RNA interference-mediated survivin gene knockdown induces growth arrest and reduced migration of vascular smooth muscle cells

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 301, Issue 5, 2011, Pages

  Nabzdyk, Christoph S ^a   Lancero, Hope ^a   Nguyen, Khanh P ^a   Salek, Sherveen ^a   Conte, Michael S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; Cell cycle

Indexed keywords

PLATELET DERIVED GROWTH FACTOR AB; PROTEIN P27; PROTEIN P53; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; SURVIVIN;

ACTIN FILAMENT; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL MIGRATION; CELL PROLIFERATION; CELL SHAPE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DNA CONTENT; GENE EXPRESSION; HUMAN; HUMAN CELL; MITOSIS; PRIORITY JOURNAL; RNA INTERFERENCE; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; VIRAL GENE DELIVERY SYSTEM;

ACTIN CYTOSKELETON; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; CELLS, CULTURED; CHEMOTAXIS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; HYPERPLASIA; INHIBITOR OF APOPTOSIS PROTEINS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PLATELET-DERIVED GROWTH FACTOR; RNA INTERFERENCE; SAPHENOUS VEIN; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 80355127958     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00089.2011     Document Type: Article

References (20)

1. Ambrosini G, Adida C, Altieri DC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 3: 917-921, 1997.
2. Beltrami E, Plescia J, Wilkinson JC, Duckett CS, Altieri DC. Acute ablation of survivin uncovers p53-dependent mitotic checkpoint functions and control of mitochondrial apoptosis. J Biol Chem 279: 2077-2084, 2004.
3. Blanc-Brude OP, Yu J, Simosa H, Conte MS, Sessa WC, Altieri DC. Inhibitor of apoptosis protein survivin regulates vascular injury. Nat Med 8: 987-994, 2002.
4. Connell CM, Wheatley SP, McNeish IA. Nuclear survivin abrogates multiple cell cycle checkpoints and enhances viral oncolysis. Cancer Res 68: 7923-7931, 2008.
5. Dohi T, Beltrami E, Wall NR, Plescia J, Altieri DC. Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis. J Clin Invest 114: 1117-1127, 2004.
6. Fortugno P, Beltrami E, Plescia J, Fontana J, Pradhan D, Marchisio PC, Sessa WC, Altieri DC. Regulation of survivin function by Hsp90. Proc Natl Acad Sci USA 100: 13791-13796, 2003.
7. Fortugno P, Wall NR, Giodini A, O'Connor DS, Plescia J, Padgett KM, Tognin S, Marchisio PC, Altieri DC. Survivin exists in immuno-chemically distinct subcellular pools and is involved in spindle microtu-bule function. J Cell Sci 115: 575-585, 2002.
8. Ghosh JC, Dohi T, Kang BH, Altieri DC. Hsp60 regulation of tumor cell apoptosis. J Biol Chem 283: 5188-5194, 2008.
9. Honda R, Korner R, Nigg EA. Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. Mol Biol Cell 14: 3325-3341, 2003.
10. Kang BH, Plescia J, Dohi T, Rosa J, Doxsey SJ, Altieri DC. Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network. Cell 131: 257-270, 2007.
11. Li F, Ambrosini G, Chu EY, Plescia J, Tognin S, Marchisio PC, Altieri DC. Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 396: 580-584, 1998.
12. McCrann DJ, Yang D, Chen H, Carroll S, Ravid K. Upregulation of Nox4 in the aging vasculature and its association with smooth muscle cell polyploidy. Cell Cycle 8: 902-908, 2009.
13. McKenzie JA, Liu T, Goodson AG, Grossman D. Survivin enhances motility of melanoma cells by supporting Akt activation and a5 integrin upregulation. Cancer Res 70: 7927-7937, 2010.
14. Mehrotra S, Languino LR, Raskett CM, Mercurio AM, Dohi T, Altieri DC. IAP regulation of metastasis. Cancer Cell 17: 53-64, 2010.
15. Mesri M, Wall NR, Li J, Kim RW, Altieri DC. Cancer gene therapy using a survivin mutant adenovirus. J Clin Invest 108: 981-990, 2001.
16. Plescia J, Salz W, Xia F, Pennati M, Zaffaroni N, Daidone MG, Meli M, Dohi T, Fortugno P, Nefedova Y, Gabrilovich DI, Colombo G, Altieri DC. Rational design of shepherdin, a novel anticancer agent. Cancer Cell 7: 457-468, 2005.
17. Simosa HF, Wang G, Sui X, Peterson T, Narra V, Altieri DC, Conte MS. Survivin expression is up-regulated in vascular injury and identifies a distinct cellular phenotype. J Vasc Surg 41: 682-690, 2005.
18. Skoufias DA, Mollinari C, Lacroix FB, Margolis RL. Human survivin is a kinetochore-associated passenger protein. J Cell Biol 151: 1575-1582, 2000.
19. kip1 in vascular smooth muscle cell migration. Circulation 103: 2967- 2972, 2001.
20. Wang GJ, Sui XX, Simosa HF, Jain MK, Altieri DC, Conte MS. Regulation of vein graft hyperplasia by survivin, an inhibitor of apoptosis protein. Arterioscler Thromb Vasc Biol 25: 2081-2087, 2005.