The proteasome inhibitor bortezomib enhances ATRA-induced differentiation of neuroblastoma cells via the JNK mitogen-activated protein kinase pathway

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Luo, Peihua ^a   Lin, Meili ^a   Li, Lin ^a   Yang, Bo ^a   He, Qiaojun ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; BORTEZOMIB; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P21; RETINOIC ACID; RETINOIC ACID RECEPTOR ALPHA; RETINOIC ACID RECEPTOR BETA; RETINOIC ACID RECEPTOR GAMMA; STRESS ACTIVATED PROTEIN KINASE; ANTINEOPLASTIC AGENT; BORONIC ACID DERIVATIVE; PROTEINASE INHIBITOR; PYRAZINE DERIVATIVE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL ASSAY; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENTIATION; FEMALE; HUMAN; HUMAN CELL; MOUSE; NERVE CELL DIFFERENTIATION; NEUROBLASTOMA; NEUROBLASTOMA CELL; NEUROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; UPREGULATION; ANIMAL; CELL DIFFERENTIATION; DRUG SCREENING; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

MUS; MUS MUSCULUS; RATTUS;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BORONIC ACIDS; CELL DIFFERENTIATION; CELL LINE, TUMOR; DRUG SYNERGISM; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MICE; NEUROBLASTOMA; PROTEASE INHIBITORS; PYRAZINES; RATS; TRETINOIN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 80455131319     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027298     Document Type: Article

References (39)

