A conductive nanostructured polymer electrodeposited on titanium as a controllable, local drug delivery platform

Journal of Biomedical Materials Research - Part A

Volumn 99 A, Issue 4, 2011, Pages 586-597

  Sirivisoot, Sirinrath ^a,b   Pareta, Rajesh A ^a,b   Webster, Thomas J ^a,b  

^a Brown University   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

bone; fibroblasts; macrophages; nanotechnology; osteoblasts; staphylococcus epidermidis

Indexed keywords

ANTI-INFLAMMATORY DRUGS; BONE-FORMING CELLS; COMMERCIALLY PURE TITANIUMS; DEXAMETHASONES; ELECTRICAL STIMULATIONS; ELECTROCHEMICAL DEPOSITION; FIBROUS TISSUE; FURTHER DEVELOPMENT; IMMUNE RESPONSE; IN-VITRO; LOCAL DRUG DELIVERY; NANO-STRUCTURED; NANOSTRUCTURED POLYMERS; ON-DEMAND DRUG DELIVERY; ORTHOPEDIC IMPLANT; ORTHOPEDIC IMPLANT INFECTIONS; PPY FILMS; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS EPIDERMIS;

BONE; CELL CULTURE; COATINGS; DRUG DELIVERY; ELECTRODEPOSITION; FIBROBLASTS; MACROPHAGES; OSTEOBLASTS; PATHOLOGY; REDUCTION; TISSUE; TITANIUM;

POLYPYRROLES;

DEXAMETHASONE; NANOMATERIAL; PENICILLIN G POTASSIUM PLUS PROCAINE PENICILLIN PLUS STREPTOMYCIN SULFATE; POLYMER; POLYPYRROLE; TITANIUM;

ANIMAL CELL; ARTICLE; BACTERICIDAL ACTIVITY; CELL DENSITY; CELL PROLIFERATION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; FIBROBLAST; FUNCTIONAL ELECTRICAL STIMULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MACROPHAGE; MOUSE; NONHUMAN; OSTEOBLAST; STAPHYLOCOCCUS EPIDERMIDIS; TREATMENT RESPONSE;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS; COATED MATERIALS, BIOCOMPATIBLE; DEXAMETHASONE; DRUG DELIVERY SYSTEMS; ELECTRIC STIMULATION; FIBROBLASTS; HUMANS; MACROPHAGES; MATERIALS TESTING; MICE; NANOSTRUCTURES; NIH 3T3 CELLS; OSTEOBLASTS; PENICILLINS; POLYMERS; PROSTHESES AND IMPLANTS; PYRROLES; STAPHYLOCOCCUS EPIDERMIDIS; STREPTOMYCIN; SURFACE PROPERTIES; TITANIUM;

EID: 80255141928     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.33210     Document Type: Article

References (64)

