Segmental-dependent membrane permeability along the intestine following oral drug administration: Evaluation of a triple single-pass intestinal perfusion (TSPIP) approach in the rat

European Journal of Pharmaceutical Sciences

Volumn 36, Issue 2-3, 2009, Pages 320-329

  Dahan, Arik ^a   West, Brady T ^a   Amidon, Gordon L ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Intestinal absorption; Oral administration; Rat perfusion; Segmental dependent permeability

Indexed keywords

CIMETIDINE; METOPROLOL; PROPRANOLOL;

ANIMAL EXPERIMENT; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG PENETRATION; ILEUM; INTESTINE MUCOSA PERMEABILITY; INTESTINE PERFUSION; JEJUNUM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEGMENTAL DEPENDENT PERMEABILITY; TRIPLE SINGLE PASS INTESTINAL PERFUSION;

ADMINISTRATION, ORAL; ALGORITHMS; ANIMALS; CIMETIDINE; ILEUM; INTESTINAL ABSORPTION; INTESTINE, SMALL; JEJUNUM; MALE; METOPROLOL; MODELS, ANIMAL; PERFUSION; PERMEABILITY; PROPRANOLOL; RATS; RATS, WISTAR;

EID: 58149168723     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2008.10.013     Document Type: Article

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