Effects of Toxoplasma gondii genotype and absence of host MAL/Myd88 on the temporal regulation of gene expression in infected microglial cells

Experimental Parasitology

Volumn 129, Issue 4, 2011, Pages 409-413

  Glaser, K C ^a   Hagos, B ^a   Molestina, R E ^a  

^a AMERICAN TYPE CULTURE COLLECTION   (United States)

Author keywords

Inflammatory response; MAL; Microglia; Myd88; NF B; Toxoplasma gondii; Type strain; Virulence

Indexed keywords

TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE TARGETING; GENOTYPE; HOST PARASITE INTERACTION; IP 10 GENE; MAL GENE; MARKER GENE; MICROGLIA; MOUSE; MYD88 GENE; NF KAPPAB GENE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANTES GENE; SIGNAL TRANSDUCTION; STRAIN DIFFERENCE; TOXOPLASMA GONDII; TOXOPLASMOSIS; TRANSCRIPTION REGULATION; WILD TYPE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; CELL LINE; CELLS, CULTURED; CYTOKINES; GENE EXPRESSION; GENOTYPE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; MYELOID DIFFERENTIATION FACTOR 88; SIGNAL TRANSDUCTION; TOXOPLASMA;

MURINAE; TOXOPLASMA GONDII;

EID: 80455160353     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2011.08.016     Document Type: Article

References (32)

