Morgana and Melusin: Two fairies chaperoning signal transduction

Cell Cycle

Volumn 10, Issue 21, 2011, Pages 3678-3683

  Ferretti, Roberta ^a,c   Sbroggiò, Mauro ^a   Di Savino, Augusta ^a   Fusella, Federica ^a   Bertero, Alessandro ^a   Michowski, Wojciech ^b   Tarone, Guido ^a   Brancaccio, Mara ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Centrosome duplication; ERK1 2; Genomic stability; Heart hypertrophy; Melusin; Morgana; ROCK

Indexed keywords

CHAPERONE; CYCLIN DEPENDENT KINASE 2; CYCLIN E; CYSTEINE; HEAT SHOCK PROTEIN 90; HISTIDINE; MELUSIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MORGANA; NUCLEOPHOSMIN; POLO LIKE KINASE; PROTEIN P58; RHO KINASE; UNCLASSIFIED DRUG;

CELL CYCLE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CENTROSOME; ENZYME ACTIVATION; GENE FUNCTION; GENE MUTATION; GENOMIC INSTABILITY; HUMAN; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; STRESS;

EID: 80655123614     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.21.18202     Document Type: Review

References (41)

1. Hartl FU, Bracher A, Hayer-Hartl M. Molecular chaperones in protein folding and proteostasis. Nature 2011; 475:324-32; PMID:21776078; DOI:10.1038/nature10317.
2. Pearl LH, Prodromou C, Workman P. The Hsp90 molecular chaperone: an open and shut case for treatment. Biochem J 2008; 410:439-53; PMID:18290764; DOI:10.1042/BJ20071640.
3. Pearl LH, Prodromou C. Structure and mechanism of the Hsp90 molecular chaperone machinery. Annu Rev Biochem 2006; 75:271-94; PMID:16756493; DOI:10.1146/annurev.biochem.75.103004.142738.
4. Brown MA, Zhu L, Schmidt C, Tucker PW. Hsp90 - from signal transduction to cell transformation. Biochem Biophys Res Commun 2007; 363:241-6; PMID:17826744; DOI:10.1016/j.bbrc.2007.08.054.
5. Gano JJ, Simon JA. A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. Mol Cell Proteomics 2010; 9:255-70; PMID:19875381; DOI:10.1074/mcp. M900261-MCP200.
6. Shirasu K, Lahaye T, Tan MW, Zhou F, Azevedo C, Schulze-Lefert P. A novel class of eukaryotic zinc-binding proteins is required for disease resistance signaling in barley and development in C. elegans. Cell 1999; 99:355-66; PMID:10571178; DOI:10.1016/S0092-8674(00)81522-6.
7. Muskett PR, Kahn K, Austin MJ, Moisan LJ, Sadanandom A, Shirasu K, et al. Arabidopsis RAR1 exerts rate-limiting control of R gene-mediated defenses against multiple pathogens. Plant Cell 2002; 14:979-92; PMID:12034891; DOI:10.1105/tpc.001040.
8. Tornero P, Merritt P, Sadanandom A, Shirasu K, Innes RW, Dangl JL. RAR1 and NDR1 contribute quantitatively to disease resistance in Arabidopsis, and their relative contributions are dependent on the R gene assayed. Plant Cell 2002; 14:1005-15; PMID:12034893; DOI:10.1105/tpc.001032.
9. Azevedo C, Sadanandom A, Kitagawa K, Freialdenhoven A, Shirasu K, Schulze-Lefert P. The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance. Science 2002; 295:2073-6; PMID:11847307; DOI:10.1126/science. 1067554.
10. Takahashi A, Casais C, Ichimura K, Shirasu K. HSP90 interacts with RAR1 and SGT1 and is essential for RPS2-mediated disease resistance in Arabidopsis. Proc Natl Acad Sci USA 2003; 100:11777-82; PMID:14504384; DOI:10.1073/pnas. 2033934100.
