Protective role of Nrf2 in age-related hearing loss and gentamicin ototoxicity

Biochemical and Biophysical Research Communications

Volumn 415, Issue 1, 2011, Pages 94-98

  Hoshino, Tomofumi ^a   Tabuchi, Keiji ^a   Nishimura, Bungo ^a   Tanaka, Shuho ^a   Nakayama, Masahiro ^a   Ishii, Tetsuro ^a   Warabi, Eiji ^a   Yanagawa, Toru ^a   Shimizu, Ritsuku ^b   Yamamoto, Masayuki ^b   Hara, Akira ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Age related hearing loss (AHL); Cochlea; Gentamicin ototoxicity; NF E2 related factor (Nrf2); Reactive oxygen species (ROS)

Indexed keywords

GENTAMICIN; TRANSCRIPTION FACTOR NRF2;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; AUDITORY RESPONSE; AUDITORY THRESHOLD; CELL LOSS; CONTROLLED STUDY; CORTI ORGAN; DETOXIFICATION; EAR PROTECTION; HAIR CELL; HEARING LOSS; MOUSE; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; PROTEIN FUNCTION; SPIRAL GANGLION;

AGING; ANIMALS; ANTI-BACTERIAL AGENTS; EAR, INNER; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENTAMICINS; HAIR CELLS, AUDITORY; HEARING LOSS; HEME OXYGENASE-1; MICE; MICE, KNOCKOUT; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; RESPONSE ELEMENTS; SPIRAL GANGLION; SUPEROXIDE DISMUTASE;

MUS;

EID: 80755188896     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.10.019     Document Type: Article

References (29)

