메뉴 건너뛰기




Volumn 33, Issue 3, 2011, Pages 309-320

Hippocampal M1 receptor function associated with spatial learning and memory in aged female rhesus macaques

Author keywords

M1 receptor; Scopolamine phMRI; Spatial maze

Indexed keywords

MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; SCOPOLAMINE;

EID: 80655125437     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-010-9184-2     Document Type: Article
Times cited : (14)

References (68)
  • 1
    • 0027421867 scopus 로고
    • Pharmacokinetics and related pharmacodynamics of anticholinergic drugs
    • Ali-Melkkila T, Kanto J, Iisalo E (1993) Pharmacokinetics and related pharmacodynamics of anticholinergic drugs. Acta Anaesthesiol Scand 37(7):633-642 (Pubitemid 23298996)
    • (1993) Acta Anaesthesiologica Scandinavica , vol.37 , Issue.7 , pp. 633-642
    • Ali-Melkkila, T.1    Kanto, J.2    Iisalo, E.3
  • 2
    • 15744390329 scopus 로고    scopus 로고
    • Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging
    • Araujo JA, Studzinski CM, Milgram NW (2005) Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging. Prog Neuropsychopharmacol Biol Psychiatry 29(3):411-422
    • (2005) Prog Neuropsychopharmacol Biol Psychiatry , vol.29 , Issue.3 , pp. 411-422
    • Araujo, J.A.1    Studzinski, C.M.2    Milgram, N.W.3
  • 3
    • 58149475814 scopus 로고    scopus 로고
    • Spatial memory and the monkey hippocampus: Not all space is created equal
    • Banta Lavenex P, Lavenex P (2009) Spatial memory and the monkey hippocampus: not all space is created equal. Hippocampus 19(1):8-19
    • (2009) Hippocampus , vol.19 , Issue.1 , pp. 8-19
    • Banta Lavenex, P.1    Lavenex, P.2
  • 4
    • 54149094281 scopus 로고    scopus 로고
    • Estradiol treatment and its interaction with the cholinergic system: Effects on cognitive function in healthy young women
    • Bartholomeusz CF, Wesnes KA, Kulkarni J, Vitetta L, Croft RJ, Nathan PJ (2008) Estradiol treatment and its interaction with the cholinergic system: effects on cognitive function in healthy young women. Horm Behav 54(5):684-693
    • (2008) Horm Behav , vol.54 , Issue.5 , pp. 684-693
    • Bartholomeusz, C.F.1    Wesnes, K.A.2    Kulkarni, J.3    Vitetta, L.4    Croft, R.J.5    Nathan, P.J.6
  • 5
    • 0030044135 scopus 로고    scopus 로고
    • Scopolamine differentially affects memory of 8-and 16-month-old rats in the double y-maze
    • Biggan SL, Ingles JL, Beninger RJ (1996) Scopolamine differentially affects memory of 8-and 16-month-old rats in the double y-maze. Neurobiol Aging 17(1):25-30
    • (1996) Neurobiol Aging , vol.17 , Issue.1 , pp. 25-30
    • Biggan, S.L.1    Ingles, J.L.2    Beninger, R.J.3
  • 6
    • 0010237809 scopus 로고    scopus 로고
    • Ibotenate lesions of the hippocampus impair spatial learning but not contextual fear conditioning in mice
    • DOI 10.1016/S0166-4328(98)00054-0, PII S0166432898000540
    • Cho YH, Friedman E, Silva AJ (1999) Ibotenate lesion of the hippocampus impair spatial learning but not contextual fear conditioning. Behav Brain Res 98:77-87 (Pubitemid 28566198)
    • (1999) Behavioural Brain Research , vol.98 , Issue.1 , pp. 77-87
    • Cho, Y.H.1    Friedman, E.2    Silva, A.J.3
  • 8
    • 0025808616 scopus 로고
    • Cholinergic activity in the rat hippocampus, cortex and striatum correlates with locomotor activity: An in vivo microdialysis study