11. Kitagawa K, Skowyra D, Elledge SJ, Harper JW, Hieter P. SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. Mol Cell 1999; 4:21-33; PMID:10445024; DOI:10.1016/S1097-2765(00)80184-7.
12. Steensgaard P, Garre M, Muradore I, Transidico P, Nigg EA, Kitagawa K, et al. Sgt1 is required for human kinetochore assembly. EMBO Rep 2004; 5:626-31; PMID:15133482; DOI:10.1038/sj.embor.7400154.
13. Martins T, Maia AF, Steffensen S, Sunkel CE. Sgt1, a co-chaperone of Hsp90 stabilizes Polo and is required for centrosome organization. EMBO J 2009; 28:234-47; PMID:19131964; DOI:10.1038/emboj.2008.283.
14. Zhang M, Kadota Y, Prodromou C, Shirasu K, Pearl LH. Structural basis for assembly of Hsp90-Sgt1-CHORD protein complexes: implications for chaperoning of NLR innate immunity receptors. Mol Cell 2010; 39:269-81; PMID:20670895; DOI:10.1016/j. molcel.2010.05.010.
15. Brancaccio M, Menini N, Bongioanni D, Ferretti R, De Acetis M, Silengo L, et al. Chp-1 and melusin, two CHORD containing proteins in vertebrates. FEBS Lett 2003; 551:47-52; PMID:12965203; DOI:10.1016/S0014-5793(03)00892-5.
16. Sbroggiò M, Ferretti R, Percivalle E, Gutkowska M, Zylicz A, Michowski W, et al. The mammalian CHORD-containing protein melusin is a stress response protein interacting with Hsp90 and Sgt1. FEBS Lett 2008; 582:1788-94; PMID:18474241; DOI:10.1016/j.febslet.2008.04.058.
17. Michowski W, Ferretti R, Wisniewska MB, Ambrozkiewicz M, Beresewicz M, Fusella F, et al. Morgana/CHP-1 is a novel chaperone able to protect cells from stress. Biochim Biophys Acta 2010; 1803:1043-9; PMID:20493909; DOI:10.1016/j. bbamcr.2010.05.005.
18. Wu J, Luo S, Jiang H, Li H. Mammalian CHORD-containing protein 1 is a novel heat shock protein 90-interacting protein. FEBS Lett 2005; 579:421-6; PMID:15642353; DOI:10.1016/j.febslet. 2004.12.005.
19. Hahn JS. Regulation of Nod1 by Hsp90 chaperone complex. FEBS Lett 2005; 579:4513- 9; PMID:16083881; DOI:10.1016/j.febslet. 2005.07.024.
20. Ferretti R, Palumbo V, Di Savino A, Velasco S, Sbroggiò M, Sportoletti P, et al. Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis. Dev Cell 2010; 18:486-95; PMID:20230755; DOI:10.1016/j.devcel. 2009.12.020.
21. Bettencourt-Dias M, Glover DM. Centrosome biogenesis and function: centrosomics brings new understanding. Nat Rev Mol Cell Biol 2007; 8:451-63; PMID:17505520; DOI:10.1038/nrm2180.
22. Bornens M. Centrosome composition and microtubule anchoring mechanisms. Curr Opin Cell Biol 2002; 14:25-34; PMID:11792541; DOI:10.1016/S0955-0674(01) 00290-3.
23. Fukasawa K. Oncogenes and tumour suppressors take on centrosomes. Nat Rev Cancer 2007; 7:911-24; PMID:18004399; DOI:10.1038/nrc2249.
24. Chevrier V, Piel M, Collomb N, Saoudi Y, Frank R, Paintrand M, et al. The Rho-associated protein kinase p160ROCK is required for centrosome positioning. J Cell Biol 2002; 157:807-17; PMID:12034773; DOI:10.1083/jcb.200203034.
25. ROCK bypasses cell cycle arrest after Aurora-A/STK15 depletion. Proc Natl Acad Sci USA 2004; 101:8975-80; PMID:15178765; DOI:10.1073/pnas.0308484101.
26. Lange BM, Bachi A, Wilm M, Gonzalez C. Hsp90 is a core centrosomal component and is required at different stages of the centrosome cycle in Drosophila and vertebrates. EMBO J 2000; 19:1252-62; PMID:10716925; DOI:10.1093/emboj/19.6.1252.
