Synthesis and biological evaluation of arylated novobiocin analogs as Hsp90 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 23, 2011, Pages 7170-7174

  Kusuma, Bhaskar Reddy ^a   Duerfeldt, Adam S ^a   Blagg, Brian S J ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

Chaperone; Hsp90; Inhibitors; Novobiocin

Indexed keywords

ANTINEOPLASTIC AGENT; AROMATIC COMPOUND; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; NOVOBIOCIN DERIVATIVE; SUGAR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; ARYLATION; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; IC 50; PROTEIN DEGRADATION; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MOLECULAR STRUCTURE; NOVOBIOCIN;

EID: 80255138632     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.09.073     Document Type: Article

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