메뉴 건너뛰기




Volumn 7, Issue 1, 2011, Pages 519-527

Critical appraisal of the role of fingolimod in the treatment of multiple sclerosis

Author keywords

FTY720; Oral drug; Spingosine 1 phosphate receptor

Indexed keywords

BETA INTERFERON; BETA1A INTERFERON; FINGOLIMOD; INTERFERON BETA SERINE; NATALIZUMAB; PLACEBO;

EID: 80955160568     PISSN: 11766328     EISSN: 11782021     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (14)

References (40)
  • 1
    • 77950610036 scopus 로고    scopus 로고
    • The changing demographic pattern of multiple sclerosis epidemiology
    • Koch-Henriksen N, Sorensen PS. The changing demographic pattern of multiple sclerosis epidemiology. Lancet Neurol. 2010;9(5):520-532.
    • (2010) Lancet Neurol , vol.9 , Issue.5 , pp. 520-532
    • Koch-Henriksen, N.1    Sorensen, P.S.2
  • 2
    • 0037312536 scopus 로고    scopus 로고
    • Evidence for widespread axonal damage at the earliest clinical stage of multiple sclerosis
    • Filippi M, Bozzali M, Rovaris M, et al. Evidence for widespread axonal damage at the earliest clinical stage of multiple sclerosis. Brain. 2003;126(Pt 2):433-437.
    • (2003) Brain , vol.126 , Issue.PART. 2 , pp. 433-437
    • Filippi, M.1    Bozzali, M.2    Rovaris, M.3
  • 3
    • 80051544967 scopus 로고    scopus 로고
    • The predictive value of gray matter atrophy in clinically isolated syndromes
    • Calabrese M, Rinaldi F, Mattisi I, et al. The predictive value of gray matter atrophy in clinically isolated syndromes. Neurology. 2011;77(3):257-263.
    • (2011) Neurology , vol.77 , Issue.3 , pp. 257-263
    • Calabrese, M.1    Rinaldi, F.2    Mattisi, I.3
  • 5
    • 79953179371 scopus 로고    scopus 로고
    • Cerebrospinal fluid CXCL13 in multiple sclerosis: A suggestive prognostic marker for the disease course
    • Khademi M, Kockum I, Andersson ML, et al. Cerebrospinal fluid CXCL13 in multiple sclerosis: a suggestive prognostic marker for the disease course. Mult Scler. 2011;17(3):335-343.
    • (2011) Mult Scler , vol.17 , Issue.3 , pp. 335-343
    • Khademi, M.1    Kockum, I.2    Andersson, M.L.3
  • 6
    • 80051546949 scopus 로고    scopus 로고
    • Predicting the development of multiple sclerosis: Is gray matter a missing piece of the puzzle?
    • Chard DT, Geurts JJ. Predicting the development of multiple sclerosis: is gray matter a missing piece of the puzzle? Neurology. 2011;77(3):210-211.
    • (2011) Neurology , vol.77 , Issue.3 , pp. 210-211
    • Chard, D.T.1    Geurts, J.J.2
  • 7
    • 56349150992 scopus 로고    scopus 로고
    • Basic and escalating immunomodulatory treatments in multiple sclerosis: Current therapeutic recommendations
    • Wiendl H, Toyka KV, Rieckmann P, Gold R, Har tung HP, Hohlfeld R. Basic and escalating immunomodulatory treatments in multiple sclerosis: current therapeutic recommendations. J Neurol. 2008;255(10):1449-1463.
    • (2008) J Neurol , vol.255 , Issue.10 , pp. 1449-1463
    • Wiendl, H.1    Toyka, K.V.2    Rieckmann, P.3    Gold, R.4    Har Tung, H.P.5    Hohlfeld, R.6
  • 8
    • 34250779802 scopus 로고    scopus 로고
    • Natalizumab for multiple sclerosis
    • Ransohoff RM. Natalizumab for multiple sclerosis. N Engl J Med. 2007;356(25):2622-2629.
    • (2007) N Engl J Med , vol.356 , Issue.25 , pp. 2622-2629
    • Ransohoff, R.M.1
  • 9
    • 17644398787 scopus 로고    scopus 로고
    • Anti-alpha4 integrin therapy for multiple sclerosis: Mechanisms and rationale
    • Rice GP, Hartung HP, Calabresi PA. Anti-alpha4 integrin therapy for multiple sclerosis: mechanisms and rationale. Neurology. 2005;64(8):1336-1342.
    • (2005) Neurology , vol.64 , Issue.8 , pp. 1336-1342
    • Rice, G.P.1    Hartung, H.P.2    Calabresi, P.A.3
  • 10
    • 33644608613 scopus 로고    scopus 로고
    • Natalizumab plus interferon beta-1a for relapsing multiple sclerosis
    • Rudick RA, Stuart WH, Calabresi PA, et al. Natalizumab plus interferon beta-1a for relapsing multiple sclerosis. N Engl J Med. 2006;354(9):911-923.
    • (2006) N Engl J Med , vol.354 , Issue.9 , pp. 911-923
    • Rudick, R.A.1    Stuart, W.H.2    Calabresi, P.A.3
  • 11
    • 33644584352 scopus 로고    scopus 로고
