Red clover and soy isoflavonesan in vitro safety assessment

Gynecological Endocrinology

Volumn 27, Issue 12, 2011, Pages 1037-1042

  Reiter, Evelyne ^a,b   Gerster, Petra ^a,b   Jungbauer, Alois ^a,b  

^a UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^b INSTITUTE FOR MICROELECTRONICS   (Austria)

Author keywords

apoptosis; cell cycle arrest; cell proliferation; isoflavones; red clover; soy

Indexed keywords

GENISTEIN; ISOFLAVONE;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CELL ASSAY; CELL CYCLE ARREST; CELL PROLIFERATION; COLON CANCER; CYTOTOXICITY; FIBROBLAST CULTURE; FLUORESCENCE ACTIVATED CELL SORTING; IN VITRO STUDY; LIVER CANCER; NECROSIS; NONHUMAN; OVARY CANCER; PANCREAS CANCER; PRIORITY JOURNAL; PROSTATE CANCER; RED CLOVER; RISK ASSESSMENT; SOYBEAN; STOMACH CANCER; UTERINE CERVIX CANCER;

APOPTOSIS; CACO-2 CELLS; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; DRUG TOXICITY; GENISTEIN; HELA CELLS; HEP G2 CELLS; HUMANS; ISOFLAVONES; PLANT EXTRACTS; SOYBEANS; TRIFOLIUM;

EID: 80955142460     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.3109/09513590.2011.588743     Document Type: Article

References (29)

