메뉴 건너뛰기




Volumn 256, Issue 3, 2011, Pages 418-424

Role of paraoxonase 1 (PON1) in organophosphate metabolism: Implications in neurodegenerative diseases

Author keywords

Alzheimer's; Organophosphate pesticides; Paraoxonase 1; Parkinson's; Polymorphism

Indexed keywords

ARYLDIALKYLPHOSPHATASE 1; CHLORPYRIFOS; CHLORPYRIFOS OXON; DIAZOXON; FREE RADICAL; LIPOPROTEIN; ORGANOPHOSPHATE PESTICIDE; PARAOXON; UNCLASSIFIED DRUG;

EID: 80855132813     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.08.009     Document Type: Review
Times cited : (72)

References (65)
  • 1
    • 0032587920 scopus 로고    scopus 로고
    • Gln→Arg 191 polymorphism of paraoxonase and Parkinson's disease
    • Akhmedova S., Anisimov S., Yakimovsky A., Schwartz E. Gln→Arg 191 polymorphism of paraoxonase and Parkinson's disease. Hum. Hered. 1999, 49:178-180.
    • (1999) Hum. Hered. , vol.49 , pp. 178-180
    • Akhmedova, S.1    Anisimov, S.2    Yakimovsky, A.3    Schwartz, E.4
  • 2
    • 0035283113 scopus 로고    scopus 로고
    • Paraoxonase 1 Met-Leu 54 polymorphism is associated with Parkinson's disease
    • Akhmedova S.N., Yakimovsky A.K., Schwartz E.I. Paraoxonase 1 Met-Leu 54 polymorphism is associated with Parkinson's disease. J. Neurol. Sci. 2001, 184:179-182.
    • (2001) J. Neurol. Sci. , vol.184 , pp. 179-182
    • Akhmedova, S.N.1    Yakimovsky, A.K.2    Schwartz, E.I.3
  • 3
    • 33745033791 scopus 로고    scopus 로고
    • Gene-environment interactions in sporadic Parkinson's disease
    • BenMoyal-Segal L., Soreq H. Gene-environment interactions in sporadic Parkinson's disease. J. Neurochem. 2006, 97:1740-1755.
    • (2006) J. Neurochem. , vol.97 , pp. 1740-1755
    • BenMoyal-Segal, L.1    Soreq, H.2
  • 5
    • 33845892752 scopus 로고    scopus 로고
    • Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
    • Bertram L., McQueen M.B., Mullin K., Blacker D., Tanzi R.E. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat. Genet. 2007, 39:17-23.
    • (2007) Nat. Genet. , vol.39 , pp. 17-23
    • Bertram, L.1    McQueen, M.B.2    Mullin, K.3    Blacker, D.4    Tanzi, R.E.5
  • 6
    • 0036651220 scopus 로고    scopus 로고
    • Further evidence for an association of the paraoxonase 1 (PON1) Met-54 allele with Parkinson's disease
    • Carmine A., Buervenich S., Sydow O., Anvret M., Olson L. Further evidence for an association of the paraoxonase 1 (PON1) Met-54 allele with Parkinson's disease. Mov. Disord. 2002, 17:764-766.
    • (2002) Mov. Disord. , vol.17 , pp. 764-766
    • Carmine, A.1    Buervenich, S.2    Sydow, O.3    Anvret, M.4    Olson, L.5
  • 8
    • 51349132496 scopus 로고    scopus 로고
    • PON1 multitasks to protect health
    • Chambers J.E. PON1 multitasks to protect health. Proc. Natl. Acad. Sci. 2008, 105:12639-12640.
    • (2008) Proc. Natl. Acad. Sci. , vol.105 , pp. 12639-12640
    • Chambers, J.E.1
  • 9
    • 64549117768 scopus 로고    scopus 로고
    • A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis
    • Chiò A., Schymick J.C., Restagno G., Scholz S.W., Lombardo F., Lai S.L., et al. A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis. Hum. Mol. Genet. 2009, 18:1524-1532.
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 1524-1532
    • Chiò, A.1    Schymick, J.C.2    Restagno, G.3    Scholz, S.W.4    Lombardo, F.5    Lai, S.L.6
  • 10
    • 4344624315 scopus 로고    scopus 로고
    • Paraoxonase 1 (PON1) gene polymorphisms and Parkinson's disease in a Finish population
    • Clarimon J., Eerola J., Hellstrom O., Tienari P.J., Singleton A. Paraoxonase 1 (PON1) gene polymorphisms and Parkinson's disease in a Finish population. Neurosci. Lett. 2004, 367:168-170.
