β 2-adrenergics in hypoxia desensitize receptors but blunt inhibition of reabsorption in rat lungs

American Journal of Respiratory Cell and Molecular Biology

Volumn 45, Issue 5, 2011, Pages 1059-1068

  Baloglu, Emel ^a   Reingruber, Thomas ^a   Bar̈tsch, Peter ^a   Mairbaürl, Heimo ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

cAMP; G proteins; GRK2; Hypoxia; Pulmonary edema

Indexed keywords

ADENOSINE PHOSPHATE; BETA 2 ADRENERGIC RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 2; OXYGEN; SODIUM CHANNEL; TERBUTALINE;

ABSORPTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; DRUG MECHANISM; HYPOXIA; LUNG; LUNG ALVEOLUS EPITHELIUM; MALE; NONHUMAN; RAT;

ABSORPTION; ADRENERGIC BETA-2 RECEPTOR AGONISTS; AMILORIDE; ANIMALS; ANOXIA; BIOLOGICAL TRANSPORT; CELLS, CULTURED; CYCLIC AMP; EPITHELIAL SODIUM CHANNEL; G-PROTEIN-COUPLED RECEPTOR KINASE 2; LUNG; MALE; PULMONARY ALVEOLI; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA-2; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION; SODIUM CHANNEL BLOCKERS; TERBUTALINE;

RATTUS;

EID: 80555156675     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2010-0273OC     Document Type: Article

References (51)

