Role of Eph/ephrin tyrosine kinase in malignant glioma

Neuro-Oncology

Volumn 13, Issue 11, 2011, Pages 1163-1170

  Nakada, Mitsutoshi ^a   Hayashi, Yutaka ^a   Hamada, Jun Ichiro ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Eph; Ephrin; Glioma; Tyrosine kinase

Indexed keywords

EPHRIN; EPHRIN A1; EPHRIN A2; EPHRIN A3; EPHRIN A4; EPHRIN A5; EPHRIN A7; EPHRIN B; EPHRIN B2; EPHRIN RECEPTOR; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 1; MEMBRANE PROTEIN; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; BRAIN FUNCTION; CANCER GROWTH; CANCER INVASION; CANCER STEM CELL; CELL CONTACT; CELL INFILTRATION; CELL MIGRATION; CELL MOTION; CELL PROLIFERATION; CELL RENEWAL; GLIOBLASTOMA; HUMAN; IMMUNOHISTOCHEMISTRY; MORPHOGENESIS; NEOVASCULARIZATION (PATHOLOGY); NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PHENOTYPE; PROGNOSIS; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; EPHRINS; GLIOMA; HUMANS; PROTEIN-TYROSINE KINASES; RECEPTORS, EPH FAMILY; SIGNAL TRANSDUCTION;

EID: 80755142709     PISSN: 15228517     EISSN: 15235866     Source Type: Journal    
DOI: 10.1093/neuonc/nor102     Document Type: Review

References (58)