27. Ma Z, Kanai M, Kawamura K, Kaibuchi K, Ye K, Fukasawa K. Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication. Mol Cell Biol 2006; 26:9016-34; PMID:17015463; DOI:10.1128/MCB. 01383-06.
28. Hanashiro K, Brancaccio M, Fukasawa K. Activated ROCK II by-passes the requirement of the CDK2 activity for centrosome duplication and amplification. Oncogene 2011; 30:2188-97; PMID:21242972; DOI:10.1038/onc.2010.607.
29. Nigg EA. Centrosome aberrations: cause or consequence of cancer progression? Nat Rev Cancer 2002; 2:815-25; PMID:12415252; DOI:10.1038/nrc924.
30. Doxsey S. Duplicating dangerously: linking centrosome duplication and aneuploidy. Mol Cell 2002; 10:439-40; PMID:12408813; DOI:10.1016/S1097-2765(02) 00654-8.
31. Sluder G, Nordberg JJ. The good, the bad and the ugly: the practical consequences of centrosome amplification. Curr Opin Cell Biol 2004; 16:49-54; PMID:15037304; DOI:10.1016/j.ceb.2003.11.006.
32. Basto R, Brunk K, Vinadogrova T, Peel N, Franz A, Khodjakov A, et al. Centrosome amplification can initiate tumorigenesis in flies. Cell 2008; 133:1032-42; PMID:18555779; DOI:10.1016/j. cell.2008.05.039.
33. Sadanandom A, Findlay K, Doonan JH, Schulze-Lefert P, Shirasu K. CHPA, a cysteine- and histidinerich-domain-containing protein, contributes to maintenance of the diploid state in Aspergillus nidulans. Eukaryot Cell 2004; 3:984-91; PMID:15302831; DOI:10.1128/EC.3.4.984-91.2004.
34. Brancaccio M, Guazzone S, Menini N, Sibona E, Hirsch E, De Andrea M, et al. Melusin is a new muscle-specific interactor for beta(1) integrin cytoplasmic domain. J Biol Chem 1999; 274:29282-8; PMID:10506186; DOI:10.1074/jbc.274.41. 29282.
35. Brancaccio M, Fratta L, Notte A, Hirsch E, Poulet R, Guazzone S, et al. Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload. Nat Med 2003; 9:68-75; PMID:12496958; DOI:10.1038/nm805.
36. De Acetis M, Notte A, Accornero F, Selvetella G, Brancaccio M, Vecchione C, et al. Cardiac over-expression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload. Circ Res 2005; 96:1087-94; PMID:15860758; DOI:10.1161/01.RES.0000168028.36081.e0.
37. Sbroggiò M, Bertero A, Velasco S, Fusella F, De Blasio E, Bahou WF, et al. ERK1/2 activation in heart is controlled by Melusin, Focal adhesion kinase and the scaffold protein IQGAP1. J Cell Sci 2011; 124:3515-24.
38. Ren JG, Li Z, Sacks DB. IQGAP1 modulates activation of B-Raf. Proc Natl Acad Sci USA 2007; 104:10465-9; PMID:17563371; DOI:10.1073/pnas.0611308104.
39. Roy M, Li Z, Sacks DB. IQGAP1 is a scaffold for mitogen-activated protein kinase signaling. Mol Cell Biol 2005; 25:7940-52; PMID:16135787; DOI:10.1128/MCB.25.18.7940-52.2005.
40. Sbroggiò M, Carnevale D, Bertero A, Cifelli G, De Blasio E, Mascio G, et al. IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload. Cardiovasc Res 2011; 91:456-64; PMID:21493702; DOI:10.1093/cvr/cvr103.
41. Waardenberg AJ, Bernardo BC, Ng DC, Shepherd PR, Cemerlang N, Sbroggiò M, et al. Phosphoinositide-3-Kinase (PI3K(p110{alpha})) Directly Regulates Key Components of the Z-disc and Cardiac Structure. J Biol Chem 2011; 286:30837-46; PMID:21757757; DOI:10.1074/jbc.M111.271684.