1. Blasi E., Mathieson B.J., Varesio L., Cleveland J.L., Borchert P.A., Rapp U.R. Selective immortalization of murine macrophages from fresh bone marrow by a raf/myc recombinant murine retrovirus. Nature 1985, 318:667-670.
2. Blasi E., Barluzzi R., Bocchini V., Mazzolla R., Bistoni F. Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus. Journal of Neuroimmunology 1990, 27:229-237.
3. Bradley P.J., Sibley L.D. Rhoptries: an arsenal of secreted virulence factors. Current Opinion in Microbiology 2007, 10:582-587.
4. Carruthers V.B., Suzuki Y. Effects of Toxoplasma gondii infection on the brain. Schizophrenia Bulletin 2007, 33:745-751.
5. Chao C.C., Anderson W.R., Hu S., Gekker G., Martella A., Peterson P.K. Activated microglia inhibit multiplication of Toxoplasma gondii via a nitric oxide mechanism. Clinical Immunology and Immunopathology 1993, 67:178-183.
6. Chao C.C., Hu S., Gekker G., Novick W.J., Remington J.S., Peterson P.K. Effects of cytokines on multiplication of Toxoplasma gondii in microglial cells. Journal of Immunology 1993, 150:3404-3410.
7. Chao C.C., Gekker G., Hu S., Peterson P.K. Human microglial cell defense against Toxoplasma gondii. The role of cytokines. Journal of Immunology 1994, 152:1246-1252.
8. Debierre-Grockiego F., Campos M.A., Azzouz N., Schmidt J., Bieker U., Resende M.G., Mansur D.S., Weingart R., Schmidt R.R., Golenbock D.T., Gazzinelli R.T., Schwarz R.T. Activation of TLR2 and TLR4 by glycosylphosphatidylinositols derived from Toxoplasma gondii. Journal of Immunology 2007, 179:1129-1137.
9. Hoffmann A., Levchenko A., Scott M.L., Baltimore D. The IκB-NF-κB signaling module: temporal control and selective gene activation. Science 2002, 298:1241-1245.
10. Kim L., Butcher B.A., Lee C.W., Uematsu S., Akira S., Denkers E.Y. Toxoplasma gondii genotype determines MyD88-dependent signaling in infected macrophages. Journal of Immunology 2006, 177:2584-2591.
11. Laliberte J., Carruthers V.B. Host cell manipulation by the human pathogen Toxoplasma gondii. Cellular and Molecular Life Sciences 2008, 65:1900-1915.
12. Lee C.W., Sukhumavasi W., Denkers E.Y. Phosphoinositide-3-kinase-dependent, MyD88-independent induction of CC-type chemokines characterizes the macrophage response to Toxoplasma gondii strains with high virulence. Infection and Immunity 2007, 75:5788-5797.
13. Leng J., Butcher B.A., Denkers E.Y. Dysregulation of macrophage signal transduction by Toxoplasma gondii: past progress and recent advances. Parasite Immunology 2009, 31:717-728.
14. Molestina R.E., Sinai A.P. Host and parasite-derived IKK activities direct distinct temporal phases of NF-κB activation and target gene expression following Toxoplasma gondii infection. Journal of Cell Science 2005, 118:5785-5796.
15. Molestina R.E., Payne T.M., Coppens I., Sinai A.P. Activation of NF-κB by Toxoplasma gondii correlates with increased expression of antiapoptotic genes and localization of phosphorylated IκB to the parasitophorous vacuole membrane. Journal of Cell Science 2003, 116:4359-4371.
16. Mun H.S., Aosai F., Norose K., Chen M., Piao L.X., Takeuchi O., Akira S., Ishikura H., Yano A. TLR2 as an essential molecule for protective immunity against Toxoplasma gondii infection. International Immunology 2003, 15:1081-1087.
17. Ong Y.C., Reese M.L., Boothroyd J.C. Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6. Journal of Biological Chemistry 2010, 285:28731-28740.
18. Plattner F., Yarovinsky F., Romero S., Didry D., Carlier M.F., Sher A., Soldati-Favre D. Toxoplasma profilin is essential for host cell invasion and TLR11-dependent induction of an interleukin-12 response. Cell Host and Microbe 2008, 3:77-87.
19. Robben P.M., Mordue D.G., Truscott S.M., Takeda K., Akira S., Sibley L.D. Production of IL-12 by macrophages infected with Toxoplasma gondii depends on the parasite genotype. Journal of Immunology 2004, 172:3686-3694.
20. Rosowski E.E., Lu D., Julien L., Rodda L., Gaiser R.A., Jensen K.D., Saeij J.P. Strain-specific activation of the NF-κB pathway by GRA15, a novel Toxoplasma gondii dense granule protein. Journal of Experimental Medicine 2011, 208:195-212.
21. Saeij J.P., Boyle J.P., Boothroyd J.C. Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected host. Trends in Parasitology 2005, 21:476-481.
22. Saeij J.P., Boyle J.P., Coller S., Taylor S., Sibley L.D., Brooke-Powell E.T., Ajioka J.W., Boothroyd J.C. Polymorphic secreted kinases are key virulence factors in toxoplasmosis. Science 2006, 314:1780-1783.
23. Saeij J.P., Coller S., Boyle J.P., Jerome M.E., White M.W., Boothroyd J.C. Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue. Nature 2007, 445:324-327.
24. Sher A., Collazzo C., Scanga C., Jankovic D., Yap G., Aliberti J. Induction and regulation of IL-12-dependent host resistance to Toxoplasma gondii. Immunologic Research 2003, 27:521-528.
25. Sibley L.D., Boothroyd J.C. Virulent strains of Toxoplasma gondii comprise a single clonal lineage. Nature 1992, 359:82-85.
26. Sibley L.D., Khan A., Ajioka J.W., Rosenthal B.M. Genetic diversity of Toxoplasma gondii in animals and humans. Philosophical Transactions of the Royal Society of London. Series B, Biological sciences 2009, 364:2749-2761.
27. Sinai A.P., Payne T.M., Carmen J.C., Hardi L., Watson S.J., Molestina R.E. Mechanisms underlying the manipulation of host apoptotic pathways by Toxoplasma gondii. International Journal for Parasitology 2004, 34:381-391.
28. Steinfeldt T., Konen-Waisman S., Tong L., Pawlowski N., Lamkemeyer T., Sibley L.D., Hunn J.P., Howard J.C. Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii. PLoS Biology 2010, 8:e1000576.
29. Taylor S., Barragan A., Su C., Fux B., Fentress S.J., Tang K., Beatty W.L., Hajj H.E., Jerome M., Behnke M.S., White M., Wootton J.C., Sibley L.D. A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii. Science 2006, 314:1776-1780.
30. Vallabhapurapu S., Karin M. Regulation and function of NF-κB transcription factors in the immune system. Annual Review of Immunology 2009, 27:693-733.
31. Yamamoto M., Sato S., Hemmi H., Sanjo H., Uematsu S., Kaisho T., Hoshino K., Takeuchi O., Kobayashi M., Fujita T., Takeda K., Akira S. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature 2002, 420:324-329.
32. Yarovinsky F. Toll-like receptors and their role in host resistance to Toxoplasma gondii. Immunology Letters 2008, 119:17-21.