메뉴 건너뛰기




Volumn 27, Issue 10, 2011, Pages 833-841

Cancer immunotherapy: Recent breakthroughs and perspectives;Immunothérapie des cancers: Succès récents et perspectives

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; CANCER VACCINE; MONOCLONAL ANTIBODY; TUMOR ANTIGEN; TUMOR PROTEIN;

EID: 80455123666     PISSN: 07670974     EISSN: None     Source Type: Journal    
DOI: 10.1051/medsci/20112710011     Document Type: Review
Times cited : (13)

References (60)
  • 1
    • 0027054597 scopus 로고
    • Current status of Interleukin-2 therapy in cancer
    • DOI 10.1016/0753-3322(92)90005-R
    • Tartour E, Mathiot C, Fndman WH. Current status of interleukin-2 therapy in cancer. Biomed Pharmacother 1992; 46 :473-84. (Pubitemid 23041384)
    • (1992) Biomedicine and Pharmacotherapy , vol.46 , Issue.10 , pp. 473-484
    • Tartour, E.1    Mathiot, C.2    Fridman, W.H.3
  • 2
    • 77956545725 scopus 로고    scopus 로고
    • Long-lasting antitumor protection by anti-CD20 antibody through cellular immune response
    • Abes R, Gelize E, Fridman WH, et al. Long-lasting antitumor protection by anti-CD20 antibody through cellular immune response. Blood 2010; 116: 926-34.
    • (2010) Blood , vol.116 , pp. 926-934
    • Abes, R.1    Gelize, E.2    Fridman, W.H.3
  • 4
    • 74749084437 scopus 로고    scopus 로고
    • Anticorps et tumeurs solides: Cibles etablies et pistes prometteuses
    • (Paris)
    • Bodmer A, Goetsch L, Favet L, et al. Anticorps et tumeurs solides: cibles etablies et pistes prometteuses. Med Sci (Paris) 2009;25:1090-8.
    • (2009) Med Sci , vol.25 , pp. 1090-1098
    • Bodmer, A.1    Goetsch, L.2    Favet, L.3
  • 5
    • 77649193013 scopus 로고    scopus 로고
    • Immune infiltration in human tumors: A prognostic factor that should not be ignored
    • Pages F, Galon J, Dieu-Nosjean MC, et al. Immune infiltration in human tumors: a prognostic factor that should not be ignored. Oncogene 2010; 29:1093-102.
    • (2010) Oncogene , vol.29 , pp. 1093-1102
    • Pages, F.1    Galon, J.2    Dieu-Nosjean, M.C.3
  • 6
    • 65249173447 scopus 로고    scopus 로고
    • Adoptive cell therapy for the treatment of patients with metastatic melanoma
    • Rosenberg SA, Dudley ME. Adoptive cell therapy for the treatment of patients with metastatic melanoma. CurrOpin Immunol 2009; 21:233-40.
    • (2009) CurrOpin Immunol , vol.21 , pp. 233-240
    • Rosenberg, S.A.1    Dudley, M.E.2
  • 7
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • Kantoff PW, Higano CS, Shore ND, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med 2010; 363 :411-22.
    • (2010) N Engl J Med , vol.363 , pp. 411-422
    • Kantoff, P.W.1    Higano, C.S.2    Shore, N.D.3
  • 8
    • 79957831345 scopus 로고    scopus 로고
    • Gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma
    • Schwartzentruber DJ, Lawson DH, Richards JM, et al. gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma. N Engl J Med 2011; 364:2119-27.
    • (2011) N Engl J Med , vol.364 , pp. 2119-2127
    • Schwartzentruber, D.J.1    Lawson, D.H.2    Richards, J.M.3
  • 9
    • 79958264390 scopus 로고    scopus 로고
    • Vaccination with patient-specific tumor-derived antigen in first remission improves disease-free survival in follicular lymphoma
    • Schuster SJ, Neelapu SS, Gause BL, et al. Vaccination with patient-specific tumor-derived antigen in first remission improves disease-free survival in follicular lymphoma. J Clin Oncol 2011; 29 : 2787-94.
