-
1
-
-
33746257209
-
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
-
DOI 10.1038/nrg1879, PII NRG1879
-
Engelman, J. A.; Luo, J.; Cantley, L. C. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism Nat. Rev. Genet. 2006, 7, 606-619 (Pubitemid 44100518)
-
(2006)
Nature Reviews Genetics
, vol.7
, Issue.8
, pp. 606-619
-
-
Engelman, J.A.1
Luo, J.2
Cantley, L.C.3
-
2
-
-
67749122122
-
Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
-
Engelman, J. A. Targeting PI3K signalling in cancer: Opportunities, challenges and limitations Nat. Rev. Genet. 2009, 9, 550-62
-
(2009)
Nat. Rev. Genet.
, vol.9
, pp. 550-562
-
-
Engelman, J.A.1
-
3
-
-
84861668771
-
Emerging Therapies based on inhibitors of phosphatidyl-inositol-3-kinases
-
Nuss, J. M; Tsuhako, A. L; Anand, N. K. Emerging Therapies based on inhibitors of phosphatidyl-inositol-3-kinases Annu. Rep. Med. Chem. 2009, 44, 339-356
-
(2009)
Annu. Rep. Med. Chem.
, vol.44
, pp. 339-356
-
-
Nuss, J.M.1
Tsuhako, A.L.2
Anand, N.K.3
-
4
-
-
11144358645
-
High Frequency of Mutations of the PIK3CA Gene in Human Cancers
-
DOI 10.1126/science.1096502
-
Samuels, Y.; Wang, Z.; Bardelli, A.; Silliman, N.; Ptak, J.; Szabo, S.; Yan, H.; Gasdar, A.; Powell, S. M.; Riggins, G. J.; Willson, J. K.; Markowitz, S.; Kinzler, K. W.; Vogelstein, B.; Velculescu, V. E. High frequency of mutations of the PIK3CA gene in human cancers Science 2004, 304, 554 (Pubitemid 38541907)
-
(2004)
Science
, vol.304
, Issue.5670
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
Silliman, N.4
Ptak, J.5
Szabo, S.6
Yan, H.7
Gazdar, A.8
Powell, S.M.9
Riggins, G.J.10
Willson, J.K.V.11
Markowitz, S.12
Kinzler, K.W.13
Vogelstein, B.14
Velculescu, V.E.15
-
5
-
-
27544500981
-
Growing roles for the mTOR pathway
-
Sarbassov, D. D.; Ali, S. M.; Sabatini, D. M. Growing roles for the mTOR pathway Curr. Opin. Cell Biol. 2005, 17, 596
-
(2005)
Curr. Opin. Cell Biol.
, vol.17
, pp. 596
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sabatini, D.M.3
-
6
-
-
79851513692
-
-
Cheng, H.; Bagrodia, S.; Bailey, S.; Edwards, M.; Hoffman, J.; Hu, Q.; Kania, R.; Knighton, D. R.; Marx, M. A.; Ninkovic, S.; Sun, S.; Zhang, E. Med. Chem. Comm. 2010, 1 (2) 139
-
(2010)
Med. Chem. Comm.
, vol.1
, Issue.2
, pp. 139
-
-
Cheng, H.1
Bagrodia, S.2
Bailey, S.3
Edwards, M.4
Hoffman, J.5
Hu, Q.6
Kania, R.7
Knighton, D.R.8
Marx, M.A.9
Ninkovic, S.10
Sun, S.11
Zhang, E.12
-
7
-
-
79851512182
-
Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors
-
Liu, K. K.-C.; Huang, X.; Bagrodia, S.; Chen, J. H.; Greasley, S.; Cheng, H.; Sun, S.; Knighton, D.; Rodgers, C.; Rafidi, K.; Zou, A.; Xiao, J.; Yan, S. Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors Bioorg. Med. Chem. Lett. 2011, 21 (4) 1270-1274
-
(2011)
Bioorg. Med. Chem. Lett.
