Mild thyroid hormone excess is associated with a decreased physical function in elderly men

Aging Male

Volumn 14, Issue 4, 2011, Pages 213-219

  Ceresini, Graziano ^a   Ceda, Gian Paolo ^a   Lauretani, Fulvio ^b   Maggio, Marcello ^a   Bandinelli, Stefania ^c   Guralnik, Jack M ^d   Cappola, Anne R ^e   Usberti, Elisa ^a   Morganti, Simonetta ^a   Valenti, Giorgio ^a   Ferrucci, Luigi ^d  

^a UNIVERSITY OF PARMA   (Italy)

^b UNIVERSITY HOSPITAL OF PARMA   (Italy)

^c SANTA MARIA ANNUNZIATA HOSPITAL   (Italy)

^d NATIONAL INSTITUTE ON AGING   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

elderly male; physical function; Subclinical hyperthyroidism

Indexed keywords

LIOTHYRONINE; THYROTROPIN; THYROXINE;

AGED; ARTICLE; BODY MASS; CALF MUSCLE CROSS SECTIONAL AREA; CLINICAL ASSESSMENT TOOL; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; EUTHYROIDISM; FEMALE; HAND GRIP; HUMAN; HYPERTHYROIDISM; LIOTHYRONINE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NERVE CONDUCTION; PARKINSON DISEASE; PHYSICAL CAPACITY; PHYSICAL PERFORMANCE; PRIORITY JOURNAL; SEX DIFFERENCE; SHORT PHYSICAL PERFORMANCE BATTERY SCORE; STROKE; THYROID FUNCTION; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL;

AGED; AGED, 80 AND OVER; ASYMPTOMATIC DISEASES; CROSS-SECTIONAL STUDIES; EXERCISE TEST; FEMALE; HAND STRENGTH; HUMANS; HYPERTHYROIDISM; LONGITUDINAL STUDIES; MALE; MUSCLE, SKELETAL; NEURAL CONDUCTION; THYROTROPIN; THYROXINE; TRIIODOTHYRONINE;

EID: 80955131492     PISSN: 13685538     EISSN: 14730790     Source Type: Journal    
DOI: 10.3109/13685538.2011.606514     Document Type: Article

References (35)

