Sex differentiation: State of the art and future prospects;La différenciation du sexe: Acquis et perspectives

Medecine/Sciences

Volumn 27, Issue 10, 2011, Pages 859-865

  Pannetier, Maëlle ^a   Pailhoux, Éric ^a  

^a INRA Institut National de la Recherche Agronomique   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FORKHEAD TRANSCRIPTION FACTOR; FOXL2 PROTEIN, HUMAN; FOXL2 PROTEIN, MOUSE; HORMONE;

ANIMAL; BIOLOGICAL MODEL; FEMALE; GENE DOSAGE; GENETICS; GOAT; GROWTH, DEVELOPMENT AND AGING; HUMAN; MALE; MAMMAL; MORPHOGENESIS; MOUSE; OVARY; PHYSIOLOGY; PRENATAL DEVELOPMENT; REVIEW; SEX CHROMOSOME; SEX DETERMINATION PROCESS; SEX DIFFERENTIATION; SEXUAL DEVELOPMENT; SPECIES DIFFERENCE; SRY GENE; TESTIS;

ANIMALS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE DOSAGE; GENES, SRY; GOATS; HORMONES; HUMANS; MALE; MAMMALS; MICE; MODELS, BIOLOGICAL; MORPHOGENESIS; OVARY; SEX CHARACTERISTICS; SEX CHROMOSOMES; SEX DETERMINATION PROCESSES; SEX DIFFERENTIATION; SPECIES SPECIFICITY; TESTIS;

CAPRA HIRCUS; MAMMALIA;

EID: 80455123661     PISSN: 07670974     EISSN: None     Source Type: Journal    
DOI: 10.1051/medsci/20112710014     Document Type: Review

References (38)

