Single-Blind, Multicenter, Placebo Controlled, Parallel Study to Assess the Safety and Efficacy of Intralesional Interferon α-2b for Minimally Invasive Treatment for Peyronie's Disease

Journal of Urology

Volumn 176, Issue 1, 2006, Pages 394-398

  Hellstrom, Wayne J G ^a   Kendirci, Muammer ^a   Matern, Richard ^a   Cockerham, Yolanda ^a   Myers, Leann ^a   Sikka, Suresh C ^a   Venable, Dennis ^b   Honig, Stanton ^d   McCullough, Andrew ^e   Hakim, Lawrence S ^f   Nehra, Ajay ^g   Templeton, Lance E ^c   Pryor, Jon L ^h  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^c Rapides Regional Medical Center   (United States)

^d UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^e NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f DEPARTMENT OF COLORECTAL SURGERY   (United States)

^g MAYO CLINIC   (United States)

^h UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Doppler; interferons; penile induration; penis; ultrasonography

Indexed keywords

ALPHA2B INTERFERON; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; ECCHYMOSIS; FLU LIKE SYNDROME; HEMODYNAMICS; HUMAN; MALE; MULTICENTER STUDY; PAIN; PARALLEL DESIGN; PENILE BLOOD FLOW; PENILE FIBROSIS; PENILE SWELLING; PENIS; PENIS ERECTION; PEYRONIE DISEASE; PRIORITY JOURNAL; SINGLE BLIND PROCEDURE; SINUSITIS;

ADULT; AGED; HUMANS; INJECTIONS, INTRALESIONAL; INTERFERON ALFA-2B; MALE; MIDDLE AGED; PAIN; PENILE ERECTION; PENILE INDURATION; PENIS; SINGLE-BLIND METHOD; SODIUM CHLORIDE;

EID: 33744814616     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(06)00517-9     Document Type: Article

References (18)

1. Weidner W., Schroeder-Printzen I., Weiske W.H., and Vosshenrich R. Sexual dysfunction in Peyronie's disease. an analysis of 222 patients without previous local plaque therapy. J Urol 157 (1997) 325
2. Schwarzer U., Sommer F., Klotz T., Braun M., Reifenrath B., and Engelmann U. The prevalence of Peyronie's disease. results of a large survey. BJU Int 88 (2001) 727
3. Kadioglu A., Oktar T., Kandirali E., Kendirci M., Sanli O., and Ozsoy C. Incidentally diagnosed Peyronie's disease in men presenting with erectile dysfunction. Int J Impot Res 16 (2004) 540
4. Hellstrom W.J., and Bivalacqua T.J. Peyronie's disease. etiology, medical, and surgical therapy. J Androl 21 (2000) 347
5. Roth M., Eickelberg O., Kohler E., Erne P., and Block L.H. Ca2+ channel blockers modulate metabolism of collagens within the extracellular matrix. Proc Natl Acad Sci USA 93 (1996) 5478
6. Duncan M.R., Berman B., and Nseyo U.O. Regulation of the proliferation and biosynthetic activities of cultured human Peyronie's disease fibroblasts by interferons-alpha, -beta and -gamma. Scand J Urol Nephrol 25 (1991) 89
7. Ahuja S., Bivalacqua T.J., Case J., Vincent M., Sikka S.C., and Hellstrom W.J. A pilot study demonstrating clinical benefit from intralesional interferon alpha 2B in the treatment of Peyronie's disease. J Androl 20 (1999) 444
8. Judge I.S., and Wisniewski Z.S. Intralesional interferon in the treatment of Peyronie's disease. a pilot study. Br J Urol 79 (1997) 40
9. Wegner H.E., Andresen R., Knispel H.H., and Miller K. Local interferon-alpha 2b is not an effective treatment in early-stage Peyronie's disease. Eur Urol 32 (1997) 190
10. Dang G., Matern R., Bivalacqua T.J., Sikka S., and Hellstrom W.J. Intralesional interferon-alpha-2B injections for the treatment of Peyronie's disease. South Med J 97 (2004) 42
11. Rosen R.C., Riley A., Wagner G., Osterloh I.H., Kirkpatrick J., and Mishra A. The international index of erectile function (IIEF). a multidimensional scale for assessment of erectile dysfunction. Urology 49 (1997) 822
12. Levine L.A., Goldman K.E., and Greenfield J.M. Experience with intraplaque injection of verapamil for Peyronie's disease. J Urol 168 (2002) 621
13. Benson R.C., and Knoll L.D. Interferon alpha-2b in the treatment of Peyronie's disease. abstract. J Urol 145 suppl. (1991) 342A
14. Wegner H.E., Andresen R., Knipsel H.H., and Miller K. Treatment of Peyronie's disease with local interferon-alpha 2b. Eur Urol 28 (1995) 236
15. Brake M., Loertzer H., Horsch R., and Keller H. Treatment of Peyronie's disease with local interferon-alpha 2b. BJU Int 87 (2001) 654
16. Gelbard M.K., James K., Riach P., and Dorey F. Collagenase versus placebo in the treatment of Peyronie's disease. a double-blind study. J Urol 149 (1993) 56
17. Kadioglu A., Tefekli A., Erol H., Cayan S., and Kandirali E. Color Doppler ultrasound assessment of penile vascular system in men with Peyronie's disease. Int J Impot Res 12 (2000) 263
18. Lopez J.A., and Jarow J.P. Penile vascular evaluation of men with Peyronie's disease. J Urol 149 (1993) 53