Invariant NKT cell defects in vitamin D receptor knockout mice prevents experimental lung inflammation

Journal of Immunology

Volumn 187, Issue 9, 2011, Pages 4907-4912

  Yu, Sanhong ^a,b   Zhao, Jun ^a   Cantorna, Margherita T ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 5; VITAMIN D RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; KNOCKOUT MOUSE; LIVER; LYMPHOCYTE COUNT; LYMPHOCYTE FUNCTION; MOUSE; NATURAL KILLER T CELL; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SPLEEN; TH2 CELL; THYMUS; WILD TYPE;

ANIMALS; BRONCHIAL HYPERREACTIVITY; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; GALACTOSYLCERAMIDES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; NATURAL KILLER T-CELLS; PNEUMONIA; RECEPTORS, CALCITRIOL; SPECIES SPECIFICITY; TH2 CELLS;

EID: 80555126053     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1101519     Document Type: Article

References (31)

1. Wills-Karp, M. 1999. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu. Rev. Immunol. 17: 255-281.
2. Robinson, D. S., Q. Hamid, S. Ying, A. Tsicopoulos, J. Barkans, A. M. Bentley, C. Corrigan, S. R. Durham, and A. B. Kay. 1992. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 326: 298-304.
3. Bendelac, A., P. B. Savage, and L. Teyton. 2007. The biology of NKT cells. Annu. Rev. Immunol. 25: 297-336.
4. Akbari, O., P. Stock, E. Meyer, M. Kronenberg, S. Sidobre, T. Nakayama, M. Taniguchi, M. J. Grusby, R. H. DeKruyff, and D. T. Umetsu. 2003. Essential role of NKT cells producing IL-4 and IL-13 in the development of allergeninduced airway hyperreactivity. Nat. Med. 9: 582-588.
5. Pichavant, M., S. Goya, E. H. Meyer, R. A. Johnston, H. Y. Kim, P. Matangkasombut,M. Zhu, Y. Iwakura, P. B. Savage, R.H. DeKruyff, et al. 2008. Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17. J. Exp. Med. 205: 385-393.
6. Kim, E. Y., J. T. Battaile, A. C. Patel, Y. You, E. Agapov, M. H. Grayson, L. A. Benoit, D. E. Byers, Y. Alevy, J. Tucker, et al. 2008. Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease. Nat. Med. 14: 633-640.
7. Meyer, E. H., S. Goya, O. Akbari, G. J. Berry, P. B. Savage, M. Kronenberg, T. Nakayama, R. H. DeKruyff, and D. T. Umetsu. 2006. Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells. Proc. Natl. Acad. Sci. USA 103: 2782-2787.
8. Bhalla, A. K., E. P. Amento, T. L. Clemens, M. F. Holick, and S. M. Krane. 1983. Specific high-affinity receptors for 1,25-dihydroxyvitamin D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation. J. Clin. Endocrinol. Metab. 57: 1308-1310.
9. Provvedini, D. M., C. D. Tsoukas, L. J. Deftos, and S. C. Manolagas. 1983. 1,25-dihydroxyvitamin D3 receptors in human leukocytes. Science 221: 1181-1183.
10. Cantorna, M. T., C. E. Hayes, and H. F. DeLuca. 1996. 1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis. Proc. Natl. Acad. Sci. USA 93: 7861-7864.
11. Cantorna, M. T., C. E. Hayes, and H. F. DeLuca. 1998. 1,25-Dihydroxycholecalciferol inhibits the progression of arthritis in murine models of human arthritis. J. Nutr. 128: 68-72.
12. Lemire, J. M. 1992. Immunomodulatory role of 1,25-dihydroxyvitamin D3. J. Cell. Biochem. 49: 26-31.
13. Mahon, B. D., A. Wittke, V. Weaver, and M. T. Cantorna. 2003. The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells. J. Cell. Biochem. 89: 922-932.