    • A randomized, placebocontrolled trial of natalizumab for relapsing multiple sclerosis
    • Polman CH, O'Connor PW, Havrdova E, et al. A randomized, placebocontrolled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med. 2006;354(9):899-910.
    • (2006) N Engl J Med , vol.354 , Issue.9 , pp. 899-910
    • Polman, C.H.1    O'Connor, P.W.2    Havrdova, E.3
  • 12
    • 79955717389 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy under natalizumab. Initial possibilities for risk stratification
    • German
    • Warnke C, Adams O, Gold R, et al. Progressive multifocal leukoencephalopathy under natalizumab. Initial possibilities for risk stratification? Nervenarzt. 2011;82(4):475-480. [German]
    • (2011) Nervenarzt , vol.82 , Issue.4 , pp. 475-480
    • Warnke, C.1    Adams, O.2    Gold, R.3
  • 13
    • 77955031189 scopus 로고    scopus 로고
    • Natalizumab and progressive multifocal leukoencephalopathy: What are the causal factors and can it be avoided?
    • Warnke C, Menge T, Hartung HP, et al. Natalizumab and progressive multifocal leukoencephalopathy: what are the causal factors and can it be avoided? Arch Neurol. 2010;67(8):923-930.
    • (2010) Arch Neurol , vol.67 , Issue.8 , pp. 923-930
    • Warnke, C.1    Menge, T.2    Hartung, H.P.3
  • 14
    • 77949279537 scopus 로고    scopus 로고
    • Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: Lessons from 28 cases
    • Clifford DB, De Luca A, Simpson DM, Arendt G, Giovannoni G, Nath A. Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: lessons from 28 cases. Lancet Neurol. 2010;9(4):438-446.
    • (2010) Lancet Neurol , vol.9 , Issue.4 , pp. 438-446
    • Clifford, D.B.1    de Luca, A.2    Simpson, D.M.3    Arendt, G.4    Giovannoni, G.5    Nath, A.6
  • 15
    • 33644605483 scopus 로고    scopus 로고
    • Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy
    • Yousry TA, Major EO, Ryschkewitsch C, et al. Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy. N Engl J Med. 2006;354(9):924-933.
    • (2006) N Engl J Med , vol.354 , Issue.9 , pp. 924-933
    • Yousry, T.A.1    Major, E.O.2    Ryschkewitsch, C.3
  • 16
    • 84859339303 scopus 로고    scopus 로고
    • Risk stratification for progressive multifocal leukoencephalopathy (PML) in MS patients: Role of prior immunosuppressant use, natalizumab-treatment duration, and anti-JCV antibody status
    • Paper Presented at: The 63rd Annual Meeting of the American Academy of Neurology Apr 9-16; Honolulu, Hawaii
    • Sandrock AHC, Richman S, Natarajan A, et al. Risk stratification for progressive multifocal leukoencephalopathy (PML) in MS patients: role of prior immunosuppressant use, natalizumab-treatment duration, and anti-JCV antibody status. Paper presented at: The 63rd Annual Meeting of the American Academy of Neurology; 2011 Apr 9-16; Honolulu, Hawaii.
    • (2011)
    • Sandrock, A.H.C.1    Richman, S.2    Natarajan, A.3
  • 17
    • 84855541359 scopus 로고    scopus 로고
    • 17. US Food and Drug Administration (FDA). FDA approves first oral drug to reduce MS relapses [press release]. Sep 22, 2010. Available at, June 1
    • US Food and Drug Administration (FDA). FDA approves first oral drug to reduce MS relapses [press release]. Sep 22, 2010. Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm226755.htm. Accessed June 1, 2011.
    • (2011)
  • 18
    • 84855541356 scopus 로고    scopus 로고
    • European Medicines Agency (EMA). Assessment report: Gilenya. Doc Ref: EMA/108602/2011. February 17, 2011. Available at, Accessed June 1
    • European Medicines Agency (EMA). Assessment report: Gilenya. Doc Ref: EMA/108602/2011. February 17, 2011. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assess ment_report/human/002202/WC500104529.pdf. Accessed June 1, 2011.
    • (2011)
  • 19
    • 0028372227 scopus 로고
    • Fungal metabolites: Part 11, a potent immunosuppressive activity found in Isaria sinclairii metabolite
    • Fujita T, Inoue K, Yamamoto S, et al. Fungal metabolites: Part 11, a potent immunosuppressive activity found in Isaria sinclairii metabolite. J Antibiot (Tokyo). 1994;47(2):208-215.
