Copy number defects of G1-Cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis

Genes Chromosomes and Cancer

Volumn 51, Issue 1, 2012, Pages 10-19

  Molenaar, Jan J ^a   Koster, Jan ^a   Ebus, Marli E ^a   van Sluis, Peter ^a   Westerhout, Ellen M ^a   de Preter, Katleen ^b   Gisselsson, David ^c   Øra, Ingrid ^a,c   Speleman, Frank ^b   Caron, Huib N ^a   Versteeg, Rogier ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

^c LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE 4; MESSENGER RNA; TRANSCRIPTION FACTOR E2F;

ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CHROMOSOME; CLUSTER ANALYSIS; COMPARATIVE GENOMIC HYBRIDIZATION; COPY NUMBER VARIATION; GENE AMPLIFICATION; GENE EXPRESSION; GENE TARGETING; HIGH THROUGHPUT SEQUENCING; HUMAN; HUMAN CELL; NEUROBLASTOMA; PRIORITY JOURNAL; PROGNOSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

CHROMOSOME ABERRATIONS; CLUSTER ANALYSIS; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR PROTEINS; CYCLIN-DEPENDENT KINASES; E2F TRANSCRIPTION FACTORS; G1 PHASE; GENE DOSAGE; GENE EXPRESSION; GENES, CDC; HUMANS; NEUROBLASTOMA; PROGNOSIS; RNA, MESSENGER;

EID: 80455150507     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.20926     Document Type: Article

References (43)

