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Volumn 25, Issue 12, 2009, Pages 1090-1098

The potential of monoclonal antibodies in cancer: Established trastuzumab and cetuximab and promising targets IGF-IR and c-MET;Anticorps et tumeurs solides: Cibles établies et pistes prometteuses

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EID: 74749084437     PISSN: 07670974     EISSN: None     Source Type: Journal    
DOI: 10.1051/medsci/200925121090     Document Type: Review
Times cited : (5)

References (41)
  • 1
    • 34347395733 scopus 로고    scopus 로고
    • Trastuzumab mechanism of action and use in clinical practice
    • Hudis CA. Trastuzumab mechanism of action and use in clinical practice. N Engl J Med 2007 ; 357 : 39-51.
    • (2007) N Engl J Med , vol.357 , pp. 39-51
    • Hudis, C.A.1
  • 2
    • 0024337144 scopus 로고
    • Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
    • Slamon DJ, Godolphin W, Jones LA, et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 1989 ; 244 : 707-12.
    • (1989) Science , vol.244 , pp. 707-712
    • Slamon, D.J.1    Godolphin, W.2    Jones, L.A.3
  • 3
    • 0032850677 scopus 로고    scopus 로고
    • Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2 overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
    • Cobleigh MA, Vogel CL, Tripathy D, et al. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2 overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol 1999 ; 17 : 2639-48.
    • (1999) J Clin Oncol , vol.17 , pp. 2639-2648
    • Cobleigh, M.A.1    Vogel, C.L.2    Tripathy, D.3
  • 4
    • 0036467826 scopus 로고    scopus 로고
    • Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
    • Vogel CL, Cobleigh MA, Tripathy D, et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 2002 ; 20 : 719-26.
    • (2002) J Clin Oncol , vol.20 , pp. 719-726
    • Vogel, C.L.1    Cobleigh, M.A.2    Tripathy, D.3
  • 5
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl Med 2001 ; 344 : 783-92.
    • (2001) N Engl Med , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 6
    • 26844536978 scopus 로고    scopus 로고
    • Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    • Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 2005 ; 353 : 1673-84.
    • (2005) N Engl J Med , vol.353 , pp. 1673-1684
    • Romond, E.H.1    Perez, E.A.2    Bryant, J.3
  • 7
    • 26844503270 scopus 로고    scopus 로고
    • Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
    • Piccart-Gebhart M, Procter M, Leyland-Jones B, et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 2005 ; 353 : 1659-72.
    • (2005) N Engl J Med , vol.353 , pp. 1659-1672
    • Piccart-Gebhart, M.1    Procter, M.2    Leyland-Jones, B.3
  • 8
    • 33846297680 scopus 로고    scopus 로고
    • Neoadjuvant therapy with paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide chemotherapy and concurrent trastuzumab in huma epidermal growth factor receptor 2-positive operable breast cancer : An update of the initial randomized study population and data of additional patients treated with the same regimen
    • Buzdar AU, Valero V, Ibrahim NK, et al. Neoadjuvant therapy with paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide chemotherapy and concurrent trastuzumab in huma epidermal growth factor receptor 2-positive operable breast cancer : an update of the initial randomized study population and data of additional patients treated with the same regimen. Clin Cancer Res 2007 ; 13 : 228-33.
    • (2007) Clin Cancer Res , vol.13 , pp. 228-233
    • Buzdar, A.U.1    Valero, V.2    Ibrahim, N.K.3
  • 9
    • 34447306848 scopus 로고    scopus 로고
    • Trastuzumab: Mechanism of action, resistance and future perspective in HER2-overexpressing breast cancer
    • Valabrega G, Montemurro F, Aglietta M. Trastuzumab: mechanism of action, resistance and future perspective in HER2-overexpressing breast cancer. Ann Oncol 2007 ; 18 : 977-84.
    • (2007) Ann Oncol , vol.18 , pp. 977-984
    • Valabrega, G.1    Montemurro, F.2    Aglietta, M.3
  • 10
    • 74749106718 scopus 로고    scopus 로고
    • Van Custem E, Kang Y, Chung H, et al. Efficacy results from the ToGA trials: a phase III study of trastuzumab added to standard chemotherapy in first-line human epidermal growth factor receptor 2 (HER2)-positive advanced gastric cancer. J Clin Oncol 2009 ; 27 : 18S (abstract LBA4509).
