Intratumoral budding as a potential parameter of tumor progression in mismatch repair-proficient and mismatch repair-deficient colorectal cancer patients

Human Pathology

Volumn 42, Issue 12, 2011, Pages 1833-1840

  Lugli, Alessandro ^a,b   Vlajnic, Tatjana ^a   Giger, Olivier ^a,b   Karamitopoulou, Eva ^c   Patsouris, Efstratios S ^c   Peros, George ^c   Terracciano, Luigi M ^a   Zlobec, Inti ^a,b  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c UNIVERSITY OF ATHENS   (Greece)

Author keywords

Colorectal cancer; Prognosis; Tumor budding

Indexed keywords

CYTOKERATIN;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER INVASION; CANCER PATIENT; COLORECTAL CANCER; DISEASE SEVERITY; DISTANT METASTASIS; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRATUMORAL BUDDING; LYMPH NODE; MAJOR CLINICAL STUDY; MALE; MISMATCH REPAIR; MULTIPLE PUNCH TISSUE MICROARRAY; PERITUMORAL BUDDING; PROGNOSIS; SENSITIVITY AND SPECIFICITY; SURVIVAL TIME; TISSUE MICROARRAY; TISSUE SECTION; TUMOR CELL; TUMOR GROWTH;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CELL DEDIFFERENTIATION; CHEMOTHERAPY, ADJUVANT; COHORT STUDIES; COLORECTAL NEOPLASMS; DNA MISMATCH REPAIR; FEMALE; HUMANS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM GRADING; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PROGNOSIS; SURVIVAL ANALYSIS; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 80955165991     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2011.02.010     Document Type: Article

References (27)

1. M. Guarino, B. Rubino, and G. Ballabio The role of epithelial-mesenchymal transition in cancer pathology Pathology 39 2007 305 318 (Pubitemid 46897605)
2. F. Prall Tumour budding in colorectal carcinoma Histopathology 50 2007 151 162 (Pubitemid 44953405)
3. C.C. Compton Prognostic factors in cancer 2006 Hoboken, NJ; Wiley-Liss
4. C.C. Compton Optimal pathologic staging: defining stage II disease Clin Cancer Res 13 2007 6862s 6870s (Pubitemid 350206828)
5. K. Guzińska-Ustymowicz The role of tumour budding at the front of invasion and recurrence of rectal carcinoma Anticancer Res 25 2005 1269 1272 (Pubitemid 40546801)
6. K. Hase, C. Shatney, D. Johnson, M. Trollope, and M. Vierra Prognostic value of tumor "budding" in patients with colorectal cancer Dis Colon Rectum 36 1993 627 635 (Pubitemid 23206317)
7. + lymphocytes/tumour-budding index: an independent prognostic factor representing a 'pro-/anti-tumour' approach to tumour host interaction in colorectal cancer Br J Cancer 101 2009 1382 1392
8. H. Ueno, H. Mochizuki, Y. Hashiguchi, K. Hatsuse, H. Fujimoto, and K. Hase Predictors of extrahepatic recurrence after resection of colorectal liver metastases Br J Surg 91 2004 327 333 (Pubitemid 38375773)
9. F. Prall, H. Nizze, and M. Barten Tumour budding as prognostic factor in stage I/II colorectal carcinoma Histopathology 47 2005 17 24 (Pubitemid 40978809)
10. H. Ueno, H. Mochizuki, and Y. Hashiguchi Risk factors for an adverse outcome in early invasive colorectal carcinoma Gastroenterology 127 2004 385 394 (Pubitemid 39091886)
11. L.M. Wang, D. Kevans, and H. Mulcahy Tumor budding is a strong and reproducible prognostic marker in T3N0 colorectal cancer Am J Surg Pathol 33 2009 134 141
12. I. Zlobec, F. Molinari, and V. Martin Tumor budding predicts response to anti-EGFR therapies in metastatic colorectal cancer patients World J Gastroenterol 16 2010 4823 4831
13. J.R. Jass, W.S. Atkin, and J. Cuzick The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases Histopathology 10 1986 437 459 (Pubitemid 16039125)
14. J.R. Jass Lymphocytic infiltration and survival in rectal cancer J Clin. Pathol 39 1986 585 589 (Pubitemid 16069660)
15. I. Zlobec, K. Baker, P. Minoo, S. Hayashi, L. Terracciano, and A. Lugli Tumor border configuration added to TNM staging better stratifies stage II colorectal cancer patients into prognostic subgroups Cancer 115 2009 4021 4029
16. J.R. Jass, M. Barker, and L. Fraser APC mutation and tumour budding in colorectal cancer J Clin Pathol 56 2003 69 73 (Pubitemid 36132478)
17. T. Morodomi, H. Isomoto, K. Shirouzu, K. Kakegawa, K. Irie, and M. Morimatsu An index for estimating the probability of lymph node metastasis in rectal cancers. Lymph node metastasis and the histopathology of actively invasive regions of cancer Cancer 63 1989 539 543 (Pubitemid 19038471)
18. I. Zlobec, A. Lugli, and K. Baker Role of APAF-1, E-cadherin and peritumoral lymphocytic infiltration in tumour budding in colorectal cancer J Pathol 212 2007 260 268 (Pubitemid 47010060)
19. I. Zlobec, and A. Lugli Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget Oncotarget 2010 651 661
20. B.H. O'Neil, and J.E. Tepper Current options for the management of rectal cancer Curr Treat Options Oncol 8 2007 331 338
21. I.R. Daniels, S.E. Fisher, R.J. Heald, and B.J. Moran Accurate staging, selective preoperative therapy and optimal surgery improves outcome in rectal cancer: a review of the recent evidence Colorectal Dis 9 2007 290 301 (Pubitemid 46563458)
22. B. Glimelius, L. Påhlman, and A. Cervantes Rectal cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up Ann Oncol 21 Suppl 5 2010 v82 v86
23. T. Akasu, G. Iinuma, M. Takawa, S. Yamamoto, Y. Muramatsu, and N. Moriyama Accuracy of high-resolution magnetic resonance imaging in preoperative staging of rectal cancer Ann. Surg Oncol 16 2009 2787 2794
24. S.A. Badger, P.B. Devlin, P.J.D. Neilly, and R. Gilliland Preoperative staging of rectal carcinoma by endorectal ultrasound: is there a learning curve? Int J Colorectal Dis 22 2007 1261 1268 (Pubitemid 47304797)
25. M. Beer-Gabel, Y. Assouline, O. Zmora, M. Venturero, S. Bar-Meir, and B. Avidan A new rectal ultrasonographic method for the staging of rectal cancer Dis Colon Rectum 52 2009 1475 1480
26. G. Brown, S. Davies, and G.T. Williams Effectiveness of preoperative staging in rectal cancer: digital rectal examination, endoluminal ultrasound or magnetic resonance imaging? Br J Cancer 91 2004 23 29 (Pubitemid 39013040)
27. N.P. West, E.J.A. Morris, O. Rotimi, A. Cairns, P.J. Finan, and P. Quirke Pathology grading of colon cancer surgical resection and its association with survival: a retrospective observational study Lancet Oncol 9 2008 857 865