1. Wilkinson DG. Multiple roles of EPH receptors and ephrins in neural development. Nat Rev Neurosci. 2001;2:155-164. (Pubitemid 33673369)
2. Kullander K, Klein R. Mechanisms and functions of Eph and ephrin signalling. Nat Rev Mol Cell Biol. 2002;3:475-486. (Pubitemid 34733429)
3. Pasquale EB. Eph receptors and ephrins in cancer: bidirectional signalling and beyond. Nat Rev Cancer. 2010;10:165-180.
4. Himanen JP, Chumley MJ, Lackmann M, et al. Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling. Nat Neurosci. 2004;7:501-509. (Pubitemid 38544589)
5. Miao H, Li DQ, Mukherjee A, et al. EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt. Cancer Cell. 2009;16:9-20.
6. Pitulescu ME, Adams RH. Eph/ephrin molecules-a hub for signaling and endocytosis. Genes Dev. 2010;24:2480-2492.
7. Pasquale EB. Eph-ephrin bidirectional signaling in physiology and disease. Cell. 2008;133:38-52. (Pubitemid 351442996)
8. Surawska H, Ma PC, Salgia R. The role of ephrins and Eph receptors in cancer. Cytokine Growth Factor Rev. 2004;15:419-433. (Pubitemid 39550453)
9. Pasquale EB. Eph receptor signalling casts a wide net on cell behaviour. Nat Rev Mol Cell Biol. 2005;6:462-475. (Pubitemid 40780558)
10. Merlos-Suarez A, Batlle E. Eph-ephrin signalling in adult tissues and cancer. Curr Opin Cell Biol. 2008;20:194-200.
11. Noberini R, Pasquale EB. Proliferation and tumor suppression: not mutually exclusive for Eph receptors. Cancer Cell. 2009;16:452-454.
12. Cheng N, Brantley DM, Chen J. The ephrins and Eph receptors in angiogenesis. Cytokine Growth Factor Rev. 2002;13:75-85. (Pubitemid 34436963)
13. Wang HU, Chen ZF, Anderson DJ. Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell. 1998;93:741-753. (Pubitemid 28257581)
14. Gerety SS, Wang HU, Chen ZF, Anderson DJ. Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. Mol Cell. 1999;4:403-414. (Pubitemid 29499793)
15. Adams RH, Wilkinson GA, Weiss C, et al. Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev. 1999;13:295-306. (Pubitemid 29095801)
16. Yamaguchi Y, Pasquale EB. Eph receptors in the adult brain. Curr Opin Neurobiol. 2004;14:288-296. (Pubitemid 38759859)
17. Liebl DJ, Morris CJ, Henkemeyer M, Parada LF. mRNA expression of ephrins and Eph receptor tyrosine kinases in the neonatal and adult mouse central nervous system. J Neurosci Res. 2003;71:7-22. (Pubitemid 36008398)
18. Nakada M, Niska JA, Miyamori H, et al. The phosphorylation of EphB2 receptor regulates migration and invasion of human glioma cells. Cancer Res. 2004;64:3179-3185. (Pubitemid 38581420)
19. Nakada M, Drake KL, Nakada S, Niska JA, Berens ME. Ephrin-B3 ligand promotes glioma invasion through activation of Rac1. Cancer Res. 2006;66:8492-8500. (Pubitemid 44449162)
20. Nakada M, Anderson EM, Demuth T, et al. The phosphorylation of ephrin-B2 ligand promotes glioma cell migration and invasion. Int J Cancer. 2010;126:1155-1165.
21. Murai KK, Nguyen LN, Irie F, Yamaguchi Y, Pasquale EB. Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling. Nat Neurosci. 2003;6:153-160. (Pubitemid 36182784)
22. Gage FH. Mammalian neural stem cells. Science. 2000;287:1433-1438. (Pubitemid 30127128)
23. Temple S. The development of neural stem cells. Nature. 2001;414:112-117. (Pubitemid 33041635)
24. Gross CG. Neurogenesis in the adult brain: death of a dogma. Nat Rev Neurosci. 2000;1:67-73.
25. Conover JC, Doetsch F, Garcia-Verdugo JM, Gale NW, Yancopoulos GD, Alvarez-Buylla A. Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone. Nat Neurosci. 2000;3:1091-1097.
26. Holmberg J, Armulik A, Senti KA, et al. Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis. Genes Dev. 2005;19:462-471. (Pubitemid 40256278)
27. Genander M, Holmberg J, Frisen J. Ephrins negatively regulate cell proliferation in the epidermis and hair follicle. Stem Cells. 2010;28:1196-1205.
28. Nomura T, Goritz C, Catchpole T, Henkemeyer M, Frisen J. EphB signaling controls lineage plasticity of adult neural stem cell niche cells. Cell Stem Cell. 2010;7:730-743.
29. Singh SK, Hawkins C, Clarke ID, et al. Identification of human brain tumour initiating cells. Nature. 2004;432:396-401. (Pubitemid 39551674)
30. + cell populations from mobilized peripheral blood. Int J Immunopathol Pharmacol. 2006;19:49-56.
31. Nakada M, Nakada S, Demuth T, Tran NL, Hoelzinger DB, Berens ME. Molecular targetsofglioma invasion. Cell Mol Life Sci. 2007;64:458-478.
32. Hoelzinger DB, Mariani L, Weis J, et al. Gene expression profile of glioblastoma multiforme invasive phenotype points to new therapeutic targets. Neoplasia. 2005;7:7-16. (Pubitemid 40209466)
