Role of mitochondrial uncoupling protein 4 in rat inner ear

Molecular and Cellular Neuroscience

Volumn 47, Issue 4, 2011, Pages 244-253

  Smorodchenko, Alina ^a,b   Rupprecht, Anne ^a,b   Fuchs, Julia ^b   Gross, Johann ^b   Pohl, Elena E ^a,b  

^a UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Cochlea development; Hair cells; Hypoxia; Merkel cell; Mitochondrial membrane protein; Oxidative stress; Reactive oxygen species; Sensory cell; Spiral ganglion neurons; Voltage dependent anion channel

Indexed keywords

MANGANESE SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN; UNCOUPLING PROTEIN 4; VOLTAGE DEPENDENT ANION CHANNEL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORTI ORGAN; EXPLANT; HAIR CELL; HYPOXIA; IMMUNOHISTOCHEMISTRY; INNER EAR; MERKEL CELL; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SENSORY NERVE CELL; STRIA VASCULARIS; WESTERN BLOTTING;

ANIMALS; CELL HYPOXIA; EAR, INNER; HAIR CELLS, AUDITORY; HAIR CELLS, VESTIBULAR; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIA; NEURONS; OXYGEN; RATS; RATS, WISTAR; SPIRAL GANGLION; VOLTAGE-DEPENDENT ANION CHANNELS;

MODIOLUS; MURINAE; RATTUS;

EID: 80955177659     PISSN: 10447431     EISSN: 10959327     Source Type: Journal    
DOI: 10.1016/j.mcn.2011.03.002     Document Type: Article

References (41)