    • (2004) Neurosci. Lett. , vol.367 , pp. 168-170
    • Clarimon, J.1    Eerola, J.2    Hellstrom, O.3    Tienari, P.J.4    Singleton, A.5
  • 12
    • 0037639963 scopus 로고    scopus 로고
    • Functional genomics of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease and drug metabolism
    • Costa L.G., Cole T.B., Jarvik G.P., Furlong C.E. Functional genomics of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease and drug metabolism. Annu. Rev. Med. 2003, 54:371-392.
    • (2003) Annu. Rev. Med. , vol.54 , pp. 371-392
    • Costa, L.G.1    Cole, T.B.2    Jarvik, G.P.3    Furlong, C.E.4
  • 13
    • 11844296648 scopus 로고    scopus 로고
    • Measurement of paraoxonase status as a potential biomarker of susceptibility to organophosphate toxicity
    • Costa L.G., Cole T.B., Vitalone A., Furlong C.E. Measurement of paraoxonase status as a potential biomarker of susceptibility to organophosphate toxicity. Clin. Chim. Acta 2005, 352:37-47.
    • (2005) Clin. Chim. Acta , vol.352 , pp. 37-47
    • Costa, L.G.1    Cole, T.B.2    Vitalone, A.3    Furlong, C.E.4
  • 15
    • 34548148966 scopus 로고    scopus 로고
    • Paraoxonase promoter and intronic variants modify risk of sporadic amyotrophic lateral sclerosis
    • Cronin S., Greenway M.J., Prehn J.H., Hardiman O. Paraoxonase promoter and intronic variants modify risk of sporadic amyotrophic lateral sclerosis. J. Neurol. Neurosurg. Psychiatry 2007, 78:984-986.
    • (2007) J. Neurol. Neurosurg. Psychiatry , vol.78 , pp. 984-986
    • Cronin, S.1    Greenway, M.J.2    Prehn, J.H.3    Hardiman, O.4
  • 18
    • 21244491480 scopus 로고    scopus 로고
    • Human paraoxonases (PON1, PON2 and PON3) are lactonases with overlapping and distinct substrate specificities
    • Draganov D.I., Teiber J.F., Speelman A., Osawa Y., Sunahara R., La Du B.N. Human paraoxonases (PON1, PON2 and PON3) are lactonases with overlapping and distinct substrate specificities. J. Lipid Res. 2005, 46:1239-1247.
    • (2005) J. Lipid Res. , vol.46 , pp. 1239-1247
    • Draganov, D.I.1    Teiber, J.F.2    Speelman, A.3    Osawa, Y.4    Sunahara, R.5    La Du, B.N.6
  • 19
    • 0034104195 scopus 로고    scopus 로고
    • Biotransformation enzyme polymorphism and pesticide susceptibility
    • Eaton D.L. Biotransformation enzyme polymorphism and pesticide susceptibility. Neurotoxicology 2000, 21:101-111.
    • (2000) Neurotoxicology , vol.21 , pp. 101-111
    • Eaton, D.L.1
  • 21
    • 85058205969 scopus 로고    scopus 로고
    • Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease.
    • Neurobiol. Aging.
    • Erlich, P.M., Lunetta, K.L., Cupples, L.A., Abraham, C.R., Green, R.C., Baldwin, C.T., Farrer, L.A., Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease. Neurobiol. Aging.
    • Erlich, P.M.1    Lunetta, K.L.2    Cupples, L.A.3    Abraham, C.R.4    Green, R.C.5    Baldwin, C.T.6    Farrer, L.A.7
  • 23
    • 21544473194 scopus 로고    scopus 로고
    • Pesticides exposure and genetic polymorphism of paraoxonase in the susceptibility of Parkinson's disease
    • Fong C.S., Cheng C.W., Wu R.M. Pesticides exposure and genetic polymorphism of paraoxonase in the susceptibility of Parkinson's disease. Acta Neurol. Taiwan 2005, 14:55-60.
    • (2005) Acta Neurol. Taiwan , vol.14 , pp. 55-60
    • Fong, C.S.1    Cheng, C.W.2    Wu, R.M.3
  • 24
    • 36048956333 scopus 로고    scopus 로고
    • Genetic variability in the cytochrome P450-paraoxonase 1 (PON1) pathway for detoxication of organophosphorous compounds
    • Furlong C.E. Genetic variability in the cytochrome P450-paraoxonase 1 (PON1) pathway for detoxication of organophosphorous compounds. J. Biochem. Mol. Toxicol. 2007, 21:197-205.
