Dynamic virulence: Real-time assessment of intracellular pathogenesis links cryptococcus neoformans phenotype with clinical outcome

mBio

Volumn 2, Issue 5, 2011, Pages

  Mansour, Michael K ^a   Vyas, Jatin M ^a   Levitz, Stuart M ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTIVE IMMUNITY; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CRYPTOCOCCUS NEOFORMANS; FLOW CYTOMETRY; FUNGAL STRAIN; FUNGAL VIRULENCE; FUNGUS ISOLATION; GENE EXPRESSION PROFILING; IMMUNE RESPONSE; LYMPHOCYTE DEPLETION; MACROPHAGE; NONHUMAN; NOTE; ORGANISMAL INTERACTION; PHAGOCYTOSIS; PHENOTYPE; PRIORITY JOURNAL;

FILOBASIDIELLA NEOFORMANS;

EID: 80455127316     PISSN: None     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.00217-11     Document Type: Note

References (9)

1. Park BJ, et al. 2009. Estimation of the current global burden of cryptococ-cal meningitis among persons living with HIV/AIDS. AIDS 23:525-530.
2. Perfect JR, et al. 2010. Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the Infectious Diseases Society of America. Clin. Infect. Dis. 50:291-322.
3. Kidd SE, et al. 2004. A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada). Proc. Natl. Acad. Sci. U. S. A. 101:17258-17263.
4. Steenbergen JN, Shuman HA, Casadevall A. 2001. Cryptococcus neofor-mans interactions with amoebae suggest an explanation for its virulence and intracellular pathogenic strategy in macrophages. Proc. Natl. Acad. Sci. U. S. A. 98:15245-15250.
5. Alanio A, Desnos-Ollivier M, Dromer F. 2011. Dynamics of Cryptococcus neoformans-macrophage interactions reveal that fungal background influences outcome during cryptococcal meningoencephalitis in humans. mBio 2:e00158-11.
6. Levitz SM. 2010. Innate recognition of fungal cell walls. PLoS Pathog. 6:e1000758.
7. Kasperkovitz PV, Cardenas ML, Vyas JM. 2010. TLR9 is actively recruited to Aspergillus fumigatus phagosomes and requires the N-terminal proteo-lytic cleavage domain for proper intracellular trafficking. J. Immunol. 185: 7614-7622.
8. Bozza S, et al. 2002. Dendritic cells transport conidia and hyphae of Aspergillus fumigatus from the airways to the draining lymph nodes and initiate disparate The responses to the fungus. J. Immunol. 168: 1362-1371.
9. Ma H, et al. 2009. The fatal fungal outbreak on Vancouver Island is char-acterizedbyenhanced intracellular parasitism driven bymitochondrial regulation. Proc. Natl. Acad. Sci. U. S. A. 106:12980-12985.