Sequencing PDX1 (insulin promoter factor1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type2 diabetes

Diabetic Medicine

Volumn 28, Issue 6, 2011, Pages 681-684

  Edghill, E L ^a   Khamis, A ^a   Weedon, M N ^a   Walker, M ^b   Hitman, G A ^c   Mccarthy, M I ^d,e,f   Owen, K R ^d,e   Ellard, S ^a   Hattersley, A T ^a   Frayling, T M ^a  

^a UNIVERSITY OF EXETER   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c BARTS HEALTH NHS TRUST   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e CHURCHILL HOSPITAL   (United Kingdom)

^f UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Diabetes; Genetics; Polygenic; Variants

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; TRANSCRIPTION FACTOR PDX 1;

ADOLESCENT; ADULT; AGED; AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DNA BINDING; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HETEROZYGOTE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MISSENSE MUTATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEOTIDE SEQUENCE; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED KINGDOM;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENOME-WIDE ASSOCIATION STUDY; GREAT BRITAIN; HOMEODOMAIN PROTEINS; HUMANS; MALE; MIDDLE AGED; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; SEQUENCE ANALYSIS, DNA; TRANS-ACTIVATORS; YOUNG ADULT;

EID: 79955973169     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2011.03269.x     Document Type: Article

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