Systemic administration of AAV8-α-galactosidase a induces humoral tolerance in nonhuman primates despite low hepatic expression

Molecular Therapy

Volumn 19, Issue 11, 2011, Pages 1999-2011

  Nietupski, Jennifer B ^a   Hurlbut, Gregory D ^a   Ziegler, Robin J ^a   Chu, Qiuming ^a   Hodges, Bradley L ^a   Ashe, Karen M ^a   Bree, Mark ^a   Cheng, Seng H ^a   Gregory, Richard J ^a   Marshall, John ^a   Scheule, Ronald K ^a  

^a GENZYME CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GALACTOSIDASE; MESSENGER RNA; PARVOVIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; DEAMINATION; DNA METHYLATION; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMORAL IMMUNITY; IMMUNOLOGICAL TOLERANCE; LIVER; MACACA; MALE; MOUSE; NONHUMAN; SPECIES COMPARISON; SYSTEMIC THERAPY; TRANSGENE; VIRAL GENE THERAPY;

MUS; PRIMATES;

EID: 80455164698     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2011.119     Document Type: Article

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