    • Day J, Damsma G, Fibiger HC (1991) Cholinergic activity in the rat hippocampus, cortex and striatum correlates with locomotor activity: an in vivo microdialysis study. Pharmacol Biochem Behav 38(4):723-729
    • (1991) Pharmacol Biochem Behav , vol.38 , Issue.4 , pp. 723-729
    • Day, J.1    Damsma, G.2    Fibiger, H.C.3
  • 10
    • 0031744035 scopus 로고    scopus 로고
    • Scopolamine model of dementia: Electroencephalogram findings and cognitive performance
    • DOI 10.1046/j.1365-2362.1998.00393.x
    • Ebert U, Kirch W (1998) Scopolamine model of dementia: electroencephalogram findings and cognitive performance. Eur J Clin Investig 28(11):944-949 (Pubitemid 28521587)
    • (1998) European Journal of Clinical Investigation , vol.28 , Issue.11 , pp. 944-949
    • Ebert, U.1    Kirch, W.2
  • 11
    • 0034747713 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynapic modeling of the elec-troencephalogram effects of scopolamine in healthy volunteers
    • Ebert U, Grossmann M, Oertel R, Gramatte T, Kirch W (2001) Pharmacokinetic-pharmacodynapic modeling of the elec-troencephalogram effects of scopolamine in healthy volunteers. J Clin Pharmacol 41:51-60
    • (2001) J Clin Pharmacol , vol.41 , pp. 51-60
    • Ebert, U.1    Grossmann, M.2    Oertel, R.3    Gramatte, T.4    Kirch, W.5
  • 13
    • 0023839651 scopus 로고
    • An evaluation of the mechanism of scopolamine-induced impairment in two passive avoidance protocols
    • Elrod K, Buccafusco JJ (1988) An evaluation of the mechanism of scopolamine-induced impairment in two passive avoidance protocols. Pharmacol Biochem Behav 29(1):15-21 (Pubitemid 18052709)
    • (1988) Pharmacology Biochemistry and Behavior , vol.29 , Issue.1 , pp. 15-21
    • Elrod, K.1    Buccafusco, J.J.2
  • 14
    • 46749118974 scopus 로고    scopus 로고
    • Cholinergic Treatments with Emphasis on M1 Muscarinic Agonists as Potential Disease-Modifying Agents for Alzheimer's Disease
    • DOI 10.1016/j.nurt.2008.05.002, PII S1933721308000913
    • Fisher A (2008) Cholinergic treatments with emphasis on M1 muscarinic agonists as potential disease-modifying agents for Alzheimer's disease. Neurotherapeutics 5(3):433-442 (Pubitemid 351952486)
    • (2008) Neurotherapeutics , vol.5 , Issue.3 , pp. 433-442
    • Fisher, A.1
  • 16
    • 0028925434 scopus 로고
    • Differential alterations in muscarinic receptor subtypes in alzheimer's disease: Implications for cholinergic-based therapies
    • Flynn DD, Ferrari-Di Leo G, Levey AI, Mash DC (1995a) Differential alterations in muscarinic receptor subtypes in alzheimer's disease: implications for cholinergic-based therapies. Life Sci 56(11-12):869-876
    • (1995) Life Sci , vol.56 , Issue.11-12 , pp. 869-876
    • Flynn, D.D.1    Ferrari-Di Leo, G.2    Levey, A.I.3    Mash, D.C.4
  • 17
    • 0028924664 scopus 로고
    • Differential regulation ofmolecular subtypes ofmuscarinic receptors in Alzheimer's disease
    • Flynn DD, Ferrari-Di Leo G, Mash DC, Levey AI (1995b) Differential regulation ofmolecular subtypes ofmuscarinic receptors in Alzheimer's disease. JNeurochem 64(4):1888-1891
    • (1995) JNeurochem , vol.64 , Issue.4 , pp. 1888-1891
    • Flynn, D.D.1    Ferrari-Di Leo, G.2    Mash, D.C.3    Levey, A.I.4
  • 18
    • 24144436151 scopus 로고    scopus 로고
    • Spontaneous low-frequency BOLD signal fluctuations: An fMRI investigation of the resting-state default mode of brain function hypothesis
    • DOI 10.1002/hbm.20113
