Estriol has different effects from 17β-estradiol in modulating mouse splenocyte function under inflammatory conditions

Journal of Immunotoxicology

Volumn 8, Issue 4, 2011, Pages 346-358

  Zhou, Ru ^a   Lai, Yanlai ^a   Yamabe, Noriko ^a   Fukui, Masayuki ^a   Ting Zhu, Bao ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

17 Estradiol; Estriol; Immune modulation; Immunological conditions; Splenocytes

Indexed keywords

ESTRADIOL; ESTRIOL; FREUND ADJUVANT; GAMMA INTERFERON; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 12;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BAGG ALBINO MOUSE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EX VIVO STUDY; FEMALE; IMMUNOMODULATION; INFLAMMATION; INTERFERON PRODUCTION; MOUSE; NONHUMAN; PERITONEAL EXUDATE CELL; PRIORITY JOURNAL; SPLEEN CELL; SPLEEN WEIGHT; SPLENOMEGALY;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CYTOKINES; DRUG ANTAGONISM; ESTRADIOL; ESTRIOL; ESTROGENS; FEMALE; FREUND'S ADJUVANT; INTERFERON-GAMMA; INTERLEUKIN-2; MICE; MICE, INBRED BALB C; ORGAN SIZE; SPLEEN; SPLENOMEGALY;

ANIMALIA; MUS;

EID: 80455130922     PISSN: 1547691X     EISSN: None     Source Type: Journal    
DOI: 10.3109/1547691X.2011.617791     Document Type: Article

References (34)

