New alkaloid antibiotics that target the DNA topoisomerase I of Streptococcus pneumoniae

Journal of Biological Chemistry

Volumn 286, Issue 8, 2011, Pages 6402-6413

  García, María Teresa ^a   Blázquez, María Amparo ^b   Ferrándiz, María José ^a   Sanz, María Jesú S ^b   Silva Martín, Noella ^c   Hermoso, Juan A ^c   De La Campa, Adela G ^a  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

^c INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL GROWTH; BOLDINE; DNA TOPOISOMERASE; DNA TOPOISOMERASE I; DOCKING CALCULATIONS; EQUIVALENT CONCENTRATIONS; FLUOROQUINOLONES; GROWTH INHIBITION; HUMAN CELLS; IN-VIVO; INHIBITORY EFFECT; NUCLEOTIDE-BINDING SITES; PROTEIN CONFORMATION; STREPTOCOCCUS PNEUMONIAE; STRONG INTERACTION; SUPERCOILING; TARGET TYPE; TOPOISOMERASE I; TOPOISOMERASES; TYPE II;

ANIMAL CELL CULTURE; ANTHRACENE; ANTIBIOTICS; CELL CULTURE; CELL GROWTH; CRYSTAL STRUCTURE; DNA; DRUG THERAPY; ENZYMES; ESCHERICHIA COLI; GROWTH KINETICS; METABOLITES; NITROGEN COMPOUNDS; NUCLEIC ACIDS;

ENZYME INHIBITION;

APORPHINE DERIVATIVE; BOLDINE; CHLORAMPHENICOL; CIPROFLOXACIN; CLINDAMYCIN; COTRIMOXAZOLE; DNA TOPOISOMERASE; ERYTHROMYCIN; N METHYLSECONEOLITSINE; NEOLITSINE; PENICILLIN G; PHENANTHRENE DERIVATIVE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SECOBOLDINE; SECONEOLITSINE; SULFAMETHOXAZOLE; TETRACYCLINE; TRIMETHOPRIM; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; BINDING AFFINITY; CELL GROWTH; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SUPERCOILING; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PARTIAL DRUG SYNTHESIS; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE;

ALKALOIDS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CELL LINE; DNA TOPOISOMERASES, TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, MOLECULAR; PHENANTHRENES; PROTEIN STRUCTURE, TERTIARY; STREPTOCOCCUS PNEUMONIAE; TOPOISOMERASE I INHIBITORS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; STREPTOCOCCUS PNEUMONIAE;

EID: 79953189416     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.148148     Document Type: Article

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