    • Fransson P (2004) Spontaneous low-frequency bold signal fluctuations: an f MRI investigation of the resting-state default mode of brain function hypothesis. Hum Brain Mapp 26(1):15-29 (Pubitemid 41232552)
    • (2005) Human Brain Mapping , vol.26 , Issue.1 , pp. 15-29
    • Fransson, P.1
  • 19
    • 48249156563 scopus 로고    scopus 로고
    • The use ofeffect sizes to characterize the nature of cognitive change in psychopharmacological studies: An example with scopolamine
    • Fredrickson A, Snyder PJ, Cromer J, Thomas E, Lewis M, Maruff P (2008) The use ofeffect sizes to characterize the nature of cognitive change in psychopharmacological studies: an example with scopolamine. Hum Psychophar-macol 23(5):425-436
    • (2008) Hum Psychophar-macol , vol.23 , Issue.5 , pp. 425-436
    • Fredrickson, A.1    Snyder, P.J.2    Cromer, J.3    Thomas, E.4    Lewis Maruff, M.P.5
  • 22
    • 0024162283 scopus 로고
    • Experimental approaches to age-related cognitive impairments
    • Gage FH, Chen KS, Buzsaki G, Armstrong D (1988) Experimental approaches to age-related cognitive impair-ments. Neurobiol Aging 9(5-6):645-655 (Pubitemid 19264159)
    • (1988) Neurobiology of Aging , vol.9 , Issue.5-6 , pp. 645-655
    • Gage, F.H.1    Chen, K.S.2    Buzsaki, G.3    Armstrong, D.4
  • 26
    • 43349083300 scopus 로고    scopus 로고
    • Chronic insomnia and cognitive functioning among older adults
    • Haimov I, Hanuka E, Horowitz Y (2008) Chronic insomnia and cognitive functioning among older adults. Behav Sleep Med 6(1):32-54
    • (2008) Behav Sleep Med , vol.6 , Issue.1 , pp. 32-54
    • Haimov, I.1    Hanuka, E.2    Horowitz, Y.3
  • 28
    • 0032984280 scopus 로고    scopus 로고
    • Cortical responses to auditory stimuli during isoflurane burst suppression anaesthesia
    • DOI 10.1046/j.1365-2044.1999.00300.x
    • Hartikainen K, Rorarius M (1999) Cortical responses to auditory stiuli during isoflurane burst suppression. Anaes-thesia 54:210-214 (Pubitemid 29126969)
    • (1999) Anaesthesia , vol.54 , Issue.3 , pp. 210-214
    • Hartikainen, K.1    Rorarius, M.G.F.2
  • 29
    • 0037378838 scopus 로고    scopus 로고
    • 18F]FP-TZTP, is greatly decreased in M2 receptor knockout mice but not in M1, M3 and M4 receptor knockout mice
    • DOI 10.1016/S0028-3908(03)00050-9
    • Jagoda EM, Kiesewetter DO, Shimoji K, Ravasi L, Yamada M, Gomeza J, Wess J, Eckelman WC (2003) Regional brain uptake of the muscarinic ligand, [18f]fp-tztp, is greatly decreased in M2 receptor knockout mice but not in M1, M3 and M4 receptor knockout mice. Neuropharmacology 44(5):653-661 (Pubitemid 36372054)
    • (2003) Neuropharmacology , vol.44 , Issue.5 , pp. 653-661
    • Jagoda, E.M.1    Kiesewetter, D.O.2    Shimoji, K.3    Ravasi, L.4    Yamada, M.5    Gomeza, J.6    Wess, J.7    Eckelman, W.C.8
  • 30
    • 77954086949 scopus 로고    scopus 로고
    • The validity ofscopolamine as a pharmacological model for cognitive impairment: A review of animal behavioral studies
    • in press
    • Klinkenberg I, Blokland A(2010) The validity ofscopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies. Neurosci Biobehav Rev (in press)
    • (2010) Neurosci Biobehav Rev
    • Klinkenberg, I.1    Blokland, A.2
  • 31
    • 33847651376 scopus 로고    scopus 로고
    • Linking nucleus accumbens dopamine and blood oxygenation
    • DOI 10.1007/s00213-006-0686-7, Dopamine - Revisited