    • (2011) J Clin Oncol , vol.29 , pp. 2787-2794
    • Schuster, S.J.1    Neelapu, S.S.2    Gause, B.L.3
  • 10
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert C, Thomas L, Bondarenko I, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 2011; 364: 2517-26.
    • (2011) N Engl J Med , Issue.364 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3
  • 11
    • 64549156573 scopus 로고    scopus 로고
    • Treatment selection for patients with metastatic renal cell carcinoma : Identification of features favoring upfront IL-2-based immunotherapy
    • Atkins MB. Treatment selection for patients with metastatic renal cell carcinoma : identification of features favoring upfront IL-2-based immunotherapy. Med Oncol 2009; 26 (suppl 1): 18-22.
    • (2009) Med Oncol , vol.26 , Issue.SUPPL. 1 , pp. 18-22
    • Atkins, M.B.1
  • 13
    • 4644324025 scopus 로고    scopus 로고
    • Cancer immunotherapy: Moving beyond current vaccines
    • DOI 10.1038/nm1100
    • Rosenberg SA, yangJC, Restifo NP. Cancer immunotherapy: moving beyond current vaccines. Nat Med 2004 ; 10 : 909-15. (Pubitemid 39273730)
    • (2004) Nature Medicine , vol.10 , Issue.9 , pp. 909-915
    • Rosenberg, S.A.1    Yang, J.C.2    Restifo, N.P.3
  • 16
    • 68249133652 scopus 로고    scopus 로고
    • Pretreatment frequency of circulating IL-17. CD4. T-cells, but not Tregs, correlates with clinical response to whole-cell vaccination in prostate cancer patients
    • Derhovanessian E, Adams V, Hahnel K, et al. Pretreatment frequency of circulating IL-17. CD4. T-cells, but not Tregs, correlates with clinical response to whole-cell vaccination in prostate cancer patients. Int J Cancer 2009 ; 125 :1372-9.
    • (2009) Int J Cancer , vol.125 , pp. 1372-1379
    • Derhovanessian, E.1    Adams, V.2    Hahnel, K.3
  • 17
    • 78649237899 scopus 로고    scopus 로고
    • Evaluation of baseline serum C-reactive protein (CRP) and benefit from tremelimumab compared to chemotherapy in first-line melanoma. ASCO meeting abstracts
    • th2010 (abstract)
    • th, 2010.; J Clin Oncol 2010; 28:2609 (abstract).
    • (2010) J Clin Oncol , Issue.28 , pp. 2609
    • Marshall, M.1    Ribas, A.2    Huang, B.3
  • 18
    • 77955406159 scopus 로고    scopus 로고
    • Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer
    • Shrimali RK, yu Z, Theoret MR, et al. Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer. Cancer Res 2010;70:6171-80.
    • (2010) Cancer Res , vol.70 , pp. 6171-6180
    • Shrimali, R.K.1    Yu, Z.2    Theoret, M.R.3
  • 19
    • 66849095271 scopus 로고    scopus 로고
    • Serum vascular endothelial growth factor and fibronectin predict clinical response to high-dose interleukin-2 therapy
    • Sabatino M, Kim-Schulze S, Panelli MC, et al. Serum vascular endothelial growth factor and fibronectin predict clinical response to high-dose interleukin-2 therapy.; J Clin Oncol 2009; 27 : 2645-52.
    • (2009) J Clin Oncol , vol.27 , pp. 2645-2652
    • Sabatino, M.1    Kim-Schulze, S.2    Panelli, M.C.3
  • 20
    • 77949780426 scopus 로고    scopus 로고
    • Biomolecular network reconstruction identifies T-cell homing factors associated with survival in colorectal cancer
    • Mlecnik B, Tosolini M, Charoentong P, et al. Biomolecular network reconstruction identifies T-cell homing factors associated with survival in colorectal cancer. Gastroenterology 2010; 138:1429-40.
