Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 23, 2011, Pages 7205-7209

  Yun, Weiya ^a   Ahmad, Mushtaq ^a   Chen, Yingsi ^a   Gillespie, Paul ^a   Conde Knape, Karin ^a   Kazmer, Sonja ^a   Li, Shiming ^a   Qian, Yimin ^a   Taub, Rebecca ^b   Wertheimer, Stanley J ^a   Whittard, Toni ^a   Bolin, David ^a  

^a HOFFMANN LA ROCHE INC   (United States)

^b Via Pharmaceuticals Inc ^*  (United States)

Author keywords

DGAT 1 inhibitor; Obesity; Phenyloxazole

Indexed keywords

2 PHENYL 5 (TRIFLUOROMETHYL)OXAZOLE AMIDE; 2 PHENYLOXAZOLE 4 CARBOXAMIDE; DIACYLGLYCEROL ACYLTRANSFERASE 1; DIACYLGLYCEROL KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DOSE RESPONSE; DRUG CLEARANCE; DRUG DEVELOPMENT; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG SOLUBILITY; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; NONHUMAN; OBESITY; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; BODY WEIGHT; DIACYLGLYCEROL O-ACYLTRANSFERASE; DISEASE MODELS, ANIMAL; DRUG DISCOVERY; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MOLECULAR STRUCTURE; OBESITY; OXAZOLES; RATS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 80255140429     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.09.039     Document Type: Article

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