Mupirocin calcium microencapsulation via spray drying: Feed solvent influence on microparticle properties, stability and antimicrobial activity

Drug Development and Industrial Pharmacy

Volumn 37, Issue 12, 2011, Pages 1402-1414

  Dürrigl, Marjana ^a   Lusina Kregar, Maja ^a   Hafner, Anita ^b   Šegvić Klarić, Maja ^b   Filipović Grčić, Jelena ^b  

^a PLIVA CROATIA LTD   (Croatia)

^b UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

antimicrobial activity; controlled release; microparticles; Mupirocin calcium; solid dispersions; spray drying; stability

Indexed keywords

2 PROPANOL; ACETONE; ALCOHOL; EUDRAGIT; METHANOL; POLYACRYLIC ACID; PSEUDOMONIC ACID;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED RELEASE FORMULATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG RELEASE; INFRARED SPECTROSCOPY; LIGHT SCATTERING; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MICROENCAPSULATION; MISCIBILITY; PHYSICAL CHEMISTRY; SCANNING ELECTRON MICROSCOPE; SPRAY DRYING; STAPHYLOCOCCUS AUREUS; THERMOGRAVIMETRY; X RAY ANALYSIS;

ANALYSIS OF VARIANCE; ANTI-BACTERIAL AGENTS; CALORIMETRY, DIFFERENTIAL SCANNING; DELAYED-ACTION PREPARATIONS; DESICCATION; DRUG COMPOUNDING; DRUG STABILITY; MUPIROCIN; NEBULIZERS AND VAPORIZERS; PARTICLE SIZE; POLYMERS; SOLUBILITY; SOLVENTS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; THERMOGRAVIMETRY;

EID: 80955132938     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2011.580350     Document Type: Article

References (38)

