar depression: an update J. Affect. Disord. 109 2008 21 34 (Pubitemid 351707705)
10. H. Galfalvy, Y.Y. Huang, M.A. Oquendo, D. Currier, and J.J. Mann Increased risk of suicide attempt in mood disorders and TPH1 genotype J. Affect. Disord. 115 2009 331 338
11. A.L. Hsu, C.T. Murphy, and C. Kenyon Regulation of aging and age-related disease by DAF-16 and heat-shock factor Science 300 2003 1142 1145 (Pubitemid 36583098)
12. K.S. Kendler "A gene for...": the nature of gene action in psychiatric disorders Am. J. Psychiatry 162 2005 1243 1252 (Pubitemid 40908922)
13. D.K. Lahiri, and J.I. Nurnberger Jr. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies Nucleic Acids Res. 11 1991 5444
14. X. Li, T.A. Ketter, and M.A. Frye Synaptic, intracellular, and neuroprotective mechanisms of anticonvulsants: are they relevant for the treatment and course of bipolar disorders? J. Affect. Disord. 69 2002 1 14 (Pubitemid 34722866)
15. Y. Li, W.J. Wang, H. Cao, J. Lu, C. Wu, F.Y. Hu, J. Guo, L. Zhao, F. Yang, Y.-X. Zhang, W. Li, G.-Y. Zheng, H. Cui, X. Chen, Z. Zhu, H. He, B. Dong, X. Mo, Y. Zeng, and X.-L. Tian Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations Hum. Mol. Genet. 18 2009 4897 4904
16. G.M. MacQueen, T. Hajek, and M. Alda The phenotypes of bipolar disorder: relevance for genetic investigations Mol. Psychiatry 10 2005 811 826 (Pubitemid 43080115)
17. L.A. Magno, D.M. Miranda, F.S. Neves, G.J. Pimenta, M.P. Mello, L.A. De Marco, H. Correa, and M.A. Romano-Silva Association between AKT1 but not AKTIP genetic variants and increased risk for suicidal behavior in bipolar patients Genes Brain Behav. 9 2010 411 418
18. H.K. Manji, and R.H. Lenox The nature of bipolar disorder J. Clin. Psychiatry 61 2000 42 57 (Pubitemid 32062305)
19. J.J. Mann Neurobiology of suicidal behaviour Nat. Rev. Neurosci. 4 2003 819 828 (Pubitemid 37314404)
20. Z. Mao, L. Liu, R. Zhang, and X. Li Lithium reduces FoxO3a transcriptional activity by decreasing its intracellular content Biol. Psychiatry 62 2007 1423 1430 (Pubitemid 350180723)
21. F. Marmol Lithium: Bipolar disorder and neurodegenerative diseases. Possible cellular mechanisms of the therapeutic effects of lithium Prog. Neuropsychopharmacol. Biol. Psychiatry 32 2008 1761 1771
22. K. Martinowich, R.J. Schloesser, and H.K. Manji Bipolar disorder: from genes to behavior pathways J. Clin. Invest. 119 2009 726 736
23. J.L.C. Murray, and A.D. Lopez Global mortality, disability, and the contribution of risk factors: global burden of disease study Lancet 349 1997 1436 1442 (Pubitemid 27212192)
24. F.S. Neves, L.F. Malloy-Diniz, M.A. Romano-Silva, G.C. Aguiar, L.O. de Matos, and H. Correa Is the serotonin transporter polymorphism (5-HTTLPR) a potential marker for suicidal behavior in bipolar disorder patients? J. Affect. Disord. 125 2010 98 102
25. F.C. Parra, R.C. Amado, J.R. Lambertucci, J. Rocha, C.M. Antunes, and S.D. Pena Color and genomic ancestry in Brazilians Proc Natl. Acad. Sci. USA 100 2003 177 182 (Pubitemid 36078048)
26. A. Polter, S. Yang, A.A. Zmijewska, T. van Groen, J.H. Paik, R.A. Depinho, S.L. Peng, R.S. Jope, and X. Li Forkhead box, class O transcription factors in brain: regulation and behavioral manifestation Biol. Psychiatry 65 2009 150 159
27. A. Roy, and N.L. Segal Suicidal behavior in twins: a replication J. Affect. Disord. 66 2001 71 74 (Pubitemid 32787047)
28. M. Sajatovic Bipolar disorder: disease burden Am. J. Manag. Care 11 2005 S80 S84
29. A. van der Horst, and B.M. Burgering Stressing the role of FOXO proteins in lifespan and disease Nat. Rev. Mol. Cell Biol. 8 2007 440 450 (Pubitemid 46809159)
30. B.J. Willcox, T.A. Donlon, Q. He, R. Chen, J.S. Grove, K. Yano, K.H. Masaki, D.C. Willcox, B. Rodriguez, and J.D. Curb FOXO3A genotype is strongly associated with human longevity Proc. Natl. Acad. Sci. USA 105 2008 13987 13992
31. W. Zhu, G.N. Bijur, N.A. Styles, and X. Li Regulation of FOXO3a by brain-derived neurotrophic factor in differentiated human SH-SY5Y neuroblastoma cells Brain Res. Mol. Brain Res. 126 2004 45 56 (Pubitemid 38781163)