    • Van Custem E, Kang Y, Chung H, et al. Efficacy results from the ToGA trials: a phase III study of trastuzumab added to standard chemotherapy in first-line human epidermal growth factor receptor 2 (HER2)-positive advanced gastric cancer. J Clin Oncol 2009 ; 27 : 18S (abstract LBA4509).
  • 11
    • 40849147041 scopus 로고    scopus 로고
    • EGFR antagonists in cancer treatment
    • Ciordello F, Tortora G. EGFR antagonists in cancer treatment. N Engl J Med 2008 ; 358 : 1160-74.
    • (2008) N Engl J Med , vol.358 , pp. 1160-1174
    • Ciordello, F.1    Tortora, G.2
  • 12
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D, Humblet Y, Siena S, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004 ; 351 : 337-45.
    • (2004) N Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 13
    • 36148941301 scopus 로고    scopus 로고
    • Cetuximab for the treatment of colorectal cancer
    • Jonker DJ, O'Callaghan CJ, Karapetis CS, et al. Cetuximab for the treatment of colorectal cancer. N Engl J Med 2007 ; 357 : 2040-8.
    • (2007) N Engl J Med , vol.357 , pp. 2040-2048
    • Jonker, D.J.1    O'Callaghan, C.J.2    Karapetis, C.S.3
  • 14
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • Van Cutsem E, Köhne CH, Hitre E, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 2009 ; 360 : 1408-17.
    • (2009) N Engl J Med , vol.360 , pp. 1408-1417
    • Van Cutsem, E.1    Köhne, C.H.2    Hitre, E.3
  • 15
    • 59749091477 scopus 로고    scopus 로고
    • Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
    • ToI J, Koopman M, Cats A, Rodenburg CJ, et al. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N Engl J Med 2009 ; 360 : 563-72.
    • (2009) N Engl J Med , vol.360 , pp. 563-572
    • ToI, J.1    Koopman, M.2    Cats, A.3    Rodenburg, C.J.4
  • 16
    • 32144433159 scopus 로고    scopus 로고
    • Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
    • Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 2006 ; 354 : 567-78.
    • (2006) N Engl J Med , vol.354 , pp. 567-578
    • Bonner, J.A.1    Harari, P.M.2    Giralt, J.3
  • 17
    • 51649085865 scopus 로고    scopus 로고
    • Platinum-based chemotherapy plus cetuximab in head and neck cancer
    • Vermorken JB, Mesia R, Rivera F, et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med 2008 ; 359 : 1116-27.
    • (2008) N Engl J Med , vol.359 , pp. 1116-1127
    • Vermorken, J.B.1    Mesia, R.2    Rivera, F.3
  • 18
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefit from cetuximab in advanced colorectal cancer
    • Karapetis CS, Khambata-Ford S, Jonker DJ, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008 ; 359 : 1757-65.
    • (2008) N Engl J Med , vol.359 , pp. 1757-1765
    • Karapetis, C.S.1    Khambata-Ford, S.2    Jonker, D.J.3
  • 19
    • 0022800838 scopus 로고
    • Insulin-like growth factor I receptor primary structure: Comparison with insulin receptor suggests structural determinants that define functional specificity
    • Ullrich A, Gray A, Tam AW, et al. Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J 1986 ; 5 : 2503-12.
    • (1986) EMBO J , vol.5 , pp. 2503-2512
    • Ullrich, A.1    Gray, A.2    Tam, A.W.3
  • 20
    • 0024465470 scopus 로고
    • Immunological relationships between receptors for insulin and insulin-like growth factor I. Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptors
    • Soos MA, Siddle K. Immunological relationships between receptors for insulin and insulin-like growth factor I. Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptors. Biochem J 1989 ; 263 : 553-63.
    • (1989) Biochem J , vol.263 , pp. 553-563
    • Soos, M.A.1    Siddle, K.2
  • 21
    • 0027955344 scopus 로고
    • Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action
    • Kato H, Faria TN, Stannard B, et al. Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action. Mol Endocrinol 1994 ; 8 : 40-50.