1. Schneider EL, Guralnik JM. The aging of America. Impact on health care costs. JAMA 1990;263:2335-2340. (Pubitemid 20143285)
2. Ceda GP, Dall'Aglio E, Maggio M, Lauretani F, Bandinelli S, Falzoi C, Grimaldi W, et al. Clinical implications of the reduced activity of the GH-IGF-I axis in older men. J Endocrinol Invest 2005;28:96-100.
3. Valenti G, Denti L, Maggio M, Ceda G, Volpato S, Bandinelli S, Ceresini G, et al. Effect of DHEAS on skeletal muscle over the life span: the InCHIANTI study. J Gerontol A Biol Sci Med Sci 2004;59:466-472. (Pubitemid 38649938)
4. Ceresini G, Lauretani F, Maggio M, Ceda GP, Morganti S, Usberti E, Chezzi C, et al. Thyroid function abnormalities and cognitive impairment in elderly people: results of the Invecchiare in Chianti study. J Am Geriatr Soc 2009;57:89-93.
5. Biondi B, Cooper DS. The clinical significance of subclinical thyroid dysfunction. Endocr Rev 2008;29:76-131. (Pubitemid 351252748)
6. Brennan MD, Powell C, Kaufman KR, Sun PC, Bahn RS, Nair KS. The impact of overt and subclinical hyperthyroidism on skeletal muscle. Thyroid 2006;16:375-380.
7. Lauretani F, Russo CR, Bandinelli S, Bartali B, Cavazzini C, Di Iorio A, Corsi AM, et al. Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia. J Appl Physiol 2003;95:1851-1860. (Pubitemid 37310367)
8. Heeringa J, Hoogendoorn EH, van der Deure WM, Hofman A, Peeters RP, Hop WC, den Heijer M, et al. High-normal thyroid function and risk of atrial fibrillation: the Rotterdam study. Arch Intern Med 2008;168:2219-2224.
9. Ferrucci L, Bandinelli S, Benvenuti E, Di Iorio A, Macchi C, Harris TB, Guralnik JM. Subsystems contributing to the decline in ability to walk: bridging the gap between epidemiology and geriatric practice in the InCHIANTI study. J Am Geriatr Soc 2000;48:1618-1625.
10. Schrager MA, Metter EJ, Simonsick E, Ble A, Bandinelli S, Lauretani F, Ferrucci L. Sarcopenic obesity and inflammation in the InCHIANTI study. J Appl Physiol 2007;102:919-925. (Pubitemid 46377013)
11. Bandinelli S, Benvenuti E, Del Lungo I, Baccini M, Benvenuti F, Di Iorio A, Ferrucci L. Measuring muscular strength of the lower limbs by hand-held dynamometer: a standard protocol. Aging (Milano) 1999;11:287-293.
12. Rantanen T, Guralnik JM, Foley D, Masaki K, Leveille S, Curb JD, White L. Midlife hand grip strength as a predictor of old age disability. JAMA 1999;281:558-560. (Pubitemid 29081310)
13. Rantanen T, Masaki K, Foley D, Izmirlian G, White L, Guralnik JM. Grip strength changes over 27 yr in Japanese-American men. J Appl Physiol 1998;85:2047-2053. (Pubitemid 28558058)
14. Rittweger J, Beller G, Ehrig J, Jung C, Koch U, Ramolla J, Schmidt F, et al. Bone-muscle strength indices for the human lower leg. Bone 2000;27:319-326. (Pubitemid 30458829)
15. Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, Scherr PA, Wallace RB. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 1994;49:M85-M94. (Pubitemid 24100267)
16. Lauretani F, Bandinelli S, Strotmeyer ES, Corsi AM, Di Iorio A, Guralnik JM, Ferrucci L. Erythropoietin and polyneuropathy in older persons. Mech Ageing Dev 2008;129:299-303.
17. Lauretani F, Bandinelli S, Bartali B, Di Iorio A, Giacomini V, Corsi AM, Guralnik JM, Ferrucci L. Axonal degeneration affects muscle density in older men and women. Neurobiol Aging 2006;27:1145-1154. (Pubitemid 43850645)
18. Radloff LS The CES-D Scale: a self-report depression scale for research in the general population. Appl Psychol Meas 1977; 1:385-401
19. Pisani P, Faggiano F, Krogh V, Palli D, Vineis P, Berrino F. Relative validity and reproducibility of a food frequency dietary questionnaire for use in the Italian EPIC centres. Int J Epidemiol 1997;26 Suppl 1:S152-S160. (Pubitemid 27129699)
20. Guralnik JM, Fried LP, Simonsick EM, Kasper JD, Lafferty ME. The Women's Health and Aging Study: Health and Social Characteristics of Older Women with Disability. Bethesda, MD, National Institute on Aging. NIH Publication 1995;No. 95 4009
21. Bandinelli S, Lauretani F, Boscherini V, Gandi F, Pozzi M, Corsi AM, Bartali B, et al. A randomized, controlled trial of disability prevention in frail older patients screened in primary care: the FRASI study. Design and baseline evaluation. Aging Clin Exp Res 2006;18:359-366. (Pubitemid 46138520)
22. Gussekloo J, van Exel E, de Craen AJ, Meinders AE, Frölich M, Westendorp RG. Thyroid status, disability and cognitive function, and survival in old age. JAMA 2004;292:2591-2599. (Pubitemid 39577515)
23. van den Beld AW, Visser TJ, Feelders RA, Grobbee DE, Lamberts SW. Thyroid hormone concentrations, disease, physical function, and mortality in elderly men. J Clin Endocrinol Metab 2005;90:6403-6409. (Pubitemid 41759292)
24. Videla LA, Sir T, Wolff C. Increased lipid peroxidation in hyperthyroid patients: suppression by propylthiouracil treatment. Free Radic Res Commun 1988;5:1-10.
25. Chan RS, Huey ED, Maecker HL, Cortopassi KM, Howard SA, Iyer AM, McIntosh LJ, et al. Endocrine modulators of necrotic neuron death. Brain Pathol 1996;6:481-491. (Pubitemid 26388718)
26. Kinoshita K, Kawashima K, Kawashima Y, Fukuchi I, Yamamura M, Matsuoka Y. Effect of TA-0910, a novel thyrotropin-releasing hormone analog, on in vivo acetylcholine release and turnover in rat brain. Jpn J Pharmacol 1996;71:139-145. (Pubitemid 26235598)
27. Kalmijn S, Mehta KM, Pols HA, Hofman A, Drexhage HA, Breteler MM. Subclinical hyperthyroidism and the risk of dementia. The Rotterdam study. Clin Endocrinol (Oxf) 2000;53:733-737. (Pubitemid 32096685)
28. Senovilla L, García-Sancho J, Villalobos C. Changes in expression of hypothalamic releasing hormone receptors in individual rat anterior pituitary cells during maturation, puberty and senescence. Endocrinology 2005;146:4627-4634. (Pubitemid 41446600)
29. Gammage MD, Parle JV, Holder RL, Roberts LM, Hobbs FD, Wilson S, Sheppard MC, Franklyn JA. Association between serum free thyroxine concentration and atrial fibrillation. Arch Intern Med 2007;167:928-934. (Pubitemid 46762755)
30. Müssig K, Leyhe T, Holzmüller S, Klein R, Weinert C, Saur R, Klingberg S, et al. Increased prevalence of antibodies to central nervous system tissue and gangliosides in Hashimoto's thyroiditis compared to other thyroid illnesses. Psychoneuroendocrinology 2009;34:1252-1256.
31. Kurne A, Aydin OF, Karabudak R. White matter alteration in a patient with Graves' disease. J Child Neurol 2007;22:1128-1131. (Pubitemid 47412689)
32. Aghini-Lombardi F, Antonangeli L, Pinchera A, Leoli F, Rago T, Bartolomei AM, Vitti P. Effect of iodized salt on thyroid volume of children living in an area previously characterized by moderate iodine deficiency. J Clin Endocrinol Metab 1997;82:1136-1139. (Pubitemid 27166654)
33. Aghini Lombardi FA, Pinchera A, Antonangeli L, Rago T, Chiovato L, Bargagna S, Bertucelli B, et al. Mild iodine deficiency during fetal/ neonatal life and neuropsychological impairment in Tuscany. J Endocrinol Invest 1995;18:57-62.
34. Castaneda-Sceppa C, Price LL, Noel SE, Bassett Midle J, Falcon LM, Tucker KL. Physical function and health status in aging puerto rican adults: the Boston puerto rican health study. J Aging Health 2010;22:653-672.
35. Boelaert K, Torlinska B, Holder RL, Franklyn JA. Older subjects with hyperthyroidism present with a paucity of symptoms and signs: a large cross-sectional study. J Clin Endocrinol Metab 2010;95:2715-2726.