Total synthesis and bioactivity of the marine alkaloid pityriacitrin and some of its derivatives

European Journal of Medicinal Chemistry

Volumn 46, Issue 12, 2011, Pages 6089-6097

  Zhang, Puyong ^a   Sun, Xiaofei ^a   Xu, Bin ^b   Bijian, Krikor ^b   Wan, Shengbiao ^a   Li, Guigen ^c   Alaoui Jamali, Moulay ^b   Jiang, Tao ^a  

^a OCEAN UNIVERSITY OF CHINA   (China)

^b MCGILL UNIVERSITY   (Canada)

^c TEXAS TECH UNIVERSITY   (United States)

Author keywords

Carboline; Antiproliferative activity; Cytotoxicity; Indole 3 glyoxal; Pityriacitrin; Total synthesis

Indexed keywords

(1H INDOL 3 YL) (6 HYDROXY 9H PYRIDO[3,4 B]INDOL 1 YL)METHANONE; (1H INDOL 3YL) (6 HYDROXY 9H PYRIDO[3,4B]INDOL 1YL)METHANONE; (5 METHOXY 1H INDOL 3YL) [9H PYRIDO(3,4B)INDOL 1YL]METHANONE; 1 (1H INDOL 3 YLCARBONYL) 9H PYRIDO[3,4 B]INDOLE 3 CARBOXYLIC ACID; 1 (1H INDOLE 3 CARBONYL) N [2 (METHYLAMINO)ETHYL] 9H PYRIDO[3,4B]INDOLE 3 CARBOXAMIDE; 1 (1H INDOLE 3 CARBONYL) N [2 METHYLAMINO)ETHYL] 9H PYRIDO[3,4 B]INDOLE 3 CARBOXAMIDE; 1 (5 METHOXY 1H INDOL 3 YLCARBONYL) 9H PYRIDO[3,4B]INDOLE 3 CARBOXYLIC ACID; 6 HYDROXY 1 (1H INDOLE 3 CARBONYL) N [2 (METHYLAMINO)ETHYL] 9H PYRIDO [3,4 B]INDOLE 3 CARBOXAMIDE; 6 HYDROXY 1 (1H INDOLE 3 CARBONYL) N [2 (METHYLAMINO)ETHYL] 9H PYRIDO[3,4B]INDOLE 3 CARBOXAMIDE; ANTINEOPLASTIC AGENT; BETA CARBOLINE DERIVATIVE; METHYL 1 (1H INDOLE 3 CARBONYL) 9H PYRIDO[3,4B]INDOLE 3 CARBOXYLATE; METHYL 6 HYDROXY 1 (1H INDOLE 3 CARBONYL) 9H PYRIDO[3,4 B]INDOLE 3 CARBOXYLATE; N (2 AMINOETHYL) 1 (1H INDOLE 3 CARBONYL) 9H PYRIDO[3,4B]INDOLE 3 CARBOXAMIDE; N (2 AMINOETHYL) 6 HYDROXY 1 (1H INDOLE 3 CARBONYL) 9H PYRIDO[3,4 B]INDOLE 3 CARBOXAMIDE; N (2 AMINOETHYL) 6 HYDROXY 1 (1H INDOLE 3 CARBONYL) 9H PYRIDO[3,4B]INDOLE 3 CARBOXAMIDE; N (3 AMINOPROPYL) 1 (1H INDOLE 3 CARBONYL) 9H PYRIDO[3,4B]INDOLE 3 CARBOXAMIDE; N (4 AMINOBUTYL) 1 (1H INDOLE 3 CARBONYL) 9H PYRIDO[3,4B]INDOLE 3 CARBOXAMIDE; N (4 AMINOBUTYL) 6 HYDROXY 1 (1H INDOLE 3 CARBONYL) 9H PYRIDO[3,4 B]INDOLE 3 CARBOXAMIDE; N (4 AMINOBUTYL) 6 HYDROXY 1 (1H INDOLE 3 CARBONYL) 9H PYRIDO[3,4B]INDOLE 3 CARBOXAMIDE; N [2 (DIMETHYLAMINO)ETHYL] 1 (1H INDOLE 3 CARBONYL) 9HPYRIDO[3,4B]INDOLE 3 CARBOXAMIDE; N [2 (DIMETHYLAMINO)ETHYL] 6 HYDROXY 1 (1H INDOLE 3 CARBONYL) 9H PYRIDO[3,4 B]INDOLE 3 CARBOXAMIDE; N [2 (DIMETHYLAMINO)ETHYL] 6 HYDROXY 1 (1H INDOLE 3 CARBONYL) 9H PYRIDO[3,4B]INDOLE 3 CARBOXAMIDE; N [3 (DIMETHYLAMINO)PROPYL] 1 (1H INDOLE 3 CARBONYL) 9HPYRIDO[3,4B]INDOLE 3 CARBOXAMIDE; N [3 (DIMETHYLAMINO)PROPYL] 6 HYDROXY 1 (1H INDOLE 3 CARBONYL) 9H PYRIDO[3,4 B]INDOLE 3 CARBOXAMIDE; N [3 (DIMETHYLAMINO)PROPYL] 6 HYDROXY 1 (1H INDOLE 3 CARBONYL) 9H PYRIDO[3,4B]INDOLE 3 CARBOXAMIDE; PACLITAXEL; PITYRIACITRIN; TRYPTOPHAN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL REACTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; PICTETE SPENGLER REACTION;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; HUMANS; INDOLE ALKALOIDS; MALASSEZIA; MALE; PROSTATIC NEOPLASMS;

EID: 80955166089     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.10.036     Document Type: Article

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