Rat as an animal model for Peyronie's disease research: A review of current methods and the peer-reviewed literature

International Journal of Impotence Research

Volumn 23, Issue 6, 2011, Pages 235-241

  Chung, E ^a   De Young, L ^b   Brock, G B ^b  

^a PRINCESS ALEXANDRA HOSPITAL   (Australia)

^b Division of Urology   (Canada)

Author keywords

Peyronie's disease; rodent animal models; TGF 1

Indexed keywords

FIBRIN; TRANSFORMING GROWTH FACTOR BETA1;

CELL CULTURE; EXPERIMENTAL RAT; FIBROSIS; GENETIC ANALYSIS; MYOFIBROBLAST; NONHUMAN; PEER REVIEW; PENILE BIOPSY; PEYRONIE DISEASE; PRIORITY JOURNAL; REVIEW; SURGICAL INJURY;

ANIMALS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FIBRIN; FIBROBLASTS; FIBROSIS; HUMANS; MALE; MEDLINE; PEER REVIEW; PENILE INDURATION; PENIS; POSTOPERATIVE COMPLICATIONS; RATS; TRANSFORMING GROWTH FACTOR BETA1; WOUND HEALING;

EID: 80955144382     PISSN: 09559930     EISSN: 14765489     Source Type: Journal    
DOI: 10.1038/ijir.2011.36     Document Type: Review

References (37)