    • (2007) J. Biochem. Mol. Toxicol. , vol.21 , pp. 197-205
    • Furlong, C.E.1
  • 26
    • 71449093018 scopus 로고    scopus 로고
    • Paraoxonases: structure, gene polymorphism & role in coronary artery disease
    • Gupta N., Gill K., Singh S. Paraoxonases: structure, gene polymorphism & role in coronary artery disease. Indian J. Med. Res. 2009, 130:361-368.
    • (2009) Indian J. Med. Res. , vol.130 , pp. 361-368
    • Gupta, N.1    Gill, K.2    Singh, S.3
  • 27
    • 33746362925 scopus 로고    scopus 로고
    • Gln192Arg polymorphism in paraoxonase 1 gene is associated with Alzheimer's disease in a Chinese Han ethnic population
    • He X.M., Zhang Z.X., Zhang J.W., Zhou Y.T., Tang M.N., Wu C.B., Hong Z. Gln192Arg polymorphism in paraoxonase 1 gene is associated with Alzheimer's disease in a Chinese Han ethnic population. Chin. Med. J. 2006, 119:1204-1209.
    • (2006) Chin. Med. J. , vol.119 , pp. 1204-1209
    • He, X.M.1    Zhang, Z.X.2    Zhang, J.W.3    Zhou, Y.T.4    Tang, M.N.5    Wu, C.B.6    Hong, Z.7
  • 28
    • 0035018975 scopus 로고    scopus 로고
    • A case-control study of Parkinson's disease in urban populations of southern Israel
    • Herishanu Y.O., Medvedovski M., Goldsmith J.R., Kordysh E. A case-control study of Parkinson's disease in urban populations of southern Israel. Can. J. Neurol. Sci. 2001, 28:144-147.
    • (2001) Can. J. Neurol. Sci. , vol.28 , pp. 144-147
    • Herishanu, Y.O.1    Medvedovski, M.2    Goldsmith, J.R.3    Kordysh, E.4
  • 30
    • 3142781649 scopus 로고    scopus 로고
    • Association of pesticide exposure with neurologic dysfunction and disease
    • Kamel F., Hoppin J.A. Association of pesticide exposure with neurologic dysfunction and disease. Environ. Health Perspect. 2004, 112:950-958.
    • (2004) Environ. Health Perspect. , vol.112 , pp. 950-958
    • Kamel, F.1    Hoppin, J.A.2
  • 31
    • 80855162342 scopus 로고    scopus 로고
    • A case report of motor neuron disease in a patient showing significant level of DDTs
    • HCHs and organophosphate metabolites in hair as well levels of hexane and toluene in blood. Toxicol. Appl.in press.
    • Kanavouras, K., Tzatzarakis, M.N., Mastorodemos, V., Plaitakis, A., Plaitakis, A., Tsatsakis, A.M., in press. A case report of motor neuron disease in a patient showing significant level of DDTs, HCHs and organophosphate metabolites in hair as well levels of hexane and toluene in blood. Toxicol. Appl.
    • Kanavouras, K.1    Tzatzarakis, M.N.2    Mastorodemos, V.3    Plaitakis, A.4    Plaitakis, A.5    Tsatsakis, A.M.6
  • 32
    • 34548237450 scopus 로고    scopus 로고
    • Large-scale pathways-based association study in amyotrophic lateral sclerosis
    • Kasperaviciute D., Weale M.E., Shianna K.V., Banks G.T., Simpson C.L., Hansen V.K., et al. Large-scale pathways-based association study in amyotrophic lateral sclerosis. Brain 2007, 2007(130):2292-2301.
    • (2007) Brain , vol.2007 , Issue.130 , pp. 2292-2301
    • Kasperaviciute, D.1    Weale, M.E.2    Shianna, K.V.3    Banks, G.T.4    Simpson, C.L.5    Hansen, V.K.6
  • 33
    • 0032574973 scopus 로고    scopus 로고
    • Acute stress facilitates long-lasting changes in cholinergic gene expression
    • Kaufer D., Friedman A., Seidman S., Soreq H. Acute stress facilitates long-lasting changes in cholinergic gene expression. Nature 1998, 393:373-377.
    • (1998) Nature , vol.393 , pp. 373-377
    • Kaufer, D.1    Friedman, A.2    Seidman, S.3    Soreq, H.4
  • 36
    • 0032531924 scopus 로고    scopus 로고
    • Parkinson's disease. First of two parts
    • Lang A.E., Lozano A.M. Parkinson's disease. First of two parts. N. Engl. J. Med. 1998, 339:1130-1143.