1. Anniko M., Thornell L.E., Ramaekers F.C., Stigbrand T. Cytokeratin diversity in epithelia of the human inner ear. Acta Otolaryngol 1989, 108:385-396.
2. Bauwens L.J., DeGroot J.C., Ramaekers F.C., Veldman J.E., Huizing E.H. Cytokeratin expression in the epithelia of the adult human cochlea. Eur Arch Otorhinolaryngol 1991, 248:293-297.
3. Beck V., Jaburek M., Breen E.P., Porter R.K., Jezek P., Pohl E.E. A new automated technique for the reconstitution of hydrophobic proteins into planar bilayer membranes. Studies of human recombinant uncoupling protein 1. Biochim Biophys Acta 2006, 1757:474-479.
4. Blokhina O., Fagerstedt K.V. Oxidative metabolism, ROS and NO under oxygen deprivation. Plant Physiol Biochem 2010, 48:359-373.
5. Borecky J., Maia I.G., Arruda P. Mitochondrial uncoupling proteins in mammals and plants. Biosci Rep 2001, 21:201-212.
6. Chan S.L., Liu D., Kyriazis G.A., Bagsiyao P., Ouyang X., Mattson M.P. Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neural cells. J Biol Chem 2006, 281:37391-37403.
7. Echtay K.S., Esteves T.C., Pakay J.L., Jekabsons M.B., Lambert A.J., Portero-Otin M., Pamplona R., Vidal-Puig A.J., Wang S., Roebuck S.J., Brand M.D. A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. EMBO J 2003, 22:4103-4110.
8. Echtay K.S., Roussel D., St Pierre J., Jekabsons M.B., Cadenas S., Stuart J.A., Harper J.A., Roebuck S.J., Morrison A., Pickering S., Clapham J.C., Brand M.D. Superoxide activates mitochondrial uncoupling proteins. Nature 2002, 415:96-99.
9. Fekete D.M., Muthukumar S., Karagogeos D. Hair cells and supporting cells share a common progenitor in the avian inner ear. J Neurosci 1998, 18:7811-7821.
10. Francis F., Koulakoff A., Boucher D., Chafey P., Schaar B., Vinet M.C., Friocourt G., McDonnell N., Reiner O., Kahn A., McConnell S.K., Berwald-Netter Y., Denoulet P., Chelly J. Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons. Neuron 1999, 23:247-256.
11. Fritzsch B., Beisel K.W., Hansen L.A. The molecular basis of neurosensory cell formation in ear development: a blueprint for hair cell and sensory neuron regeneration?. Bioessays 2006, 28:1181-1193.
12. Gross J., Machulik A., Amarjargal N., Moller R., Ungethum U., Kuban R.J., Fuchs F.U., Andreeva N., Fuchs J., Henke W., Pohl E.E., Szczepek A.J., Haupt H., Mazurek B. Expression of apoptosis-related genes in the organ of Corti, modiolus and stria vascularis of newborn rats. Brain Res 2007, 1162:56-68.
13. Gross J., Stute K., Moller R., Fuchs J., Amarjargal N., Pohl E.E., Angerstein M., Smorodchenko A., Mazurek B. Expression of prestin and Gata-3,-2,-1 mRNA in the rat organ of Corti during the postnatal period and in culture. Hear Res 2010, 261:9-21.
14. Hanak P., Jezek P. Mitochondrial uncoupling proteins and phylogenesis-UCP4 as the ancestral uncoupling protein. FEBS Lett 2001, 495:137-141.
15. Ho P.W., Chan D.Y., Kwok K.H., Chu A.C., Ho J.W., Kung M.H., Ramsden D.B., Ho S.L. Methyl-4-phenylpyridinium ion modulates expression of mitochondrial uncoupling proteins 2, 4, and 5 in catecholaminergic (SK-N-SH) cells. J Neurosci Res 2005, 81:261-268.
16. Jezek P., Krasinskaya I.P., Smirnova I., Drahota Z. Carnitine cycle in brown adipose tissue mitochondria as a tool for studying the regulatory role of fatty acids in the uncoupling protein function. FEBS Lett 1989, 243:37-40.
17. Jones J.E., Corwin J.T. Regeneration of sensory cells after laser ablation in the lateral line system: hair cell lineage and macrophage behavior revealed by time-lapse video microscopy. J Neurosci 1996, 16:649-662.
18. Kim D.K., Holbrook K.A. The appearance, density, and distribution of Merkel cells in human embryonic and fetal skin: their relation to sweat gland and hair follicle development. J Invest Dermatol 1995, 104:411-416.
19. Kitahara T., Horii A., Kizawa K., Maekawa C., Kubo T. Changes in mitochondrial uncoupling protein expression in the rat vestibular nerve after labyrinthectomy. Neurosci Res 2007, 59:237-242.
20. Kitahara T., Li H.S., Balaban C.D. Localization of the mitochondrial uncoupling protein family in the rat inner ear. Hear Res 2004, 196:39-48.
21. Kitahara T., Li-Korotky H.S., Balaban C.D. Regulation of mitochondrial uncoupling proteins in mouse inner ear ganglion cells in response to systemic kanamycin challenge. Neuroscience 2005, 135:639-653.
22. Klingenberg M., Winkler E., Echtay K. Uncoupling protein, H+ transport and regulation. Biochem Soc Trans 2001, 29:806-811.
23. Kuijpers W., Peters T.A., Tonnaer E.L., Ramaekers F.C. Expression of cytokeratin polypeptides during development of the rat inner ear. Histochemistry 1991, 96:511-521.
24. Liu D., Chan S.L., Souza-Pinto N.C., Slevin J.R., Wersto R.P., Zhan M., Mustafa K., de Cabo R., Mattson M.P. Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress. Neuromolecular Med 2006, 8:389-414.
25. Lucarz A., Brand G. Current considerations about Merkel cells. Eur J Cell Biol 2007, 86:243-251.
26. Mao W., Yu X.X., Zhong A., Li W., Brush J., Sherwood S.W., Adams S.H., Pan G. UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. FEBS Lett 1999, 443:326-330.
27. Mattson M.P., Liu D. Mitochondrial potassium channels and uncoupling proteins in synaptic plasticity and neuronal cell death. Biochem Biophys Res Commun 2003, 304:539-549.
28. Mazurek B., Winter E., Fuchs J., Haupt H., Gross J. Susceptibility of the hair cells of the newborn rat cochlea to hypoxia and ischemia. Hear Res 2003, 182:2-8.
29. Orita Y., Sando I., Miura M., Haginomori S., Hirsch B.E. Cochleosaccular pathology after perinatal and postnatal asphyxia: histopathologic findings. Otol Neurotol 2002, 23:34-38.
30. Raphael Y., Kim Y.H., Osumi Y., Izumikawa M. Non-sensory cells in the deafened organ of Corti: approaches for repair. Int J Dev Biol 2007, 51:649-654.
31. Raphael Y., Marshak G., Barash A., Geiger B. Modulation of intermediate-filament expression in developing cochlear epithelium. Differentiation 1987, 35:151-162.
32. Rio C., Dikkes P., Liberman M.C., Corfas G. Glial fibrillary acidic protein expression and promoter activity in the inner ear of developing and adult mice. J Comp Neurol 2002, 442:156-162.
33. Rupprecht A., Sokolenko E.A., Beck V., Ninnemann O., Jaburek M., Trimbuch T., Klishin S.S., Jezek P., Skulachev V.P., Pohl E.E. Role of the transmembrane potential in the membrane proton leak. Biophys J 2010, 98:1503-1511.
34. Saito K. Fine structure of the sensory epithelium of guinea-pig organ of Corti: subsurface cisternae and lamellar bodies in the outer hair cells. Cell Tissue Res 1983, 229:467-481.
35. Smorodchenko A., Rupprecht A., Sarilova I., Ninnemann O., Brauer A.U., Franke K., Schumacher S., Techritz S., Nitsch R., Schuelke M., Pohl E.E. Comparative analysis of uncoupling protein 4 distribution in various tissues under physiological conditions and during development. Biochim Biophys Acta 2009, 1788:2309-2319.
36. Sobkowicz H.M., Loftus J.M., Slapnick S.M. Tissue culture of the organ of Corti. Acta Otolaryngol Suppl 1993, 502:3-36.
37. Szeder V., Grim M., Halata Z., Sieber-Blum M. Neural crest origin of mammalian Merkel cells. Dev Biol 2003, 253:258-263.
38. Urbankova E., Voltchenko A., Pohl P., Jezek P., Pohl E.E. Transport kinetics of uncoupling proteins: analysis of UCP1 reconstituted in planar lipid bilayers. J Biol Chem 2003, 278:32497-32500.
39. von Bohlen und Halbach H.O. Immunohistological markers for staging neurogenesis in adult hippocampus. Cell Tissue Res 2007, 329:409-420.
40. Wu Z., Zhang J., Zhao B. Superoxide anion regulates the mitochondrial free Ca2+ through uncoupling proteins. Antioxid Redox Signal 2009, 11:1805-1818.
41. Zhang M., Wang B., Ni Y.H., Liu F., Fei L., Pan X.Q., Guo M., Chen R.H., Guo X.R. Overexpression of uncoupling protein 4 promotes proliferation and inhibits apoptosis and differentiation of preadipocytes. Life Sci 2006, 79:1428-1435.