33. Bellail AC, Hunter SB, Brat DJ, Tan C, Van Meir EG. Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasion. Int J Biochem Cell Biol. 2004;36:1046-1069. (Pubitemid 38501557)
34. Wykosky J, Gibo DM, Stanton C, Debinski W. EphA2 as a novel molecular marker and target in glioblastoma multiforme. Mol Cancer Res. 2005;3:541-551. (Pubitemid 41567273)
35. Wykosky J, Gibo DM, Debinski W. A novel, potent, and specific ephrinA1-based cytotoxin against EphA2 receptor expressing tumor cells. Mol Cancer Ther. 2007;6:3208-3218.
36. Wykosky J, Debinski W. The EphA2 receptor and ephrinA1 ligand in solid tumors: function and therapeutic targeting. Mol Cancer Res. 2008;6:1795-1806.
37. Liu F, Park PJ, Lai W, et al. A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma. Cancer Res. 2006;66:10815-10823. (Pubitemid 44876977)
38. Wang LF, Fokas E, Bieker M, et al. Increased expression of EphA2 correlates with adverse outcome in primary and recurrent glioblastoma multiforme patients. Oncol Rep. 2008;19:151-156. (Pubitemid 351176143)
39. Wu N, Zhao X, Liu M, et al. Role of MicroRNA-26b in glioma development and its mediated regulation on EphA2. PLoS One. 2011;6:e16264.
40. Liu DP, Wang Y, Koeffler HP, Xie D. Ephrin-A1 is a negative regulator in glioma through down-regulation of EphA2 and FAK. Int J Oncol. 2007;30:865-871.
41. Hatano M, Eguchi J, Tatsumi T, et al. EphA2 as a glioma-associated antigen: a novel target for glioma vaccines. Neoplasia. 2005;7:717-722.
42. Macrae M, Neve RM, Rodriguez-Viciana P, et al. A conditional feedback loop regulates Ras activity through EphA2. Cancer Cell. 2005;8:111-118. (Pubitemid 41132740)
43. Zelinski DP, Zantek ND, Stewart JC, Irizarry AR, Kinch MS. EphA2 overexpression causes tumorigenesis of mammary epithelial cells. Cancer Res. 2001;61:2301-2306. (Pubitemid 32692063)
44. Chen J, Zhuang G, Frieden L, Debinski W. Eph receptors and ephrins in cancer: common themes and controversies. Cancer Res. 2008;68:10031-10033.
45. Fukai J, Yokote H, Yamanaka R, Arao T, Nishio K, Itakura T. EphA4 promotes cell proliferation and migration through a novel EphA4-FGFR1 signaling pathway in the human glioma U251 cell line. Mol Cancer Ther. 2008;7:2768-2778.
46. Wang LF, Fokas E, Juricko J, et al. Increased expression of EphA7 correlates with adverse outcome in primary and recurrent glioblastoma multiforme patients. BMC Cancer. 2008;8:79.
47. Miescher GC, Taylor V, Olivieri G, Mindermann T, Schrock E, Steck AJ. Extensive splice variation and localization of the EHK-1 receptor tyrosine kinase in adult human brain and glial tumors. Brain Res Mol Brain Res. 1997;46:17-24. (Pubitemid 27214351)
48. Bruce V, Olivieri G, Eickelberg O, Miescher GC. Functional activation of EphA5 receptor does not promote cell proliferation in the aberrant EphA5 expressing human glioblastoma U-118 MG cell line. Brain Res. 1999;821:169-176. (Pubitemid 29219693)
49. Li JJ, Liu DP, Liu GT, Xie D. EphrinA5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor. Oncogene. 2009;28:1759-1768.
50. Nakada M, Niska JA, Tran NL, McDonough WS, Berens ME. EphB2/R-Ras signaling regulates glioma cell adhesion, growth, and invasion. Am J Pathol. 2005;167:565-576. (Pubitemid 43026110)
51. Cortina C, Palomo-Ponce S, Iglesias M, et al. EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells. Nat Genet. 2007;39:1376-1383. (Pubitemid 350034995)
52. Huusko P, Ponciano-Jackson D, Wolf M, et al. Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer. Nat Genet. 2004;36:979-983. (Pubitemid 39167494)
53. Erber R, Eichelsbacher U, Powajbo V, et al. EphB4 controls blood vascular morphogenesis during postnatal angiogenesis. EMBO J. 2006;25:628-641. (Pubitemid 43237669)
54. Sawamiphak S, Seidel S, Essmann CL, et al. Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis. Nature. 2010;465:487-491.
55. Karaman MW, Herrgard S, Treiber DK, et al. A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol. 2008;26:127-132.
56. Garber K. Of Ephs and ephrins: companies target guidance molecules in cancer. J Natl Cancer Inst. 2010;102:1692-1694.
57. Hatano M, Kuwashima N, Tatsumi T, et al. Vaccination with EphA2-derived T cell-epitopes promotes immunity against both EphA2-expressing and EphA2-negative tumors. J Transl Med. 2004;2:40.
58. Kuijper S, Turner CJ, Adams RH. Regulation of angiogenesis by Eph-ephrin interactions. Trends Cardiovasc Med. 2007;17:145-151. (Pubitemid 46898841)