1. Nowak D, Stewart D, Koeffler HP, (2009) Differentation therapy of leukemia: 3 decades of development. Blood 113: 3655-3665.
2. Altucci L, Gronemeyer H, (2001) The promise of retinoids to fight against cancer. Nat Rev Cancer 1: 181-193.
3. Garattini E, Gianni M, Terao M, (2007) Retinoids as differentiating agents in oncology: a network of interactions with intracellular pathways as the basis for rational therapeutic combinations. Curr Pharm Des 13: 1375-1400.
4. De los Santos M, Zambrano A, Aranda A, (2007) Combined effects of retinoic acid and histone deacetylase inhibitors on human neuroblastoma SHSY5Y cells. Mol Cancer Ther 6: 1425-1432.
5. Adamson PC, Matthay KK, O'BrienM, Reaman GH, Sato JK, et al. (2007) A phase 2 trial of all-trans-retinoic acid in combination with interferon-a2a in children with recurrent neuroblastoma or Wilms tumor: A Pediatric Oncology Branch, NCI and Children's Oncology Group study. Pediatr Blood Cancer 49: 661-665.
6. Redova M, Chlapek P, Loja T, Zitterbart K, Hermanova M, et al. (2010) Influence of LOX/COX inhibitors on cell differentiation induced by all-trans retinoic acid in neuroblastoma cells. Int J Mol Med 25: 271-280.
7. Maris JM, Hogarty MD, Bagatell R, Cohn SL, (2007) Neuroblastoma. Lancet 369: 2106-2120.
8. Maris JM, Matthay KK, (1999) Molecular biology of neuroblastoma. J Clin Oncol 17: 2264-2279.
9. Marimpietri D, Brignole C, Nico B, et al. (2007) Combined therapeutic effects of vinblastine and rapamycin on human neuroblastoma growth, apoptosis, and angiogenesis. Clin Cancer Res 13: 3977-3988.
10. van Noesel MM, Versteeg R, (2004) Pediatric neuroblastomas: genetic and epigenetic 'danse macabre'. Gene 325: 1-15.
11. Zhu J, Gianni M, Kopf E, Honoré N, Chelbi-Alix M, et al. (1999) Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor α and oncogenic RARα fusion proteins. Proc Natl Acad Sci U S A 96: 14807-14812.
12. Nagai J, Yazawa T, Okudela K, Kigasawa H, Kitamura H, et al. (2004) Retinoic acid induces neuroblastoma cell death by inhibiting proteasomal degradation of retinoic acid receptor α. Cancer Res 64: 7910-7917.
13. Orlowski RZ, Kuhn DJ, (2008) Proteasome inhibitors in cancer therapy: lessons fromthe first decade. Clin Cancer Res 14: 1649-1657.
14. Horton TM, Pati D, Plon SE, Thompson PA, Bomgaars LR, et al. (2007) A phase 1study of the proteasome inhibitor bortezomib in pediatric patients with refractory leukemia: a Children's Oncology Group study. Clin Cancer Res 13: 1516-1522.
15. Cavaletti G, Gilardini A, Canta A, Rigamonti L, Rodriguez-Menendez V, et al. (2007) Bortezomib-induced peripheral neurotoxicity: a neurophysiological and pathological study in the rat. Exp Neurol 204: 317-325.
16. Wang D, Weng Q, Zhang L, He Q, Yang B, (2009) VEGF and Bcl-2 interact via MAPKs signaling pathway in the response to hypoxia in neuroblastoma. Cell Mol Neurobiol 29: 391-401.
17. Veith NM, Plattner H, Stuermer CA, Schulz-Schaeffer WJ, Bürkle A, (2009) Immunolocalisation of PrPSc in scrapie-infected N2a mouse neuroblastoma cells by light and electron microscopy. Eur J Cell Biol 88: 45-63.
18. Karlsson J, Pietras A, Beckman S, Pettersson HM, Larsson C, et al. (2007) Arsenic trioxide-induced neuroblastoma cell death is accompanied by proteolytic activation of nuclear Bax. Oncogene 26: 6150-6159.
19. Muth D, Ghazaryan S, Eckerle I, Beckett E, Pöhler C, et al. (2010) Transcriptional repression of SKP2 is impaired in MYCN-amplified neuroblastoma. Cancer Res 70: 3791-3802.
20. Lee A, Kessler JD, Read TA, Kaiser C, Corbeil D, et al. (2005) Isolation of neural stem cells from the postnatal cerebellum. Nat Neurosci 8: 723-729.
21. Luo PH, He QJ, He XG, Hu YZ, Lu W, et al. (2006) Potent antitumor activity of 10-methoxy-9-nitrocamptothecin. Molecular Cancer Therapeutics 5: 1-7.
22. Yang B, Reynolds CP, (2005) Tirapazamine cytotoxicity for neuroblastoma is p53 dependent. Clin Cancer Res 1: 2774-2780.
23. Zhang C, Qu G, Sun Y, Yang T, Yao Z, et al. (2008) Biological evaluation of N-octyl-O-sulfate chitosan as a new nano-carrier of intravenous drugs. Eur J Pharm Sci 33: 415-423.
24. Murakami M, Ito H, Hagiwara K, Yoshida K, Sobue S, et al. (2010) ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells: the role of COUP-TFI. J Neurochem 112: 511-520.
25. Mangelsdorf DJ, Evans RM, (1995) The RXR heterodimers and orphan receptors. Cell 83: 841-850.
26. Pé rez-Juste G, Aranda A, (1999) Differentiation of neuroblastoma cells by phorbol esters and insulin-like growth factor 1 is associated with induction of retinoic acid receptor gene β gene expression. Oncogene 18: 5393-5402.
27. Marshall GM, Cheung B, Stacey KP, Camacho ML, Simpson AM, et al. (1995) Increased retinoic acid receptor gamma expression suppresses the malignant phenotype and alters the differentiation potential of human neuroblastoma cells. Oncogene 11: 485-491.
28. Nordstrom, EK, Luhr, KM, Ibanez, C, Kristensson K, (2005) Inhibitors of the mitogen-activated protein kinase kinase 1/2 signaling pathway clear prion-infected cells from PrPSc. J Neurosci 25: 8451-8456.
29. Rocchi P, Tonelli R, Camerin C, Purgato S, Fronza R, et al. (2005) p21Waf1/Cip1 is a common target induced by short-chain fatty acid HDAC inhibitors (valproic acid, tributyrin and sodium butyrate) in neuroblastoma cells. Oncol Rep 13: 1139-1144.
30. Brignole C, Marimpietri D, Pastorino F, Nico B, Di Paolo D, et al. (2006) Effect of bortezomib on human neuroblastoma cell growth, apoptosis, and angiogenesis. J Natl Cancer Inst 98: 1142-1157.
31. Liu Y, Kagechika H, Ishikawa J, Hirano H, Matsukuma S, et al. (2008) Effects of retinoic acids on the dendritic morphology of cultured hippocampal neurons. J Neurochem 106: 1104-1116.
32. Maris JM, (2010) Recent advances in neuroblastoma. N Engl J Med 362: 2202-2211.
33. Herbst RS, Heymach JV, Lippman SM, (2008) Lung cancer. N Engl J Med 359: 1367-1380.
34. Zhang L, Kavanagh BD, Thorburn AM, Camidge DR, (2010) Preclinical and clinical estimates of the basal apoptotic rate of a cancer predict the amount of apoptosis induced by subsequent proapoptotic stimuli. Clin Cancer Res 16: 4478-4489.
35. Soriano SG, Liu Q, Li J, Liu JR, Han XH et al, (2010) Ketamine activates cell cycle signaling and apoptosis in the neonatal rat brain. Anesthesiology 112: 1155-1163.
36. Pang L, Sawada T, Decker SJ, Saltiel AR, (1995) Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. J Biol Chem 270: 13585-13588.
37. Encinas M, Iglesias M, Llecha N, Comella JX, (1999) Extracellular-regulated kinases and phosphatidylinositol 3-kinase are involved in brain-derived neurotrophic factor-mediated survival and neuritogenesis of the neuroblastoma cell line SH-SY5Y. J Neurochem 73: 1409-1421.
38. Washio A, Kitamura C, Jimi E, Terashita M, Nishihara T, (2009) Mechanisms involved in suppression of NGF-induced neuronal differentiation of PC12 cells by hyaluronic acid. Exp Cell Res 315: 3036-3043.
39. Zhang J, Krishnamurthy PK, Johnson GV, (2002) Cdk5 phosphorylates p53 and regulates its activity. J Neurochem 81: 307-313.