Sustained GM-CSF and PEI condensed pDNA presentation increases the level and duration of gene expression in dendritic cells

Journal of Controlled Release

Volumn 132, Issue 3, 2008, Pages 273-278

  Ali, Omar A ^a   Mooney, David J ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

Dendritic cell; Gene expression; GM CSF; Immunotherapy; pDNA; Protein assay; T cell; Vaccine

Indexed keywords

DENDRITIC CELL; GM-CSF; IMMUNOTHERAPY; PDNA; PROTEIN ASSAY; T-CELL;

BIOACTIVITY; BIOLOGICAL MATERIALS; CELLS; CYTOLOGY; DENDRIMERS; DNA; GENE EXPRESSION; GENE TRANSFER; GENES; NUCLEIC ACIDS; ORGANIC ACIDS;

GRANULAR MATERIALS;

CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; NAKED DNA; PLASMID DNA; POLYETHYLENEIMINE; POLYGLACTIN;

ARTICLE; CELL BASED GENE THERAPY; CONTROLLED STUDY; DENDRITIC CELL; DNA DEGRADATION; DRUG DELIVERY SYSTEM; DRUG UPTAKE; GENE EXPRESSION; GENE VECTOR; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOTHERAPY; POLYMERIZATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; DENDRITIC CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GENE THERAPY; GENES, REPORTER; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; IMMUNOTHERAPY; LACTIC ACID; LUCIFERASES; MICE; NUCLEIC ACID CONFORMATION; PLASMIDS; POLYETHYLENEIMINE; POLYGLYCOLIC ACID; TIME FACTORS; TRANSFECTION;

EID: 56949099020     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2008.07.005     Document Type: Article

References (44)