1. Heeger AJ,. Semiconducting and metallic polymers: The fourth generation of polymeric materials. J Phys Chem B 2001; 105: 8475-8491. (Pubitemid 35338780)
2. Sirivisoot S, Pareta R, Webster TJ,. Electrically controlled drug release from nanostructured polypyrrole coated on titanium. Nanotechnology 2011; 22: 085101.
3. Abidian MR, Kim DH, Martin DC,. Conducting-polymer nanotubes for controlled drug release. Adv Mater 2006; 18: 405-409.
4. Luo X, Cui XT,. Sponge-like nanostructured conducting polymers for electrically controlled drug release. Electrochem Commun 2009; 11: 1956.
5. Wadhwa R, Lagenaur CF, Cui XT,. Electrochemically controlled release of dexamethasone from conducting polymer polypyrrole coated electrode. J Controlled Release 2006; 110: 531-541. (Pubitemid 43163443)
6. Abidian MR, Martin DC,. Experimental and theoretical characterization of implantable neural microelectrodes modified with conducting polymer nanotubes. Biomaterials 2008; 29: 1273-1283.
7. Cui X, Wiler J, Dzaman M, Altschuler RA, Martin DC,. In vivo studies of polypyrrole/peptide coated neural probes. Biomaterials 2003; 24: 777-787. (Pubitemid 35449830)
8. Lee JY, Bashur CA, Goldstein AS, Schmidt CE,. Polypyrrole-coated electrospun PLGA nanofibers for neural tissue applications. Biomaterials 2009; 30: 4325-4335.
9. Li M, Guo Y, Wei Y, MacDiarmid AG, Lelkes PI,. Electrospinning polyaniline-contained gelatin nanofibers for tissue engineering applications. Biomaterials 2006; 27: 2705-2715. (Pubitemid 43122074)
10. Waugaman M, Sannigrahi B, McGeady P, Khan IM,. Synthesis, characterization and biocompatibility studies of oligosiloxane modified polythiophenes. Eur Polym J 2003; 39: 1405-1412.
11. Rivers TJ, Hudson TW, Schmidt CE,. Synthesis of a novel, biodegradable electrically conducting polymer for biomedical applications. Adv Funct Mater 2002; 12: 33-37. (Pubitemid 34125070)
12. Spinks GM, Mottaghitalab V, Bahrami-Samani M, Whitten PG, Wallace GG,. Carbon-nanotube-reinforced polyaniline fibers for high-strength artificial muscles. Adv Mater 2006; 18: 637-640. (Pubitemid 43385787)
13. Spinks GM, Campbell TE, Wallace GG,. Force generation from polypyrrole actuators. Smart Mater Struct 2005; 14: 406-412. (Pubitemid 40541033)
14. Wong JY, Langer R, Ingber DE,. Electrically conducting polymers can noninvasively control the shape and growth of mammalian cells. PNAS 1994; 91: 3201-3204. (Pubitemid 24130203)
15. Kotwal A, Schmidt CE,. Electrical stimulation alters protein adsorption and nerve cell interactions with electrically conducting biomaterials. Biomaterials 2001; 22: 1055-1064. (Pubitemid 32229931)
16. Gomez N, Schmidt CE,. Nerve growth factor-immobilized polypyrrole: Bioactive electrically conducting polymer for enhanced neurite extension. J Biomed Mater Res A 2007; 81A: 135-149. (Pubitemid 46435461)
17. Thompson BC, Richardson RT, Moulton SE, Evans AJ, O'Leary S, Clark GM, Wallace GG,. Conducting polymers, dual neurotrophins and pulsed electrical stimulation-Dramatic effects on neurite outgrowth. J Control Release 2010; 141: 161-167.
18. Li YL, Neoh KG, Kang ET,. Controlled release of heparin from polypyrrole-poly(vinyl alcohol) assembly by electrical stimulation. J Biomed Mater Res A 2005; 73A: 171-181. (Pubitemid 40571539)
19. Winkler H, Kaudela K, Stoiber A, Menschik F,. Bone grafts impregnated with antibiotics as a tool for treating infected implants in orthopedic surgery-One stage revision results. Cell Tissue Bank 2006; 7: 319-323. (Pubitemid 44724555)
20. Lew PDP, Waldvogel PFA,. Osteomyelitis. The Lancet 2004; 364: 369-379. (Pubitemid 38976521)
21. Campoccia D, Montanaro L, Arciola CR,. The significance of infection related to orthopedic devices and issues of antibiotic resistance. Biomaterials 2006; 27: 2331-2339. (Pubitemid 41821812)
22. Fisman DN, Reilly DT, Karchmer AW, Goldie SJ,. Clinical effectiveness and cost-effectiveness of 2 management strategies for infected total hip arthroplasty in the elderly. Clin Infect Dis 2001; 32: 419-430. (Pubitemid 32173628)
23. Trebse R, Pisot V, Trampuz A,. Treatment of infected retained implants. J Bone Joint Surg Br 2005; 87: 249-256. (Pubitemid 40278028)