1. Adhikary S, Eilers M. 2005. Transcriptional regulation and transformation by Myc proteins. Nat Rev Mol Cell Biol 6: 635-645.
2. An HX, Beckmann MW, Reifenberger G, Bender HG, Niederacher D. 1999. Gene amplification and overexpression of CDK4 in sporadic breast carcinomas is associated with high tumor cell proliferation. Am J Pathol 154: 113-118.
3. Attiyeh EF, London WB, Mosse YP, Wang Q, Winter C, Khazi D, McGrady PW, Seeger RC, Look AT, Shimada H, Brodeur GM, Cohn SL, Matthay KK, Maris JM. 2005. Chromosome 1p and 11q deletions and outcome in neuroblastoma. N Engl J Med 353: 2243-2253.
4. Bell E, Lunec J, Tweddle DA. 2007. Cell cycle regulation targets of MYCN identified by gene expression microarrays. Cell Cycle 6: 1249-1256.
5. Bergmann E, Wanzel M, Weber A, Shin I, Christiansen H, Eilers M. 2001. Expression of P27(KIP1) is prognostic and independent of MYCN amplification in human neuroblastoma. Int J Cancer 95: 176-183.
6. Boon K, Caron HN, van Asperen R, Valentijn L, Hermus MC, Van Sluis P, Roobeek I, Weis I, Voute PA, Schwab M, Versteeg R. 2001. N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis. EMBO J 20: 1383-1393.
7. Bouchard C, Thieke K, Maier A, Saffrich R, Hanley-Hyde J, Ansorge W, Reed S, Sicinski P, Bartek J, Eilers M. 1999. Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27. EMBO J 18: 5321-5333.
8. Caren H, Erichsen J, Olsson L, Enerback C, Sjoberg RM, Abrahamsson J, Kogner P, Martinsson T. 2008. High-resolution array copy number analyses for detection of deletion, gain, amplification and copy-neutral LOH in primary neuroblastoma tumors: Four cases of homozygous deletions of the CDKN2A gene. BMC Genomics 9: 353.
9. Cole MD, Cowling VH. 2008. Transcription-independent functions of MYC: Regulation of translation and DNA replication. Nat Rev Mol Cell Biol 9: 810-815.
10. Coverley D, Laman H, Laskey RA. 2002. Distinct roles for cyclins E and A during DNA replication complex assembly and activation. Nat Cell Biol 4: 523-528.
11. Fan X, Gomez L, Nistal M, Sierrasesumaga L, Castresana JS. 1999. Lack of gene amplification as a mechanism of CDK4 activation in human neuroblastoma. Oncol Rep 6: 647-650.
12. Gartel AL, Ye X, Goufman E, Shianov P, Hay N, Najmabadi F, Tyner AL. 2001. Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3. Proc Natl Acad Sci USA 98: 4510-4515.
13. Hermeking H, Rago C, Schuhmacher M, Li Q, Barrett JF, Obaya AJ, O'Connell BC, Mateyak MK, Tam W, Kohlhuber F, Dang CV, Sedivy JM, Eick D, Vogelstein B, Kinzler KW. 2000. Identification of CDK4 as a target of c-MYC. Proc Natl Acad Sci USA 97: 2229-2234.
14. Hiyama E, Hiyama K, Ohtsu K, Yamaoka H, Fukuba I, Matsuura Y, Yokoyama T. 2001. Biological characteristics of neuroblastoma with partial deletion in the short arm of chromosome 1. Med Pediatr Oncol 36: 67-74.
15. Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Kamiyama H, Jimeno A, Hong SM, Fu B, Lin MT, Calhoun ES, Kamiyama M, Walter K, Nikolskaya T, Nikolsky Y, Hartigan J, Smith DR, Hidalgo M, Leach SD, Klein AP, Jaffee EM, Goggins M, Maitra A, Iacobuzio-Donahue C, Eshleman JR, Kern SE, Hruban RH, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, Kinzler KW. 2008. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321: 1801-1806.
16. Kanoe H, Nakayama T, Murakami H, Hosaka T, Yamamoto H, Nakashima Y, Tsuboyama T, Nakamura T, Sasaki MS, Toguchida J. 1998. Amplification of the CDK4 gene in sarcomas: Tumor specificity and relationship with the RB gene mutation. Anticancer Res 18: 2317-2321.
17. Kawamata N, Seriu T, Koeffler HP, Bartram CR. 1996. Molecular analysis of the cyclin-dependent kinase inhibitor family: p16(CDKN2/MTS1/INK4A), p18(INK4C) and p27(Kip1) genes in neuroblastomas. Cancer 77: 570-575.
18. Koppen A, Ait-Aissa R, Koster J, van Sluis PG, Ora I, Caron HN, Volckmann R, Versteeg R, Valentijn LJ. 2007. Direct regulation of the minichromosome maintenance complex by MYCN in neuroblastoma. Eur J Cancer 43: 2413-2422.
19. Kops GJ, Weaver BA, Cleveland DW. 2005. On the road to cancer: Aneuploidy and the mitotic checkpoint. Nat Rev Cancer 5: 773-785.
20. Lukas J, Lukas C, Bartek J. 2004. Mammalian cell cycle checkpoints: Signalling pathways and their organization in space and time. DNA Repair (Amst) 3: 997-1007.
21. Maris JM, Hogarty MD, Bagatell R, Cohn SL. 2007. Neuroblastoma. Lancet 369: 2106-2120.
