In vitro assessment of the antiviral potential of trans-cinnamic acid, quercetin and morin against equid herpesvirus 1

Research in Veterinary Science

Volumn 91, Issue 3, 2011, Pages

  Gravina, H D ^a   Tafuri, N F ^a   Silva Junior A ^a   Fietto, J L R ^a   Oliveira, T T ^a   Diaz, M A N ^a   Almeida, M R ^a  

^a FEDERAL UNIVERSITY OF VIÇOSA   (Brazil)

Author keywords

Antiviral activity; EHV 1; Flavonoids

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CINNAMIC ACID; DIMETHYL SULFOXIDE; MORIN; QUERCETIN;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CELL ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; EQUINE HERPES VIRUS; IN VITRO STUDY; NONHUMAN; VIRUS INHIBITION; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; CINNAMATES; FLAVONOIDS; HERPESVIRUS 1, EQUID; QUERCETIN; VERO CELLS;

EQUID HERPESVIRUS 1;

EID: 80555151055     PISSN: 00345288     EISSN: 15322661     Source Type: Journal    
DOI: 10.1016/j.rvsc.2010.11.010     Document Type: Article

References (35)

1. Andres A., Donovan S.M., Kuhlenschmidt M.S. Soy isoflavones and virus infections. Journal of Nutritional Biochemistry 2009, 20:563-569.
2. Bhattacharya R.K., Firozi P.F. Effect of plant flavonoids on microsome catalyzed reactions of aflatoxin B1 leading to activation and DNA adduct formation. Cancer Letters 1988, 39:85-91.
3. Choi H.J., Kim J.H., Lee C.H., Ahn Y.J., Song J.H., Baek S.H., Kwon D.H. Antiviral activity of quercetin 7-rhamnoside against porcine epidemic. Antiviral Research 2009, 81:77-81.
4. Cos P., Vlietinck A.J., Berghe D.V., Maes L. Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'. Journal of Ethnopharmacology 2006, 106:290-302.
5. Davis J.M., Murphy E.A., McClellan J.L., Carmichaeland M.D., Gangemi J.D. Quercetin reduces susceptibility to influenza infection following stressful exercise. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 2008, 295:505-509.
6. Douglas J.L., Panis M.L., Ho E., Lin K.Y., Krawczyk S.H., Grant D.M., Cai R., Swaminathan S., Cihlar T. Inhibition of respiratory syncytial virus fusion by the small molecule VP-14637 via specific interactions with F protein. Journal of Virology 2003, 77:5054-5064.
7. Felipe A.M.M., Rincão V.P., Benati F.J., Linhares R.E., Galina K.J., de Toledo C.E., Lopes G.C., de Mello J.C., Nozawa C. Antiviral effect of Guazuma ulmifolia and Stryhnodendron adstringens on poliovirus and bovine herpesvirus. Biological & Pharmaceutical Bulletin 2006, 29:1092-1095.
8. Field H.J., Biswas S., Mohammad I.T. Herpesvirus latency and therapy - from a veterinary perspective. Antiviral Research 2006, 71:127-133.
9. Formica J.V., Regelson W. Review of biology of quercetin and related bioflavonoids. Food and Chemical Toxicology 1995, 33:1061-1080.
10. Galvez J., Coelho G., Crespo M.E., Cruz T., Rodriguez-Cabezas M.E., Concha A., Gonzalez M., Zarzuelo A. Intestinal anti-inflammatory activity of morin on chronic experimental colitis in the rat. Alimentary Pharmacology & Therapeutics 2001, 15:2027-2039.
11. Garré B., van der Meulen K., Nugent J., Neyts J., Croubels S., De Backer P., Nauwynck H. In vitro susceptibility of six isolates of equine herpesvirus 1 to acyclovir, ganciclovir, cidofovir, adefovir, PMEDAP and foscarnet. Veterinary Microbiology 2007, 122:43-51.
12. Haslam E. Natural polyphenols (vegetable tannins) as drugs: possible modes of action. Journal of Natural Products 1996, 59:205-215.
13. Hudson J.B. Antiviral Compounds from Plants 1990, CRC Press Inc., Boca Raton, Florida, pp. 119-131.
14. Justino G.C., Rodrigues M., Florêncio M.R., Mira L. Structure and antioxidant activity of brominated flavonols and flavanones. Journal of Mass Spectrometry 2009, 44:1459-1468.
15. Kim J.W., Lee J.H., Hwang B.Y., Mun S.H., Ko N.Y., Kim do K., Kim B., Kim H.S., Kim Y.M., Choi W.S. Morin inhibits Fyn kinase in mast cells and IgE-mediated type I hypersensitivity response in vivo. Biochemical Pharmacology 2009, 77:1506-1512.