24. Ratner BD,. Biomaterials Science: An Introduction to Materials in Medicine. Amsterdam, Boston: Elsevier Academic Press; 2004. 864 p.
25. Goodman SB,. Wear particles, periprosthetic osteolysis and the immune system. Biomaterials 2007; 28: 5044-5048. (Pubitemid 47488481)
26. Poon M, Gertz SD, Fallon JT, Wiegman P, Berman JW, Sarembock IJ, Taubman MB,. Dexamethasone inhibits macrophage accumulation after balloon arterial injury in cholesterol fed rabbits. Atherosclerosis 2001; 155: 371-380. (Pubitemid 32209307)
27. Gewert K, Tapper H, Naucler C, Sundler R,. Dexamethasone downregulates lysosomal secretion in mouse macrophages: Involvement of signaling through protein kinase C. J Inflamm 1995; 47: 115-125. (Pubitemid 27057414)
28. Cheng S, Yang J, Rifas L, Zhang S, Avioli L,. Differentiation of human bone marrow osteogenic stromal cells in vitro: Induction of the osteoblast phenotype by dexamethasone. Endocrinology 1994; 134: 277-286. (Pubitemid 24021999)
29. Trampuz A, Zimmerli W,. Diagnosis and treatment of infections associated with fracture-fixation devices. Injury 2006; 37 (Suppl 1): S59-S66.
30. Edin ML, Miclau T, Lester GE, Lindsey RW, Dahners LE,. Effect of cefazolin and vancomycin on osteoblasts in vitro. Clin Orthop Relat Res 1996; 333: 245-251. (Pubitemid 26428036)
31. Miclau T, Edin ML, Lester GE, Lindsey RW, Dahners LE,. Bone toxicity of locally applied aminoglycosides. J Orthop Trauma 1995; 9: 401-406.
32. Salzmann GM, Naal FD, von Knoch F, Tuebel J, Gradinger R, Imhoff AB, Schauwecker J,. Effects of cefuroxime on human osteoblasts in vitro. J Biomed Mater Res A 2007; 82A: 462-468. (Pubitemid 47051678)
33. Krisanapiboon A, Buranapanitkit B, Oungbho K,. Biocompatability of hydroxyapatite composite as a local drug delivery system. J Orthop Surg 2006; 14: 315-318.
34. Wang Z, Roberge C, Dao LH, Wan Y, Shi G, Rouabhia M, Guidoin R, Zhang Z,. In vivo evaluation of a novel electrically conductive polypyrrole/poly(D,L -lactide) composite and polypyrrole-coated poly(D,L -lactide-co-glycolide) membranes. J Biomed Mater Res A 2004; 70A: 28-38. (Pubitemid 38849810)
35. Wang Z, Roberge C, Wan Y, Dao LH, Guidoin R, Zhang Z,. A biodegradable electrical bioconductor made of polypyrrole nanoparticle/poly(D,L -lactide) composite: A preliminary in vitro biostability study. J Biomed Mater Res A 2003; 66A: 738-746. (Pubitemid 37521397)
36. Durgam H, Sapp S, Deister C, Khaing Z, Chang E, Luebben S, Schmidt CE,. Novel degradable co-polymers of polypyrrole support cell proliferation and enhance neurite out-growth with electrical stimulation. J Biomater Sci Polym Ed 2010; 21: 1265-1282.
37. Shi G, Zhang Z, Rouabhia M,. The regulation of cell functions electrically using biodegradable polypyrrole-polylactide conductors. Biomaterials 2008; 29: 3792-3798.
38. Shi G, Rouabhia M, Wang Z, Dao LH, Zhang Z,. A novel electrically conductive and biodegradable composite made of polypyrrole nanoparticles and polylactide. Biomaterials 2004; 25: 2477-2488. (Pubitemid 38147438)
39. Rücker M, Laschke MW, Junker D, Carvalho C, Schramm A, Mülhaupt R, Gellrich N-C, Menger MD,. Angiogenic and inflammatory response to biodegradable scaffolds in dorsal skinfold chambers of mice. Biomaterials 2006; 27: 5027-5038. (Pubitemid 43949420)
40. Noerr B,. Dexamethasone. Neonatal Netw 1997; 16 (8): 67-70.
41. Chiara O, Padalino P, Fattori L, Ravizzini C, Turconi MG, Tiberio G,. Classical corticosteroids and new lipid peroxidation inhibitors in the therapy of multiple organ failure (MOF). Minerva Chir 1997; 52: 1095-1102. (Pubitemid 27489166)
42. Pauletto N, Silver JG, Larjava H,. Nonsteroidal anti-inflammatory agents: Potential modifiers of periodontal disease progression. J Can Dent Assoc 1997; 63: 824-829, 832.
43. Hickey T, Kreutzer D, Burgess DJ, Moussy F,. In vivo evaluation of a dexamethasone/PLGA microsphere system designed to suppress the inflammatory tissue response to implantable medical devices. J Biomed Mater Res 2002; 61: 180-187. (Pubitemid 34602364)