    • Knutson B, Gibbs SE (2007) Linking nucleus accumbens dopamine and blood oxygenation. Psychopharmacology (Berl) 191(3):813-822 (Pubitemid 46355904)
    • (2007) Psychopharmacology , vol.191 , Issue.3 , pp. 813-822
    • Knutson, B.1    Gibbs, S.E.B.2
  • 32
    • 33646851212 scopus 로고    scopus 로고
    • Hippocampal lesion prevents spatial relational learning in adult macaque monkeys
    • DOI 10.1523/JNEUROSCI.5412-05.2006
    • Lavenex PB, Amaral DG, Lavenex P (2006) Hippocampal lesion prevents spatial relational learning in adult macaque monkeys. J Neurosci 26(17):4546-4558 (Pubitemid 44315354)
    • (2006) Journal of Neuroscience , vol.26 , Issue.17 , pp. 4546-4558
    • Lavenex, P.B.1    Amaral, D.G.2    Lavenex, P.3
  • 33
    • 0030030035 scopus 로고    scopus 로고
    • Cholinergic regulation of the suprachiasmatic nucleus circadian rhythm via a muscarinic mechanism at night
    • Liu C, Gillette MU (1996) Cholinergic regulation of the suprachiasmatic nucleus circadian rhythm via a muscarinic mechanism at night. J Neurosci 16(2):744-751 (Pubitemid 26028833)
    • (1996) Journal of Neuroscience , vol.16 , Issue.2 , pp. 744-751
    • Liu, C.1    Gillette, M.U.2
  • 37
    • 4944230923 scopus 로고    scopus 로고
    • Functional analysis of muscarinic acetylcholine receptors using knockout mice
    • DOI 10.1016/j.lfs.2004.05.034, PII S0024320504007453
    • Matsui M, Yamada S, Oki T, Manabe T, Taketo MM, Ehlert FJ (2004) Functional analysis of muscarinic acetylcholine receptors using knockout mice. Life Sci 75(25):2971-2981 (Pubitemid 39330580)
    • (2004) Life Sciences , vol.75 , Issue.25 , pp. 2971-2981
    • Matsui, M.1    Yamada, S.2    Oki, T.3    Manabe, T.4    Taketo, M.M.5    Ehlert, F.J.6
  • 38
    • 0000610790 scopus 로고    scopus 로고
    • Sleep disturbances in late life
    • Hersen M, Van Hasselt VB (eds Plenum, New York
    • Morin CM, Blais FC, Mimeault V (1998) Sleep disturbances in late life. In: Hersen M, Van Hasselt VB (eds) Handbook of clinical geropsychology Plenum, New York, pp 273-299
    • (1998) Handbook of Clinical Geropsychology , pp. 273-299
    • Morin, C.M.1    Blais, F.C.2    Mimeault, V.3
  • 39
    • 44649100161 scopus 로고    scopus 로고
    • Comparative effects of halothane, isoflurane, sevoflurane and desflurane on the electroencephalogram of the rat
    • DOI 10.1258/la.2007.06019e
    • Murrell JC, Waters D, Johnson CB (2008) Comparative effects ofhalothane, isoflurane, sevoflurane, and desflurane on the electroencephalogram of the rat Lab Anim 42:161-170 (Pubitemid 351786019)
    • (2008) Laboratory Animals , vol.42 , Issue.2 , pp. 161-170
    • Murrell, J.C.1    Waters, D.2    Johnson, C.B.3
  • 40
  • 41
    • 46149126361 scopus 로고    scopus 로고
    • Synthesis trafficking, and localization ofmuscarinic acetylcholine receptors
    • Nathanson NM (2008) Synthesis, trafficking, and localization ofmuscarinic acetylcholine receptors. Pharmacol Ther 119 (1):33-43
    • (2008) Pharmacol Ther , vol.119 , Issue.1 , pp. 33-43
    • Nathanson, N.M.1
  • 42
    • 0026563986 scopus 로고
    • The divergent actions of volatile anaesthetics on background neuronal activity and reactive capability in the central nervous system in cats
    • Ogawa T, Shingu K, Shibata M, Osawa M, Mori K (1992) The divergent actions of volatile anaesthetics on background neuronal activity and reactive capability in the central nervous system in cats. Can J Anaesth 39:862-872
    • (1992) Can J Anaesth , vol.39 , pp. 862-872