16. Kitagawa S., Sakamoto H., Tano H. Inhibitory effects of flavonoids on free radical-induced hemolysis and their oxidative effects on hemoglobin. Chemical & Pharmaceutical Bulletin 2004, 52:999-1001.
17. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods 1983, 65:55-63.
18. Mucsi I., Pragai B.M. Inhibition of virus multiplication and alteration of cyclic AMP level in cell cultures by flavonoids. Experientia 1985, 41:930-931.
19. Muller V., Chávez J.H., Reginatto F.H., Zucolotto S.M., Niero R., Navarro D., Yunes R.A., Schenkel E.P., Barardi C.R.M., Zanetti C.R., Simões C.M.O. Evaluation of antiviral activity of South American plant extracts against herpes simplex virus type 1 and rabies virus. Phytotherapy Research 2007, 21:970-974.
20. Neves F.M., Kawano C.Y., Said S. Effect of benzene compounds from plants on the growth and hyphal morphology in Neurospora crassa. Brazilian Journal of Microbiology 2005, 36:190-195.
21. Ostlund E.N. The equine herpesviruses. The Veterinary Clinics of North America: Equine Practice 1993, 9:283-294.
22. Ozcelik B., Aslan M., Orhan I., Karaoglu T. Antibacterial, antifungal, and antiviral activities of the lipophilic extracts of Pistacia vera. Microbiological Research 2005, 160:159-164.
23. Ozcelik B., Gurbuz I., Karaoglu T., Yesilada E. Antiviral and antimicrobial activities of three sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis. Microbiological Research 2009, 164:545-552.
24. Qian Y., Zhang H.J., Zhang H., Xu C., Zhao J., Zhu H.L. Synthesis, molecular modeling, and biological evaluation of cinnamic acid metronidazole ester derivatives as novel anticancer agents. Bioorganic & Medicinal Chemistry 2010, 18:4991-4996.
25. Patel J.R., Heldens J. Equine herpesviruses 1 (EHV-1) and 4 (EHV-4) - epidemiology, disease and immunoprophylaxis: a brief review. The Veterinary Journal 2005, 170:14-23.
26. Rastogi N., Goh K.S., Lionel Horgen L., Barrow W.W. Synergistic activities of antituberculous drugs with cerulenin and trans-cinnamic acid against Mycobacterium tuberculosis. FEMS Immunology and Medical Microbiology 1998, 21:149-157.
27. Reed L., Muench H. A simple method of estimating fifty percent endpoints. American Journal of Tropical Medicine and Hygiene 1938, 18:493-494.
28. Reed S.M., Toribio R.E. Equine herpesvirus 1 and 4. Veterinary Clinics of North America: Equine Practice 2004, 20:631-642.
29. Rees C.R., Costin J.M., Fink R.C., McMichael M., Fontaine K.A., Isern S., Michael S.F. In vitro inhibition of dengue virus entry by p-sulfoxy-cinnamic acid and structurally related combinatorial chemistries. Antiviral Research 2008, 80:135-142.
30. Said S., Neves F.M., Griffths A.J.F. Cinnamic acid inhibits the growth of the fungus Neurospora crassa, but is eliminated as acetophenone. International Biodeterioration & Biodegradation 2004, 54:1-6.
31. Schnitzler P., Nolkemper S., Stintzing F.C., Reichling J. Comparative in vitro study on the anti-herpetic effect of phytochemically characterized aqueous and ethanolic extracts of Salvia officinalis grown at two different locations. Phytomedicine 2008, 15:62-70.
32. Selway A. Plant flavonoids in biology and medicine. Biochemical, Pharmacological and Structure-Activity Relationships 1986, 213:521-536.
33. Serkedjieva J., Ivancheva S. Antiherpes virus of extracts from the medicinal plant Geranium sanguineum L. Journal of Ethnopharmacology 1999, 64:59-68.
34. Si D., Wang Y., Zhou Y.H., Guo Y., Wang J., Zhou H., Li Z.S., Fawcett J.P. Mechanism of CYP2C9 inhibition by flavones and flavonols. Drug Metabolism and Disposition 2009, 37:629-634.
35. Summerfield A., Keil G.M., Mettenleiter T.C., Rziha H.J., Saalmuller A. Antiviral activity of an extract from leaves of the tropical plant Acanthospermum hispidum. Antiviral Research 1997, 36:55-62.