Solvent-free, microwave assisted Knoevenagel condensation of novel 2,5-disubstituted indole analogues and their biological evaluation

European Journal of Medicinal Chemistry

Volumn 46, Issue 12, 2011, Pages 6112-6118

  Biradar, J S ^a   Sasidhar, B S ^a  

^a GULBARGA UNIVERSITY   (India)

Author keywords

2,5 disubstituted indole 3 carboxaldehydes; Antioxidant activity; Cytotoxic activity; Knoevenagel condensation; Microwave irradiation

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 3 METHYL 4 [(5 METHYL 2 PHENYL 1H INDOL 3 YL)METHYLENE] 1H PYRAZOL 5 (4H)ONE; 4 [(1H INDOL 3 YL)METHYLENE] 3 METHYL 1H PYRAZOL 5 (4H)ONE; 4 [(5 CHLORO 2 PHENYL 1H INDOL 3 YL)METHYLENE] 3 METHYL 1H PYRAZOL 5 (4H)ONE; 5 [(1H INDOL 3 YL)METHYLENE]DIHYDRO 2 THIOXOPYRIMIDINE 4,6 (1H,5H)DIONE; 5 [(1H INDOL 3 YL)METHYLENE]PYRIMIDINE 2,4,6 (1H,3H,5H)TRIONE; 5 [(1H INDOL 3 YL)METHYLENE]THIAZOLIDINE 2,4 DIONE; 5 [(5 CHLORO 2 PHENYL 1H INDOL 3 YL)METHYLENE]DIHYDRO 2 THIOXOPYRIMIDINE 4,6 (1H,5H)DIONE; 5 [(5 CHLORO 2 PHENYL 1H INDOL 3 YL)METHYLENE]THIAZOLIDINE 2,4 DIONE; 5 [(5 METHYL 2 PHENYL 1H INDOL 3 YL)METHYLENE]DIHYDRO 2 THIOXOPYRIMIDINE 4,6 (1H,5H)DIONE; 5 [(5 METHYL 2 PHENYL 1H INDOL 3 YL)METHYLENE]PYRIMIDINE 2,4,6 (1H,3H,5H)TRIONE; 5 [(5 METHYL 2 PHENYL 1H INDOL 3 YL)METHYLENE]THIAZOLIDINE 2,4 DIONE; 5 [(5CHLORO 2 PHENYL 1H INDOL 3 YL)METHYLENE]PYRIMIDINE 2,4,6 (1H,3H,5H)TRIONE; ANTIOXIDANT; BARBITURIC ACID DERIVATIVE; DOXORUBICIN; INDOLE DERIVATIVE; SCAVENGER; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; HELA CELL; HEP 2 CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; INFRARED SPECTROSCOPY; KNOEVENAGEL CONDENSATION; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; HUMANS; INDOLES; MICROWAVES; NEOPLASMS;

EID: 80955159780     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.10.004     Document Type: Article

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