    • Ogawa, T.1    Shingu, K.2    Shibata, M.3    Osawa, M.4    Mori, K.5
  • 45
    • 77954953410 scopus 로고    scopus 로고
    • Hippocampal-cortical structural connectivity disruptions in schizophrenia: an integrated perspective from hippocampal shape, cortical thickness, and integrity of white matter bundles
    • in press
    • Qiu A, Tuan TA, Woon PS, Abdul-Rahman MF, Graham S, Sim K (2010) Hippocampal-cortical structural connectivity disruptions in schizophrenia: an integrated perspective from hippocampal shape, cortical thickness, and integrity of white matter bundles. Neuro Image (in press)
    • (2010) Neuro Image
    • Qiu, A.1    Tuan, T.A.2    Woon, P.S.3    Abdul-Rahman, M.F.4    Graham, S.5    Sim, K.6
  • 46
    • 3843075154 scopus 로고    scopus 로고
    • Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis
    • DOI 10.1667/RR3206
    • Raber J, Rola R, Le Fevour A, Morhardt D, Curley J, Mizumatsu S, Vanden Berg SR, Fike JR (2004) Radiation-induced cognitive impairments are associated with changes in indicators of hippocampalneurogenesis. Radiat Res 162:39-47 (Pubitemid 39044717)
    • (2004) Radiation Research , vol.162 , Issue.1 , pp. 39-47
    • Raber, J.1    Rola, R.2    LeFevour, A.3    Morhardt, D.4    Curley, J.5    Mizumatsu, S.6    VandenBerg, S.R.7    Fike, J.R.8
  • 47
    • 0031915220 scopus 로고    scopus 로고
    • Scopolamine-induced impairment of delayed recognition of abstract visual shapes
    • DOI 10.1159/000026486
    • Rosier A, Cornette L, Orban GA (1998) Scopolamine-induced impairment of delayed recognition of abstract visual shapes. Neuropsychobiology 37(2):98-103 (Pubitemid 28143025)
    • (1998) Neuropsychobiology , vol.37 , Issue.2 , pp. 98-103
    • Rosier, A.1    Cornette, L.2    Orban, G.A.3
  • 48
    • 0034724784 scopus 로고    scopus 로고
    • 2 muscarinic acetylcholine receptor protein in cholinergic and non-cholinergic terminals in rat hippocampus
    • DOI 10.1016/S0304-3940(00)01011-9, PII S0304394000010119
    • Rouse ST, Edmunds SM, Yi H, Gilmor ML, Levey AI (2000) Localization of m(2) muscarinic acetylcholine receptor protein in cholinergic and non-cholinergic terminals in rat hippocampus. Neurosci Lett 284(3):182-186 (Pubitemid 30204543)
    • (2000) Neuroscience Letters , vol.284 , Issue.3 , pp. 182-186
    • Rouse, S.T.1    Edmunds, S.M.2    Yi, H.3    Gilmor, M.L.4    Levey, A.I.5
  • 49
    • 0036133816 scopus 로고    scopus 로고
    • Age- and dementia-associated impairments in divided attention: Psychological constructs, animal models, and underlying neuronal mechanisms
    • DOI 10.1159/000048633
    • Sarter M, Turchi J (2002) Age-and dementia-associated impairments in divided attention: psychological con-structs, animal models, and underlying neuronal mecha-nisms. Dement Geriatr Cogn Disord 13(1):46-58 (Pubitemid 33153188)
    • (2002) Dementia and Geriatric Cognitive Disorders , vol.13 , Issue.1 , pp. 46-58
    • Sarter, M.1    Turchi, J.2
  • 50
    • 9044221365 scopus 로고    scopus 로고
    • Effects of scopolamine on learning and memory in monkeys
    • DOI 10.1007/BF02246275
    • Savage UC, Faust WB, Lambert P, Moerschbaecher JM (1996) Effects of scopolamine on learning and memory in monkeys. Psychopharmacology (Berl) 123(1):9-14 (Pubitemid 26040248)
    • (1996) Psychopharmacology , vol.123 , Issue.1 , pp. 9-14
    • Savage, U.C.1    Faust, W.B.2    Lambert, P.3    Moerschbaecher, J.M.4
  • 51
    • 0029128858 scopus 로고