1. Itoh K., Ishii T., Wakabayashi N., Yamamoto M. Regulatory mechanisms of cellular response to oxidative stress. Free Radic. Res. 1999, 31:319-324.
2. Itoh K., Wakabayashi N., Katoh Y., Ishii T., O'Connor T., Yamamoto M. Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells 2003, 8:379-391.
3. Ishii T., Itoh K., Takahashi S., Sato H., Yanagawa T., Katoh Y., Bannai S., Yamatomo M. Transcriptional factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J. Biol. Chem. 2000, 275:16023-16029.
4. Schreibelt G., Van Horssen J., van Rossum S., Dijkstra C.D., Drukarch B., de Vries H.E. Therapeutic potential and biological role of endogenous antioxidant enzymes in multiple sclerosis pathway. Brain Res. Rev. 2007, 56:322-330.
5. Johnson J.A., Johnson D.A., Kraft A.D., Calkins M.J., Jakel R., Vargas M.R., Chen P.C. The Nrf2-ARE pathway. An indicator and modulator of oxidative stress in neurodegeneration. Ann. N. Y. Acad. Sci. 2008, 1147:61-69.
6. Tabuchi K., Ito Z., Wada T., Hara A., Kusakari J. The effect of mannitol upon cochlear dysfunction induced by transient local anoxia. Hear. Res. 1998, 126:28-36.
7. Tabuchi K., Kusakari J., Ito Z., Takahashi K., Wada T., Hara A. Effect of nitric oxide synthase inhibitor on cochlear dysfunction induced by transient local anoxia. Acta Otolaryngol. 1999, 119:179-184.
8. Tabuchi K., Okubo H., Fujihira K., Tsuji S., Hara A., Kusakari J. Protection of outer hair cells from reperfusion injury by an iron chelator and a nitric oxide synthase inhibitor in the guinea pig cochlea. Neurosci. Lett. 2001, 307:29-32.
9. Tabuchi K., Tsuji S., Fujihira K., Oikawa K., Hara A., Kusakari J. Outer hair cells functionally and structurally deteriorate during reperfusion. Hear. Res. 2002, 173:153-163.
10. Yamasoba T., Schacht J., Shoji F., Miller J.M. Attenuation of cochlear damage from noise trauma by an iron chelator, a free radical scavenger and glial cell line-derived neurotrophic factor in vitro. Brain Res. 1999, 815:317-325.
11. Murashita H., Tabuchi K., Hoshino T., Tsuji S., Hara A. The effects of tempol, 3-aminobenzamide and nitric oxide synthase inhibitors on acoustic injury of the mouse cochlea. Hear. Res. 2006, 214:1-6.
12. Hoshino T., Tabuchi K., Hirose Y., Uemaetomari I., Murashita H., Tobita T., Hara A. The non-steroidal anti-inflammatory drugs protect mouse cochlea against acoustic injury. Tohoku J. Exp. Med. 2008, 216:53-59.
13. Choung Y.H., Taura A., Pak K., Choi S.J., Masuda M., Ryan A.F. Generation of highly-reactive oxygen species is closely related to hair cell damage in rat organ of corti treated with gentamicin. Neuroscience 2009, 161:214-226.
14. Riva C., Donadieu E., Maqnan J., Lavielle J.P. Age-related hearing loss in CD/1 mice is associated to ROS formation and HIF target proteins up-regulation in the cochlea. Exp. Gerontol. 2007, 42:327-336.
15. McFadden S.L., Ding D.L., Reaume A.G., Flood D.G., Salvi R.J. Age-related cochlear hair cell loss is enhanced in mice lacking copper/zinc superoxide dismutase. Neurobiol. Aging 1999, 20:1-8.
16. McFadden S.L., Ding D.L., Burkard R.F., Jiang H., Reaume A.G., Flood D.G., Salvi R.J. Cu/Zn SOD deficiency potentiates hearing loss and cochlear pathology in aged 129, CD-1 mice. J. Comp. Neurol. 1999, 413:101-112.
17. Ohlemiller K.K., McFadden S.L., Ding D.L., Flood D.G., Reaume A.G., Hoffman E.K., Scott R.W., Wright J.S., Putcha G.V., Salvi R.J. Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss. Audiol. Neurotol. 1999, 4:237-246.
18. Fairfield D.A., Kanicki A.C., Lomax M.I., Altschuler R.A. Induction of heat shock protein 32 (Hsp32) in the rat cochlea following hyperthermia. Hear. Res. 2004, 188:1-11.
19. Kim H.J., So H.S., Lee J.H., Lee J.H., Park C., Park S.Y., Kim Y.H., Youn M.J., Kim S.J., Chung S.Y., Lee K.M., Park R. Heme oxygenase-1 attenuates the cisplatin-induced apoptosis of auditory cells via down-regulation of reactive oxygen species generation. Free Radic. Biol. Med. 2006, 40:1810-1819.
20. So H.S., Kim H.J., Lee J.H., Lee J.H., Park S.Y., Park C., Kim Y.H., Kim J.K., Lee K.M., Kim K.S., Chung S.Y., Jang W.C., Moon S.K., Chung H.T., Park R.K. Flunarizine induces Nrf2-mediated transcriptional activation of heme oxygenase-1 in protection of auditory cells from cisplatin. Cell Death Differ. 2006, 13:1763-1775.
21. Kil J., Pierce C., Tran H., Gu R., Lynch E.D. Ebselen treatment reduces noise induced hearing loss via the mimicry and induction of glutathione peroxidase. Hear. Res. 2007, 226:44-51.
22. Tabuchi K., Suzuki M., Mizuno A., Hara A. Hearing impairment in TRPV4 knockout mice. Neurosci. Lett. 2005, 382:304-308.
23. Tabuchi K., Pak K., Chavez E., Ryan A.F. Role of inhibitor of apoptosis protein in gentamicin-induced cochlear hair cell damage. Neuroscience 2007, 149:213-222.
24. Chung W.H., Pak K., Lin B., Webster N., Ryan A.F. A PI3K pathway mediates hair cell survival and opposes gentamicin toxicity in neonatal rat organ of Corti. J. Assoc. Res. Otolaryngol. 2006, 7:373-382.
25. Suzuki T., Kelly V.P., Motohashi H., Nakajima O., Takahashi S., Nishimura S., Yamamoto M. Deletion of the selenocysteine tRNA gene in macrophages and liver results in compensatory gene induction of cytoprotective enzymes by Nrf2. J. Biol. Chem. 2008, 283:2021-2030.
26. Liu X.Z., Yan D. Ageing and hearing loss. J. Pathol. 2007, 211:188-197.
27. Kong L., Zhou X., McGinnis J.F., Li F., Cao W. Molecular mechanisms underlying cochlear degeneration in the tubby mouse and the therapeutic effect of sulforaphane. Neurochem. Int. 2008, 54:172-179.
28. Sun J., Hoshino H., Takaku K., Nakajima O., Muto A., Suzuki H., Tashiro S., Takahashi S., Shibahara S., Alam J., Taketo M.M., Yamamoto M., Igarashi K. Hemoprotein Bach1 regulates enhancer availability of hemo oxygenase-1 gene. EMBO J. 2002, 21:5216-5224.
29. Zhang J., Ohta T., Maruyama A., Hosoya T., Nishikawa K., Maher J.M., Shibahara S., Itoh K., Yamamoto M. BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress. Mol. Cell. Biol. 2006, 26:7942-7952.