    • (1994) J Antibiot (Tokyo) , vol.47 , Issue.2 , pp. 208-215
    • Fujita, T.1    Inoue, K.2    Yamamoto, S.3
  • 20
    • 84855538494 scopus 로고    scopus 로고
    • Novartis Pharmaceutical Corporation, Prescribing information. Available at, Accessed June 1
    • Novartis Pharmaceutical Corporation. Prescribing information. Available at: http://www.pharma.us.novartis.com/product/pi/pdf/gilenya.pdf. Accessed June 1, 2011.
    • (2011)
  • 21
    • 79952027563 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation
    • Hla T, Brinkmann V. Sphingosine 1-phosphate (S1P): physiology and the effects of S1P receptor modulation. Neurology. 2011;76 (8 Suppl 3):S3-S8.
    • (2011) Neurology , vol.76 , Issue.8 SUPPL. 3
    • Hla, T.1    Brinkmann, V.2
  • 22
    • 77954864204 scopus 로고    scopus 로고
    • Fingolimod is a potential novel therapy for multiple sclerosis
    • Aktas O, Kury P, Kieseier B, Hartung HP. Fingolimod is a potential novel therapy for multiple sclerosis. Nat Rev Neurol. 2010;6(7): 373-382.
    • (2010) Nat Rev Neurol , vol.6 , Issue.7 , pp. 373-382
    • Aktas, O.1    Kury, P.2    Kieseier, B.3    Hartung, H.P.4
  • 23
    • 1642580757 scopus 로고    scopus 로고
    • Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
    • Matloubian M, Lo CG, Cinamon G, et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature. 2004;427(6972):355-360.
    • (2004) Nature , vol.427 , Issue.6972 , pp. 355-360
    • Matloubian, M.1    Lo, C.G.2    Cinamon, G.3
  • 24
    • 0037077308 scopus 로고    scopus 로고
    • The immune modulator FTY720 targets sphingosine 1-phosphate receptors
    • Brinkmann V, Davis MD, Heise CE, et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem. 2002;277(24):21453-21457.
    • (2002) J Biol Chem , vol.277 , Issue.24 , pp. 21453-21457
    • Brinkmann, V.1    Davis, M.D.2    Heise, C.E.3
  • 25
    • 0037066466 scopus 로고    scopus 로고
    • Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
    • Mandala S, Hajdu R, Bergstrom J, et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science. 2002;296(5566):346-349.
    • (2002) Science , vol.296 , Issue.5566 , pp. 346-349
    • Mandala, S.1    Hajdu, R.2    Bergstrom, J.3
  • 26
    • 28544436950 scopus 로고    scopus 로고
    • Diagnostic criteria for multiple sclerosis: 2005 revisions to the McDonald Criteria
    • Polman CH, Reingold SC, Edan G, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria". Ann Neurol. 2005;58(6):840-846.
    • (2005) Ann Neurol , vol.58 , Issue.6 , pp. 840-846
    • Polman, C.H.1    Reingold, S.C.2    Edan, G.3
  • 27
    • 0021035886 scopus 로고
    • Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
    • Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983;33(11): 1444-1452.
    • (1983) Neurology , vol.33 , Issue.11 , pp. 1444-1452
    • Kurtzke, J.F.1
  • 28
    • 76149093586 scopus 로고    scopus 로고
    • A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis
    • Kappos L, Radue EW, O'Connor P, et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med. 2010;362(5):387-401.
    • (2010) N Engl J Med , vol.362 , Issue.5 , pp. 387-401
    • Kappos, L.1    Radue, E.W.2    O'Connor, P.3
  • 29
    • 76149140914 scopus 로고    scopus 로고
    • Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis
    • Cohen JA, Barkhof F, Comi G, et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med. 2010;362(5):402-415.
    • (2010) N Engl J Med , vol.362 , Issue.5 , pp. 402-415
    • Cohen, J.A.1    Barkhof, F.2    Comi, G.3
  • 30
    • 79956024142 scopus 로고    scopus 로고
    • Comparison of fingolimod with interferon beta-1a in relapsing-remitting multiple sclerosis: A randomised extension of the TRANSFORMS study
    • Khatri B, Barkhof F, Comi G, et al. Comparison of fingolimod with interferon beta-1a in relapsing-remitting multiple sclerosis: a randomised extension of the TRANSFORMS study. Lancet Neurol. 2011;10(6):520-529.
    • (2011) Lancet Neurol , vol.10 , Issue.6 , pp. 520-529
    • Khatri, B.1    Barkhof, F.2    Comi, G.3
  • 31
    • 84855541355 scopus 로고    scopus 로고