    • Peripherally injected scopolamine differentially modulates acetylcholine release in vivo in the young and aged rats
    • Scali C, Vannucchi MG, Pepeu G, Casamenti F (1995) Peripherally injected scopolamine differentially modulates acetylcholine release in vivo in the young and aged rats. Neurosci Lett 197(3):171-174
    • (1995) Neurosci Lett , vol.197 , Issue.3 , pp. 171-174
    • Scali, C.1    Vannucchi, M.G.2    Pepeu, G.3    Casamenti, F.4
  • 53
    • 0032723131 scopus 로고    scopus 로고
    • Scopolamine alters rhesus monkey performance on a novel neuropsychological test battery
    • DOI 10.1016/S0926-6410(99)00021-X, PII S092664109900021X
    • Taffe MA, Weed MR, Gold LH (1999) Scopolamine alters rhesus monkey performance on a novel neuropsychological test battery. Brain Res Cogn Brain Res 8(3):203-212 (Pubitemid 29518307)
    • (1999) Cognitive Brain Research , vol.8 , Issue.3 , pp. 203-212
    • Taffe, M.A.1    Weed, M.R.2    Gold, L.H.3
  • 54
    • 33748529631 scopus 로고    scopus 로고
    • The neurobiology of cognition in schizophrenia
    • Tamminga CA (2006) The neurobiology of cognition in schizophrenia. J Clin Psychiatry 67(9):e1 1
    • (2006) J Clin Psychiatry , vol.67 , Issue.9
    • Tamminga, C.A.1
  • 55
    • 77952351441 scopus 로고    scopus 로고
    • G protein-coupled receptors, cholinergic dysfunction, and A beta toxicity in Alzheimer's disease
    • Thathiah A, De Strooper B (2009) G protein-coupled receptors, cholinergic dysfunction, and A beta toxicity in Alzheimer's disease. Sci Signal 2(93):re8
    • (2009) Sci Signal , vol.2 , Issue.93
    • Thathiah, A.1    De Strooper, B.2
  • 56
    • 0141763651 scopus 로고    scopus 로고
    • Cholinergic modulation of learning and memory in the human brain as detected with functional neuroimaging
    • DOI 10.1016/S1074-7427(03)00076-5
    • Thiel CM (2003) Cholinergic modulation of learning and memory in the human brain as detected with functional neuroimaging. Neurobiol Learn Mem 80:234-244 (Pubitemid 37159351)
    • (2003) Neurobiology of Learning and Memory , vol.80 , Issue.3 , pp. 234-244
    • Thiel, C.M.1
  • 57
    • 44649130626 scopus 로고    scopus 로고
    • Specific impairments in visuospatial working and short-term memory following low-dose scopolamine challenge in healthy older adults
    • Thomas E, Snyder PJ, Pietrzak RH, Jackson CE, Bednar M, Maruff P (2008) Specific impairments in visuospatial working and short-term memory following low-dose scopolamine challenge in healthy older adults. Neuro-psychologia 46(10):2476-2484
    • (2008) Neuro-psychologia , vol.46 , Issue.10 , pp. 2476-2484
    • Thomas, E.1    Snyder, P.J.2    Pietrzak, R.H.3    Jackson, C.E.4    Bednar, M.5    Maruff, P.6
  • 58
    • 15744375350 scopus 로고    scopus 로고
    • Estrogen modulates cognitive and cholinergic processes in surgically menopausal monkeys
    • DOI 10.1016/j.pnpbp.2004.12.016, Canine Model of Cognitive Aging: Further Developments and Practical Applications
    • Tinkler GP, Voytko ML (2005) Estrogen modulates cognitive and cholinergic processes in surgically menopausal monkeys. Prog Neuropsychopharmacol Biol Psychiatry 29(3):423-431 (Pubitemid 40417594)
    • (2005) Progress in Neuro-Psychopharmacology and Biological Psychiatry , vol.29 , Issue.3 , pp. 423-431
    • Tinkler, G.P.1    Voytko, M.L.2
  • 60
    • 79955713207 scopus 로고    scopus 로고