    • (2010) Gastroenterology , vol.138 , pp. 1429-1440
    • Mlecnik, B.1    Tosolini, M.2    Charoentong, P.3
  • 21
    • 79953087601 scopus 로고    scopus 로고
    • Molecular profiling to identify relevant immune resistance mechanisms in the tumor microenvironment
    • Gajewski TF, Fuertes M, Spaapen R, et al. Molecular profiling to identify relevant immune resistance mechanisms in the tumor microenvironment. Curr Opin Immunol 2010 ; 23 : 286-92.
    • (2010) Curr Opin Immunol , vol.23 , pp. 286-292
    • Gajewski, T.F.1    Fuertes, M.2    Spaapen, R.3
  • 24
    • 51349124402 scopus 로고    scopus 로고
    • Clinical development of MVA-based therapeutic cancer vaccines
    • Acres B, Bonnefoy jy. J Clinical development of MVA-based therapeutic cancer vaccines. Exp Rev Vaccines 2008 ; 7 : 889-93.
    • (2008) Exp Rev Vaccines , vol.7 , pp. 889-893
    • Acres, B.1    Bonnefoy, J.Y.2
  • 25
    • 70350772293 scopus 로고    scopus 로고
    • Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia
    • Kenter GG, Welters MJ, Valentijn AR, et al. Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia. N Engl J Med 2009; 361:1838-47.
    • (2009) N Engl J Med , vol.361 , pp. 1838-1847
    • Kenter, G.G.1    Welters, M.J.2    Valentijn, A.R.3
  • 26
    • 42549138499 scopus 로고    scopus 로고
    • Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines
    • DOI 10.1038/nrc2373, PII NRC2373
    • Melief CJ, van der Burg SH. Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines. Nat Rev Cancer 2008 ; 8 : 351-60. (Pubitemid 351589701)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.5 , pp. 351-360
    • Melief, C.J.M.1    Van Der Burg, S.H.2
  • 27
    • 67649961713 scopus 로고    scopus 로고
    • Placebo-controlled phase III trial of patient-specific immunotherapy with mitumprotimut-T and granulocyte-macrophage colony-stimulating factor after rituximab in patients with follicular lymphoma
    • Freedman A, Neelapu SS, Nichols C, et al. Placebo-controlled phase III trial of patient-specific immunotherapy with mitumprotimut-T and granulocyte-macrophage colony-stimulating factor after rituximab in patients with follicular lymphoma.; J Clin Oncol 2009; 27: 3036-43.
    • (2009) J Clin Oncol , vol.27 , pp. 3036-3043
    • Freedman, A.1    Neelapu, S.S.2    Nichols, C.3
  • 28
    • 34748815649 scopus 로고    scopus 로고
    • GSK's antigen-specific cancer immunotherapy programme: Pilot results leading to Phase III clinical development
    • DOI 10.1016/j.vaccine.2007.06.038, PII S0264410X07007049
    • Brichard VG, Lejeune D. GSK's antigen-specific cancer immunotherapy programme : pilot results leading to Phase III J Clinical development. Vaccine 2007 ; 25 (suppl 2): B61-71. (Pubitemid 47488551)
    • (2007) Vaccine , vol.25 , Issue.SUPPL. 2
    • Brichard, V.G.1    Lejeune, D.2
  • 30
    • 77957273591 scopus 로고    scopus 로고
    • Improved endpoints for cancer immunotherapy trials
    • Hoos A, Eggermont AM, Janetzki S, et al. Improved endpoints for cancer immunotherapy trials. ; J Natl Cancer Inst 2010 ; 102 :1388-97.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 1388-1397
    • Hoos, A.1    Eggermont, A.M.2    Janetzki, S.3
  • 31
    • 77949895922 scopus 로고    scopus 로고
    • Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castrationresistant prostate cancer
    • Kantoff PW, Schuetz TJ, Blumenstein BA, et al. Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castrationresistant prostate cancer.; J Clin Oncol 2010 ; 28 :1099-105.