1. Berthiaume Y, Folkesson HG, Matthay MA. Lung edema clearance: 20 years of progress. Invited review: alveolar edema fluid clearance in the injured lung. J Appl Physiol 2002;93:2207-2213. (Pubitemid 35379349)
2. McAuley DF, Brown LM, Matthay MA. Assessing the quantity of pulmonary edema in critically ill children. Crit Care 2010;14:189.
3. Dada LA, Sznajder JI. Hypoxic inhibition of alveolar fluid reabsorption. Adv Exp Med Biol 2007;618:159-168.
4. Planes C, Blot-Chabaud M, Matthay MA, Couette S, Uchida T, Clerici C. Hypoxia and beta 2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells. J Biol Chem 2002;277:47318-47324. (Pubitemid 36159245)
5. Mairbäurl H, Mayer K, Kim KJ, Borok Z, Bärtsch P, Crandall ED. Hypoxia decreases active Na transport across primary rat alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol 2002;282:L659-L665. (Pubitemid 34665580)
6. +channels in lung alveolar Type II epithelial cells. Proc Am Thorac Soc 2004;1:10-16.
7. Goodman BE, Anderson JL, Clemens JW. Evidence for regulation of sodium transport from airspace to vascular space by cAMP. Am J Physiol 1989;257:L86-L93.
8. Goodman BE, Brown SE, Crandall ED. Regulation of transport across pulmonary alveolar epithelial cell monolayers. J Appl Physiol 1984;57:703-710. (Pubitemid 14048787)
9. Loeh B, Baloglu E, Ke A, Bä rtsch P, Mairbäurl H. Beta2-adrenergic stimulation blunts inhibition of epithelial ion transport by hypoxia of rat alveolar epithelial cells. Cell Physiol Biochem 2010;25:123-134.
10. +-ATPase by cAMP and dexamethasone in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 2001;281:L217-L230.
11. Dumasius V, Sznajder JI, Azzam ZS, Boja J, Mutlu GM, Maron MB, Factor P. Beta(2)-adrenergic receptor overexpression increases alveolar fluid clearance and responsiveness to endogenous catecholamines in rats. Circ Res 2001;89:907-914. (Pubitemid 34627896)
12. Perkins GD, McAuley DF, Thickett DR, Gao F. The Beta-Agonist Lung Injury Trial (BALTI): a randomized placebo-controlled clinical trial. Am J Respir Crit Care Med 2006;173:281-287. (Pubitemid 43209082)
13. Sartori C, Allemann Y, Duplain H, Lepori M, Egli M, Lipp E, Hutter D, Turini P, Hugli O, Cook S, et al. Salmeterol for the prevention of high-altitude pulmonary edema. N Engl J Med 2002;346:1631-1636. (Pubitemid 34755671)
14. Atabai K, Ware LB, Snider ME, Koch P, Daniel B, Nuckton TJ, Matthay MA. Aerosolized beta(2)-adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute respiratory failure. Intensive Care Med 2002;28:705-711. (Pubitemid 34639482)
15. Mutlu GM, Factor P. Alveolar epithelial beta2-adrenergic receptors. Am J Respir Cell Mol Biol 2008;38:127-134.
16. Baloǧlu E, Ke A, Abu-Taha IH, Bärtsch P, Mairbäurl H. In vitro hypoxia impairs beta2-adrenergic receptor signaling in primary rat alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 2009;296:L500-L509.
17. Vivona ML, Matthay M, Chabaud MB, Friedlander G, Clerici C. Hypoxia reduces alveolar epithelial sodium and fluid transport in rats: reversal by beta-adrenergic agonist treatment. Am J Respir Cell Mol Biol 2001;25:554-561. (Pubitemid 33087105)
18. Litvan J, Briva A, Wilson MS, Budinger GR, Sznajder JI, Ridge KM. Beta-adrenergic receptor stimulation and adenoviral overexpression of superoxide dismutase prevent the hypoxia-mediated decrease in Na/K-ATPase and alveolar fluid reabsorption. J Biol Chem 2006;281:19892-19898. (Pubitemid 44065762)
19. Birnkrant DJ, Mader SL, Van Lunteren E, Davis PB. Chronic hypoxia increases beta-adrenergic receptor density in the lungs of young and old rats. Mech Ageing Dev 1991;60:135-142.
20. Ferguson SS. Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol Rev 2001;53:1-24. (Pubitemid 32173106)
21. Strasser RH, Stiles GL, Lefkowitz RJ. Translocation and uncoupling of the beta-adrenergic receptor in rat lung after catecholamine promoted desensitization in vivo. Endocrinology 1984;115:1392-1400. (Pubitemid 14000301)
22. Nerme V, Abrahamsson T, Vauquelin G. Chronic isoproterenol administration causes altered beta adrenoceptor-Gs-coupling in guinea pig lung. J Pharmacol Exp Ther 1990;252:1341-1346. (Pubitemid 20127449)
23. Sartori C, Fang X, McGraw DW, Koch P, Snider ME, Folkesson HG, Matthay MA. Selected contribution: long-term effects of beta(2)- adrenergic receptor stimulation on alveolar fluid clearance in mice. J Appl Physiol 2002;93:1875-1880. (Pubitemid 36083004)
24. Maron MB, Folkesson HG, Stader SM, Walro JM. PKA delivery to the distal lung air spaces increases alveolar liquid clearance after isoproterenol-induced alveolar epithelial PKA desensitization. Am J Physiol Lung Cell Mol Physiol 2005;289:L349-L354. (Pubitemid 41008919)
25. Morgan EE, Stader SM, Hodnichak CM, Mavrich KE, Folkesson HG, Maron MB. Postreceptor defects in alveolar epithelial beta-adrenergic signaling after prolonged isoproterenol infusion. Am J Physiol Lung Cell Mol Physiol 2003;285:L578-L583. (Pubitemid 37022858)
