Robust multi-drug therapy design and application to insulin resistance in type 2 diabetes

International Journal of Robust and Nonlinear Control

Volumn 21, Issue 15, 2011, Pages 1730-1741

  Luni, Camilla ^a,b   Doyle III, Francis J ^a,b,c  

^a University of California   (United States)

^b SANSUM DIABETES RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

diabetes; drug screening; performance; robustness; structured singular value; systems biology

Indexed keywords

COMPLEX DISEASE; DESIGN REQUIREMENTS; DRUG SCREENING; ENVIRONMENTAL CONDITIONS; EXPERIMENTAL DATA; INSULIN RESISTANCE; INTRINSIC PROPERTY; PERFORMANCE; PERFORMANCE ROBUSTNESS; STRUCTURED SINGULAR VALUES; SYSTEMS BIOLOGY; THERAPY DESIGN; TYPE-2 DIABETES;

AVAILABILITY; BIOLOGICAL SYSTEMS; DESIGN; DISEASE CONTROL; INSULIN; MATHEMATICAL MODELS; MEDICAL PROBLEMS; MULTIVARIABLE CONTROL SYSTEMS; ROBUST CONTROL; ROBUSTNESS (CONTROL SYSTEMS);

DRUG THERAPY;

EID: 80955177525     PISSN: 10498923     EISSN: 10991239     Source Type: Journal    
DOI: 10.1002/rnc.1756     Document Type: Article

References (20)

1. Kitano H,. Biological robustness. Nature Reviews Genetics 2004; 5 (11): 826-837. (Pubitemid 39457498)
2. Kitano H,. Innovation-a robustness-based approach to systems-oriented drug design. Nature Reviews Drug Discovery 2007; 6 (3): 202-210. (Pubitemid 46344624)
3. Bonhoeffer S, May RM, Shaw GM, Nowak MA,. Virus dynamics and drug therapy. Proceedings of the National Academy of Sciences of the United States of America 1997; 94 (13): 6971-6976. (Pubitemid 27281975)
4. Agoston V, Csermely P, Pongor S,. Multiple weak hits confuse complex systems: a transcriptional regulatory network as an example. Physical Review E 2005; 71 (5): 051909/1-051909/7.
5. Araujo RP, Liotta LA, Petricoin EF,. Proteins, drug targets and the mechanisms they control: the simple truth about complex networks. Nature Reviews Drug Discovery 2007; 6: 871-880. (Pubitemid 350042395)
6. Schoeberl B, Eichler-Jonsson C, Gilles ED, Muller G,. Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors. Nature Biotechnology 2002; 20 (4): 370-375. (Pubitemid 34286330)
7. Doyle J,. Analysis of feedback-systems with structured uncertainties. IEE Proceedings-D 1982; 129 (6): 242-250.
8. Shoemaker JE, Doyle III FJ,. Identifying fragilities in biochemical networks: robust performance analysis of FAS signaling-induced apoptosis. Biophysical Journal 2008; 95 (6): 2610-2623.
9. Jacobsen EW, Trane C,. Using dynamic perturbations to identify fragilities in biochemical networks. International Journal of Robust and Nonlinear Control 2010; 20 (9): 1027-1046.
10. Kim JS, Valeyev NV, Postlethwaite I, Heslop-Harrison P, Cho KH, Bates DG,. Analysis and extension of a biochemical network model using robust control theory. International Journal of Robust and Nonlinear Control 2010; 20 (9): 1017-1026.
11. Luni C, Shoemaker JE, Sanft KR, Petzold LR, Doyle III FJ,. Confidence from uncertainty-a multi-target drug screening method from robust control theory. BMC Systems Biology 2010; 4 (1): 161.
12. Defronzo RA, Ferrannini E,. Insulin resistance-a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 1991; 14 (3): 173-194.
13. Rosen ED, Spiegelman BM,. Adipocytes as regulators of energy balance and glucose homeostasis. Nature 2006; 444 (7121): 847-853. (Pubitemid 46024991)
14. Sedaghat AR, Sherman A, Quon MJ,. A mathematical model of metabolic insulin signaling pathways. American Journal of Physiology-Endocrinology and Metabolism 2002; 283 (5): E1084-E1101. (Pubitemid 35216969)
15. Skogestad S, Postlethwaite I,. Multivariable Feedback Control: Analysis and Design. Wiley: Chichester, West Sussex, England, 2005.
16. Goldstein BJ, Li PM, Ding WD, Ahmad F, Zhang WR,. Regulation of insulin action by protein tyrosine phosphatases. Vitamins and Hormones 1998; 54: 67-96.
17. Vintonyak VV, Antonchick AP, Rauh D, Waldmann H,. The therapeutic potential of phosphatase inhibitors. Current Opinion in Chemical Biology 2009; 13 (3): 272-283.
18. Kwei EC, Sanft KR, Petzold LR, Doyle III FJ,. Systems analysis of the insulin signaling pathway. Proceedings of the 17th IFAC World Congress, Coex, South Korea, vol. 17 (1), 2008. DOI: 10.3182/20080706-20080705-KR-20081001. 20083822.
19. Kanoh Y, Bandyopadhyay G, Sajan MP, Standaert ML, Farese RV,. Thiazolidinedione treatment enhances insulin effects on protein kinase C-zeta/lambda activation and glucose transport in adipocytes of nondiabetic and Goto-Kakizaki type II diabetic rats. Journal of Biological Chemistry 2000; 275 (22): 16690-16696. (Pubitemid 30398898)
20. Farese RV,. Function and dysfunction of aPKC isoforms for glucose transport in insulin-sensitive and insulin-resistant states. American Journal of Physiology-Endocrinology and Metabolism 2002; 283 (1): E1-E11. (Pubitemid 34686661)