    • (2010) J Clin Oncol , vol.28 , pp. 1099-1105
    • Kantoff, P.W.1    Schuetz, T.J.2    Blumenstein, B.A.3
  • 34
  • 35
    • 24944459890 scopus 로고    scopus 로고
    • Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4
    • Attia P, Phan GO, Maker AV, et al. Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4.; J Clin Oncol 2005 ; 23:6043-53.
    • (2005) J Clin Oncol , vol.23 , pp. 6043-6053
    • Attia, P.1    Phan, G.O.2    Maker, A.V.3
  • 36
    • 78149488860 scopus 로고    scopus 로고
    • CD20 B cells : The other tumor-infiltrating lymphocytes
    • Nelson BH. CD20. B cells : the other tumor-infiltrating lymphocytes.; Immunol 2010; 185 : 4977-82.
    • (2010) Immunol , vol.185 , pp. 4977-4982
    • Nelson, B.H.1
  • 37
    • 50349090322 scopus 로고    scopus 로고
    • A phase II study of Tg4010 (Mva-Mud-112) in association with chemotherapy in patients with stage 11 l/l V Non-small cell lung cancer
    • Ramlau R, Quoix E, Rolski J, et al. A phase II study of Tg4010 (Mva-Mud-112) in association with chemotherapy in patients with stage 11 l/l V Non-small cell lung cancer.; Thome Oncol 2008; 3:735-44.
    • (2008) Thome Oncol , vol.3 , pp. 735-744
    • Ramlau, R.1    Quoix, E.2    Rolski, J.3
  • 39
    • 58149380739 scopus 로고    scopus 로고
    • Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses
    • Leibundgut-Landmann S, Osorio F, Brown GD, et al. Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses. Blood 2008 ; 112 :4971-80.
    • (2008) Blood , vol.112 , pp. 4971-4980
    • Leibundgut-Landmann, S.1    Osorio, F.2    Brown, G.D.3
  • 40
    • 34548731406 scopus 로고    scopus 로고
    • Eradication of large tumors in mice by a tritherapy targeting the innate, adaptive, and regulatory components of the immune system
    • DOI 10.1158/0008-5472.CAN-07-0321
    • Berraondo P, Nouze C, Preville X, et al. Eradication of large tumors in mice by a tritherapy targeting the innate, adaptive, and regulatory components of the immune system. Cancer Res 2007 ; 67 : 8847-55. (Pubitemid 47437461)
    • (2007) Cancer Research , vol.67 , Issue.18 , pp. 8847-8855
    • Berraondo, P.1    Nouze, C.2    Preville, X.3    Ladant, D.4    Leclerc, C.5
  • 41
    • 38049021296 scopus 로고    scopus 로고
    • B Subunit of Shiga toxin-Based vaccines synergize with (alpha)-Galactosylceramide to break tolerance against self antigen and elicit antiviral immunity
    • Adotevi 0, Vingert B, Freyburger L, et al. B Subunit of Shiga toxin-based vaccines synergize with (alpha)-galactosylceramide to break tolerance against self antigen and elicit antiviral immunity. ; J Immunol 2007; 179 : 3371-9.
    • (2007) J Immunol , vol.179 , pp. 3371-3379
    • Adotevi, O.1    Vingert, B.2    Freyburger, L.3
  • 42
    • 33646569995 scopus 로고    scopus 로고
    • The Shiga toxin B-subunit targets antigen in vivo to dendritic cells and elicits anti-tumor immunity
    • Vingert B, Adotevi 0, Patin D, et al. The Shiga toxin B-subunit targets antigen in vivo to dendritic cells and elicits anti-tumor immunity. Eur J Immunol 2006 ; 36 :1124-35.