22. McKenzie PP, Danks MK, Kriwacki RW, Harris LC. 2003. P21Waf1/Cip1 dysfunction in neuroblastoma: A novel mechanism of attenuating G0-G1 cell cycle arrest. Cancer Res 63: 3840-3844.
23. Michels E, Vandesompele J, De Preter K, Hoebeeck J, Vermeulen J, Schramm A, Molenaar JJ, Menten B, Marques B, Stallings RL, Combaret V, Devalck C, De Paepe A, Versteeg R, Eggert A, Laureys G, Van Roy N, Speleman F. 2007. ArrayCGH-based classification of neuroblastoma into genomic subgroups. Genes Chromosomes Cancer 46: 1098-1108.
24. Molenaar JJ, van SP, Boon K, Versteeg R, Caron HN. 2003. Rearrangements and increased expression of cyclin D1 (CCND1) in neuroblastoma. Genes Chromosomes Cancer 36: 242-249.
25. Molenaar JJ, Ebus ME, Koster J, Van Sluis P, van Noesel CJ, Versteeg R, Caron HN. 2008. Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma. Cancer Res 68: 2599-2609.
26. Mosse YP, Laudenslager M, Longo L, Cole KA, Wood A, Attiyeh EF, Laquaglia MJ, Sennett R, Lynch JE, Perri P, Laureys G, Speleman F, Kim C, Hou C, Hakonarson H, Torkamani A, Schork NJ, Brodeur GM, Tonini GP, Rappaport E, Devoto M, Maris JM. 2008. Identification of ALK as a major familial neuroblastoma predisposition gene. Nature 455: 930-935.
27. Nakamura Y, Ozaki T, Koseki H, Nakagawara A, Sakiyama S. 2003. Accumulation of p27 KIP1 is associated with BMP2-induced growth arrest and neuronal differentiation of human neuroblastoma-derived cell lines. Biochem Biophys Res Commun 307: 206-213.
28. Okuda M, Horn HF, Tarapore P, Tokuyama Y, Smulian AG, Chan PK, Knudsen ES, Hofmann IA, Snyder JD, Bove KE, Fukasawa K. 2000. Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell 103: 127-140.
29. Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Siu IM, Gallia GL, Olivi A, McLendon R, Rasheed BA, Keir S, Nikolskaya T, Nikolsky Y, Busam DA, Tekleab H, Diaz LA Jr., Hartigan J, Smith DR, Strausberg RL, Marie SK, Shinjo SM, Yan H, Riggins GJ, Bigner DD, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, Kinzler KW. 2008. An integrated genomic analysis of human glioblastoma multiforme. Science 321: 1807-1812.
30. Poluha W, Poluha DK, Chang B, Crosbie NE, Schonhoff CM, Kilpatrick DL, Ross AH. 1996. The cyclin-dependent kinase inhibitor p21 (WAF1) is required for survival of differentiating neuroblastoma cells. Mol Cell Biol 16: 1335-1341.
31. Santamaria D, Barriere C, Cerqueira A, Hunt S, Tardy C, Newton K, Caceres JF, Dubus P, Malumbres M, Barbacid M. 2007. Cdk1 is sufficient to drive the mammalian cell cycle. Nature 448: 811-815.
32. Schmidt EE, Ichimura K, Reifenberger G, Collins VP. 1994. CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas. Cancer Res 54: 6321-6324.
33. Sherr CJ. 1996. Cancer cell cycles. Science 274: 1672-1677.
34. Sherr CJ, Roberts JM. 1999. CDK inhibitors: Positive and negative regulators of G1-phase progression. Genes Dev 13: 1501-1512.
35. Sherr CJ, Roberts JM. 2004. Living with or without cyclins and cyclin-dependent kinases. Genes Dev 18: 2699-2711.
36. Sun F, Fu H, Liu Q, Tie Y, Zhu J, Xing R, Sun Z, Zheng X. 2008. Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest. FEBS Lett 582: 1564-1568.
37. Trimarchi JM, Fairchild B, Verona R, Moberg K, Andon N, Lees JA. 1998. E2F-6, a member of the E2F family that can behave as a transcriptional repressor. Proc Natl Acad Sci USA 95: 2850-2855.
38. van Noesel MM, Versteeg R. 2004. Pediatric neuroblastomas: Genetic and epigenetic 'danse macabre.' Gene 325: 1-15.
39. Van Roy N, Forus A, Myklebost O, Cheng NC, Versteeg R, Speleman F. 1995. Identification of two distinct chromosome 12-derived amplification units in neuroblastoma cell line NGP. Cancer Genet Cytogenet 82: 151-154.
40. van Limpt V, Schramm A, van Lakeman A, Sluis P, Chan A, van Noesel M, Baas F, Caron H, Eggert A, Versteeg R. 2004. The Phox2B homeobox gene is mutated in sporadic neuroblastomas. Oncogene 23: 9280-9288.
41. Wartiovaara K, Barnabe-Heider F, Miller FD, Kaplan DR. 2002. N-myc promotes survival and induces S-phase entry of postmitotic sympathetic neurons. J Neurosci 22: 815-824.
42. Woo CW, Tan F, Cassano H, Lee J, Lee KC, Thiele CJ. 2008. Use of RNA interference to elucidate the effect of MYCN on cell cycle in neuroblastoma. Pediatr Blood Cancer 50: 208-212.
43. Woo RA, Poon RY. 2003. Cyclin-dependent kinases and S phase control in mammalian cells. Cell Cycle 2: 316-324.