, vol.21
, Issue.4
, pp. 1270-1274
-
-
Liu, K.K.-C.1
Huang, X.2
Bagrodia, S.3
Chen, J.H.4
Greasley, S.5
Cheng, H.6
Sun, S.7
Knighton, D.8
Rodgers, C.9
Rafidi, K.10
Zou, A.11
Xiao, J.12
Yan, S.13
-
8
-
-
77956939303
-
4-Methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors
-
Liu, K. K.-C.; Bagrodia, S.; Bailey, S.; Cheng, H.; Chen, H.; Gao, L.; Greasley, S.; Hoffman, J. E.; Hu, Q.; Johnson, T. O.; Knighton, D.; Liu, Z.; Marx, M. A.; Nambu, M. D.; Ninkovic, S.; Pascual, B.; Rafidi, K.; Rodgers, C. M.-L.; Smith, G. L.; Sun, S.; Wang, H.; Yang, A.; Yuan, J.; Zou, A. 4-Methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors Bioorg. Med. Chem. Lett. 2010, 20 (20) 6096-6099
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, Issue.20
, pp. 6096-6099
-
-
Liu, K.K.-C.1
Bagrodia, S.2
Bailey, S.3
Cheng, H.4
Chen, H.5
Gao, L.6
Greasley, S.7
Hoffman, J.E.8
Hu, Q.9
Johnson, T.O.10
Knighton, D.11
Liu, Z.12
Marx, M.A.13
Nambu, M.D.14
Ninkovic, S.15
Pascual, B.16
Rafidi, K.17
Rodgers, C.M.-L.18
Smith, G.L.19
Sun, S.20
Wang, H.21
Yang, A.22
Yuan, J.23
Zou, A.24
more..
-
9
-
-
84866762779
-
1(Metabolism, Pharmacokinetics and Toxicity of Functional Groups), Carboxylic acids and their bioisosteres
-
Kalgutkar, A. S.; Daniels, J. S. 1(Metabolism, Pharmacokinetics and Toxicity of Functional Groups), Carboxylic acids and their bioisosteres RSC Drug Discovery Ser. 2010, 99-167
-
(2010)
RSC Drug Discovery Ser.
, pp. 99-167
-
-
Kalgutkar, A.S.1
Daniels, J.S.2
-
10
-
-
80955152200
-
-
WO2005070916.
-
Castano-Mansanet, A. M.; Dominguez-Manzanares, E.; Escribano, A. M.; Fernandez, M. C.; Hornback, W. J; Jimenez-Aguado, A. M.; Tromiczak, E. G.; Wu, Z.; Zarrinmayeh, H.; Zimmerman, D. M. Preparation of thiophene and furan compounds for potentiating glutamate receptor function. WO2005070916, 2005.
-
(2005)
Preparation of Thiophene and Furan Compounds for Potentiating Glutamate Receptor Function
-
-
Castano-Mansanet, A.M.1
Dominguez-Manzanares, E.2
Escribano, A.M.3
Fernandez, M.C.4
Hornback, W.J.5
Jimenez-Aguado, A.M.6
Tromiczak, E.G.7
Wu, Z.8
Zarrinmayeh, H.9
Zimmerman, D.M.10
-
11
-
-
79957451449
-
Development of Scalable Syntheses of Selective PI3K inhibitors
-
For a detailed discussion of the synthetic chemistry, see; ()
-
For a detailed discussion of the synthetic chemistry, see Huang, Q; Richardson, P. F.; Sach, N. W.; Zhu, J; Liu, K. K.-C.; Smith, G. L.; Bowles, D. M. Development of Scalable Syntheses of Selective PI3K inhibitors Org. Process Res. Dev. 2011, 15 (3) 556-564
-
(2011)
Org. Process Res. Dev.
, vol.15
, Issue.3
, pp. 556-564
-
-
Huang, Q.1
Richardson, P.F.2
Sach, N.W.3
Zhu, J.4
Liu, K.K.-C.5
Smith, G.L.6
Bowles, D.M.7
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