    • (1994) Mol Endocrinol , vol.8 , pp. 40-50
    • Kato, H.1    Faria, T.N.2    Stannard, B.3
  • 22
    • 0028332092 scopus 로고
    • Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts
    • Sell C, Dumenil G, Deveaud C, et al. Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts, Mol Cell Biol 1994 ; 14 : 3604-12.
    • (1994) Mol Cell Biol , vol.14 , pp. 3604-3612
    • Sell, C.1    Dumenil, G.2    Deveaud, C.3
  • 23
    • 0031558028 scopus 로고    scopus 로고
    • The IGF-I receptor in cell growth, transformation and apoptosis
    • Baserga R, Hongo A, Rubini M, et al. The IGF-I receptor in cell growth, transformation and apoptosis. Biochim Biophys Acta 1997 ; 1332 : F105-F126.
    • (1997) Biochim Biophys Acta , vol.1332
    • Baserga, R.1    Hongo, A.2    Rubini, M.3
  • 24
    • 0035915421 scopus 로고    scopus 로고
    • Lu y, Zi X, Zhao Y, et al. Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). J Natl Cancer Inst 2001 ; 93 : 1852-7.
    • Lu y, Zi X, Zhao Y, et al. Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). J Natl Cancer Inst 2001 ; 93 : 1852-7.
  • 25
    • 46749156706 scopus 로고    scopus 로고
    • Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins
    • Guix M, Faber AC, Wang SE, et al. Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins. J Clin Invest 2008 ; 118 : 2609-19.
    • (2008) J Clin Invest , vol.118 , pp. 2609-2619
    • Guix, M.1    Faber, A.C.2    Wang, S.E.3
  • 26
    • 10344247119 scopus 로고    scopus 로고
    • A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts, lnt
    • Goetsch L, Gonzalez A, Leger O, et al. A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts, lnt J Cancer 2005 ; 113 : 316-28.
    • (2005) J Cancer , vol.113 , pp. 316-328
    • Goetsch, L.1    Gonzalez, A.2    Leger, O.3
  • 27
    • 9144234724 scopus 로고    scopus 로고
    • A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo
    • Burtrum D, Zhu Z, Lu D, et al. A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo. Cancer Res 2003 ; 63 : 8912-21.
    • (2003) Cancer Res , vol.63 , pp. 8912-8921
    • Burtrum, D.1    Zhu, Z.2    Lu, D.3
  • 28
    • 34548039766 scopus 로고    scopus 로고
    • Characterization of a recombinant, fully human monoclonal antibody directed against the human insulin-like growth factor-I receptor
    • Schnitzer T, Kuenkele KP, Rebers F, et al. Characterization of a recombinant, fully human monoclonal antibody directed against the human insulin-like growth factor-I receptor. Eur J Cancer 2006 ; 4 (suppl) : 66-7.
    • (2006) Eur J Cancer , vol.4 , Issue.SUPPL. , pp. 66-67
    • Schnitzer, T.1    Kuenkele, K.P.2    Rebers, F.3
  • 30
    • 34147140962 scopus 로고    scopus 로고
    • The glycotope-specific RAV12 monoclonal antibody induces oncosis in vitro and has antitumor activity against gastrointestinal adenocarcinoma tumor xenografts in vivo
    • Loo D, Pryer N, Young P, et al. The glycotope-specific RAV12 monoclonal antibody induces oncosis in vitro and has antitumor activity against gastrointestinal adenocarcinoma tumor xenografts in vivo. Mol Cancer Ther 2007 ; 6 : 856-65.
    • (2007) Mol Cancer Ther , vol.6 , pp. 856-865
    • Loo, D.1    Pryer, N.2    Young, P.3
  • 31
    • 23844521596 scopus 로고    scopus 로고
    • Inhibition of insulin-like growth factor-I receptor (IGFIR) signaling and tumor cell growth by a fully human neutralizing anti-IGF-IR antibody
    • Wang Y, Hailey J, Williams D, et al. Inhibition of insulin-like growth factor-I receptor (IGFIR) signaling and tumor cell growth by a fully human neutralizing anti-IGF-IR antibody. Mol Cancer Ther 2005 ; 4 : 1214-21.