1. Aluvihare V. R., Kallikourdis M., and Betz A. G. 2004. Regulatory T-cells mediate maternal tolerance to the fetus. Nat. Immunol. 5:266-271.
2. Amura C. R., Kamei T., Ito N., Soares M. J., and Morrison D. C. 1998. Differential regulation of lipopolysaccharide (LPS) activation pathways in mouse macrophages by LPS-binding proteins. J. Immunol. 161:2552-2560.
3. Baker A. E., Brautigam V. M., and Watters J. J. 2004. Estrogen modulates microglial inflammatory mediator production via interactions with estrogen receptor ß. Endocrinology 145:5021-5532.
4. Cargnello M, and Roux PP. 2011. Activation and function ofthe MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol. Mol. Biol. Rev. 75:50-83.
5. Clarke A. G., and Kendall M. D. 1989. Histological changes in the thymus during mouse pregnancy. Thymus 14:65-78.
6. Clarke A. G., and Kendall M. D. 1994. The thymus in pregnancy: The interplay of neural, endocrine, and immune influences. Immunol. Today 15:545-551.
7. Ding J., and Zhu B. T. 2008. Unique effect of the pregnancy hormone estriol on antigen-induced production of specific antibodies in female BALB/c mice. Steroids 73:289-298.
8. Elloso M. M., Phiel K., Henderson R. A., Harris H. A., and Adelman S. J. 2005. Suppression of experimental autoimmune encephalomyelitis using estrogen receptor-selective ligands. J. Endocrinol. 185:243-252.
9. Fotsis T. 1987. The multicomponent analysis of estrogens in urine by ion exchange chromatography and GC-MS. II. Fractionation and quantitation of the main groups of estrogen conjugates. J. Steroid Biochem. 28:215-226.
10. Funeshima-Fuji N., Fujino M., Xie L., Kimura H., Takahara S., Ezaki T., Zhu B. T., and Li X. K. 2009. Prolongation of rat major histocompatibility complex-compatible cardiac allograft survival during pregnancy. J. Heart Lung Transplant. 28:176-182.
11. Hitti E., and Kotlyarov A. 2007. The ERK and p38MAPK pathways as targets for anti-inflammatory therapy. Anti-inflamm. Anti-allergy Agents Med. Chem. 6:85-97.
12. Igarashi H., Kouro T., Yokota T., Comp P. C., and Kincade P. W. 2001. Age and stage dependency of estrogen receptor expression by lymphocyte precursors. Proc. Natl. Acad. Sci. USA 98:15131-15136.
13. Jansson L., Olsson T., and Holmdahl R. 1994. Estrogen induces a potent suppression of experimental autoimmune encephalomyelitis and collagen-induced arthritis in mice. J. Neuroimmunol. 53:203-207.
14. Johnston B. A., Eisen H., and Fry D. 1991. An evaluation of several adjuvant emulsion regimens for the production of polyclonal antisera in rabbits. Lab. Anim. Sci. 41:15-21.
15. Lang T. J. 2004. Estrogen as an immunomodulator. Clin. Immunol. 113:224-230.
16. Maret A., Coudert J. D., Garidou L., Foucras G., Gourdy P., Krust A., Dupont S.. Chambon P., Druet P., Bayard F., and Guery J. C. 2003. Estradiol enhances primary antigen-specific CD4 T-cell responses and TH1 development in vivo. Essential role of estrogen receptor-a expression in hematopoietic cells. Eur. J. Immunol. 33:512-521.
17. Novotny E. A., Raveche E. S., Sharrow S., Ottinger M., and Steinberg A. D. 1983. Analysis of thymocyte subpopulations following treatment with sex hormones. Clin. Immunol. Immunopathol. 28:205-217.
18. Palaszynski K. M., Liu H., Loo K. K., and Voskuhl R. R. 2004. Estriol treatment ameliorates disease in males with experimental autoimmune encephalomyelitis: Implications for multiple sclerosis. J. Neuroimmunol. 149:84-89.
19. Pernis A. B. 2007. Estrogen and CD4+ T-cells. Curr. Opin. Rheumatol. 19:414-420.
20. Polanczyk M., Zamora A., Subramanian S., Matejuk A., Hess D. L., Blankenhorn E. P., Teuscher C., Vandenbark A. A., and Offner H. 2003. The protective effect of 17ß- estradiol on experimental autoimmune encephalomyelitis is mediated through estrogen receptor-a. Am. J. Pathol. 163:1599-1605.
21. Qin H. Y., Sadelain M. W., Hitchon C., Lauzon J., and Singh B. 1993. Complete Freund's adjuvant-induced T-cells prevent the development and adoptive transfer of diabetes in non- obese diabetic mice. J. Immunol. 150:2072-2080.
22. Sakazaki H., Ueno H., and Nakamuro K. 2002. Estrogen receptor-a in mouse splenic lymphocytes: Possible involvement in immunity. Toxicol. Lett. 133:221-229.
23. Salem M. L., Hossain M. S., and Nomoto K. 2000. Mediation of the immunomodulatory effect of ß-estradiol on inflammatory responses by inhibition of recruitment and activation of inflammatory cells and their gene expression of TNFa and IFN?. Int. Arch. Allergy Immunol. 121:235-245.
24. Smithson G., Medina K., Ponting I., and Kincade P. W. 1995. Estrogen suppresses stromal cell-dependent lymphopoiesis in culture. J. Immunol. 155:3409-3417.
25. Soldan S. S., Retuerto A. I. A., Sicotte N. L., and Voskuhl R. R. 2003. Immune modulation in multiple sclerosis patients treated with the pregnancy hormone estriol. J. Immunol. 171:6267-6274.
26. Staples J. E., Gasiewicz T. A., Fiore N. C., Lubahn D. B., Korach K. S., and Silverstone A. E. 1999. Estrogen receptor-a is necessary in thymic development and estradiol-induced thymic alterations. J. Immunol. 163:4168-4174.
27. Tang H., Nishishita T., Fitzgerald T., Landon E. J., Inagami T. 2000. Inhibition of AT1 receptor internalization by concanavalin A blocks angiotensin II-induced ERK activation in vascular smooth muscle cells. Involvement of epidermal growth factor receptor proteolysis but not AT1 receptor internalization. J. Biol. Chem. 275:13420-13426.
28. Utsuyama M., and Hirokawa K. 1989. Hypertrophy of the thymus and restoration of immune functions in mice and rats by gonadectomy. Mech. Ageing Dev. 47:175-185.
29. Wang J. X, Tang W., Yang Z. S., Wan J., Shi L. P., Zhang Y., Zhou R., Ni J., Hou L. F., Zhou Y., He P. L., Yang Y. F., Li Y., Zuo J. P. 2007. Suppressive effect of a novel water-soluble artemisinin derivative SM905 on T cell activation and proliferation in vitro and in vivo. Eur. J. Pharmacol. 564: 211-218.
30. Zhang Y., Graubard B. I., Klebanoff M. A., Ronckers C., Stanczyk F. Z. Longnecker M. P., and McGlynn K. A. 2005. Maternal hormone levels among populations at high and low risk of testicular germ cell cancer. Br. J. Cancer 92:1787-1793.
31. Zhou R., Zheng S. X., Tang W., He P. L., Li X. Y., Yang Y. F., Li Y. C., Geng J. G., and Zuo J. P. 2006. Inhibition of inducible nitric-oxide synthase expression by (5R)-5-hydroxy-triptolide (LLDT-8) in interferon-? and bacterial lipopolysaccharide-stimulated macrophages. J. Pharmacol. Exp. Ther. 316:121-128.
32. Zhu B. T. 2008. Is it necessary to control the level of estrogen receptor-a and -ß activation in post-menopausal hormone replacement therapy in order to achieve the optimal outcome? Mol. Med. Reports 1:15-20.
33. Zhu B. T., and Conney A. H. 1998. Functional role of estrogen metabolism in target cells: Review and perspectives. Carcinogenesis 19:1-27.
34. Zhu B. T., Han G. Z., Shim J. Y., Wen Y., and Jiang X. R. 2006. Quantitative structure- activity relationship of various endogenous estrogen metabolites for human estrogen receptor-a and -ß subtypes: Insights into the structural determinants favoring a differential subtype binding. Endocrinology 147:4132-4150.