Early differential cell death and survival mechanisms initiate and contribute to the development of OPIDN: A study of molecular, cellular, and anatomical parameters

Toxicology and Applied Pharmacology

Volumn 256, Issue 3, 2011, Pages 348-359

  Damodaran, T V ^a,b   Attia, M K ^a   Abou Donia, M B ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b NORTH CAROLINA CENTRAL UNIVERSITY   (United States)

Author keywords

Anticholinergics; Apoptotis; BCL2; Central nervous system (CNS); Diisopropylphosphorofluoridate (DFP); GADD45; Necrosis; Neurodegeneration; OPIDN; Organophosphate induced delayed neurotoxicity; Peripheral nervous system (PNS)

Indexed keywords

ATROPINE; BETA ACTIN; DIMETHYL SULFOXIDE; DYFLOS; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; MESSENGER RNA; PHOSPHATE BUFFERED SALINE; PHYSOSTIGMINE; PROPYLENE GLYCOL; PROTEIN BCL 2;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; BRAIN; BRAIN STEM; CELL SURVIVAL; CEREBELLUM; CLINICAL FEATURE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DELAYED NEUROTOXICITY; DISEASE COURSE; DISEASE SEVERITY; FEMALE; GENE EXPRESSION; HEN; HISTOLOGY; MESENCEPHALON; NERVE CELL NECROSIS; NERVE FIBER DEGENERATION; NEUROANATOMY; NEUROPATHY; NISSL SUBSTANCE; NONHUMAN; NORTHERN BLOTTING; ORGANOPHOSPHORUS ESTER INDUCED DELAYED NEUROTOXICITY; PARALYSIS; QUANTITATIVE ANALYSIS; SPINAL CORD;

ANIMALS; APOPTOSIS; ATROPINE; BLOTTING, NORTHERN; BRAIN; CELL DEATH; CELL SURVIVAL; CHICKENS; CHOLINESTERASE INHIBITORS; FEMALE; ISOFLUROPHATE; NEUROTOXICITY SYNDROMES; ORGANOPHOSPHORUS COMPOUNDS; PHYSOSTIGMINE; SPINAL CORD; TIME FACTORS;

EID: 80855139726     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.07.017     Document Type: Article

References (45)

