No evidence for association between DRD3 and COMT with schizophrenia in a Malay population

Genetics and Molecular Research

Volumn 10, Issue 3, 2011, Pages 1850-1855

  Tee, S F ^a   Tang, P Y ^a   Loh, H C ^a  

^a UNIVERSITI TUNKU ABDUL RAHMAN   (Malaysia)

Author keywords

Cathechol o methyltransferase; Dopamine D3 receptor; Polymerase chain reaction; Restriction fragment length polymorphism; Schizophrenia; Single nucleotide polymorphism

Indexed keywords

CATECHOL METHYLTRANSFERASE; DOPAMINE 3 RECEPTOR; GLYCINE; SERINE;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; CASE CONTROL STUDY; COMT GENE; CONTROLLED STUDY; DRD3 GENE; ETHNIC GROUP; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALAY; MALE; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; POPULATION GENETICS; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; CATECHOL O-METHYLTRANSFERASE; FEMALE; GENETIC VARIATION; GENOTYPE; HUMANS; MALAYSIA; MALE; MIDDLE AGED; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, DOPAMINE D3; SCHIZOPHRENIA;

EID: 80955124628     PISSN: None     EISSN: 16765680     Source Type: Journal    
DOI: 10.4238/vol10-3gmr1237     Document Type: Article

References (28)

1. Chang HA, Lu RB, Lin WW, Chang CC, et al. (2007). Lack of association between dopamine D3 receptor Ser9Gly polymorphism and schizophrenia in Han Chinese population. Acta Neuropsychiatr. 19: 344-350.
2. Chen J, Lipska BK, Halim N, Ma QD, et al. (2004). Functional analysis of genetic variation in catechol-o-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. Am. J. Hum. Genet. 75: 807-821.
3. Crocq MA, Mant R, Asherson P, Williams J, et al. (1992). Association between schizophrenia and homozygosity at the dopamine D3 receptor gene. J. Med. Genet. 29: 858-860.
4. De Luca V, Tharmalingam S, Müller DJ, Wong G, et al. (2006). Gene-gene interaction between MAOA and COMT in suicidal behavior: analysis in schizophrenia. Brain Res. 1097: 26-30.
5. Durany N, Thome J, Palomo A, Foley P, et al. (1996). Homozygosity at the dopamine D3 receptor gene in schizophrenic patients. Neurosci. Lett. 220: 151-154.
6. Ebstein RP, Macciardi F, Heresco-Levi U, Serretti A, et al. (1997). Evidence for an association between the dopamine D3 receptor gene DRD3 and schizophrenia. Hum. Hered. 47: 6-16.
7. Fathalli F, Rouleau GA, Xiong L, Tabbane K, et al. (2008). No association between the DRD3 Ser9Gly polymorphism and schizophrenia. Schizophr. Res. 98: 98-104.
8. Hoogendoorn ML, Bakker SC, Schnack HG, Selten JP, et al. (2005). No association between 12 dopaminergic genes and schizophrenia in a large Dutch sample. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 134B: 6-9.
9. Ioannidis JP, Ntzani EE, Trikalinos TA and Contopoulos-Ioannidis DG (2001). Replication validity of genetic association studies. Nat. Genet. 29: 306-309.
10. Jonsson EG, Flyckt L, Burgert E, Crocq MA, et al. (2003). Dopamine D3 receptor gene Ser9Gly variant and schizophrenia: association study and meta-analysis. Psychiatr. Genet. 13: 1-12.
11. Jonsson EG, Kaiser R, Brockmoller J, Nimgaonkar VL, et al. (2004). Meta-analysis of the dopamine D3 receptor gene (DRD3) Ser9Gly variant and schizophrenia. Psychiatr. Genet. 14: 9-12.
12. Kunugi H, Vallada HP, Hoda F, Kirov G, et al. (1997). No evidence for an association of affective disorders with high-or low-activity allele of catechol-o-methyltransferase gene. Biol. Psychiatry. 42: 282-285.
13. Lannfelt L, Sokoloff P, Martres MP, Pilon C, et al. (1992). Amino acid substitution in the dopamine D3 receptor as a useful polymorphism for investigating psychiatric disorders. Psychiatr. Genet. 2: 249-252.
14. Le Coniat M, Sokoloff P, Hillion J, Martres MP, et al. (1991). Chromosomal localization of the human D3 dopamine receptor gene. Hum. Genet. 87: 618-620.
15. Nagaraj S, Lee KH, Tey NP and Ng CW (2008). Counting and Integration: The Experience of Malaysia, Working Paper Series, No 2008-3. Faculty of Economics and Administration, University of Malaya, Malaya.
16. National Mental Health Registry Report (2003-2005). Department of Psychiatric and Mental Health, Hospital Kuala Lumpur, National Mental Health Registry, Kuala Lumpur.
17. Pal P, Mihanovic M, Molnar S, Xi H, et al. (2009). Association of tagging single nucleotide polymorphisms on 8 candidate genes in dopaminergic pathway with schizophrenia in Croatian population. Croat. Med. J. 50: 361-369.
18. Scharfetter J, Chaudhry HR, Hornik K, Fuchs K, et al. (1999). Dopamine D3 receptor gene polymorphism and response to clozapine in schizophrenic Pakistani patients. Eur. Neuropsychopharmacol. 10: 17-20.
19. Schulze TG and McMahon FJ (2002). Genetic association mapping at the crossroads: which test and why? Overview and practical guidelines. Am. J. Med. Genet. 114: 1-11.
20. Schwab SG and Wildenauer DB (2008). Research on causes for schizophrenia: are we close? Schizophr. Res. 102: 29-30.
21. Shifman S, Bronstein M, Sternfeld M, Pisante A, et al. (2004). COMT: a common susceptibility gene in bipolar disorder and schizophrenia. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 128B: 61-64.
22. Spurlock G, Williams J, McGuffin P, Aschauer HN, et al. (1998). European multicentre association study of schizophrenia: a study of the DRD2 Ser311Cys and DRD3 Ser9Gly polymorphisms. Am. J. Med. Genet. 81: 24-28.
23. Staddon S, Arranz MJ, Mancama D, Perez-Nievas F, et al. (2005). Association between dopamine D3 receptor gene polymorphisms and schizophrenia in an isolate population. Schizophr. Res. 73: 49-54.
24. Suzuki M, Hurd YL, Sokoloff P, Schwartz JC, et al. (1998). D3 dopamine receptor mRNA is widely expressed in the human brain. Brain Res. 779: 58-74.
25. Talkowski ME, Mansour H, Chowdari KV, Wood J, et al. (2006). Novel, replicated associations between dopamine D3 receptor gene polymorphisms and schizophrenia in two independent samples. Biol. Psychiatry 60: 570-577.
26. Tenhunen J, Salminen M, Lundstrom K, Kiviluoto T, et al. (1994). Genomic organization of the human catechol-o-methyltransferase gene and its expression from two distinct promoters. Eur. J. Biochem. 223: 1049-1059.
27. Utsunomiya K, Shinkai T, De Luca V, Hwang R, et al. (2008). Genetic association between the dopamine D3 gene polymorphism (Ser9Gly) and schizophrenia in Japanese populations: evidence from a case-control study and meta-analysis. Neurosci. Lett. 444: 161-165.
28. Zhang K, Gao J, An C, Gao X, et al. (2007). An association study between cathechol-o-methyltransferase gene and mental retardation in the Chinese Han population. Neurosci. Lett. 419: 83-87.