    • (2005) Mol Cancer Ther , vol.4 , pp. 1214-1221
    • Wang, Y.1    Hailey, J.2    Williams, D.3
  • 32
    • 74749107968 scopus 로고    scopus 로고
    • Hariharan K, Dong J, Demarest S, et al. BIIB022, a fully human nonglycosylated g4P antibody targeting IGF-IR for cancer therapy. Houston (TX-USA) : AACR Meeting Abstracts (3 Molecular Targets Meeting), 2007 : B210.
    • Hariharan K, Dong J, Demarest S, et al. BIIB022, a fully human nonglycosylated g4P antibody targeting IGF-IR for cancer therapy. Houston (TX-USA) : AACR Meeting Abstracts (3 Molecular Targets Meeting), 2007 : B210.
  • 33
    • 20144386856 scopus 로고    scopus 로고
    • Combination therapy enhances the inhibition af tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871
    • Cohen BD, Baker DA, Soderstrom C, et al. Combination therapy enhances the inhibition af tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871. Clin Cancer Res 2005 ; 11 : 2063-73.
    • (2005) Clin Cancer Res , vol.11 , pp. 2063-2073
    • Cohen, B.D.1    Baker, D.A.2    Soderstrom, C.3
  • 34
    • 0032057514 scopus 로고    scopus 로고
    • Antitumor effects elicited by antisense-mediated downregulation of the insulin-like growth factor I receptor
    • Resnicoff M. Antitumor effects elicited by antisense-mediated downregulation of the insulin-like growth factor I receptor, Int J Mol Med 1998 ; 1 : 883-8.
    • (1998) Int J Mol Med , vol.1 , pp. 883-888
    • Resnicoff, M.1
  • 35
    • 33644555493 scopus 로고    scopus 로고
    • Yee D. Down-regulation of insulin receptor by antibodies against the type I insulin-like growth factor receptor: Implications for anti-insulin-like growth factor therapy in breast cancer
    • Sachdev D, Singh R, Fujita-Yamaguchi Y, Yee D. Down-regulation of insulin receptor by antibodies against the type I insulin-like growth factor receptor: implications for anti-insulin-like growth factor therapy in breast cancer. Cancer Res 2006 ; 66 : 2391-2402.
    • (2006) Cancer Res , vol.66 , pp. 2391-2402
    • Sachdev, D.1    Singh, R.2    Fujita-Yamaguchi, Y.3
  • 36
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman JA, Zejnullahu K, Mitsudomi T, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007 ; 316 : 1039-43.
    • (2007) Science , vol.316 , pp. 1039-1043
    • Engelman, J.A.1    Zejnullahu, K.2    Mitsudomi, T.3
  • 37
    • 40449113978 scopus 로고    scopus 로고
    • Met receptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cells
    • Shattuck DL, Miller JK, Carraway KL, III, Sweeney C. Met receptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cells. Cancer Res 2008 ; 68 : 1471-7.
    • (2008) Cancer Res , vol.68 , pp. 1471-1477
    • Shattuck, D.L.1    Miller, J.K.2    Carraway III, K.L.3    Sweeney, C.4
  • 38
    • 44449151030 scopus 로고    scopus 로고
    • Drug development of MET inhibitors: Targeting oncogene addiction and expedience
    • Comoglio PM, Giordano S, Trusolino L. Drug development of MET inhibitors: targeting oncogene addiction and expedience. Nat Rev Drug Discov 2008 ; 7 : 504-16.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 504-516
    • Comoglio, P.M.1    Giordano, S.2    Trusolino, L.3
  • 39
    • 33750683969 scopus 로고    scopus 로고
    • Novel one-armed anti-c-Met antibody inhibits glioblastoma growth in vivo
    • Martens T, Schmidt NO, Eckerich C, et al. Novel one-armed anti-c-Met antibody inhibits glioblastoma growth in vivo Clin Cancer Res 2006 ; 12 : 6144-52.
    • (2006) Clin Cancer Res , vol.12 , pp. 6144-6152
    • Martens, T.1    Schmidt, N.O.2    Eckerich, C.3


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