Activation of regenerating gene Reg in rat and human hearts in response to acute stress

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 289, Issue 1 58-1, 2005, Pages

  Kiji, Tatsuya ^a   Dohi, Yoshiko ^a   Takasawa, Shin ^b   Okamoto, Hiroshi ^b   Nonomura, Akitaka ^a   Taniguchi, Shigeki ^a  

^a NARA MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Heart failure; Myocardial infarction; Pressure overload; Receptor

Indexed keywords

COMPLEMENTARY DNA; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERLEUKIN 6; RECOMBINANT PROTEIN; REG 1 PROTEIN; UNCLASSIFIED DRUG;

ABDOMINAL AORTA; ACUTE HEART INFARCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; CONTROLLED STUDY; EXPERIMENTAL MODEL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HEART MUSCLE CELL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REG GENE; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRESS; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

ANIMALS; AORTA; CALCIUM-BINDING PROTEINS; CARDIAC OUTPUT, LOW; CONSTRICTION; CORONARY VESSELS; GENE EXPRESSION; GENE EXPRESSION REGULATION; HEART; HUMANS; HYPERTENSION; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-6; LIGATION; LITHOSTATHINE; MALE; MYOCARDIAL INFARCTION; MYOCARDIUM; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; RATS; RATS, WISTAR; RNA, MESSENGER; STAINING AND LABELING;

EID: 21644462260     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.01206.2004     Document Type: Article

References (29)

