The X and y chromosome in meiosis: How and why they keep silent

Asian Journal of Andrology

Volumn 13, Issue 6, 2011, Pages 779-780

  Van Der Heijden, Godfried W ^a   Eijpe, Maureen ^a   Baarends, Willy M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; HISTONE H2AX;

ANEUPLOIDY; APOPTOSIS; CELL CYCLE; CELL DEGENERATION; CHROMATIN; DNA DAMAGE; DNA REPAIR; DNA SEQUENCE; GENE EXPRESSION; HUMAN; KNOCKOUT MOUSE; MEIOSIS; NONHUMAN; OOCYTE; PACHYTENE; SHORT SURVEY; SOMATIC CELL; SPERM; SPERMATOGENESIS; X CHROMOSOME; Y CHROMOSOME;

CHROMOSOMES, HUMAN, X; CHROMOSOMES, HUMAN, Y; HUMANS; MEIOSIS;

EID: 80755143511     PISSN: 1008682X     EISSN: 17457262     Source Type: Journal    
DOI: 10.1038/aja.2011.93     Document Type: Short Survey

References (20)

1. Monesi V. Differential rate of ribonucleic acid synthesis in the autosomes and sex chromosomes during male meiosis in the mouse. Chromosoma 1965; 17: 11-21.
2. Turner JM. Meiotic sex chromosome inactivation. Development 2007; 134: 1823-31. (Pubitemid 46939228)
3. Inagaki A, Schoenmakers S, Baarends WM. DNA double strand break repair, chromosome synapsis and transcriptional silencing in meiosis. Epigenetics 2010; 5: 255-66.
4. Ichijima Y, Ichijima M, Lou Z, Nussenzweig A, Camerini-Otero RD et al. MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells. Genes Dev 2011; 25: 959-71.
5. Royo H, Polikiewicz G, Mahadevaiah SK, Prosser H, Mitchell M et al. Evidence that meiotic sex chromosome inactivation is essential for male fertility. Curr Biol 2010; 20: 2117-23.
6. Fernandez-Capetillo O, Mahadevaiah SK, Celeste A, Romanienko PJ, Camerini-Otero RD et al. H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis. Dev Cell 2003; 4: 497-508. (Pubitemid 36437557)
7. Mahadevaiah SK, Turner JM, Baudat F, Rogakou EP, de Boer P et al. Recombinational DNA double-strand breaks in mice precede synapsis. Nat Genet 2001; 27: 271-6. (Pubitemid 32201847)
8. Turner JM, Aprelikova O, Xu X, Wang R, Kim S et al. BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation. Curr Biol 2004; 14: 2135-42. (Pubitemid 39623196)
9. Nakamura TM, Du LL, Redon C, Russell P. Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast. Mol Cell Biol 2004; 24: 6215-30. (Pubitemid 38891124)
10. Lukas C, Melander F, Stucki M, Falck J, Bekker-Jensen S et al. Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. EMBO J 2004; 23: 2674-83. (Pubitemid 38988238)
11. Shanbhag NM, Rafalska-Metcalf IU, Balane-Bolivar C, Janicki SM, Greenberg RA. ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks. Cell 2010; 141: 970-81.
12. Moens PB, Chen DJ, Shen Z, Kolas N, Tarsounas M et al. Rad51 immunocytology in rat and mouse sperma-tocytes and oocytes. Chromosoma 1997; 106: 207-15. (Pubitemid 27426408)
13. Mahadevaiah SK, Bourc'his D, de Rooij DG, Bestor TH, Turner JM et al. Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation. J Cell Biol 2008; 182: 263-76.
14. Yuan L, Liu JG, Hoja MR, Wilbertz J, Nordqvist K et al. Female germ cell aneuploidy and embryo death in mice lacking the meiosis-specific protein SCP3. Science 2002; 296: 1115-8. (Pubitemid 34517127)
15. Vernet N, Mahadevaiah SK, Ojarikre OA, Longepied G, Prosser HM et al. The y-encoded gene zfy2 acts to remove cells with unpaired chromosomes at the first meiotic metaphase in male mice. Curr Biol 2011; 21: 787-93.
16. de Boer P, Ramos L, de Vries M, Gochhait S. Memoirs of an insult: sperm as a possible source of transgenera-tional epimutations and genetic instability. Mol Human Reprod 2010; 16: 48-56.
17. Sciurano RB, Rahn MI, Pigozzi MI, Olmedo SB, Solari AJ. An azoospermic man with a double-strand DNA break-processing deficiency in the spermatocyte nuclei: case report. Hum Reprod 2006; 21: 1194-203.
18. Ma S, Yuen BH, Penaherrera M, Koehn D, Ness L et al. ICSI and the transmission of X-autosomal translocation: a three-generation evaluation of X;20 translocation: case report. Hum Reprod 2003; 18: 1377-82. (Pubitemid 36840942)
19. Solari AJ, Rey Valzacchi G. The prevalence of a YY synaptonemal complex over XY synapsis in an XYY man with exclusive XYY spermatocytes. Chromosome Res 1997; 5: 467-74. (Pubitemid 27503569)
20. Mulugeta Achame E, Baarends WM, Gribnau J, Grootegoed JA. Evaluating the relationship between spermatogenic silencing of the X chromosome and evolution of the Y chromosome in chimpanzee and human. PloS One 2010; 5: e15598.