1. Banchereau J., and Steinman R.M. Taking dendritic cells into medicine. Nature 49 (2007) 419-426
2. Schuler G., Schuler-Thurner B., and Steinman R.M. The use of dendritic cells in cancer immunotherapy. Curr. Opin. Immunol. 15 (2003) 138-147
3. Lanzavecchia A., and Sallusto F. Regulation of T cell immunity by dendritic cells. Cell 106 (2001) 263-266
4. Gilboa E. Dendritic cell based vaccines. J. Clin. Invest. 117 (2007) 1195-1203
5. Ferratini M., Capone I., and Belardelli. Dendritic cells and cytokines in immune rejection of cancer. Cytokine and Growth Factor Rev 19 (2007) 93-107
6. Collins M.K., and Cerundolo V. Gene therapy meets vaccine development. Trends Biotechnol. 12 (2004) 623-626
7. Kleina C., Buelera H., and Mulligan R.C. Comparative analysis of genetically modified dendritic cells and tumor cells as therapeutic cancer vaccines. J. Exp. Med. 191 (2000) 1699-1708
8. Rettig G.R., and Rice K.G. Non-viral gene delivery: from the needle to the nucleus. Biol Ther. 7 6 (2007) 799-808
9. Levy M.Y., Barron L.G., Meyer K.B., and Szoka Jr. F.C. Characterization of plasmid DNA transfer into mouse skeletal muscle: evaluation of uptake mechanism, expression and secretion of gene products into blood. Gene Ther. 3 (1996) 201-211
10. Kaplan J.M., Armentano D., Sparer T.E., Wynn S.G., Peterson P.A., Wadsworth S.C., Couture K.K., Pennington S.E., St George J.A., Gooding L.R., and Smith A.E. Characterization of factors involved in modulating persistence of transgene expression from recombinant adenovirus in the mouse lung. Hum. Gene Ther. 8 (1997) 45-56
11. Godbey W.T., Wu K.K., and Mikos A.G. Poly(ethylenimine)-mediated transfection: a new paradigm for gene delivery. J of Biomed Mater Res 45 (1999) 268-275
12. Christiano R. Viral and non-viral vectors for cancer gene therapy. Anticancer Res. 18 (1998) 3241-3246
13. Godbey W.T., Wu K.K., and Mikos A.G. Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery. Proc Natl Acad Sci U S A. 96 9 (1999) 5177-5181
14. Plum G., et al. Condensation of DNA by trivalent cations. 2. Effects of cation structure. Biopolymers 30 (1990) 631:643
15. Kircheis R., Wightman L., and Wagner E. Design and gene delivery activity of modified polyethylenimines. Adv Drug Deliv Rev. 53 (2001) 341-358
16. Haynes J.R. Particle-mediated DNA vaccine delivery to the skin 4 6 (2004) 889-900
17. McElvaney N.G. Is gene therapy in cystic fibrosis a realistic expectation?. Curr. Opin. Pulm. Med. 2 (1996) 466-471
18. Park S., and Healy K.E. Nanoparticulate DNA packaging using terpolymers of poly(lysine-g-(lactide-b-ethylene glycol)). Bioconjug. Chem. 14 (1999) 311-319
19. Levine T.P., and Chain B.M. Endocytosis by antigen presenting cells: dendritic cells are as endocytically active as other antigen presenting cells. PNAS. 89 (1992) 8342-8346
20. Donnelly J.J., Wahren B., and Liu M.A. DNA vaccines: progress and challenges. J of Immun. 175 (2005) 633-639
21. Dranoff G. Cytokines in cancer. Nat. Rev. Cancer 4 (2004) 11-22
22. Hamilton J., and Anderson G. GM-CSF biology. Growth Factors 22 4 (2004) 225-231
23. Hamilton J. GM-CSF in inflammation and autoimmunity. Trends in Immunol 23 (2002) 403-408
24. Disis M.L. Clinical use of subcutaneous G-CSF or GM-CSF in malignancy. Oncology 19 4 (2005) 5-9
25. Jinushi M., et al. MFG-E8-mediated uptake of apoptotic cells by APCs links the pro- and anti-inflammatory activities of GM-CSF. J. Clin. Inv. 17 (2007) 1902-1913
26. Matsuno K., et al. Presentation of tumor antigens by phagocytic dendritic cell clusters generated from human CD341 hematopoietic progenitor cells: induction of autologous cytotoxic T lymphocytes against leukemic cells in acute myelogenous leukemia patients. Can. Res. 59 (1999) 2150-2158
27. Mao Z., Yan J., Yan M., Gao C., and Shen J. The gene transfection efficiency of thermoresponsive N,N,N-trimethyl chitosan chloride-g-poly(N-isopropylacrylamide) copolymer. J. Biomaterials. 28 (2007) 4488-4500
28. Csabaa N., Sáncheza A., and Alonso M.J. PLGA: poloxamer and PLGA: poloxamine blend nanostructures as carriers for nasal gene delivery. J. Cont. Rel. 113 2 (2006) 164-172
29. Shea L.D., Smiley E., Bonadio J., and Mooney D.J. DNA delivery from polymer matrices for tissue engineering. Nat. Biotechnol. 17 6 (1999) 551-554
30. Huang Y.C., Riddle K., Rice K.G., and Mooney D.J. Long-term in vivo gene expression via delivery of PEI-DNA condensates from porous polymer scaffolds. Hum. Gene. Ther. 5 (2005) 609-617
31. Ali O.A., and Mooney D.J. Converging cell therapy with biomaterials. Cell Transplantation from Laboratory to Clinic (2006), Elsevier Inc, Burlington, MA 591-609
32. Fang J., Zhu Y.Y., Smiley E., et al. Stimulation of new bone formation by direct transfer of osteogenic plasmid genes. Natl. Acad. Sci. USA 93 (1996) 5753-5758
33. Donnelly J.J., Wahren B., and Liu M.A. DNA vaccines: progress and challenges. J. Immun. 175 (2005) 633-639
34. Yu M., and Finn O.J. DNA vaccines for cancer too. Cancer Immunol. Immunother. (2005) 119-113
35. Kong H.J., Liu J.D., Riddle K., Matsumoto T., Leach K., and Mooney D.J. Gene delivery regulated by substrate rigidity. Nat. Mat. 4 (2005) 460-464 - Highlighted by Nature 435, 250 (2005)
36. Huang Y.C., Connell M., Park Y., Mooney D.J., and Rice K.G. Fabrication and in vitro testing of polymeric delivery system for condensed DNA. J. Biomed. Mat. Res. 67 (2003) 1384-1392
37. Riddle K., et al. Modifying the proliferative state of target cells to control DNA expression and identifying cell types transfected in vivo. Mol. Ther. 15 2 (2007) 361-368
38. Metcalf D. The molecular biology and functions of the granulocyte-macrophage colony-stimulating factors. Blood. 67 2 (1986) 257-267
39. Sullivan R., et al. Effects of recombinant human granulocyte-macrophage colony-stimulating factor on intracellular pH in mature granulocytes. Blood. 72 5 (1988) 1665-1673
40. Sullivan R., Fredette J.P., Socinski M., Elias A., Antman K., Schnipper L., and Griffin J.D. Enhancement of superoxide anion release by granulocytes harvested from patients receiving granulocyte-macrophage colony-stimulating factor. J. Haematol. 71 4 (1989) 475-479
41. Haynes J.R. Particle-mediated DNA vaccine delivery to the skin 4 6 (2004) 889-900
42. Dietz A.B., and Vuk-Pavlovic S. High efficiency adenovirus-mediated gene transfer to human dendritic cells. Blood. 91 (1998) 392-398
43. Augst A.D., Kong H.J., and Mooney D.J. Alginate hydrogels as biomaterials. Macromol. Biosci. 6 8 (2006) 623-633
44. Dranoff G. GM-CSF-based cancer vaccines. Immunol. Rev. 188 (2002) 147-154