Comparison of the distribution pattern of PEG-b-PCL polymersomes delivered into the rat inner ear via different methods

Acta Oto-Laryngologica

Volumn 131, Issue 12, 2011, Pages 1249-1256

  Zhang, Ya ^a   Zhang, Weikai ^a   Johnston, Alexander H ^b   Newman, Tracey A ^c   Pyykkö, Ilmari ^a   Zou, Jing ^a  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

animal; Drug delivery; imaging; nanocarrier

Indexed keywords

DRUG VEHICLE; GELATIN; MACROGOL; POLY(EPSILON CAPROLACTONE) BLOCK POLY(ETHYLENE GLYCOL); POLYCAPROLACTONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COCHLEA FENESTRA; COCHLEAR NERVE; COCHLEOSTOMY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORTI ORGAN; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; EAR SURGERY; INFECTION; INNER EAR; INTERMETHOD COMPARISON; MALE; MESOTHELIUM CELL; NONHUMAN; OSMOTIC PUMP; PRIORITY JOURNAL; RAT; SCALA TYMPANI; SEMICIRCULAR CANAL; SPIRAL GANGLION; SPIRAL LIGAMENT; STRIA VASCULARIS; TOPICAL TREATMENT; TRANSTYMPANIC INJECTION; UTRICLE; VESTIBULE;

ADMINISTRATION, TOPICAL; ANIMALS; COCHLEA; CRYOULTRAMICROTOMY; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; EAR, INNER; GELATIN SPONGE, ABSORBABLE; INJECTIONS; LACTONES; MALE; MICROSCOPY, CONFOCAL; NANOPARTICLES; OSMOSIS; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 80955160567     PISSN: 00016489     EISSN: 16512553     Source Type: Journal    
DOI: 10.3109/00016489.2011.615066     Document Type: Article

References (21)

1. Johnston AH, Dalton PD, Newman TA. Polymersomes, smaller than you think: ferrocene as a TEM probe to determine core structure. J Nanopart Res 2010;12:1997-2001.
2. Zhang Y, Zhang W, Johnston AH, Newman TA, Pyykko I, Zou J. Improving the visualization of fluorescently tagged nanoparticles and fluorophore-labeled molecular probes by treatment with CuSO4 to quench autofluorescence in the rat inner ear. Hear Res 2010;269:1-11.
3. Anderson M, Johnston AH, Newman TA, Dalton PD, Rask-Andersen H. Internalization of nanoparticles into spiral ganglion cells. Journal of Nanoneuroscience 2008;1:1-10.
4. Roy S, Johnston AH, Newman TA, Glueckert R, Dudas J, Bitsche M, et al. Cell-specific targeting in the mouse inner ear using nanoparticles conjugated with a neurotrophin-derived peptide ligand: Potential tool for drug delivery. Int J Pharm 2010;390:214-24.
5. Thomsen J, Charabi S, Tos M. Preliminary results of a new delivery system for gentamicin to the inner ear in patients with Meniere's disease. Eur Arch Otorhinolaryngol 2000; 257:362-5.
6. Zou J, Ramadan UA, Pyykko I. Gadolinium uptake in the rat inner ear perilymph evaluated with 4.7 TMRI: A comparison between transtympanic injection and gelatin sponge-based diffusion through the round window membrane. Otol Neurotol 2010;31:637-41.
7. Kaasinen S, Pyykko I, Ishizaki H, Aalto H. Intratympanic gentamicin in Meniere's disease. Acta Otolaryngol 1998;118: 294-8. (Pubitemid 28273167)
8. McCall AA, Swan EE, Borenstein JT, Sewell WF, Kujawa SG, McKenna MJ. Drug delivery for treatment of inner ear disease: Current state of knowledge. Ear Hear 2010; 31:156-65.
9. PrieskornDM,Miller JM. Technical report: Chronic and acute intracochlear infusion in rodents. Hear Res 2000;140:212-15. (Pubitemid 30079647)
10. Kania RE, Herman P, Tran Ba Huy P, Ar A. Role of nitrogen in transmucosal gas exchange rate in the rat middle ear. J Appl Physiol 2006;101:1281-7.
11. Zou J, Sood R, Ranjan S, Poe D, Ramadan UA, Kinnunen PK, et al. Manufacturing and in vivo inner ear visualization of MRI traceable liposome nanoparticles encapsulating gadolinium. J Nanobiotechnology 2010;8:32.
12. Goycoolea MV, Lundman L. Round window membrane. Structure function and permeability: A review. Microsc Res Tech 1997;36:201-11.
13. Salt AN, Ma Y. Quantification of solute entry into cochlear perilymph through the round window membrane. Hear Res 2001;154:88-97. (Pubitemid 32567538)
14. Lundman L, Juhn SK, Bagger-Sjoback D, Svanborg C. Permeability of the normal round window membrane to Haemophilus influenzae type b endotoxin. Acta Otolaryngol 1992;112:524-9.
15. Ohashi M, Ide S, Sawaguchi A, Suganuma T, Kimitsuki T, Komune S. Histochemical localization of the extracellular matrix components in the annular ligament of rat stapediovestibular joint with special reference to fibrillin, 36-kDa microfibril-associated glycoprotein (MAGP-36), and hyaluronic acid. Med Mol Morphol 2008;41:28-33. (Pubitemid 351677141)
16. Zou J, Yoshida T, Ramadan UA, Pyykkö I. Dynamic enhancement of the rat inner ear after ultra-small volume administration of Gd-DOTA to the medial wall of the middle ear cavity. ORL J Otorhinolaryngol Relat Spec 2011 (in press).
17. Ulfendahl M, Scarfone E, Flock A, Le Calvez S, Conradi P. Perilymphatic fluid compartments and intercellular spaces of the inner ear and the organ of Corti. Neuroimage 2000;12: 307-13.
18. Zou J, Saulnier P, Perrier T, Zhang Y, Manninen T, Toppila E, et al. Distribution of lipid nanocapsules in different cochlear cell populations after round window membrane permeation. JBiomedMaterResBApplBiomater2008;87:10-18.
19. Zou J, Pyykko I, Counter S, Klason T, Bretlau P, Bjelke B. In vivo observation of dynamic perilymph formation using 4.7 T MRI with gadolinium as a tracer. Acta Otolaryngol 2003; 123:910-15. (Pubitemid 37346546)
20. Rask-Andersen H, Schrott-Fischer A, Pfaller K, Glueckert R. Perilymph/modiolar communication routes in the human cochlea. Ear Hear 2006;27:457-65. (Pubitemid 44371242)
21. Zou J, Poe D, Bjelke B, Pyykko I. Visualization of inner ear disorders with MRI in vivo: from animal models to human application. Acta Otolaryngol Suppl 2009:22-31.