1. Abdel-Rahman A., Shetty A.K., Abou-Donia M.B. Acute exposure to sarin increases blood brain barrier permeability and induces neuropathological changes in the rat brain. Dose-response relationships. Neuroscience 2002, 113:721-741.
2. Abou-Donia M.B., Viana M.E., Gupta R.P., Anderson J.K. Enhanced calmodulin binding concurrent with increased kinase-dependent phosphorylation of cytoskeletal proteins following a single subcutaneous injection of diisopropyl phosphorofluoridate in hens. Neurochem. Int. 1993, 22:165-173.
3. Abou-Donia M.B. Organophosphorus ester-induced chronic neurotoxicity. Arch. Environ. Heal. 2003, 58:484-497.
4. Allsopp T.E., Wyatt S., Paterson H.F., Davies A.M. The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Cell 1993, 73:295-307.
5. Baille V., Clarke P.G., Brochier G., Dorandeu F., Verna J.M., Four E., Lallement G., Carpentier P. Soman-induced convulsions: the neuropathology revisited. Toxicol 2005, 215:1-24.
6. Barron K.D., Doolin P.E. Neuronal response to axon injury. Motor Neuron Disease. Research on Amyotrophic Lateral Sclerosis and Related Disorders 1968, Grune and Stratton, New York and London. F.H. Norris, L.T. Kurland (Eds.).
7. Coleman M.P., Freeman M.R. Wallerian degeneration, WldS, and Nmnat. Annu. Rev. Neurosci. 2010, 33:245-267.
8. Damodaran T.V., Abou-Donia M.B. Alterations in levels of mRNAs coding for glial fibrillary acidic protein (GFAP) and vimentin genes in the central nervous system of hens treated with diisopropyl phosphorofluoridate (DFP). Neurochem. Res. 2000, 25:809-816.
9. Damodaran T.V., Rahman A.A., Abou-Donia M.B. Early differential induction of c-jun in the central nervous system of hens treated with diisopropylphosphorofluoridate (DFP). Neurochem. Res. 2000, 25:1579-1586.
10. Damodaran T.V., Abdel-Rahman A., Abou-Donia M.B. Altered time course of mRNA expression of alpha tubulin in the central nervous system of hens treated with diisopropyl phosphorofluoridate (DFP). Neurochem. Res. 2001, 26(1):43-50.
11. Damodaran T.V., Mecklai A.A., Abou-Donia M.B. Sarin causes altered time course of mRNA expression of alpha tubulin in the central nervous system of rats. Neurochem. Res. 2002, 27:177-181.
12. Damodaran T.V., Rehman A.A., EL-sourady M., Abou-Donia M.B. Elevation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA in hens treated with diisopropyl phosphorofluoridate (DFP), an OPIDN-causing compound. Neurochem. Int. 2002, 40:371-379.
13. Damodaran T.V., Bilska M.A., Rahman A.A., Abou-Donia M.B. Sarin causes early differential alteration and persistent overexpression in mRNAs coding for glial fibrillary acidic protein (GFAP) and vimentin genes in the central nervous system of rats. Neurochem. Res. 2002, 27:407-415.
14. Damodaran T.V., Abdel-Rahman A.A., Suliman H.B., Abou-Donia M.B. Early differential elevation and persistence of phosphorylated cAMP-response element binding protein (p-CREB) in the central nervous system of hens treated with diisopropyl phosphorofluoridate, an OPIDN-causing compound. Neurochem. Res. 2002, 27:183-193.
15. Damodaran T.V., Jones K.H., Patel A.G., Abou-Donia M.B. Sarin (nerve agent GB)-induced differential expression of mRNA coding for the acetylcholinesterase gene in rat central nervous system. Biochem. Pharmacol. 2003, 65:2041-2047.
16. Damodaran T.V., Patel A.G., Greenfield S.T., Dressman H.K., Lin S.M., Abou-Donia M.B. Gene expression profiles of the rat brain both immediately and 3months following acute sarin exposure. Biochem. Pharmacol. 2006, 71:497-520.
17. Damodaran T.V., Greenfled S.T., Patel A.G., Dressman H.K., Lin S.A., Abou-Donia M.B. Toxicogenomic studies of the rat brain at an early time point following acute sarin exposure. Neurochem. Res. 2006, 31:361-381.
18. Damodaran T.V. Molecular and transcriptional responses to sarin exposure. Handbook of Toxicology of Chemical Warfare Agents 2009, 665-682. Academic Press, San Francisco. R.C. Gupta (Ed.).
19. Damodaran T.V., Gupta R.P., Attia M.K., Abou-Donia M.B. DFP initiated early alterations of PKA/p-CREB pathway and differential persistence ofβ-tubulin subtypes in the CNS of hens contributes to OPIDN. Toxicol. Appl. Pharmacol. 2009, 240:132-142.
20. Deckwerth T.L., Johnson E.M. Neurites can remain viable after destruction of the neuronal soma by programmed cell death (apoptosis). Dev. Biol. 1994, 165:63-72.
21. Doherty J.D. Screening pesticides for neuropathogenicity. J. Biomed. Biotechnol. 2006, 3:70414.
22. Dubois-Dauphin M., Frankowski H., Tsujimoto Y., Huarte J., Martinou J.C. Neonatal motoneurons overexpressing the bcl-2 protooncogene in transgenic mice are protected from axotomy-induced cell death. Proc. Natl. Acad. Sci. U. S. A. 1994, 91:3309-3313.