1. Akiyama T, Takasawa S, Nata K, Kobayashi S, Abe M, Shervani NJ, Ikeda T, Nakagawa K, Unno M, Matsuno S, and Okamoto H. Activation of Reg gene, a gene for insulin-producing β-cell regeneration: poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation. Proc Natl Acad Sci USA 98: 48-53, 2001.
2. Asahara M, Mushiake S, Shimada S, Fukui H, Kinoshita Y, Kawanami C, Watanabe T, Tanaka S, Ichikawa A, Uchiyama Y, Narushima Y, Takasawa S, Okamoto H, Tohyama M, and Chiba T. Reg gene expression is increased in rat gastric enterochromaffin-like cells following water immersion stress. Gastroenterology 111: 45-55, 1996.
3. Braun MU, La Rosee P, Schon S, Borst MM, and Strasser RH. Differential regulation of cardiac protein kinase C isozyme expression after aortic banding in rat. Cardiovasc Res 56: 52-63, 2002.
4. Chiba T, Fukui H, and Kinoshita Y. Reg protein: a possible mediator of gastrin-induced mucosal cell growth. J Gastroenterol 35, Suppl 12: 52-56, 2000.
5. Cook SA, Novikov MS, Ahn Y, Matsui T, and Rosenzweig A. A20 is dynamically regulated in the heart and inhibits the hypertrophic response. Circulation 108: 664-667, 2003.
6. Dhar DK, Udagawa J, Ishihara S, Otani H, Kinoshita Y, Takasawa S, Okamoto H, Kubota H, Fujii T, Tachibana M, and Nagasue N. Expression of regenerating gene I in gastric adenocarcinomas: correlation with tumor differentiation status and patient survival. Cancer 100: 1130-1136, 2004.
7. Doyama K, Fukumoto M, Takemura G, Tanaka M, Oda T, Hasegawa K, Inada T, Ohtani S, Fujiwara T, Itoh H, Nakao K, Sasayama S, and Fujiwara H. Expression and distribution of brain natriuretic peptide in human right atria. J Am Coll Cardiol 32: 1832-1838, 1998.
8. Fukui H, Fujii S, Takeda J, Kayahara T, Sekikawa A, Nanakin A, Suzuki K, Hisatsune H, Seno H, Sawada M, Fujimori T, and Chiba T. Expression of Reg I protein in human gastric cancers. Digestion 69: 177-184, 2004.
9. Gardner DG, Wirtz H, and Dobbs LG. Stretch-dependent regulation of atrial peptide synthesis and secretion in cultured atrial cardiocytes. Am J Physiol Endocrinol Metab 263: E239-E244, 1992.
10. Hama N, Itoh H, Shirakami G, Nakagawa O, Suga S, Ogawa Y, Masuda I, Nakanishi K, Yoshimasa T, Hashimoto Y, Yamaguchi M, Hovi R, Yasue H, and Nakao K. Rapid ventricular induction of brain natriuretic peptide gene expression in experimental acute myocardial infarction. Circulation 92: 1558-1564, 1995.
11. Heid CA, Stevens J, Livak KJ, and Williams PM. Real time quantitative PCR. Genome Res 6: 986-994, 1996.
12. Hirano S, Imamura T, Onitsuka H, Matsuo T, Kitamura K, Koiwaya Y, and Eto T. Rapid increase in cardiac adrenomedullin gene expression caused by acute pressure overload: effect of the renin-angiotensin system on gene expression. Circ Res 66: 397-402, 2002.
13. Hirano T. Interleukin 6 and its receptor: ten years later. Int Rev Immunol 16: 249-284, 1998.
14. Kiji T, Dohi Y, Nishizaki K, Takasawa S, Okamoto H, Nagasaka S, Naito H, Yonemasu K, and Taniguchi S. Enhancement of cell viability in cryopreserved rat vascular grafts by administration of regenerating gene (Reg) inducers. J Vasc Res 40: 132-139, 2003.
15. Knecht M, Pagel I, Langenickel T, Philipp S, Scheuermann-Freestone M, Willnow T, Bruemmer D, Graf K, Dietz R, and Willenbrock R. Increased expression of renal neutral endopeptidase in severe heart failure. Life Sci 71: 2701-2712, 2002.
16. Kobayashi S, Akiyama T, Nata K, Abe M, Tajima M, Shervani NJ, Unno M, Matsuno S, Sasaki H, Takasawa S, and Okamoto H. Identification of a receptor for reg (regenerating gene) protein, a pancreatic β-cell regeneration factor. J Biol Chem 275: 10723-10726, 2000.
17. Livesey FJ, O'Brien JA, Li M, Smith AG, Murphy LJ, and Hunt SP. A Schwann cell mitogen accompanying regeneration of motor neurons. Nature 390: 614-618, 1997.
18. Modesti PA, Vanni S, Bertolozzi I, Cecioni I, Polidori G, Paniccia R, Bandinelli B, Perna A, Liguori P, Boddi M, Galanti G, and Serneri GG. Early sequence of cardiac adaptations and growth factor formation in pressure- and volume-overload hypertrophy. Am J Physiol Heart Circ Physiol 279: H976-H985, 2000.
19. Nakagawa O, Ogawa Y, Itoh H, Suga S, Komatsu Y, Kishimoto I, Nishino K, Yoshimasa T, and Nakao K. Rapid transcriptional activation and early mRNA turnover of brain natriuretic peptide in cardiocyte hypertrophy. Evidence for brain natriuretic peptide as an "emergency" cardiac hormone against ventricular overload. J Clin Invest 96: 1280-1287, 1995.
20. Nishimune H, Vasseur S, Wiese S, Birling MC, Holtmann B, Sendtner M, Iovanna JL, and Henderson CE. Reg-2 is a motoneuron neurotrophic factor and a signalling intermediate in the CNTF survival pathway. Nat Cell Biol 2: 906-914, 2000.
21. Okamoto H. The Reg gene family and Reg proteins: with special attention to the regeneration of pancreatic β-cells. J Hepatoblliary Pancreat Surg 6: 254-262, 1999.
22. Okamoto H and Takasawa S. Recent advances in the Okamoto model: the CD38-cyclic ADP-ribose signal system and the regenerating gene protein (Reg)-Reg receptor system in β-cells. Diabetes 51, Suppl 3: S462-S473, 2002.
23. Shyu KG, Wang MT, Wang BW, Chang CC, Leu JG, Kuan P, and Chang H. Intramyocardial injection of naked DNA encoding HIF-1α/ VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat. Cardiovasc Res 54: 576-583, 2002.
24. Terazono K, Uchiyama Y, Ide M, Watanabe T, Yonekura H, Yamamoto H, and Okamoto H. Expression of reg protein in rat regenerating islets and its co-localization with insulin in the beta cell secretory granules. Diabetologia 33: 250-252, 1990.
25. Terazono K, Yamamoto H, Takasawa S, Shiga K, Yonemura Y, Tochino Y, and Okamoto H. A novel gene activated in regenerating islets. J Biol Chem 263: 2111-2114, 1988.
26. Unno M, Nata K, Noguchi N, Narushima Y, Akiyama T, Ikeda T, Nakagawa K, Takasawa S, and Okamoto H. Production and characterization of Reg knockout mice: reduced proliferation of pancreatic -cells in Reg knockout mice. Diabetes 51, Suppl 3: S478-S483, 2002.
27. Watanabe T, Yonekura H, Terazono K, Yamamoto H, and Okamoto H. Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. J Biol Chem 265: 7432-7439, 1990.
28. Yonemura Y, Sakurai S, Yamamoto H, Endou Y, Kawamura T, Bandou E, Elnemr A, Sugiyama K, Sasaki T, Akiyama T, Takasawa S, and Okamoto H. REG gene expression is associated with the infiltrating growth of gastric carcinoma. Cancer 98: 1394-1400, 2003.
29. Yonemura Y, Takashima T, Miwa K, Miyazaki I, Yamamoto H, and Okamoto H. Amelioration of diabetes mellitus in partially depancreatized rats by poly(ADP-ribose) synthetase inhibitors. Evidence of islet B-cell regeneration. Diabetes 33: 401-404, 1984.