26. Morgan EE, Hodnichak CM, Stader SM, Maender KC, Boja JW, Folkesson HG, Maron MB. Prolonged isoproterenol infusion impairs the ability of beta(2)-agonists to increase alveolar liquid clearance. Am J Physiol Lung Cell Mol Physiol 2002;282:L666-L674.
27. The National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Randomized, placebo-controlled clinical trial of an aerosolized β2-agonist for treatment of acute lung injury. Am J Respir Crit Care Med 2011;184:561-568.
28. Dobbs LG, Gonzalez R, Williams MC. An improved method for isolating Type II cells in high yield and purity. Am Rev Respir Dis 1986;134:141-145. (Pubitemid 16057475)
29. Wenzel-Seifert K, Seifert R. Molecular analysis of beta(2)-adrenoceptor coupling to G(s)-, G(i)-, and G(q)-proteins. Mol Pharmacol 2000;58:954-966.
30. Benovic JL, DeBlasi A, Stone WC, Caron MG, Lefkowitz RJ. Betaadrenergic receptor kinase: primary structure delineates a multigene family. Science 1989;246:235-240. (Pubitemid 19264636)
31. Maggiorini M, Melot C, Pierre S, Pfeiffer F, Greve I, Sartori C, Lepori M, Hauser M, Scherrer U, Naeije R. High-altitude pulmonary edema is initially caused by an increase in capillary pressure. Circulation 2001;103:2078-2083. (Pubitemid 32373011)
32. Matthay MA, Clerici C, Saumon G. Invited review: active fluid clearance from the distal air spaces of the lung. J Appl Physiol 2002;93:1533-1541.
33. Winter RJ, Dickinson KE, Rudd RM, Sever PS. Tissue specific modulation of beta-adrenoceptor number in rats with chronic hypoxia with an attenuated response to down-regulation by salbutamol. Clin Sci (Lond) 1986;70:159-165. (Pubitemid 16189783)
34. Richalet JP, Kacimi R, Antezana AM. The control of cardiac chronotropic function in hypobaric hypoxia. Int J Sports Med 1992;13:S22-S24.
35. Hornbein TF. Adrenal cortical response to chronic hypoxia. J Appl Physiol 1962;17:246-248.
36. Sutton JR, Viol GW, Gray GW, McFadden M, Keane PM. Renin, aldosterone, electrolyte, and cortisol responses to hypoxic decompression. J Appl Physiol 1977;43:421-424. (Pubitemid 8190214)
37. Cheng JB, Goldfien A, Ballard PL, Roberts JM. Glucocorticoids increase pulmonary beta-adrenergic receptors in fetal rabbit. Endocrinology 1980;107:1646-1648. (Pubitemid 10029766)
38. Lewis V, Goldfien AC, Day JP, Roberts JM. Rabbit alveolar betaadrenergic receptors increase with gestational age. Am J Obstet Gynecol 1990;162:269-272. (Pubitemid 20055464)
39. Fraser CM, Venter JC. The synthesis of beta-adrenergic receptors in cultured human lung cells: induction by glucocorticoids. Biochem Biophys Res Commun 1980;94:390-397.
40. Krupnick JG, Benovic JL. The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Annu Rev Pharmacol Toxicol 1998;38:289-319. (Pubitemid 28231497)
41. Liebler JM, Borok Z, Li X, Zhou B, Sandoval AJ, Kim KJ, Crandall ED. Alveolar epithelial Type I cells express beta2-adrenergic receptors and G-protein receptor kinase 2. J Histochem Cytochem 2004;52:759-767. (Pubitemid 38703130)
42. Benovic JL, Strasser RH, Caron MG, Lefkowitz RJ. Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc Natl Acad Sci USA 1986;83:2797-2801. (Pubitemid 16041750)
43. Krasel C, Bunemann M, Lorenz K, Lohse MJ. Beta-arrestin binding to the beta2-adrenergic receptor requires both receptor phosphorylation and receptor activation. J Biol Chem 2005;280:9528-9535. (Pubitemid 40409648)
44. + channels. Am J Physiol Lung Cell Mol Physiol 2007;293:L1332-L1338.
45. Garat C, Carter EP, Matthay MA. New in situ mouse model to quantify alveolar epithelial fluid clearance. J Appl Physiol 1998;84:1763-1767. (Pubitemid 28225919)
46. Sakuma T, Tuchihara C, Ishigaki M, Osanai K, Nambu Y, Toga H, Takahashi K, Ohya N, Inoue M, Matthay MA. Beta1-adrenoceptor stimulation by high-dose terbutaline downregulates terbutaline-stimulated alveolar fluid clearance in ex vivo rat lung. Exp Lung Res 2001;27:453-468. (Pubitemid 32641830)
47. Sakuma T, Zhao Y, Sugita M, Sagawa M, Hida M, Toga H. A prostacyclin analogue, OP-41483alpha-CD, restores the ability of a beta2- adrenergic agonist to stimulate alveolar fluid clearance in rats. Surg Today 2004;34:429-436. (Pubitemid 38626491)
48. Smedira N, Gates L, Hastings R, Jayr C, Sakuma T, Pittet JF, Matthay MA. Alveolar and lung liquid clearance in anesthetized rabbits. J Appl Physiol 1991;70:1827-1835.
49. Davis IC, Xu A, Gao Z, Hickman-Davis JM, Factor P, Sullender WM, Matalon S. Respiratory syncytial virus induces insensitivity to beta-adrenergic agonists in mouse lung epithelium in vivo. Am J Physiol Lung Cell Mol Physiol 2007;293:L281-L289. (Pubitemid 47205007)
50. +-ATPase expression in alveolar Type II cells. Am J Physiol 1998;275:L414-L422.
51. Cohen TS, Gray LG, Margulies SS. Cultured alveolar epithelial cells from septic rats mimic in vivo septic lung. PLoS ONE 2010;5:e11322.