1. Taylor FL, Levine LA. Peyronie's disease. Urol Clin North Am 2007; 34: 517-534. (Pubitemid 350029957)
2. Mulhall JP, Creech SD, Boorjian SA, Ghaly S, Kim ED, Moty A et al. Subjective and objective analysis of the prevalence of Peyronie's disease in a population of men presenting for prostate cancer screening. J Urol 2004; 171: 2350-2353. (Pubitemid 38625468)
3. Nelson CJ, Diblasio C, Kendirci M, hellstrom W, Guhring P, Mulhall JP. The chronology of depression and distress in men with Peyronie's disease. J Sex Med 2008; 5: 1985-1990.
4. Hauck EW, Hauptmann A, Schmelz HU, Bein G, Weidner W, Hackstein H. Prospective analysis of single nucleotide polymorphisms of the transforming growth factor b-1 gene in Peyronie's disease. J Urol 2003; 169: 369-372. (Pubitemid 35461648)
5. El-Sakka AI, Hassoba HM, Pillarisetty RJ, Dahiya R, Lue TF. Peyronie's disease is associated with an increase in transforming growth factor-beta protein expression. J Urol 1997; 158: 1391-1394.
6. Gonzalez-Cadavid NF, Rajfer J. Mechanisms of disease: new insights into the cellular and molecular pathology of Peyr-onie's disease. Nat Clin Pract Urol 2005; 2: 291-297. (Pubitemid 40903186)
7. Mulhall JP, Anderson MS, Lubrano T, Shankey TV. Peyronie's cell culture model: phenotypic, genotypic and functional analyses. Int J Impot Res 2002; 14: 397-405. (Pubitemid 35285291)
8. Tomasek JJ, Gabbiani G, Hinz B, Chapponier C, Brown RA. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 2002; 3: 349-363. (Pubitemid 34619269)
9. Vernet D, Nolazco G, Cantini L, Magee TR, Qian A, Rajfer J et al. Evidence that osteogenic progenitor cells in the human tunica albuginea may originate from stem cells: implications for Peyronie's disease. Biol Reprod 2005; 73: 1199-1210. (Pubitemid 41698610)
10. Vernet D, Ferrini MG, Valente EG, Magee TR, Bou-Gharios G, Rajfer J et al. Effect of nitric oxide on the differentiation of fibroblasts into myofibroblasts in the Peyronie's fibrotic plaque and in its rat model. Nitric Oxide 2002; 7: 262-276. (Pubitemid 35365671)
11. Mulhall JP, Nicholson B, Pierpaoli S, Lubrano T, Shankey TV. Chromosomal instability is demonstrated by fibroblasts derived from tunica of men with Peyronie's disease. Int J Impot Res 2004; 16: 288-293. (Pubitemid 38858964)
12. De Young LX, Bella AJ, O'Gorman DB, Gan BS, Lim KB, Brock GB. Protein biomarker analysis of primary Peyronie's disease cells. J Sex Med 2010; 7: 99-106.
13. Magee TR, Qian A, Rajfer J, Sander FC, Levine LA, Gonzalez-Cadavid NF. Gene expression profiles in the Peyronie's disease plaque. Urology 2002; 59: 451-457. (Pubitemid 34189763)
14. El-Sakka AI, Hassoba HM, Chui RM, Bhatnagar RS, Dahiya R, Lue TF. An animal model of Peyronie's-like condition associated with an increase of transforming growth factor beta mRNA and protein expression. J Urol 1997; 158: 2284-2290. (Pubitemid 27481391)
15. Lutz M, Knaus P. Integration of the TGF-beta pathway into the cellular signalling network. Cell Signal 2002; 14: 977-988. (Pubitemid 35279422)
16. Haag SM, Hauck EW, Szardening-Kirchner C, Diemer T, Cha ES, Weidner W et al. Alterations in the transforming growth factor (TGF)-b pathway as a potential factor in the pathogen-esis of Peyronie's disease. Eur Urol 2007; 51: 255-261. (Pubitemid 44821507)
17. Border WA, Ruoslahti E. Transforming growth factor beta in disease: the dark side of tissue repair. J Clin Invest 1992; 90: 1-7.
18. Bivalacqua TJ, Diner EK, Novak TE, Vohra Y, Sikka SC, Champion HC et al. A rat model of Peyronie's disease associated with a decrease in erectile activity and an increase in inducible nitric-oxide synthase protein expression. J Urol 2000; 163: 1992-1998. (Pubitemid 30366800)
19. Ferrini MG, Vernet D, Magee TR, Shahed A, Qian A, Rajfer J et al. Antifibrotic role of inducible nitric oxide synthase. Nitric Oxide 2002; 6: 283-294. (Pubitemid 34852372)
20. Cantini LP, Ferrini MG, Vernet D, Magee TR, Qian A, Gelfand RA et al. Profibrotic role of myostatin in Peyronie's disease. J Sex Med 2008; 5: 1607-1622. (Pubitemid 352044418)
21. Artaza J, Singh R, Ferrini MG, Braga M, Tsao J, Gonzalez-Cadavid NF. Myostatin promotes a fibrotic phenotypic switch in multipotent C3H10T1/1 cells without affecting their differentiation into myofibroblasts. J Endocrinol 2008; 196: 235-249. (Pubitemid 351298509)
22. Ferrini MG, Kovanecz I, Nolazco G, Rajfer J, Gonzalez-Cadavid NF. Effects of long-term treatment with vardenafil on the development of the fibrotic plaque model in rat model of Peyronie's disease. BJU Int 2006; 97: 625-633.
23. Valente EG, Vernet D, Ferrini MG, Qian A, Rajfer J, Gonzalez-Cadavid NF. L-arginine and PDE inhibitors counteract fibrosis in Peyronie's plaque and related fibroblast cultures. Nitric Oxide 2003; 9: 229-244. (Pubitemid 38294362)
24. Wen FQ, Liu X, Kobayashi T, Abe S, Fang Q, Kohyama T et al. Interferon-gamma inhibits transforming growth factor-beta production in human epithelial cells by targeting Smads. Am J Respir Cell Mol Biol 2004; 30: 816-822. (Pubitemid 38736905)
25. Hellstrom WJ, Kendirci M, Matern R, Cockerham Y, Myers L, Sikka SC et al. Single-blind, mulicenter, placebo controlled, parallel study to assess the safety and efficacy of intralesional interferon alpha-2B for minimally invasive treatment for Peyronie's disease. J Urol 2006; 176: 394-398. (Pubitemid 43833173)
26. Piao S, Ryu JK, Shin HY, Zhang L, Song SU, Han JY et al. Repeated intratunical injection of adenovirus expressing transforming growth factor-beta 1 in rat induces penile curvature with tunical fibrotic plaque: a useful model for the study of Peyronie's disease. Int J Androl 2007; 31: 346-353. (Pubitemid 351652031)
27. Mosesson MW. Fibrinogen and fibrin structure and functions. J Thromb Haemost 2005; 3: 1894-1904. (Pubitemid 41716577)
28. Somers KD, Dawson DM, Wright Jr GL, Leffell MS, Rowe MJ, Bluemink GG et al. Cell culture of Peyronie's disease plaque and normal penile tissue. J Urol 1982; 127: 585-588. (Pubitemid 12147661)
29. Somers KD, Dawson DM. Fibrin deposition in Peyronie's disease plaque. J Urol 1997; 157: 311-315. (Pubitemid 26414981)
30. Merlo G, Ambroggio GP, Castagna B, Mosca A, Oberto E. Fibrin/fibrinogen and fibronolytic activity of the palmar fascia in Dupuytren's contracture. J Hand Surg 1986; 11: 55-57.
31. Somers KD, Winters BM, Dawson DM, Leffell MS, Wright Jr GL, Devine Jr CJ et al. Chromosomal abnormalities in Peyronie's disease. J Urol 1987; 137: 672-675.
32. Davila HH, Ferrini MG, Rajfer J, Gonzalez-Cadavid NF. Fibrin as an inducer of fibrosis in the tunica albuginea of rat: a new animal model of Peyronie's disease. BJU Int 2003; 91: 830-838. (Pubitemid 36724070)
33. Davila HH, Magee TR, Zuniga FI, Rajfer J, Gonzalez-Cadavid NF. Peyronie's disease associated with increase in plasmino-gen activator inhibitor in fibrotic plaque. Urology 2005; 65: 645-648. (Pubitemid 40522991)
34. El-Sakka AI, Selph CA, Yen TS, Dahiya R, Lue TF. The effect of surgical trauma on rat tunica albuginea. J Urol 1998; 159: 1700-1707. (Pubitemid 29117387)
35. Lucattelli M, Lunghi B, Fineshi S, Mirone V, d'Emmanuele di Villa Bianca R, Longo N et al. A new mouse model of Peyronie's disease: an increased expression of hypoxia-inducible factor-1 target genes during the development of penile changes. Int J Biochem Cell Biol 2008; 40: 2638-2648.
36. Lemaire R, Bayle J, Lafyatis R. Fibrillin in Marfan syndrome and tight skin mice provides new insights into transforming growth factor beta regulation and systemic sclerosis. Curr Opin Rheumatol 2006; 18: 582-587. (Pubitemid 44607410)
37. Del Carlo M, Cole AA, Levine LA. Differential calcium independent regulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases by interleu-kins-1b and transforming growth factor-b in Peyronie's plaque fibroblasts. J Urol 2008; 179: 2447-2455.