1. Re MI. (2006). Formulating drug delivery systems by spray drying. Drying Technology, 24:433-446.
2. Vehring R. (2008). Pharmaceutical particle engineering via spray drying. Pharm Res, 25:999-1022.
3. Soundrapandian C, Basu D, Sa B, Datta S. (2011). Local drug delivery system for the treatment of osteomyelitis: In vitro evaluation. Drug Dev Ind Pharm, 37:538-546.
4. Jain D, Carvalho E, Banthia AK, Banerjee R. (2011). Development of polyvinyl alcohol-gelatin membranes for antibiotic delivery in the eye. Drug Dev Ind Pharm, 37:167-177.
5. Freiberg S, Zhu XX. (2004). Polymer microspheres for controlled drug release. Int J Pharm, 282:1-18. (Pubitemid 39178480)
6. Hadinoto K, Cheow WS. (2009). Hollow spherical nanoparticulate aggregates as potential ultrasound contrast agent: Shell thickness characterization. Drug Dev Ind Pharm, 35:1167-1179.
7. Nekkanti V, Muniyappan T, Karatgi P, Hari MS, Marella S, Pillai R. (2009). Spray-drying process optimization for manufacture of drug-cyclodextrin complex powder using design of experiments. Drug Dev Ind Pharm, 35:1219-1229.
8. Miller-Chou BA, Koenig JL. (2003). A review of polymer dissolution. Prog Polym Sci, 28:1223-1270.
9. Raula J, Eerikäinen H, Kauppinen EI. (2004). Influence of the solvent composition on the aerosol synthesis of pharmaceutical polymer nanoparticles. Int J Pharm, 284:13-21. (Pubitemid 39349134)
10. Wulsten E, Kiekens F, van Dycke F, Voorspoels J, Lee G. (2009). Levitated single-droplet drying: Case study with itraconazole dried in binary organic solvent mixtures. Int J Pharm, 378:116-121.
11. Esposito E, Roncarati R, Cortesi R, Cervellati F, Nastruzzi C. (2000). Production of Eudragit microparticles by spraydrying technique: Influence of experimental parameters on morphological and dimensional characteristics. Pharm Dev Technol, 5:267-278. (Pubitemid 30247107)
12. Gander B, Wehrli E, Alder R, Merkle HP. (1995). Quality improvement of spray-dried, protein-loaded D,L-PLA microspheres by appropriate polymer solvent selection. J Microencapsul, 12:83-97.
13. Zhang ZY, Ping QN, Xiao B. (2000). Microencapsulation and characterization of tramadol-resin complexes. J Control Release, 66:107-113. (Pubitemid 30160849)
14. Bain DF, Munday DL, Smith A. (1999). Solvent influence on spraydried biodegradable microspheres. J Microencapsul, 16:453-474. (Pubitemid 29332733)
15. Luna-Barcenas G, Meredith JC, Sanchez IC, Johnston KP. (1997). Relationship between polymer chain conformation and phase boundaries in a supercritical fluid. J Chem Phys, 107:10782-10792. (Pubitemid 127627228)
16. Al-Obaidi H, Brocchini S, Buckton G. (2009). Anomalous properties of spray dried solid dispersions. J Pharm Sci, 98:4724-4737.
17. Rosilio V, Deyme M, Benoit JP, Madelmont G. (1998). Physical aging of progesterone-loaded poly(D,L,-lactide-co-glycolide) microspheres. Pharm Res, 15:794-798. (Pubitemid 28275660)
18. Allison SD. (2008). Effect of structural relaxation on the preparation and drug release behavior of poly(lactic-coglycolic) acid microparticle drug delivery systems. J Pharm Sci, 97:2022-2035.
19. Sipos P, Szabó A, Eros I, Szabó-Révész P. (2008). A DSC and Raman spectroscopic study of microspheres prepared with polar cosolvents by different techniques. J Therm Anal Calorim, 94:109-118.
20. Dürrigl M, Kwokal A, Hafner A, Segvic Klaric M, Dumicic A, Cetina-Cižmek B et al. (2011). Spray dried microparticles for controlled delivery of mupirocin calcium: Process-tailored modulation of drug release. J Microencapsul, 28:108-121.
21. Parenti MA, Hatfield SM, Leyden JJ. (1987). Mupirocin: A topical antibiotic with a unique structure and mechanism of action. Clin Pharm, 6:761-770. (Pubitemid 17153593)
22. Embil K, Nacht S. (1996). The Microsponge Delivery System (MDS): A topical delivery system with reduced irritancy incorporating multiple triggering mechanisms for the release of actives. J Microencapsul, 13:575-588. (Pubitemid 26283810)
23. Beck RC, Pohlmann AR, Hoffmeister C, Gallas MR, Collnot E, Schaefer UF et al. (2007). Dexamethasone-loaded nanoparticlecoated microparticles: Correlation between in vitro drug release and drug transport across Caco-2 cell monolayers. Eur J Pharm Biopharm, 67:18-30. (Pubitemid 46991337)
24. Lionzo MI, Ré MI, Guterres SS, Pohlmann AR. (2007). Microparticles prepared with poly(hydroxybutyrate-cohydroxyvalerate) and poly(epsilon- caprolactone) blends to control the release of a drug model. J Microencapsul, 24:175-186. (Pubitemid 46502159)
25. Rassu G, Gavini E, Spada G, Giunchedi P, Marceddu S. (2008). Ketoprofen spray-dried microspheres based on Eudragit RS and RL: Study of the manufacturing parameters. Drug Dev Ind Pharm, 34:1178-1187.
26. Wang FJ, Wang CH. (2002). Effects of fabrication conditions onthe characteristics of etanidazole spray-dried microspheres. J Microencapsul, 19:495-510.
27. Palmieri GF, Bonacucina G, Di Martino P, Martelli S. (2001). Spraydrying as a method for microparticulate controlled release systems preparation: Advantages and limits. I. Water-soluble drugs. Drug Dev Ind Pharm, 27:195-204. (Pubitemid 32244941)
28. Rizi K, Green RJ, Donaldson M, Williams AC. (2011). Production of pH-responsive microparticles by spray drying: Investigation of experimental parameter effects on morphological and release properties. J Pharm Sci, 100:566-579.
29. da Silva AA Jr, de Matos JR, Formariz TP, Rossanezi G, Scarpa MV, do Egito ES et al. (2009). Thermal behavior and stability of biodegradable spray-dried microparticles containing triamcinolone. Int J Pharm, 368:45-55.
30. DiNunzio JC, Hughey JR, Brough C, Miller DA, Williams RO 3rd, McGinity JW. (2010). Production of advanced solid dispersions for enhanced bioavailability of itraconazole using KinetiSol Dispersing. Drug Dev Ind Pharm, 36:1064-1078.
31. Hancock BC, Zografi G. (1997). Characteristics and significance of the amorphous state in pharmaceutical systems. J Pharm Sci, 86:1-12.
32. Weuts I, Kempen D, Decorte A, Verreck G, Peeters J, Brewster M et al. (2004). Phase behaviour analysis of solid dispersions of loperamide and two structurally related compounds with the polymers PVP-K30 and PVP-VA64. Eur J Pharm Sci, 22:375-385. (Pubitemid 38953896)
33. van Drooge DJ, Hinrichs WL, Visser MR, Frijlink HW. (2006). Characterization of the molecular distribution of drugs in glassy solid dispersions at the nano-meter scale, using differential scanning calorimetry and gravimetric water vapour sorption techniques. Int J Pharm, 310:220-229. (Pubitemid 43287987)
34. Tajber L, Corrigan OI, Healy AM. (2005). Physicochemical evaluation of PVP-thiazide diuretic interactions in co-spray-dried composites-analysis of glass transition composition relationships. Eur J Pharm Sci, 24:553-563. (Pubitemid 40387269)
35. Janssens S, De Zeure A, Paudel A, Van Humbeeck J, Rombaut P, Van den Mooter G. (2010). Influence of preparation methods on solid state supersaturation of amorphous solid dispersions: A case study with itraconazole and Eudragit e100. Pharm Res, 27:775-785.
36. Yeo Y, Park K. (2004). Control of encapsulation efficiency and initial burst in polymeric microparticle systems. Arch Pharm Res, 27:1-12. (Pubitemid 43158226)
37. Bouissou C, Rouse JJ, Price R, van der Walle CF. (2006). The influence of surfactant on PLGA microsphere glass transition and water sorption: Remodeling the surface morphology to attenuate the burst release. Pharm Res, 23:1295-1305. (Pubitemid 43946151)
38. Kresken M, Hafner D, Schmitz FJ, Wichelhaus TA; Paul-Ehrlich- Society for Chemotherapy. (2004). Prevalence of mupirocin resistance in clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis: Results of the Antimicrobial Resistance Surveillance Study of the Paul-Ehrlich-Society for Chemotherapy, 2001. Int J Antimicrob Agents, 23:577-581. (Pubitemid 38759673)