    • (1998) N. Engl. J. Med. , vol.339 , pp. 1130-1143
    • Lang, A.E.1    Lozano, A.M.2
  • 38
    • 40449106435 scopus 로고    scopus 로고
    • Polymorphisms at the paraoxonase 1 L55M and Q192R loci affect the pathophysiology of Alzheimer's disease: emphasis on the cholinergic system and beta-amyloid levels
    • Leduc V., Poirier J. Polymorphisms at the paraoxonase 1 L55M and Q192R loci affect the pathophysiology of Alzheimer's disease: emphasis on the cholinergic system and beta-amyloid levels. Neurodegener. Dis. 2008, 5:225-227.
    • (2008) Neurodegener. Dis. , vol.5 , pp. 225-227
    • Leduc, V.1    Poirier, J.2
  • 39
    • 70350787098 scopus 로고    scopus 로고
    • Involvement of paraoxonase 1 genetic variants in Alzheimer's disease neuropathology
    • Leduc V., Theroux L., Dea D., Robitaille Y., Poirier J. Involvement of paraoxonase 1 genetic variants in Alzheimer's disease neuropathology. Eur. J. Neurosci. 2009, 30:1823-1830.
    • (2009) Eur. J. Neurosci. , vol.30 , pp. 1823-1830
    • Leduc, V.1    Theroux, L.2    Dea, D.3    Robitaille, Y.4    Poirier, J.5
  • 40
    • 0346095221 scopus 로고    scopus 로고
    • Paraoxonase gene polymorphisms, oxidative stress, and diseases
    • Li H.L., Liu D.P., Liang C.C. Paraoxonase gene polymorphisms, oxidative stress, and diseases. J. Mol. Med. 2003, 81:766-779.
    • (2003) J. Mol. Med. , vol.81 , pp. 766-779
    • Li, H.L.1    Liu, D.P.2    Liang, C.C.3
  • 41
    • 0028958850 scopus 로고
    • Paraoxonase protects against chlorpyrifos toxicity in mice
    • Li W.F., Furlong C.E., Costa L.G. Paraoxonase protects against chlorpyrifos toxicity in mice. Toxicol. Lett. 1995, 76:219-226.
    • (1995) Toxicol. Lett. , vol.76 , pp. 219-226
    • Li, W.F.1    Furlong, C.E.2    Costa, L.G.3
  • 43
    • 0030827926 scopus 로고    scopus 로고
    • Effect of the molecular polymorphisms of human paraoxonase (PON1) on the rate of hydrolysis of paraoxon
    • Mackness B., Mackness M.I., Arrol S., Turkie W., Durrington P.N. Effect of the molecular polymorphisms of human paraoxonase (PON1) on the rate of hydrolysis of paraoxon. Br. J. Pharmacol. 1997, 122:265-268.
    • (1997) Br. J. Pharmacol. , vol.122 , pp. 265-268
    • Mackness, B.1    Mackness, M.I.2    Arrol, S.3    Turkie, W.4    Durrington, P.N.5
  • 45
    • 34249734238 scopus 로고    scopus 로고
    • A gene-environment study of the paraoxonase 1 gene and pesticides in amyotrophic lateral sclerosis
    • Morahan J.M., Yu B., Trent R.J., Pamphlett R. A gene-environment study of the paraoxonase 1 gene and pesticides in amyotrophic lateral sclerosis. Neurotoxicology 2007, 28(3):532-540.
    • (2007) Neurotoxicology , vol.28 , Issue.3 , pp. 532-540
    • Morahan, J.M.1    Yu, B.2    Trent, R.J.3    Pamphlett, R.4
  • 48
    • 19544392168 scopus 로고    scopus 로고
    • Responsiveness to cholinesterase inhibitors in Alzheimer's disease: a possible role for the 192 Q/R polymorphism of the PON-1 gene
    • Pola R., Flex A., Ciaburri M., Rovella E., Valiani A., Reali G., Silveri M.C., Bernabei R. Responsiveness to cholinesterase inhibitors in Alzheimer's disease: a possible role for the 192 Q/R polymorphism of the PON-1 gene. Neurosci. Lett. 2005, 382:338-341.
    • (2005) Neurosci. Lett. , vol.382 , pp. 338-341
    • Pola, R.1    Flex, A.2    Ciaburri, M.3    Rovella, E.4    Valiani, A.5    Reali, G.6    Silveri, M.C.7    Bernabei, R.8
  • 55
    • 61449148378 scopus 로고    scopus 로고
    • Relation of PON1 and CYP1A1 genetic polymorphisms to clinical findings in a cross sectional study of a Greek rural population professionally exposed to pesticides
    • Tsatsakis A.M., Zafiropoulos A., Tzatzarakis M.N., Tzanakakis G.N., Kafatos A. Relation of PON1 and CYP1A1 genetic polymorphisms to clinical findings in a cross sectional study of a Greek rural population professionally exposed to pesticides. Toxicol. Lett. 2009, 186:66-72.
