Oncocytic mucoepidermoid carcinoma: Clinicopathologic description in a series of 12 cases

American Journal of Surgical Pathology

Volumn 33, Issue 3, 2009, Pages 409-416

  Weinreb, Ilan ^a   Seethala, Raja R ^b   Perez Ordoñez, Bayardo ^a   Chetty, Runjan ^a   Hoschar, Aaron P ^c   Hunt, Jennifer L ^c  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Grading; Mucoepidermoid carcinoma; Oncocytic; P63; Salivary gland

Indexed keywords

MUCIN; PROTEIN P63; CKAP4 PROTEIN, HUMAN; MEMBRANE PROTEIN; TUMOR MARKER;

ADENOSQUAMOUS CARCINOMA; ADULT; AGED; ARTICLE; CANCER GRADING; CLINICAL ARTICLE; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; FEMALE; FOLLOW UP; HARD PALATE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PROGNOSIS; SOLID TUMOR; BIOSYNTHESIS; METABOLISM; MIDDLE AGED; ONCOCYTOMA; PATHOLOGY; SALIVARY GLAND TUMOR;

ADENOMA, OXYPHILIC; ADULT; AGED; CARCINOMA, MUCOEPIDERMOID; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE PROTEINS; MIDDLE AGED; SALIVARY GLAND NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 62849086604     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e318184b36d     Document Type: Article

References (33)