    • (2006) Eur J Immunol , vol.36 , pp. 1124-1135
    • Vingert, B.1    Adotevi, O.2    Patin, D.3
  • 43
    • 70349211735 scopus 로고    scopus 로고
    • Tumor emergence is sensed by self-Specific CD44hi memory Tregs that create a dominant tolerogenic environment for tumors in mice
    • Darrasse-Jeze G, Bergot AS, Durgeau A, et al. Tumor emergence is sensed by self-specific CD44hi memory Tregs that create a dominant tolerogenic environment for tumors in mice.; J Clin Invest 2009; 119 : 2648-62.
    • (2009) J Clin Invest , vol.119 , pp. 2648-2662
    • Darrasse-Jeze, G.1    Bergot, A.S.2    Durgeau, A.3
  • 44
    • 77955411096 scopus 로고    scopus 로고
    • Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responses
    • USA
    • Welters MJ, Kenter GG, De Vos Van Steenwijk PJ, et al. Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responses. Proc Natl Acad Sci USA 2010; 107 : 11895-9.
    • (2010) Proc Natl Acad Sci , vol.107 , pp. 11895-11899
    • Welters, M.J.1    Kenter, G.G.2    De Vos Van Steenwijk, P.J.3
  • 45
    • 77957723967 scopus 로고    scopus 로고
    • Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8' T cell dysfunction in melanoma patients
    • Fourcade J, Sun Z, Benallaoua M, et al. Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8' T cell dysfunction in melanoma patients.; Exp Med 2010 ; 207 : 2175-86.
    • (2010) Exp Med , vol.207 , pp. 2175-2186
    • Fourcade, J.1    Sun, Z.2    Benallaoua, M.3
  • 46
    • 74949125667 scopus 로고    scopus 로고
    • BTLA mediates inhibition of human tumorspecific CD8. T cells that can be partially reversed by vaccination
    • Derre L, Rivals JP, Jandus C, et al. BTLA mediates inhibition of human tumorspecific CD8. T cells that can be partially reversed by vaccination.; J Clin Invest 2010; 120:157-67.
    • (2010) J Clin Invest , vol.120 , pp. 157-167
    • Derre, L.1    Rivals, J.P.2    Jandus, C.3
  • 47
    • 45549100198 scopus 로고    scopus 로고
    • The soluble alpha chain of interleukin-15 receptor: A proinflammatory molecule associated with tumor progression in head and neck cancer
    • Badoual C, Bouchaud G, Agueznay Nel H, et al. The soluble alpha chain of interleukin-15 receptor: a proinflammatory molecule associated with tumor progression in head and neck cancer. Cancer Res 2008; 68 : 3907-14.
    • (2008) Cancer Res , vol.68 , pp. 3907-3914
    • Badoual, C.1    Bouchaud, G.2    Agueznay Nel, H.3
  • 51
    • 70149113060 scopus 로고    scopus 로고
    • Therapeutic effects of ablative radiation on local tumor require CD8 T cells: Changing strategies for cancer treatment
    • Lee y, Auh SL, Wang Y, et al. Therapeutic effects of ablative radiation on local tumor require CD8 T cells: changing strategies for cancer treatment. Blood 2009; 114: 589-95.
    • (2009) Blood , vol.114 , pp. 589-595
    • Lee, Y.1    Auh, S.L.2    Wang, Y.3
  • 52
    • 0032741283 scopus 로고    scopus 로고
    • Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function
    • Gabnlovich Dl, Ishida T, Nadaf S, et al. Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function. J Clin Cancer Res 1999; 5 : 2963-70. (Pubitemid 29493976)
    • (1999) Clinical Cancer Research , vol.5 , Issue.10 , pp. 2963-2970
    • Gabrilovich, D.I.1    Ishida, T.2    Nadaf, S.3    Ohm, J.E.4    Carbone, D.P.5
  • 53
    • 78149281950 scopus 로고    scopus 로고
    • A decrease of regulatory T cells correlates with overall survival after Sunitmib-Based antiangiogenic therapy in metastatic renal cancer patients
    • Adotevi O, Pere H, Ravel P, et al. A decrease of regulatory T cells correlates with overall survival after sunitmib-based antiangiogenic therapy in metastatic renal cancer patients.; Immunother 2010; 33: 991-8.
