Influence of lipid type on bis (2-ethylhexyl)phthalate (DEHP) leaching from infusion line sets in parenteral nutrition

Journal of Parenteral and Enteral Nutrition

Volumn 35, Issue 6, 2011, Pages 770-775

  Bagel, Sandrine ^a   Dessaigne, Bérangère ^a   Bourdeaux, Daniel ^a,b   Boyer, Anne ^a,b   Bouteloup, Corinne ^c   Bazin, Jean Etienne ^c   Chopineau, Jean ^a,b   Sautou, Valérie ^a,b  

^a SERVICE DE RHUMATOLOGIE   (France)

^b UNIVERSITÉ CLERMONT AUVERGNE   (France)

^c UNIVERSITY HOSPITAL OF CLERMONT FERRAND   (France)

Author keywords

bis(ethylhexyl)phthalate; intravenous fat emulsion (IVFE); leaching; olive oil; parenteral nutrition

Indexed keywords

CLINOLEIC; COCONUT OIL; COD LIVER OIL; INTRALIPID; LIPID EMULSION; LIPIDEM; MEDIALIPIDE; OLIVE OIL; OMEGAVEN; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; POLYVINYLCHLORIDE; SOYBEAN OIL EMULSION; STRUCTOLIPID; UNCLASSIFIED DRUG;

ARTICLE; HUMAN; INFUSION SYSTEM; LEACHING; LIPID COMPOSITION; LIQUID CHROMATOGRAPHY; MASS FRAGMENTOGRAPHY; PARENTERAL NUTRITION; PRIORITY JOURNAL;

CHROMATOGRAPHY, LIQUID; DIETARY FATS; DIETHYLHEXYL PHTHALATE; FAT EMULSIONS, INTRAVENOUS; FISH OILS; HUMANS; PARENTERAL NUTRITION; PLANT OILS; POLYVINYL CHLORIDE; SOYBEAN OIL;

GLYCINE MAX;

EID: 80455123721     PISSN: 01486071     EISSN: None     Source Type: Journal    
DOI: 10.1177/0148607111414021     Document Type: Article

References (20)

1. Safety Assessment of Di(2-ethylhexyl)phthlate (DEHP) Release From Medical Devices. Rockville, MD: FDA ; 2001 :
2. Hinberg I EAP on DEHP in Medical Devices MDB Report: An Exposure and Toxicity Assessment. Ottawa: Health Canada ; 2002 :
3. Heudorf U, Mersch-Sundermann V, Angerer J. Phthalates: toxicology and exposure. Int J Hyg Environ Health. 2007 ; 210: 623-634 (Pubitemid 47539285)
4. Preliminary Report on the Safety of Medical Devices Containing DEHP-Plasticized PVC or Other Plasticizers on Neonates and Other Groups Possibly at Risk. Brussels: European Commission ; 2008 :
5. Opinion on the Results of a Second Risk Assessment of Bis(2-ethylhexyl) phthalate (DEHP). Human Health part. Brussels: European Commission ; 2004 :
6. Expert Panel Re-evaluation of DEHP: Meeting Summary, October 14 2005. Research Triangle Park, NC: National Toxicology Program ; 2000 :
7. Loff S, Kabs F, Witt K, et al. Polyvinylchloride infusion lines expose infants to large amounts of toxic plasticizers. J Pediatr Surg. 2000 ; 35 (12). 1775-1781
8. Loff S, Kabs F, Subotic U, et al. Kinetics of diethylhexylphtalate extraction from polyvinylchloride infusion lines. JPEN J Parenter Enteral Nutr. 2002 ; 26 (5). 305-309 (Pubitemid 34913120)
9. Loff S, Subotic U, Reinicke F, Wischmann H, Brade J. Extraction of diethylhexylphtalate from infusion lines of various material, length and brand by lipid emulsions. J Pediatr Gastroenterol Nutr. 2004 ; 39: 341-345
10. Loff S, Hannmann T, Subotic U, Reinecke FM, Wischmann H, Brade J. Extraction of diethylhexylphtalate by home parenteral nutrition from polyvinylchloride infusion lines commonly used in the home. J Pediatr Gastroenterol Nutr. 2008 ; 47: 81-86
11. Kambia K, Dine T, Gressier B, et al. Evaluation of childhood exposure to di(2-ethylhexyl) phthalate from perfusion kits during long-term parenteral nutrition. Int J Pharm. 2003 ; 262: 83-91 (Pubitemid 36966696)
12. Bagel-Boithias S, Sautou-Miranda V, Bourdeaux D, et al. Leaching of diethylhexylphtalate from multilayer tubing into etoposide infusion solutions. Am J Health Syst Pharm. 2005 ; 62 (2). 182-188 (Pubitemid 40674549)
13. Bourdeaux D, Sautou-Miranda V, Bagel-Boithias S, Boyer A, Chopineau J. Analysis by liquid chromatography and infrared spectrometry of di(2-ethylhexyl)phthalate released by multilayer infusion tubing. J Pharm Biomed Anal. 2004 ; 35: 57-64 (Pubitemid 38368860)
14. European Union Risk Assessment Report for Bis(2-ethylhexyl) phthalate. Ispra, Italy: ECB ; 2006 :
15. Causse R, Sirdey T. Paris: ; 2009 :
16. von Rettberg H, Hannman T, Subotic U, et al. Use of di(2-Ethylhexyl) phthalate-containing infusion system increases the risk for cholestasis. Pediatrics. 2009 ; 24: 710-716
17. Gourlay T, Samartzis I, Stefanou D, Taylor K. Inflammatory response of rat and human neutrophils exposed to di(2-Ethylhexyl)phthalate plasticized polyvinyl chloride. Artif Organs. 2003 ; 27 (3). 256-260 (Pubitemid 36423482)
18. Gourlay T, Stefanou D, Asimakopoulos G, Taylor K. The effect of circuit surface area on CD11b (mac-1) expression in a rat recirculation model. Artif Organs. 2001 ; 25 (6). 475-479 (Pubitemid 32868570)
19. Carpentier YA, Deckelbaum RJ, Dupont I, Haumont D, Siderova VS Traité de nutrition artificielle de l'adulte. 2 nd ed.Paris: Springer; 2001:537-545. Paris: Springer ; 2001: 537-545.
20. Wanten G. An update on parenteral lipids and immune function: only smoke, or is there any fire?. Clin Nutr Metab Care. 2006 ; 9: 79-83 (Pubitemid 44090028)