Spray-dried oil-in-water emulsion to improve the intestinal absorption and oral bioavailability of ZLR-8, a nitric oxide-releasing derivative of diclofenac

Journal of Pharmacy and Pharmacology

Volumn 63, Issue 12, 2011, Pages 1531-1538

  Zhang, Jianjun ^a   Zheng, Zengjuan ^b   Gao, Yuan ^c   Zhang, Yihua ^d  

^a Department of Pharmaceutics ^*  (Germany)

^b Center of Drug Discovery   (Germany)

^c CHINA PHARMACEUTICAL UNIVERSITY   (China)

^d WEIFANG MEDICAL UNIVERSITY   (China)

Author keywords

bioavailability; intestinal absorption; spray dried emulsion; ZLR 8

Indexed keywords

[2 (2,6 DICHLOROPHENYLAMINO)BENZENEACETIC ACID 4 (4 PHENYL 1,2,5 OXADIAZOLE 2 OXIDE)METHOXYPHENYL ESTER]; DICLOFENAC; DICLOFENAC DERIVATIVE; UNCLASSIFIED DRUG; ZLR 8;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG PENETRATION; DRUG RELEASE; DRUG STRUCTURE; EMULSION; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; LIMIT OF DETECTION; MALE; NONHUMAN; PARTICLE SIZE; PLASMA CONCENTRATION-TIME CURVE; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SPRAY DRYING;

ALGORITHMS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DESICCATION; DICLOFENAC; EMULSIONS; INTESTINAL ABSORPTION; MALE; NITRIC OXIDE DONORS; PARTICLE SIZE; PERMEABILITY; PHARMACEUTICAL SOLUTIONS; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY;

EID: 80855139562     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2011.01357.x     Document Type: Article

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