44. Ramanaviciene A, Kausaite A, Tautkus S, Ramanavicius A,. Biocompatibility of polypyrrole particles: An in-vivo study in mice. J Pharm Pharmacol 2007; 59: 311-315. (Pubitemid 46203069)
45. Wang X, Gu X, Yuan C, Chen S, Zhang P, Zhang T, Yao J, Chen F, Chen G,. Evaluation of biocompatibility of polypyrrole in vitro and in vivo. J Biomed Mater Res A 2004; 68A: 411-422. (Pubitemid 38250362)
46. Eberhardt A, Szczypiorski P, Korytowski G,. Effect of transcutaneous electrostimulation on the cell composition of skin exudate. Acta Physiol Pol 1986; 37: 41-46.
47. Mertz PM, Davis SC, Cazzaniga AL, Cheng K, Reich JD, Eaglstein WH,. Electrical stimulation: Acceleration of soft tissue repair by varying polarity. Wounds 1993; 5: 153-159.
48. Supronowicz PR, Ajayan PM, Ullmann KR, Arulanandam BP, Metzger DW, Bizios R,. Novel current-conducting composite substrates for exposing osteoblasts to alternating current stimulation. J Biomed Mater Res 2002; 59: 499-506. (Pubitemid 34037494)
49. Fang KS, Ionides E, Oster G, Nuccitelli R, Isseroff RR,. Epidermal growth factor receptor relocalization and kinase activity are necessary for directional migration of keratinocytes in DC electric fields. J Cell Sci 1999; 112: 1967-1978. (Pubitemid 29338821)
50. Bedlack RSJ, Wei MD, Loew LM,. Localized membrane depolarizations and localized calcium influx during electric field-guided neurite growth. Neuron 1992; 9: 393-403.
51. Onuma EK, Hui SW,. Electric field-directed cell shape changes, displacement, and cytoskeletal reorganization are calcium dependent. J Cell Biol 1988; 106: 2067-2075.
52. Luther PW, Peng HB, Lin JJ-C,. Changes in cell shape and actin distribution induced by constant electric fields. Nature 1983; 303: 61-64. (Pubitemid 13125072)
53. Baker LP, Peng HB,. Tyrosine phosphorylation and acetylcholine receptor cluster formation in cultured Xenopus muscle cells. J Cell Biol 1993; 120: 185-195.
54. Peng HB, Baker LP, Dai Z,. A role of tyrosine phosphorylation in the formation of acetylcholine receptor clusters induced by electric fields in cultured Xenopus muscle cells. J Cell Biol 1993; 120: 197-204. (Pubitemid 23014079)
55. Daeschlein G, Assadian O, Kloth LC, Meinl C, Ney F, Kramer A,. Antibacterial activity of positive and negative polarity low-voltage pulsed current (LVPC) on six typical Gram-positive and Gram-negative bacterial pathogens of chronic wounds. Wound Repair Regen 2007; 15: 399-403. (Pubitemid 46817416)
56. Merriman HL, Hegyi CA, Albright-Overton CR, Carlos J Jr, Putnam RW, Mulcare JA,. A comparison of four electrical stimulation types on Staphylococcus aureus growth in vitro. J Rehabil Res Dev 2004; 41: 139-146. (Pubitemid 38715860)
57. Bassett CA, Becker RO,. Generation of electric potentials by bone in response to mechanical stress. Science 1962; 137: 1063-1064.
58. McLeod KJ, Donahue HJ, Levin PE, Fontaine M-A, Rubin CT,. Electric fields modulate bone cell function in a density-dependent manner. J Bone Miner Res 1993; 8: 977-984. (Pubitemid 23219387)
59. Fredericks DC, Smucker J, Petersen EB, Bobst JA, Gan JC, Simon BJ, Glazer P,. Effects of direct current electrical stimulation on gene expression of osteopromotive factors in a posterolateral spinal fusion model. Spine 2007; 32: 174-181. (Pubitemid 46115953)
60. Gan JC, Glazer PA,. Electrical stimulation therapies for spinal fusions: Current concepts. Eur Spine J 2006; 15: 1301-1311. (Pubitemid 44379272)
61. Kloth LC,. Electrical stimulation for wound healing: A review of evidence from in vitro studies, animal experiments, and clinical trials. Int J Low Extrem Wounds 2005; 4: 23-44. (Pubitemid 41435504)
62. Alvaro M, Kumar D, Julka IS,. Transcutaneous electrostimulation: Emerging treatment for diabetic neuropathic pain. Diabetes Technol Ther 1999; 1: 77-80.
63. Sirivisoot S, Webster TJ,. Multiwalled carbon nanotubes enhance electrochemical properties of titanium to determine in situ bone formation. Nanotechnology 2008; 19: 295101.
64. Sirivisoot S, Yao C, Xiao X, Sheldon BW, Webster TJ,. Greater osteoblast functions on multiwalled carbon nanotubes grown from anodized nanotubular titanium for orthopedic applications. Nanotechnology 2007; 18: 365102.