    • (2009) Toxicol. Lett. , vol.186 , pp. 66-72
    • Tsatsakis, A.M.1    Zafiropoulos, A.2    Tzatzarakis, M.N.3    Tzanakakis, G.N.4    Kafatos, A.5
  • 56
    • 80052915354 scopus 로고    scopus 로고
    • Associations of xenobiotic-metabolizing enzyme-genotypes PON1Q192R, PON1L55M AND CYP1A1*2A MspI with pathological symptoms of a rural population in south Greece
    • Tsatsakis A.M., Androutsopoulos V.P., Zafiropoulos A., Babatsikou F., Alegakis A., Dialyna I., Tzatzarakis M., Koutis C. Associations of xenobiotic-metabolizing enzyme-genotypes PON1Q192R, PON1L55M AND CYP1A1*2A MspI with pathological symptoms of a rural population in south Greece. Xenobiotica 2011, 41(10):914-925.
    • (2011) Xenobiotica , vol.41 , Issue.10 , pp. 914-925
    • Tsatsakis, A.M.1    Androutsopoulos, V.P.2    Zafiropoulos, A.3    Babatsikou, F.4    Alegakis, A.5    Dialyna, I.6    Tzatzarakis, M.7    Koutis, C.8
  • 57
    • 58749096379 scopus 로고    scopus 로고
    • The relationship of oral disturbances of diabetes mellitus patients with paraoxonase gene polymorphisms
    • Unur M., Demirez E., Agachan B., Gormus U., Ergen A., Dalan B., Isbir T. The relationship of oral disturbances of diabetes mellitus patients with paraoxonase gene polymorphisms. Cell Biochem. Funct. 2008, 26:870-873.
    • (2008) Cell Biochem. Funct. , vol.26 , pp. 870-873
    • Unur, M.1    Demirez, E.2    Agachan, B.3    Gormus, U.4    Ergen, A.5    Dalan, B.6    Isbir, T.7
  • 59
    • 70349592269 scopus 로고    scopus 로고
    • Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis
    • van Es M.A., Veldink J.H., Saris C.G., Blauw H.M., van Vught P.W., Birve A., et al. Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis. Nat. Genet. 2009, 41:1083-1087.
    • (2009) Nat. Genet. , vol.41 , pp. 1083-1087
    • van Es, M.A.1    Veldink, J.H.2    Saris, C.G.3    Blauw, H.M.4    van Vught, P.W.5    Birve, A.6
  • 62
    • 80855146008 scopus 로고    scopus 로고
    • Paraoxonase-1 polymorphisms in Alzheimer's disease, Parkinson's disease, and AD-PD spectrum diseases.
    • Neurobiol. Ag.in press.
    • Wingo, T.S., Rosen, A., Cutler, D.J., Lah, J.J., Levey, A.I., in press. Paraoxonase-1 polymorphisms in Alzheimer's disease, Parkinson's disease, and AD-PD spectrum diseases. Neurobiol. Ag.
    • Wingo, T.S.1    Rosen, A.2    Cutler, D.J.3    Lah, J.J.4    Levey, A.I.5
  • 63
    • 77953481405 scopus 로고    scopus 로고
    • Paraoxonase 1 R/Q alleles are associated with differential accumulation of saturated versus 20:5n3 fatty acid in human adipose tissue
    • Zafiropoulos A., Linardakis M., Jansen E.H., Tsatsakis A.M., Kafatos A., Tsanakakis G.N. Paraoxonase 1 R/Q alleles are associated with differential accumulation of saturated versus 20:5n3 fatty acid in human adipose tissue. J. Lipid Res. 2010, 51:1991-2000.
    • (2010) J. Lipid Res. , vol.51 , pp. 1991-2000
    • Zafiropoulos, A.1    Linardakis, M.2    Jansen, E.H.3    Tsatsakis, A.M.4    Kafatos, A.5    Tsanakakis, G.N.6
  • 65
    • 4744363276 scopus 로고    scopus 로고
    • Association of paraoxonase 1 gene polymorphisms with risk of Parkinson's disease: a meta-analysis
    • Zintzaras E., Hadjigeorgiou G.M. Association of paraoxonase 1 gene polymorphisms with risk of Parkinson's disease: a meta-analysis. J. Hum. Genet. 2004, 49:474-481.
    • (2004) J. Hum. Genet. , vol.49 , pp. 474-481
    • Zintzaras, E.1    Hadjigeorgiou, G.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.