    • ClinicalTrials.gov [database online]. Bethesda, MD; US National Institutes of Health. Available at, Accessed June 1
    • ClinicalTrials.gov [database online]. Bethesda, MD; US National Institutes of Health. Available at: http://clinicaltrials.gov/ct2/results?term=fingolimod+AND+multiple+sclerosis. Accessed June 1, 2011.
    • (2011)
  • 32
    • 80655128161 scopus 로고    scopus 로고
    • Delayed fingolimod-associated asystole
    • In press
    • Espinosa PS, Berger JR. Delayed fingolimod-associated asystole. Mult Scler. 2011. In press.
    • (2011) Mult Scler
    • Espinosa, P.S.1    Berger, J.R.2
  • 33
    • 80955165689 scopus 로고    scopus 로고
    • Lack of interaction between fingolimod (FTY720) and oral contraceptives, and pregnancy experience in the clinical program of fingolimod in multiple sclerosis
    • Paper Presented at: The 63rd Annual Meeting of the American Academy of Neurology Apr 9-16; Honolulu, Hawaii
    • Collins W, Francis G, Koren, et al. Lack of interaction between fingolimod (FTY720) and oral contraceptives, and pregnancy experience in the clinical program of fingolimod in multiple sclerosis. Paper presented at: The 63rd Annual Meeting of the American Academy of Neurology; 2011 Apr 9-16; Honolulu, Hawaii.
    • (2011)
    • Collins, W.1    Francis, G.2
  • 34
    • 79956003227 scopus 로고    scopus 로고
    • Transforming multiple sclerosis trials into practical reality
    • Kieseier BC, Wiendl H. Transforming multiple sclerosis trials into practical reality. Lancet Neurol. 2011;10(6):493-494.
    • (2011) Lancet Neurol , vol.10 , Issue.6 , pp. 493-494
    • Kieseier, B.C.1    Wiendl, H.2
  • 35
    • 60849112559 scopus 로고    scopus 로고
    • Injection anxiety remains a long-term barrier to medication adherence in multiple sclerosis
    • Turner AP, Williams RM, Sloan AP, Haselkorn JK. Injection anxiety remains a long-term barrier to medication adherence in multiple sclerosis. Rehabil Psychol. 2009;54(1):116-121.
    • (2009) Rehabil Psychol , vol.54 , Issue.1 , pp. 116-121
    • Turner, A.P.1    Williams, R.M.2    Sloan, A.P.3    Haselkorn, J.K.4
  • 36
    • 79952015024 scopus 로고    scopus 로고
    • Impact of sphingosine 1-phosphate modulation on immune outcomes
    • Pinschewer DD, Brinkmann V, Merkler D. Impact of sphingosine 1-phosphate modulation on immune outcomes. Neurology. 2011; 76 (8 Suppl 3):S15-S19.
    • (2011) Neurology , vol.76 , Issue.8 SUPPL. 3
    • Pinschewer, D.D.1    Brinkmann, V.2    Merkler, D.3
  • 37
    • 79952026310 scopus 로고    scopus 로고
    • Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis
    • Mehling M, Johnson TA, Antel J, Kappos L, Bar-Or A. Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis. Neurology. 2011;76(8 Suppl 3): S20-S27.
    • (2011) Neurology , vol.76 , Issue.8 SUPPL. 3
    • Mehling, M.1    Johnson, T.A.2    Antel, J.3    Kappos, L.4    Bar-Or, A.5
  • 38
    • 79954611536 scopus 로고    scopus 로고
    • Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS
    • Kowarik MC, Pellkofer HL, Cepok S, et al. Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS. Neurology. 2011;76(14):1214-1221.
    • (2011) Neurology , vol.76 , Issue.14 , pp. 1214-1221
    • Kowarik, M.C.1    Pellkofer, H.L.2    Cepok, S.3
  • 39
    • 33749588466 scopus 로고    scopus 로고
    • Altered CD4+/CD8+ T-cell ratios in cerebrospinal fluid of natalizumab-treated patients with multiple sclerosis
    • Stüve O, Marra CM, Bar-Or A, et al. Altered CD4+/CD8+ T-cell ratios in cerebrospinal fluid of natalizumab-treated patients with multiple sclerosis. Arch Neurol. 2006;63(10):1383-1387.
    • (2006) Arch Neurol , vol.63 , Issue.10 , pp. 1383-1387
    • Stüve, O.1    Marra, C.M.2    Bar-Or, A.3
  • 40
    • 79952524342 scopus 로고    scopus 로고
    • Antigen-specific adaptive immune responses in fingolimod-treated multiple sclerosis patients
    • Mehling M, Hilbert P, Fritz S, et al. Antigen-specific adaptive immune responses in fingolimod-treated multiple sclerosis patients. Ann Neurol. 2011;69(2):408-413.
    • (2011) Ann Neurol , vol.69 , Issue.2 , pp. 408-413
    • Mehling, M.1    Hilbert, P.2    Fritz, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.