14. Froicu, M., V. Weaver, T. A. Wynn, M. A. McDowell, J. E. Welsh, and M. T. Cantorna. 2003. A crucial role for the vitamin D receptor in experimental inflammatory bowel diseases. Mol. Endocrinol. 17: 2386-2392.
15. van Etten, E., and C. Mathieu. 2005. Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts. J. Steroid Biochem. Mol. Biol. 97: 93-101.
16. Yu, S., D. Bruce, M. Froicu, V. Weaver, and M. T. Cantorna. 2008. Failure of T cell homing, reduced CD4/CD8alphaalpha intraepithelial lymphocytes, and inflammation in the gut of vitamin D receptor KO mice. Proc. Natl. Acad. Sci. USA 105: 20834-20839.
17. Yu, S., and M. T. Cantorna. 2008. The vitamin D receptor is required for iNKT cell development. Proc. Natl. Acad. Sci. USA 105: 5207-5212.
18. Wittke, A., V. Weaver, B. D. Mahon, A. August, and M. T. Cantorna. 2004. Vitamin D receptor-deficient mice fail to develop experimental allergic asthma. J. Immunol. 173: 3432-3436.
19. Wittke, A., A. Chang, M. Froicu, O. F. Harandi, V. Weaver, A. August, R. F. Paulson, and M. T. Cantorna. 2007. Vitamin D receptor expression by the lung micro-environment is required for maximal induction of lung inflammation. Arch. Biochem. Biophys. 460: 306-313.
20. Boonstra, A., F. J. Barrat, C. Crain, V. L. Heath, H. F. Savelkoul, and A. O'Garra. 2001. 1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. J. Immunol. 167: 4974-4980.
21. Staeva-Vieira, T. P., and L. P. Freedman. 2002. 1,25-dihydroxyvitamin D3 inhibits IFN-gamma and IL-4 levels during in vitro polarization of primary murine CD4+ T cells. J. Immunol. 168: 1181-1189.
22. Gorman, S., M. A. Judge, J. T. Burchell, D. J. Turner, and P. H. Hart. 2010. 1,25-dihydroxyvitamin D3 enhances the ability of transferred CD4+ CD25+ cells to modulate T helper type 2-driven asthmatic responses. Immunology 130: 181-192.
23. Iwamura, C., and T. Nakayama. 2010. Role of NKT cells in allergic asthma. Curr. Opin. Immunol. 22: 807-813.
24. Lloyd, C. M., and E. M. Hessel. 2010. Functions of T cells in asthma: more than just T(H)2 cells. Nat. Rev. Immunol. 10: 838-848.
25. Zosky, G. R., L. J. Berry, J. G. Elliot, A. L. James, S. Gorman, and P. H. Hart. 2011. Vitamin D deficiency causes deficits in lung function and alters lung structure. Am. J. Respir. Crit. Care Med. 183: 1336-1343.
26. Lange, N. E., A. Litonjua, C. M. Hawrylowicz, and S. Weiss. 2009. Vitamin D, the immune system and asthma. Expert Rev. Clin. Immunol. 5: 693-702.
27. Taher, Y. A., B. C. van Esch, G. A. Hofman, P. A. Henricks, and A. J. van Oosterhout. 2008. 1alpha,25-dihydroxyvitamin D3 potentiates the beneficial effects of allergen immunotherapy in a mouse model of allergic asthma: role for IL-10 and TGF-beta. J. Immunol. 180: 5211-5221.
28. Bruce, D., S. Yu, J. H. Ooi, and M. T. Cantorna. 2011. Converging pathways lead to overproduction of IL-17 in the absence of vitamin D signaling. Int. Immunol. 23: 519-528.
29. Wjst, M., and S. Dold. 1999. Genes, factor X, and allergens: what causes allergic diseases? Allergy 54: 757-759.
30. Vijayanand, P., G. Seumois, C. Pickard, R. M. Powell, G. Angco, D. Sammut, S. D. Gadola, P. S. Friedmann, and R. Djukanovic. 2007. Invariant natural killer T cells in asthma and chronic obstructive pulmonary disease. N. Engl. J. Med. 356: 1410-1422.
31. Akbari, O., J. L. Faul, E. G. Hoyte, G. J. Berry, J. Wahlström, M. Kronenberg, R. H. DeKruyff, and D. T. Umetsu. 2006. CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma. N. Engl. J. Med. 354: 1117-1129.