1. Badinter E. L'un est I'autre: des relations entre hommes et femmes. Collection Points. Pans: Odile Jacob, 1986.
2. Aristote. De la génération des ammawc. Lme IV. Paris : Les Belles Lettres, 1963.
3. Jacobs PA, Strong JA. A case of human intersexuality having a possible XXy sex-determining mechanism. Nature 1959; 183 : 302-3.
4. Russell LB. Genetics of mammalian sex chromosomes. Science 1961; 133 :1795-803.
5. Jost A. Recherches sur le contrôle hormonal de I'organogè nese sexuelle du lapin et remarques sur certaines malformations de I'appareil génital humain. Gyn Obstet 1950; 49 :44-60.
6. Uhlenhaut N, Jakob S, Anlag K, et al. Somatic sex reprogramming of adult ovaries to testes by F0XL2 ablation. Cell 2009 ; 139 :1130-42.
7. Pannetier M, Pailhoux E. FOXL2, le gardien de I'identité ovarienne. Med Sci (Paris) 2010; 26 : 470-3.
8. S. Kreidberg JA, Sariola H, Loring JM, et al. WT-1 is required for early kidney development. Cell 1993;74:679-91. (Pubitemid 23259748)
9. Luo X, Ikeda y, Parker KL. A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell 1994 ; 77:481-90. (Pubitemid 24153989)
10. Brennan J, Capel B. One tissue, two fates: molecular genetic events that underlie testis versus ovary development. Nat Rev Genet 2004 ; 5 : 509-21. (Pubitemid 38868507)
11. Capel B. The battle of the sexes. Mech Dev 2000; 92:89-103. (Pubitemid 30125964)
12. Sekido R, Lovell-Badge R. Sex determination involves synergistic action of SRy and SF1 on a specific Sox9 enhancer.Nature 2008; 453 : 930-4. (Pubitemid 351832560)
13. Brennan J, Karl J, Capel B. Divergent vascular mechanisms downstream of Sry establish the arterial system in the Xy gonad. Dev Biol 2002; 244 : 418-28. (Pubitemid 34450654)
14. Combes AN, Wilhelm 0, Davidson T, et al. Endothelial cell migration directs testis cord formation. Dev Biol 2009: 326:112-20.
15. Kerr CL, Hill CM, Blumenthal PD, Gearhart JD. Expression of plunpotent stem cell markers in the human fetal ovary. Hum Reprod 2008 ; 23: 589-99. (Pubitemid 351651216)
16. Pannetier M, Fabre S, Batista F, et al. FOXL2 activates P450 aromatase gene transcription: towards a better characterization of the early steps of mammalian ovarian development. J Mol Endocrinol 2006 ; 36 : 399-413. (Pubitemid 43904936)
17. George FW, Wilson JD. Conversion of androgen to estrogen by the human fetal ovary.J Clin Endocrinol Metab 1978 ; 47 : 550-5. (Pubitemid 9010405)
18. Gessler M, Poustka A, Cavenee W, et al. Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping. Nature 1990;343:774-8.
19. PelletierJ, Bruening W, Li F, et al. WT1 mutations contribute to abnormal genital system development and hereditary Wilms' tumour. Nature 1991; 353:431-4. (Pubitemid 21912529)
20. Foster J, Dominguez-Steglich M, Guioli S, etal. Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRy-related gene. Nature 1994;372:525-30. (Pubitemid 24368528)
21. Wagner T, Wirth J, Meyer J, et al. Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRy-related gene SOX9. Cell 1994; 79:1111-20.
22. Chaboissier M, Kobayashi A, Vidal V, et al. Functional analysis of Sox8 and Sox9 during sex determination in the mouse. Development 2004 ; 131:1891-901. (Pubitemid 38702025)
23. Lavery R, Lardenois A, Ranc-Jianmotamedi F, et al. Xy Sox9 embryonic loss-of-function mouse mutants show complete sex reversal and produce partially fertile XY oocytes. Dev Biol 2011; 354 :111-22.
24. Hammes A, Guo JK, Lutsch G, et al. Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation. Cell 2001; 106 : 319-29. (Pubitemid 32772616)
25. Raymond CS, Parker ED, Kettlewell JR, et al. A region of human chromosome 9p required for testis development contains two genes related to known sexual regulators. Hum Mol Genet 1999 ; 8 : 989-96. (Pubitemid 29250886)
26. Ottolenghi C, Veitia R, Quintana-Murci L, et al. The region on 9p associated with 46,Xy sex reversal contains several transcripts expressed in the urogenital system and a novel doublesex-related domain. Genomics 2000; 64:170-8. (Pubitemid 30191986)
27. Raymond CS, Murphy MW, O'Sullivan MG, et al. Dmrtl, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation. Genes Dev 2000 ; 14 : 2587-95.
28. Ottolenghi C, McElreavey K. Deletions of 9p and the quest for a conserved mechanism of sex determination. Mol Genet Metab 2000 ; 71: 397-404.
29. Koopman P. Sex determination: the power of DMRTl. Trends Genet 2009; 25 : 479-81.
30. Zanaria E, Muscatelli F, Bardoni B, et al. An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita. Nature 1994; 372: 635-41.
31. Swam A, Narvaez V, Burgoyne P, et al. Daxl antagonizes Sry action in mammalian sex determination. Nature 1998; 391:761-7. (Pubitemid 28099667)
32. yu RN, Ito M, Saunders TL, et al. Role of Ahch in gonadal development and gametagenesis. Nat Genet 1998 ; 20: 353-7. (Pubitemid 28541632)
33. Pailhoux E, Vigier B, Chaffaux S, et al. A 11.7-kb deletion triggers intersexuality and palledness in goats. Nat Genet 2001; 29 :453-8. (Pubitemid 34326697)
34. Pannetier M, Elzaiat M, Thépot D, et al. Telling the story of XX sex-reversal in the goat: highlighting the sex-crossroad in domestic mammals. Sex Dev 2011 (sous presse).
35. Cnsponi L, Deiana M, Lot A, et al. The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome. Nat Genet 2001; 27 :159-66. (Pubitemid 32157442)
36. Schmidt D, Ovitt C, Anlag K, et al. The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance. Development 2004 ; 131: 933-42. (Pubitemid 38263207)
37. Jordan B. Du bon usage des exomes. Med Sci (Pans) 2010; 26:1111-
38. Matson CK, Murphy MW, Sarver AL, et al. DMRTl prevents female reprogramming in the postnatal mammalian testis. Nature 2011; 476:101-4.