Type 2 diabetic obese db/db mice are refractory to myocardial ischaemic post-conditioning in vivo: Potential role for Hsp20, F1-ATPase δ and Echs1

Journal of Cellular and Molecular Medicine

Volumn 16, Issue 4, 2012, Pages 950-958

  Zhu, Shu Guang ^a   Xi, Lei ^a   Kukreja, Rakesh C ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Cardioprotection; Diabetes; Hyperglycaemia; Ischaemia reperfusion; Myocardial infarction; Post conditioning; Proteomics

Indexed keywords

MUS;

ENOYL COENZYME A HYDRATASE; HEAT SHOCK PROTEIN 20; MITOCHONDRIAL PROTEIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE;

ANIMAL; ARTICLE; BODY WEIGHT; C57BL MOUSE; GLUCOSE BLOOD LEVEL; MALE; MASS SPECTROMETRY; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY; PHYSIOLOGY; REPERFUSION INJURY;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, TYPE 2; ENOYL-COA HYDRATASE; HSP20 HEAT-SHOCK PROTEINS; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIAL PROTEINS; MYOCARDIAL REPERFUSION INJURY; PROTON-TRANSLOCATING ATPASES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 80455167403     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2011.01376.x     Document Type: Article

References (23)

1. Zhao ZQ, Corvera JS, Halkos ME, et al. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol. 2003; 285: H579-88.
2. Staat P, Rioufol G, Piot C, et al. Postconditioning the human heart. Circulation. 2005; 112: 2143-8.
3. Heusch G, Buchert A, Feldhaus S, et al. No loss of cardioprotection by postconditioning in connexin 43-deficient mice. Basic Res Cardiol. 2006; 101: 354-6.
4. Kaljusto ML, Mori T, Mohammad Husain RS, et al. Postconditioning in rats and mice. Scand Cardiovasc J. 2006; 40: 334-41.
5. Lim SY, Davidson SM, Hausenloy DJ, et al. Preconditioning and postconditioning: the essential role of the mitochondrial permeability transition pore. Cardiovasc Res. 2007; 75: 530-5.
6. Nishino Y, Webb IG, Davidson SM, et al. Glycogen synthase kinase-3 inactivation is not required for ischemic preconditioning or postconditioning in the mouse. Circ Res. 2008; 103: 307-14.
7. 2 receptors gene knockout mice. Circulation. 2008; 118: S32-7.
8. Lin XM, Zhang ZY, Wang LF, et al. Attenuation of tumour necrosis factoralpha elevation and improved heart function by postconditioning for 60seconds in patients with acute myocardial infarction. Chin Med J (Engl). 2010; 123: 1833-9.
9. Lonborg J, Kelbaek H, Vejlstrup N, et al. Cardioprotective effects of ischemic postconditioning in patients treated with primary percutaneous coronary intervention, evaluated by magnetic resonance. Circ Cardiovasc Interv. 2010; 3: 34-41.
10. Juhasz B, Der P, Turoczi T, et al. Preconditioning in intact and previously diseased myocardium: laboratory or clinical dilemma? Antioxid Redox Signal. 2004; 6: 325-33.
11. Tosaki A, Engelman DT, Engelman RM, et al. The evolution of diabetic response to ischemia/reperfusion and preconditioning in isolated working rat hearts. Cardiovasc Res. 1996; 31: 526-36.
12. Tosaki A, Pali T, Droy-Lefaix MT. Effects of Ginkgo biloba extract and preconditioning on the diabetic rat myocardium. Diabetologia. 1996; 39: 1255-62.
13. Bouhidel O, Pons S, Souktani R, et al. Myocardial ischemic postconditioning against ischemia-reperfusion is impaired in ob/ob mice. Am J Physiol Heart Circ Physiol. 2008; 295: H1580-6.
14. Xi L, Zhu SG, Hobbs DC, et al. Identification of protein targets underlying dietary nitrate-induced protection against doxorubicin cardiotoxicity. J Cell Mol Med. 2011; doi:10.1111/j.1582-4934.2011. 01257.x.
15. Boengler K, Buechert A, Heinen Y, et al. Cardioprotection by ischemic postconditioning is lost in aged and STAT3-deficient mice. Circ Res. 2008; 102: 131-5.
16. Iliodromitis EK, Zoga A, Vrettou A, et al. The effectiveness of postconditioning and preconditioning on infarct size in hypercholesterolemic and normal anesthetized rabbits. Atherosclerosis. 2006; 188: 356-62.
17. Wang W, Poole B, Mitra A, et al. Role of leptin deficiency in early acute renal failure during endotoxemia in ob/ob mice. J Am Soc Nephrol. 2004; 15: 645-9.
18. Faggioni R, Fantuzzi G, Gabay C, et al. Leptin deficiency enhances sensitivity to endotoxin-induced lethality. Am J Physiol. 1999; 276: R136-42.
19. Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996; 334: 292-5.
20. Wauters M, Considine RV, Yudkin JS, et al. Leptin levels in type 2 diabetes: associations with measures of insulin resistance and insulin secretion. Horm Metab Res. 2003; 35: 92-6.
21. Przyklenk K, Maynard M, Greiner DL, et al. Cardioprotection with postconditioning: loss of efficacy in murine models of type-2 and type-1 diabetes. Antioxid Redox Signal. 2011; 14: 781-90.
22. Fan GC, Ren X, Qian J, et al. Novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia/reperfusion injury. Circulation. 2005; 111: 1792-9.
23. Lopaschuk GD, Ussher JR, Folmes CD, et al. Myocardial fatty acid metabolism in health and disease. Physiol Rev. 2010; 90: 207-58.