1. Brandwein MS, Ivanov K, Wallace DI, et al. Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol. 2001;25: 835-845.
2. Brannon RB, Willard CC. Oncocytic mucoepidermoid carcinoma of parotid gland origin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;96:727-733.
3. Choi D, Kim H, Lee KS, et al. Mucoepidermoid carcinoma of the liver diagnosed as a liver abscess: report of a case. Surg Today. 2004;34:968-972.
4. Chomette G, Auriol M, Tereau Y, et al. Mucoepidermoid tumors of minor salivary glands. Clinical and pathologic correlations. Histoenzymologic and ultrastructural studies. Ann Pathol. 1982;2: 29-40.
5. Corcione L, Giordano G, Gnetti L, et al. Oncocytic mucoepider-moid carcinoma of a submandibular gland: a case report and review of the literature. Int J Oral Maxillofac Surg. 2007;36:560-563.
6. Dardick I, Birek C, Lingen MW, et al. Differentiation and the cytomorphology of salivary gland tumors with specific reference to oncocytic metaplasia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;88:691-701.
7. Deveci MS, Deveci G, Gunhan O, et al. Oncocytic mucoepidermoid carcinoma of the parotid gland: report of a case with DNA ploidy analysis and review of the literature. Pathol Int. 2000;50: 905-909.
8. Ferreiro JA, Stylopoulos N. Oncocytic differentiation in salivary gland tumours. J Laryngol Otol. 1995;109:569-571.
9. Foschini MP, Marucci G, Eusebi V. Low-grade mucoepidermoid carcinoma of salivary glands: characteristic immunohistochemical profile and evidence of striated duct differentiation. Virchows Arch. 2002;440:536-542.
10. Goode RK, El-Naggar AK. Mucoepidermoid carcinoma. In: Barnes EL, Eveson JW, Reichart P, et al, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Head and Neck Tumours. Lyon: IARC Press; 2005:219-220.
11. Goode RK, Auclair PL, Ellis GL. Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria. Cancer. 1998;82: 1217-1224.
12. Hamed G, Shmookler BM, Ellis GL, et al. Oncocytic mucoepider-moid carcinoma of the parotid gland. Arch Pathol Lab Med. 1994; 118:313-314.
13. Henley JD, Rehan J, Oda D, et al. Oncocytic metaplastic tumors of salivary gland origin (abstract). Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;84:187-188.
14. Hunt JL, LiVolsi VA, Barnes EL. p63 expression in sclerosing mucoepidermoid carcinomas with eosinophilia arising in the thyroid. Mod Pathol. 2004;17:526-529.
15. Jahan-Parwar B, Huberman RM, Donovan DT, et al. Oncocytic mucoepidermoid carcinoma of the salivary glands. Am J Surg Pathol. 1999;23:523-529.
16. Krishnanand G, Kaur M, Rao RV, et al. Oncocytic variant of mucoepidermoid carcinoma of submandibular gland: an unusual clinical and morphological entity. Indian J Pathol Microbiol. 2007; 50:538-540.
17. Kusafuka K, Takizawa Y, Iida Y, et al. Primary nasopharyngeal mucoepidermoid carcinoma in Japanese patients: two case reports with histochemical and immunohistochemical analysis and a review of the literature. Virchows Arch. 2007;450:343-348.
18. Levin LA, Popham J, To K, et al. Mucoepidermoid carcinoma of the lacrimal gland. Report of a case with oncocytic features arising in a patient with chronic dacryops. Ophthalmology. 1991;98: 1551-1555.
19. López-Terrada D, Bloom MG, Cagle PT, et al. Oncocytic mucoepidermoid carcinoma of the trachea. Arch Pathol Lab Med. 1999;123:635-637.
20. Luna MA. Salivary mucoepidermoid carcinoma: revisited. Adv Anat Pathol. 2006;13:293-307.
21. Martins C, Cavaco B, Tonon G, et al. A study of MECT1-MAML2 in mucoepidermoid carcinoma and Warthin's tumor of salivary glands. J Mol Diagn. 2004;6:205-210.
22. McHugh JB, Hoschar AP, Dvorakova M, et al. P63 immunohis-tochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma. Head Neck Pathol. 2007;1:31-34.
23. Michal M, Hrabal P, Skálová A. Oncocytic cystadenoma of the parotid gland with prominent signet-ring cell features. Pathol Int. 1998;48:629-633.
24. Pulitzer DR, Eckert ER. Mucoepidermoid carcinoma of the lacrimal gland. An oxyphilic variant. Arch Ophthalmol. 1987;105:1406-1409.
25. Prasad AR, Savera AT, Gown AM, et al. The myoepithelial immunophenotype in 135 benign and malignant salivary gland tumors other than pleomorphic adenoma. Arch Pathol Lab Med. 1999;123:801-806.
26. Prasad AR, Savera AT, Regezi JA, et al. Antimitochondrial antibody-a diagnostic discriminant of salivary gland oncocytic tumors and acinic cell carcinomas (abstract 756). Modern Pathol. 1999;12:130A.
27. Rizkalla H, Toner M. Necrotizing sialometaplasia versus invasive carcinoma of the head and neck: the use of myoepithelial markers and keratin subtypes as an adjunct to diagnosis. Histopathology. 2007;51:184-189.
28. Seethala RR, LiVolsi VA, Zhang PJ, et al. Comparison of p63 and p73 expression in benign and malignant salivary gland lesions. Head Neck. 2005;27:696-702.
29. Sidhu GS, Waldo ED. Oncocytic change in mucoepidermoid carcinoma of the parotid gland. Arch Pathol. 1975;99:663-666.
30. Simpson RH, Prasad AR, Lewis JE, et al. Mucin-rich variant of salivary duct carcinoma: a clinicopathologic and immunohisto-chemical study of four cases. Am J Surg Pathol. 2003;27:1070-1079.
31. Skalova A, Michal M, Ryska A, et al. Oncocytic myoepithelioma and pleomorphic adenoma of the salivary glands. Virchows Arch. 1999;434:537-546.
32. Stafford JR, Pollock WJ, Wenzel BC. Oncocytic mucoepidermoid tumor of the bronchus. Cancer. 1984;54:94-99.
33. Weinreb I, Tabanda-Lichauco R, Van der Kwast T, et al. Low-grade intraductal carcinoma of salivary gland: report of 3 cases with marked apocrine differentiation. Am J Surg Pathol. 2006;30:1014-1021.