23. Farlie P.G., Dringen R., Rees S.M., Kannourakis G., Bernard O. bcl-2 transgene expression can protect neurons against developmental and induced cell death. Proc. Natl. Acad. Sci. U. S. A. 1995, 92:4397-4401.
24. Fink S.L., Cookson B.T. Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect. Immun. 2005, 73:1907-1916.
25. Funk K.A., Henderson J.D., Liu C., Higgins R.J., Wilson B.W. Neuropathology of organophosphate-induced delayed neuropathy (OPIDN) in young chicks. Arch. Toxicol. 1994, 68:308-316.
26. Gao M., Guo N., Huang C., Song L. Diverse roles of GADD45alpha in stress signaling. Curr. Protein Pept. Sci. 2009, 10:388-394.
27. Gupta R.P., Abdel-Rahman A.A., Wilmarth K.W., Abou-Donia M.B. Alterations in neurofilament axonal transport in the sciatic nerve of diisopropyl phosphorofluridate (DFP)-treated hen. Biochem. Pharm. 1997, 53:1799-1806.
28. 2+/calmodulin-dependent protein kinase II a subunit and its mRNA expression in diisopropyl phosphorofluoridate (DFP)-treated hen central nervous system. Mol. Cell. Biochem. 1998, 181:29-39.
29. 2+/calmodulin (CaM)-dependent phosphorylation by the brain supernatant of diisopropyl phosphorofluoridate (DFP)-treated hen: tau mutants indicate phosphorylation of more amino acids in tau by CaM kinase II. Brain Res. 1998, 813:32-43.
30. Gupta R.P., Lin W.W., Abou-Donia M.B. Enhanced mRNA expression of neurofilament subunits in the brain and spinal cord of diisopropyl phosphorofluoridate-treated hens. Biochem. Pharmacol. 1999, 57:1245-1251.
31. Gupta R.P., Damodaran T.V., Abou-Donia M.B. c-fos mRNA induction in the central and peripheral nervous system of diisopropyl phosphorofluoridate (DFP)-treated hens. Neurochem. Res. 2000, 25:327-334.
32. Gupta R.P., Abdel-Rahman A., Jensen K.F., Abou-Donia M.B. Altered expression of neurofilament subunits in diisopropyl phosphorofluoridate-treated hen spinal cord and their presence in axonal aggregations. Brain Res. 2000, 878:32-47.
33. Gupta R.P., Abou-Donia M.B. Enhanced activity and level of protein kinase A in the spinal cord supernant of diisopropyl phosphrofluoridate (DFP)-treated hens. Distribution of protein kinases and phosphatases in spinal cord subcellular fractions. Mol. Cell Biochem. 2001, 220:15-23.
34. Golomb B.A. Acetlycholinesterase inhibitors and Gulf War illness. PNAS 2008, 105:4295-4300.
35. Henshall D.C., Sinclair J., Simon R.P. Relationship between seizure-induced transcription of the DNA damage-inducible gene GADD45, DNA fragmentation, and neuronal death in focally evoked limbic epilepsy. J. Neurochem. 1999, 73:1573-1583.
36. Kim Y.H., Lee K.H., Han Y.S., Shin S. A role of nitric oxide in organophosphate-induced convulsions. Environ. Toxicol. Pharmacol. 1997, 3:53-56.
37. Kim Y.H.K.H., Shin S., Sok D.E., Kang J.K., Lee Y.S. Organophosphate-induced brain injuries: delayed apoptosis mediated by nitric oxide. Environ. Toxicol. Pharmacol. 1999, 7:147-152.
38. Kroeme G., Galluzzi L., Vandenabeele P., Abrams J., Alnemri E.H., Baehrecke E.S., Blagosklonny M.V., El-DeirY W.S., Golstein P., Green D.R., Hengartner M., Knight R.A., Kumar S., Lipton S.A., Malorni W., Nuñez G., Peter M.E., Tschopp J., Yuan J., Piacentini M., Zhivotovsky B., Melino G. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death. Cell Death Differ. 2009, 16:3-11.
39. Lee A.W., Champagne N., Wang X., Su X.D., Goodyer C., Leblanc A.C. Alternatively spliced caspase-6B isoform inhibits the activation of caspase-6A. J Biol Chem. 2010, 285:31974-31984. Epub 2010 Aug 3.
40. Li Y., Lein P.J., Liu C., Bruun D.A., Tewolde T., Ford G., Ford B.D. Spatiotemporal pattern of neuronal injury induced by DFP in rats: A model for delayed neuronal cell death following acute OP intoxication. Toxicol. Appl. Pharmacol. 2011, 251:261-269.
41. Masoud A., Kiran R., Sandhir R. Impaired mitochondrial functions in organophosphate induced delayed neuropathy in rats. Cell. Mol. Neurobiol. 2009, 29:1245-1255.
42. Michaelidis T.M., Sendtner M., Cooper J.D., Airaksinen M.S., Holtmann B., et al. Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development. Neuron 1996, 17:75-89.
43. Price D.L., Porter K.R. The response of the ventral horn neurons to axonal transaction. J. Cell Biol. 1972, 53:24-53:.
44. Tsang J.L.Y., Parodo J.C., Marshall J.C. DFP significantly increases exteriorization of phosphatidylserine in neutrophils. J. Inflamm. 2010, 7:32.
45. Xing Xin, Tao Zeng, Dou D.D., Sheng Zhao, Du J.Y., Pei J.J., Xie K.Q., Zhao X.L. Changes of mitochondrial ultrastructures and function in central nervous tissue of hens treated with tri-ortho-cresyl phosphate (TOCP). Hum. Exp. Toxicol. 2011, 30:1062-1072. (Electronic publication ahead of print, 2010 Oct 21).