1. Liggins J, Bluck LJ, Runswick S, Atkinson C, Coward WA, Bingham SA. Daidzein and genistein contents of vegetables. Br J Nutr 2000;84:717-725.
2. Valsta LM, Kilkkinen A, Mazur W, Nurmi T, Lampi AM, Ovaskainen ML, Korhonen T, et al. Phyto-oestrogen database of foods and avge intake in Finland. Br J Nutr 2003;89 (Suppl 1):S31-S38.
3. Lindner HR. Occurrence of anabolic agents in plants and their importance. Environ Qual Saf Suppl 1976;151-158.
4. Medjakovic S, Jungbauer A. Red clover isoflavones biochanin A and formononetin are potent ligands of the human aryl hydrocarbon receptor. J Steroid Biochem Mol Biol 2008;108:171-177.
5. Mueller M, Jungbauer A. Red clover extract: A putative source for simultaneous treatment of menopausal disorders and the metabolic syndrome. Menopause 2008;15:1120-1131.
6. Mueller M, Jungbauer A. Peroxisome proliftor-activated receptor gamma is constitutively activated in yeast. Anal Biochem 2009;385:365-367.
7. Soto AM, Sonnenschein C, Chung KL, Fernandez MF, Olea N, Serrano FO. The E-SCREEN assay as a tool to identify estrogens: An update on estrogenic environmental pollutants. Environ Health Perspect 1995;103 (Suppl 7):113-122.
8. Murata M, Midorikawa K, Koh M, Umezawa K, Kawanishi S. Genistein and daidzein induce cell proliftion and their metabolites cause oxidative DNA damage in relation to isoflavone-induced cancer of estrogen-sensitive organs. Biochemistry 2004;43:2569-2577.
9. Stroheker T, Picard K, Lhuguenot JC, Canivenc-Lavier MC, Chagnon MC. Steroid activities comparison of natural and food wrap compounds in human breast cancer cell lines. Food Chem Toxicol 2004;42:887-897.
10. Li Y, Upadhyay S, Bhuiyan M, Sarkar FH. Induction of apoptosis in breast cancer cells MDA-MB-231 by genistein. Oncogene 1999;18:3166-3172.
11. Lian F, Bhuiyan M, Li YW, Wall N, Kraut M, Sarkar FH. Genisteininduced G2-M arrest, p21WAF1 upregulation, and apoptosis in a non-small-cell lung cancer cell line. Nutr Cancer 1998;31:184-191.
12. Peterson G, Barnes S. Genistein inhibits both estrogen and growth factor-stimulated proliftion of human breast cancer cells. Cell Growth Differ 1996;7:1345-1351.
13. Peterson G, Barnes S. Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation. Prostate 1993;22:335-345.
14. Peterson G, Barnes S. Genistein inhibition of the growth of human breast cancer cells: independence from estrogen receptors and the multi-drug resistance gene. Biochem Biophys Res Commun 1991;179:661-667.
15. Shao ZM, Alpaugh ML, Fontana JA, Barsky SH. Genistein inhibits proliftion similarly in estrogen receptor-positive and negative human reast carcinoma cell lines characterized by P21WAF1/ CIP1 induction, G2/M arrest, and apoptosis. J Cell Biochem 1998;69:44-54.
16. Chang KL, Kung ML, Chow NH, Su SJ. Genistein arrests hepatoma cells at G2/M phase: involvement of ATM activation and upregulation of p21waf1/cip1 and Wee1. Biochem Pharmacol 2004;67:717-726.
17. Reiter E, Reiter E, Beck V, Medjakovic S, Jungbauer A. Isoflavones are safe compounds for thpeutical applications-evaluation of in vitro data. Gynecol Endocrinol 2009;25:554-580.
18. Shao ZM, Wu J, Shen ZZ, Barsky SH. Genistein exerts multiple suppressive effects on human breast carcinoma cells. Cancer Res 1998;58:4851-4857.
19. Constantinou AI, Krygier AE, Mehta RR. Genistein induces maturation of cultured human breast cancer cells and prevents tumor growth in nude mice. Am J Clin Nutr 1998;68:1426S-1430S.
20. Zhou JR, Gugger ET, Tanaka T, Guo Y, Blackburn GL, Clinton SK. Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice. J Nutr 1999;129:1628-1635.
21. Vantyghem SA, Wilson SM, Postenka CO, Al-Katib W, Tuck AB, Chambers AF. Dietary genistein reduces metastasis in a postsurgical orthotopic breast cancer model. Cancer Res 2005;65:3396-3403.
22. Power KA, Saarinen NM, Chen JM, Thompson LU. Mammalian lignans enterolactone and enterodiol, alone and in combination with the isoflavone genistein, do not promote the growth of MCF-7 xenografts in ovariectomized athymic nude mice. Int J Cancer 2006;118:1316-1320.
23. Moon YJ, Shin BS, An G, Morris ME. Biochanin A inhibits breast cancer tumor growth in a murine xenograft model. Pharm Res 008;25:2158-2163.
24. Allred CD, Allred KF, Ju YH, Virant SM, Helferich WG. Soy diets containing varying amounts of genistein stimulate growth of estrogendependent (MCF-7) tumors in a dose-dependent manner. Cancer Res 2001;61:5045-5050.
25. Ju YH, Fultz J, Allred KF, Doerge DR, Helferich WG. Effects of dietary daidzein and its metabolite, equol, at physiological concentrations on the growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in ovariectomized athymic mice. Carcinogenesis 2006;27:856-863.
26. Jiang X, Patterson NM, Ling Y, Xie J, Helferich WG, Shapiro DJ. Low concentrations of the soy phytoestrogen genistein induce proteinase inhibitor 9 and block killing of breast cancer cells by immune cells. Endocrinology 2008;149:5366-5373.
27. Ju YH, Doerge DR, Woodling KA, Hartman JA, Kwak J, Helferich WG. Dietary genistein negates the inhibitory effect of letrozole on the growth of aromatase-expressing estrogen-dependent human breast cancer cells (MCF-7Ca) in vivo. Carcinogenesis 2008;29:2162-2168.
28. Ju YH, Doerge DR, Allred KF, Allred CD, Helferich WG. Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice. Cancer Res 2002;62:2474-2477.
29. Bronikowska J, Szliszka E, Czuba ZP, Zwolinski D, Szmydki D, Krol W. The combination of TRAIL and isoflavones enhances apoptosis in cancer cells. Molecules 2010;15:2000-2015.