    • (2010) Immunother , vol.33 , pp. 991-998
    • Adotevi, O.1    Pere, H.2    Ravel, P.3
  • 54
    • 63549105681 scopus 로고    scopus 로고
    • Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients
    • Ko JS, Zea AH, Rini Bl, et al. Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients. J Clin Cancer Res 2009; 15 : 2148-57.
    • (2009) J Clin Cancer Res , vol.15 , pp. 2148-2157
    • Ko, J.S.1    Zea, A.H.2    Rini, B.L.3
  • 55
    • 77957061892 scopus 로고    scopus 로고
    • Combining antiangiogenic therapy with immunotherapy exerts better therapeutical effects on large tumors in a woodchuck hepatoma model
    • USA
    • Huang KW, Wu HL, Lin HL, et at. Combining antiangiogenic therapy with immunotherapy exerts better therapeutical effects on large tumors in a woodchuck hepatoma model. Proc Natl Acad Sci USA 2010; 107 :14769-74.
    • (2010) Proc Natl Acad Sci , vol.107 , pp. 14769-14774
    • Huang, K.W.1    Wu, H.L.2    Lin, H.L.3
  • 56
    • 74749097572 scopus 로고    scopus 로고
    • Les anticorps: Mieux les connaître pour mieux s'en servir
    • (Paris)
    • Abès R, Dutertre CA, Teillaud JL Les anticorps: mieux les connaître pour mieux s'en servir. Med Sci (Paris) 2009 ; 25 :1011-9
    • (2009) Med Sci , vol.25 , pp. 1011-1019
    • Abès, R.1    Dutertre, C.A.2    Teillaud, J.L.3
  • 57
    • 80455123662 scopus 로고    scopus 로고
    • Anticorps anti-CTLA 4 : Une avancée thérapeutique majeure dans le traitement du melanome metastatique
    • (Paris)
    • Robert C, Mateus C. Anticorps anti-CTLA 4 : une avancée thérapeutique majeure dans le traitement du melanome metastatique. Med Sci (Paris) 2011;27:850-8.
    • (2011) Med Sci , Issue.27 , pp. 850-858
    • Robert, C.1    Mateus, C.2
  • 58
    • 33947509571 scopus 로고    scopus 로고
    • La calreticuline détermine I'lmmunogénicité de la chimiothérapie et de la radiothérapie antitumorales
    • (Paris)
    • Apetoh L, Ghiringhelli F, Zitvogel L. La calreticuline détermine I'lmmunogénicité de la chimiothérapie et de la radiothérapie antitumorales . Med Sci (Paris) 2007; 23 : 257-8.
    • (2007) Med Sci , vol.23 , pp. 257-258
    • Apetoh, L.1    Ghiringhelli, F.2    Zitvogel, L.3
  • 59
    • 53049087751 scopus 로고    scopus 로고
    • L'intrusion des régulateurs de I'épigénome mâle dans les cellules somatiques cancéreuses
    • (Paris)
    • Rousseaux S, Reynoird N, Gaucher J, Khochbin S. L'intrusion des régulateurs de I'épigénome mâle dans les cellules somatiques cancéreuses. Med Sci (Paris) 2008 ; 24: 735-41.
    • (2008) Med Sci , vol.24 , pp. 735-741
    • Rousseaux, S.1    Reynoird, N.2    Gaucher, J.3    Khochbin, S.4
  • 60
    • 80455176697 scopus 로고    scopus 로고
    • Role de CTLA-4 dans la cosignalisation négative du système immunitaire
    • (Paris)
    • Olive D, le Thi S, Xerri L, et al. Role de CTLA-4 dans la cosignalisation négative du système immunitaire. Med Sci (Paris) 2011; 27: 842-9.
    • (2011) Med Sci , Issue.27 , pp. 842-849
    • Olive, D.1    Le Thi, S.2    Xerri, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.