Neonatal diabetes: An expanding list of genes allows for improved diagnosis and treatment

Current Diabetes Reports

Volumn 11, Issue 6, 2011, Pages 519-532

  Greeley, Siri Atma W ^a   Naylor, Rochelle N ^a   Philipson, Louis H ^a   Bell, Graeme I ^a  

^a University of Chicago ^*  (United States)

Author keywords

6q24; ABCC8; DIDMOAD; EIF2AK3; FOXP3; GCK; GLIS3; HNF1B; IER3IP1; INS; IPEX; K ATP; KCNJ11; MODY; Monogenic diabetes; NDM; Neonatal diabetes; NEUROD1; NEUROG3; PDX1; PNDM; PTF1A; RFX6; SLC19A2; SLC2A2; TNDM; TRMA; WFS1

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CHROMOGRANIN A; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLUCOSE; INSULIN; INSULINASE; SULFONYLUREA DERIVATIVE;

ABCC8 GENE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD GLUCOSE MONITORING; BRAIN MALFORMATION; CEREBELLUM HYPOPLASIA; CHROMOSOME 6Q; CHROMOSOME ABERRATION; CLINICAL FEATURE; CONGENITAL DISORDER; DIABETES CONTROL; DIABETES INSIPIDUS; DIABETES MELLITUS; DISEASE COURSE; DISEASE SEVERITY; DYSPLASIA; EIF2AK3 GENE; ENDOPLASMIC RETICULUM STRESS; ENTEROPATHY; FOXP3 GENE; GCK GENE; GENE; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC RISK; GENOME IMPRINTING; GLIS3 GENE; HEARING IMPAIRMENT; HNF1B GENE; HUMAN; HYMA1 GENE; HYPERGLYCEMIA; HYPOGLYCEMIA; HYPOPLASIA; HYPOTHYROIDISM; IER3IP1 GENE; IMMUNE DYSREGULATION; INFANTILE DIARRHEA; INFANTILE SPASM; INS GENE; INSULIN TREATMENT; INTESTINE ATRESIA; INTRAUTERINE GROWTH RETARDATION; IPEX SYNDROME; KCNJ11 GENE; KIDNEY DISEASE; KIDNEY MALFORMATION; LIVER DYSFUNCTION; MEDICAL RESEARCH; MEGALOBLASTIC ANEMIA; MICROCEPHALY; MICROPHTHALMIA; NEUROD1 GENE; NEUROG3 GENE; NEWBORN DIABETES MELLITUS; NEWBORN DISEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ONSET AGE; OPTIC NERVE ATROPHY; PANCREAS FUNCTION DISORDER; PAX6 GENE; PDX1 GENE; PERSONALIZED MEDICINE; PHARMACOLOGICAL BLOCKING; PLAGL1 GENE; POLYENDOCRINOPATHY; PROGNOSIS; PTF1A GENE; QUALITY OF LIFE; RFX6 GENE; RISK FACTOR; SCL19A2 GENE; SIGNAL TRANSDUCTION; SLC2A2 GENE; TREATMENT OUTCOME; TREATMENT RESPONSE; WFS1 GENE; ZFP57 GENE;

ATP-BINDING CASSETTE TRANSPORTERS; DIABETES MELLITUS; HUMANS; HYPOGLYCEMIC AGENTS; INFANT, NEWBORN; INFANT, NEWBORN, DISEASES; MUTATION; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RECEPTORS, DRUG; SULFONYLUREA COMPOUNDS;

EID: 80755145978     PISSN: 15344827     EISSN: 15390829     Source Type: Journal    
DOI: 10.1007/s11892-011-0234-7     Document Type: Article

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102. A Bonnefond E Durand O Sand, et al. 2010 Molecular diagnosis of neonatal diabetes mellitus using next-generation sequencing of the whole exome PLoS ONE 5 10 e13630 21049026 10.1371/journal.pone.0013630 1:CAS:528:DC%2BC3cXhsVSht73M This study demonstrates what will surely be the future direction of genetic testing, especially for Mendelian disorders such as neonatal diabetes that have many possible causes, including presumed unknown genes