    • Agonist-induced resto-ration of hippocampal neurogenesis and cognitive im-provement in a model of cholinergic denervation
    • in press)
    • Van Kampen JM, Eckman CB (2009) Agonist-induced resto-ration of hippocampal neurogenesis and cognitive im-provement in a model of cholinergic denervation. Neuropharmacology (in press)
    • (2009) Neuropharmacology (
    • Van Kampen, J.M.1    Eckman, C.B.2
  • 63
    • 0025482502 scopus 로고
    • Laminar organization and age-related loss of cholinergic receptors in temporal neocortex of rhesus monkey
    • Wagster MV, Whitehouse PJ, Walker LC, Kellar KJ, Price DL (1990) Laminar organization and age-related loss of cholinergic receptors in temporal neocortex of rhesus monkey. J Neurosci 10(9):2879-2885
    • (1990) J Neurosci , vol.10 , Issue.9 , pp. 2879-2885
    • Wagster, M.V.1    Whitehouse, P.J.2    Walker, L.C.3    Kellar, K.J.4    Price, D.L.5
  • 64
    • 0018822768 scopus 로고
    • Muscarinic cholinergic receptors: Autoradiographic localization of high and low affinity agonist binding sites
    • DOI 10.1016/0006-8993(80)91089-6
    • Wamsley JK, Zarbin MA, Birdsall NJM, Kuhar MJ (1980) Muscarinic cholinergic receptors: autoradiographic locali-zation ofhigh and low affinity agonist binding sites. Brain Res 200:1-12 (Pubitemid 10061587)
    • (1980) Brain Research , vol.200 , Issue.1 , pp. 1-12
    • Wamsley, J.K.1    Zarbin, M.A.2    Birdsall, N.J.M.3    Kuhar, M.J.4
  • 65
    • 33646859532 scopus 로고    scopus 로고
    • Age and cholinergic effects on hemodynamics and functional coherence of human hippocampus
    • DOI 10.1016/j.neurobiolaging.2005.08.011, PII S0197458005002186
    • Wink AM, Bernard F, Salvador R, Bullmore E, Suckling J (2006) Age and cholinergic effects on hemodynamics and functional coherence of human hippocampus. Neurobiol Aging 27:1395-1404 (Pubitemid 44313873)
    • (2006) Neurobiology of Aging , vol.27 , Issue.10 , pp. 1395-1404
    • Wink, A.M.1    Bernard, F.2    Salvador, R.3    Bullmore, E.4    Suckling, J.5
  • 66
    • 33744767131 scopus 로고    scopus 로고
    • The role of f MRI in drug discovery
    • Wise RG, Tracey I (2006) The role of f MRI in drug discovery. J Magn Reson Imaging 23(6):862-876
    • (2006) J Magn Reson Imaging , vol.23 , Issue.6 , pp. 862-876
    • Wise, R.G.1    Tracey, I.2
  • 67
    • 50349102902 scopus 로고    scopus 로고
    • Functional convergence of dopaminergic and cholinergic input is critical for hippocampus-dependent working memory
    • Wisman LA, Sahin G, Maingay M, Leanza G, Kirik D (2008) Functional convergence of dopaminergic and cholinergic input is critical for hippocampus-dependent working memory. J Neurosci 28(31):7797-7807
    • (2008) J Neurosci , vol.28 , Issue.31 , pp. 7797-7807
    • Wisman, L.A.1    Sahin, G.2    Maingay, M.3    Leanza, G.4    Kirik, D.5
  • 68
    • 33749264922 scopus 로고    scopus 로고
    • Assessing nigrostriatal dysfunctions by pharmacological MRI in parkinsonian rhesus macaques
    • DOI 10.1016/j.neuroimage.2006.07.004, PII S1053811906007464
    • Zhang Z, Andersen AH, Ai Y, Loveland A, Hardy PA, Gerhardt GA, Gash DM (2006) Assessing nigrostriatal dysfunctions by pharmacological MRI in Parkinsonian rhesus maca-ques. Neuroimage 33(2):636-643 (Pubitemid 44485558)
    • (2006) NeuroImage , vol.33 , Issue.2 , pp. 636-643
    • Zhang, Z.1    Andersen, A.H.2    Ai, Y.3    Loveland, A.4    Hardy, P.A.5    Gerhardt, G.A.6    Gash, D.M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.